Hearing Impairment in Parkinson's Disease: Expanding the Nonmotor Phenotype
Identifieur interne : 000053 ( PascalFrancis/Corpus ); précédent : 000052; suivant : 000054Hearing Impairment in Parkinson's Disease: Expanding the Nonmotor Phenotype
Auteurs : Carmine Vitale ; Vincenzo Marcelli ; Roberto Allocca ; Gabriella Santangelo ; Pasquale Riccardi ; Roberto Erro ; Marianna Amboni ; Maria Teresa Pellecchia ; Autilia Cozzolino ; Katia Longo ; Marina Picillo ; Marcello Moccia ; Valeria Agosti ; G. Sorrentino ; Michele Cavaliere ; Elio Marciano ; Paolo BaroneSource :
- Movement disorders [ 0885-3185 ] ; 2012.
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Abstract
The objective of this study was to evaluate hearing impairment in patients affected by Parkinson's disease compared with hearing scores observed in normal age- and sex-matched controls. One hundred eighteen consecutive patients with a clinical diagnosis of Parkinson's disease were screened. Severity of motor symptoms and staging were measured with the Unified Parkinson's Disease Rating Scale (section III) and the Hoehn and Yahr scale. Audiometric evaluation consisted of a comprehensive audiologic case history and questionnaire, visual otoscopic examination, acoustic immittance measures (tympanogram and acoustic reflexes), pure tone audiometry, and measurement of brain stem auditory-evoked potentials. Healthy age- and sex-matched subjects were selected as the control group. One hundred six of 118 patients were enrolled. Pure tone audiometry revealed age-dependent high-frequency hearing loss in patients with Parkinson's disease compared with both normative values and values for healthy age- and sex-matched controls (75/106 [71%], χ2 = 5.959, P = .02; 92/106 [86.8%] vs 60/106 [56.6%], χ2 = 23.804, P < .001, respectively). Pure tone audiometry scores correlated with Hoehn and Yahr scale scores (P < .05). Brain stem auditory-evoked potentials were normal in all patients. Our patients with Parkinson's disease showed age-dependent peripheral, unilateral, or bilateral hearing impairment. Whether these auditory deficits are intrinsic to Parkinson's disease or secondary to a more complex impaired processing of sensorial inputs occurring over the course of illness remains to be determined. Because α-synuclein is located predominately in the efferent neuronal system within the inner ear, it could affect susceptibility to noise-induced hearing loss or presbycusis. It is feasible that the natural aging process combined with neurodegenerative changes intrinsic to Parkinson's disease might interfere with cochlear transduction mechanisms, thus anticipating presbycusis.
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Format Inist (serveur)
| NO : | PASCAL 12-0423954 INIST |
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| ET : | Hearing Impairment in Parkinson's Disease: Expanding the Nonmotor Phenotype |
| AU : | VITALE (Carmine); MARCELLI (Vincenzo); ALLOCCA (Roberto); SANTANGELO (Gabriella); RICCARDI (Pasquale); ERRO (Roberto); AMBONI (Marianna); PELLECCHIA (Maria Teresa); COZZOLINO (Autilia); LONGO (Katia); PICILLO (Marina); MOCCIA (Marcello); AGOSTI (Valeria); SORRENTINO (G.); CAVALIERE (Michele); MARCIANO (Elio); BARONE (Paolo) |
| AF : | University of Naples "Parthenope,"/Naples/Italie (1 aut., 7 aut., 13 aut., 14 aut.); IDC, Hermitage Capodimonte/Naples/Italie (1 aut., 4 aut., 7 aut., 10 aut., 13 aut., 14 aut., 17 aut.); Audiology and Vestibology Unit, Department of Neuroscience, University of Naples Federico II/Naples/Italie (2 aut., 3 aut., 5 aut., 16 aut.); Department of Psychology, Second University of Naples/Caserta/Italie (4 aut.); Department of Neurological Sciences, University of Naples Federico II/Naples/Italie (6 aut., 8 aut., 9 aut., 10 aut., 11 aut., 12 aut.); Neurodegenerative Diseases Center, University of Salerno/Salerno/Italie (9 aut., 17 aut.); Department of Otolaryngology, University of Naples Federico II/Naples/Italie (15 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 12; Pp. 1530-1535; Bibl. 40 ref. |
| LA : | Anglais |
| EA : | The objective of this study was to evaluate hearing impairment in patients affected by Parkinson's disease compared with hearing scores observed in normal age- and sex-matched controls. One hundred eighteen consecutive patients with a clinical diagnosis of Parkinson's disease were screened. Severity of motor symptoms and staging were measured with the Unified Parkinson's Disease Rating Scale (section III) and the Hoehn and Yahr scale. Audiometric evaluation consisted of a comprehensive audiologic case history and questionnaire, visual otoscopic examination, acoustic immittance measures (tympanogram and acoustic reflexes), pure tone audiometry, and measurement of brain stem auditory-evoked potentials. Healthy age- and sex-matched subjects were selected as the control group. One hundred six of 118 patients were enrolled. Pure tone audiometry revealed age-dependent high-frequency hearing loss in patients with Parkinson's disease compared with both normative values and values for healthy age- and sex-matched controls (75/106 [71%], χ2 = 5.959, P = .02; 92/106 [86.8%] vs 60/106 [56.6%], χ2 = 23.804, P < .001, respectively). Pure tone audiometry scores correlated with Hoehn and Yahr scale scores (P < .05). Brain stem auditory-evoked potentials were normal in all patients. Our patients with Parkinson's disease showed age-dependent peripheral, unilateral, or bilateral hearing impairment. Whether these auditory deficits are intrinsic to Parkinson's disease or secondary to a more complex impaired processing of sensorial inputs occurring over the course of illness remains to be determined. Because α-synuclein is located predominately in the efferent neuronal system within the inner ear, it could affect susceptibility to noise-induced hearing loss or presbycusis. It is feasible that the natural aging process combined with neurodegenerative changes intrinsic to Parkinson's disease might interfere with cochlear transduction mechanisms, thus anticipating presbycusis. |
| CC : | 002B17; 002B17G |
| FD : | Trouble de l'audition; Maladie de Parkinson; Pathologie du système nerveux; Phénotype; Son pur; Audiométrie |
| FG : | Pathologie ORL; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
| ED : | Auditory disorder; Parkinson disease; Nervous system diseases; Phenotype; Pure tone; Audiometry |
| EG : | ENT disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
| SD : | Trastorno auditivo; Parkinson enfermedad; Sistema nervioso patología; Fenotipo; Sonido puro; Audiometría |
| LO : | INIST-20953.354000502081650110 |
| ID : | 12-0423954 |
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Sorrentino</name><affiliation><inist:fA14 i1="01"><s1>University of Naples "Parthenope,"</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cavaliere, Michele" sort="Cavaliere, Michele" uniqKey="Cavaliere M" first="Michele" last="Cavaliere">Michele Cavaliere</name><affiliation><inist:fA14 i1="07"><s1>Department of Otolaryngology, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Marciano, Elio" sort="Marciano, Elio" uniqKey="Marciano E" first="Elio" last="Marciano">Elio Marciano</name><affiliation><inist:fA14 i1="03"><s1>Audiology and Vestibology Unit, Department of Neuroscience, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Neurodegenerative Diseases Center, University of Salerno</s1><s2>Salerno</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0423954</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0423954 INIST</idno><idno type="RBID">Pascal:12-0423954</idno><idno type="wicri:Area/PascalFrancis/Corpus">000053</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Hearing Impairment in Parkinson's Disease: Expanding the Nonmotor Phenotype</title><author><name sortKey="Vitale, Carmine" sort="Vitale, Carmine" uniqKey="Vitale C" first="Carmine" last="Vitale">Carmine Vitale</name><affiliation><inist:fA14 i1="01"><s1>University of Naples "Parthenope,"</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Marcelli, Vincenzo" sort="Marcelli, Vincenzo" uniqKey="Marcelli V" first="Vincenzo" last="Marcelli">Vincenzo Marcelli</name><affiliation><inist:fA14 i1="03"><s1>Audiology and Vestibology Unit, Department of Neuroscience, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Allocca, Roberto" sort="Allocca, Roberto" uniqKey="Allocca R" first="Roberto" last="Allocca">Roberto Allocca</name><affiliation><inist:fA14 i1="03"><s1>Audiology and Vestibology Unit, Department of Neuroscience, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Santangelo, Gabriella" sort="Santangelo, Gabriella" uniqKey="Santangelo G" first="Gabriella" last="Santangelo">Gabriella Santangelo</name><affiliation><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>Department of Psychology, Second University of Naples</s1><s2>Caserta</s2><s3>ITA</s3><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Riccardi, Pasquale" sort="Riccardi, Pasquale" uniqKey="Riccardi P" first="Pasquale" last="Riccardi">Pasquale Riccardi</name><affiliation><inist:fA14 i1="03"><s1>Audiology and Vestibology Unit, Department of Neuroscience, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Erro, Roberto" sort="Erro, Roberto" uniqKey="Erro R" first="Roberto" last="Erro">Roberto Erro</name><affiliation><inist:fA14 i1="05"><s1>Department of Neurological Sciences, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Amboni, Marianna" sort="Amboni, Marianna" uniqKey="Amboni M" first="Marianna" last="Amboni">Marianna Amboni</name><affiliation><inist:fA14 i1="01"><s1>University of Naples "Parthenope,"</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name><affiliation><inist:fA14 i1="05"><s1>Department of Neurological Sciences, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name><affiliation><inist:fA14 i1="05"><s1>Department of Neurological Sciences, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Neurodegenerative Diseases Center, University of Salerno</s1><s2>Salerno</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name><affiliation><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>Department of Neurological Sciences, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Picillo, Marina" sort="Picillo, Marina" uniqKey="Picillo M" first="Marina" last="Picillo">Marina Picillo</name><affiliation><inist:fA14 i1="05"><s1>Department of Neurological Sciences, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Moccia, Marcello" sort="Moccia, Marcello" uniqKey="Moccia M" first="Marcello" last="Moccia">Marcello Moccia</name><affiliation><inist:fA14 i1="05"><s1>Department of Neurological Sciences, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Agosti, Valeria" sort="Agosti, Valeria" uniqKey="Agosti V" first="Valeria" last="Agosti">Valeria Agosti</name><affiliation><inist:fA14 i1="01"><s1>University of Naples "Parthenope,"</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Sorrentino, G" sort="Sorrentino, G" uniqKey="Sorrentino G" first="G." last="Sorrentino">G. Sorrentino</name><affiliation><inist:fA14 i1="01"><s1>University of Naples "Parthenope,"</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cavaliere, Michele" sort="Cavaliere, Michele" uniqKey="Cavaliere M" first="Michele" last="Cavaliere">Michele Cavaliere</name><affiliation><inist:fA14 i1="07"><s1>Department of Otolaryngology, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Marciano, Elio" sort="Marciano, Elio" uniqKey="Marciano E" first="Elio" last="Marciano">Elio Marciano</name><affiliation><inist:fA14 i1="03"><s1>Audiology and Vestibology Unit, Department of Neuroscience, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><inist:fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Neurodegenerative Diseases Center, University of Salerno</s1><s2>Salerno</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Audiometry</term><term>Auditory disorder</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Phenotype</term><term>Pure tone</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Trouble de l'audition</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Phénotype</term><term>Son pur</term><term>Audiométrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to evaluate hearing impairment in patients affected by Parkinson's disease compared with hearing scores observed in normal age- and sex-matched controls. One hundred eighteen consecutive patients with a clinical diagnosis of Parkinson's disease were screened. Severity of motor symptoms and staging were measured with the Unified Parkinson's Disease Rating Scale (section III) and the Hoehn and Yahr scale. Audiometric evaluation consisted of a comprehensive audiologic case history and questionnaire, visual otoscopic examination, acoustic immittance measures (tympanogram and acoustic reflexes), pure tone audiometry, and measurement of brain stem auditory-evoked potentials. Healthy age- and sex-matched subjects were selected as the control group. One hundred six of 118 patients were enrolled. Pure tone audiometry revealed age-dependent high-frequency hearing loss in patients with Parkinson's disease compared with both normative values and values for healthy age- and sex-matched controls (75/106 [71%],<sub> </sub>χ<sup>2</sup> = 5.959, P = .02; 92/106 [86.8%] vs 60/106 [56.6%], χ<sup>2</sup> = 23.804, P < .001, respectively). Pure tone audiometry scores correlated with Hoehn and Yahr scale scores (P < .05). Brain stem auditory-evoked potentials were normal in all patients. Our patients with Parkinson's disease showed age-dependent peripheral, unilateral, or bilateral hearing impairment. Whether these auditory deficits are intrinsic to Parkinson's disease or secondary to a more complex impaired processing of sensorial inputs occurring over the course of illness remains to be determined. Because α-synuclein is located predominately in the efferent neuronal system within the inner ear, it could affect susceptibility to noise-induced hearing loss or presbycusis. It is feasible that the natural aging process combined with neurodegenerative changes intrinsic to Parkinson's disease might interfere with cochlear transduction mechanisms, thus anticipating presbycusis.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>27</s2></fA05><fA06><s2>12</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Hearing Impairment in Parkinson's Disease: Expanding the Nonmotor Phenotype</s1></fA08><fA11 i1="01" i2="1"><s1>VITALE (Carmine)</s1></fA11><fA11 i1="02" i2="1"><s1>MARCELLI (Vincenzo)</s1></fA11><fA11 i1="03" i2="1"><s1>ALLOCCA (Roberto)</s1></fA11><fA11 i1="04" i2="1"><s1>SANTANGELO (Gabriella)</s1></fA11><fA11 i1="05" i2="1"><s1>RICCARDI (Pasquale)</s1></fA11><fA11 i1="06" i2="1"><s1>ERRO (Roberto)</s1></fA11><fA11 i1="07" i2="1"><s1>AMBONI (Marianna)</s1></fA11><fA11 i1="08" i2="1"><s1>PELLECCHIA (Maria Teresa)</s1></fA11><fA11 i1="09" i2="1"><s1>COZZOLINO (Autilia)</s1></fA11><fA11 i1="10" i2="1"><s1>LONGO (Katia)</s1></fA11><fA11 i1="11" i2="1"><s1>PICILLO (Marina)</s1></fA11><fA11 i1="12" i2="1"><s1>MOCCIA (Marcello)</s1></fA11><fA11 i1="13" i2="1"><s1>AGOSTI (Valeria)</s1></fA11><fA11 i1="14" i2="1"><s1>SORRENTINO (G.)</s1></fA11><fA11 i1="15" i2="1"><s1>CAVALIERE (Michele)</s1></fA11><fA11 i1="16" i2="1"><s1>MARCIANO (Elio)</s1></fA11><fA11 i1="17" i2="1"><s1>BARONE (Paolo)</s1></fA11><fA14 i1="01"><s1>University of Naples "Parthenope,"</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></fA14><fA14 i1="02"><s1>IDC, Hermitage Capodimonte</s1><s2>Naples</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ></fA14><fA14 i1="03"><s1>Audiology and Vestibology Unit, Department of Neuroscience, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>16 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Psychology, Second University of Naples</s1><s2>Caserta</s2><s3>ITA</s3><sZ>4 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Neurological Sciences, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></fA14><fA14 i1="06"><s1>Neurodegenerative Diseases Center, University of Salerno</s1><s2>Salerno</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>17 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Otolaryngology, University of Naples Federico II</s1><s2>Naples</s2><s3>ITA</s3><sZ>15 aut.</sZ></fA14><fA20><s1>1530-1535</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000502081650110</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>40 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0423954</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>The objective of this study was to evaluate hearing impairment in patients affected by Parkinson's disease compared with hearing scores observed in normal age- and sex-matched controls. One hundred eighteen consecutive patients with a clinical diagnosis of Parkinson's disease were screened. Severity of motor symptoms and staging were measured with the Unified Parkinson's Disease Rating Scale (section III) and the Hoehn and Yahr scale. Audiometric evaluation consisted of a comprehensive audiologic case history and questionnaire, visual otoscopic examination, acoustic immittance measures (tympanogram and acoustic reflexes), pure tone audiometry, and measurement of brain stem auditory-evoked potentials. Healthy age- and sex-matched subjects were selected as the control group. One hundred six of 118 patients were enrolled. Pure tone audiometry revealed age-dependent high-frequency hearing loss in patients with Parkinson's disease compared with both normative values and values for healthy age- and sex-matched controls (75/106 [71%],<sub> </sub>χ<sup>2</sup> = 5.959, P = .02; 92/106 [86.8%] vs 60/106 [56.6%], χ<sup>2</sup> = 23.804, P < .001, respectively). Pure tone audiometry scores correlated with Hoehn and Yahr scale scores (P < .05). Brain stem auditory-evoked potentials were normal in all patients. Our patients with Parkinson's disease showed age-dependent peripheral, unilateral, or bilateral hearing impairment. Whether these auditory deficits are intrinsic to Parkinson's disease or secondary to a more complex impaired processing of sensorial inputs occurring over the course of illness remains to be determined. Because α-synuclein is located predominately in the efferent neuronal system within the inner ear, it could affect susceptibility to noise-induced hearing loss or presbycusis. It is feasible that the natural aging process combined with neurodegenerative changes intrinsic to Parkinson's disease might interfere with cochlear transduction mechanisms, thus anticipating presbycusis.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Trouble de l'audition</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Auditory disorder</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Trastorno auditivo</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Phénotype</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Phenotype</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Fenotipo</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Son pur</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Pure tone</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Sonido puro</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Audiométrie</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Audiometry</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Audiometría</s0><s5>11</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie ORL</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>ENT disease</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>ORL patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>41</s5></fC07><fN21><s1>331</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 12-0423954 INIST</NO><ET>Hearing Impairment in Parkinson's Disease: Expanding the Nonmotor Phenotype</ET><AU>VITALE (Carmine); MARCELLI (Vincenzo); ALLOCCA (Roberto); SANTANGELO (Gabriella); RICCARDI (Pasquale); ERRO (Roberto); AMBONI (Marianna); PELLECCHIA (Maria Teresa); COZZOLINO (Autilia); LONGO (Katia); PICILLO (Marina); MOCCIA (Marcello); AGOSTI (Valeria); SORRENTINO (G.); CAVALIERE (Michele); MARCIANO (Elio); BARONE (Paolo)</AU><AF>University of Naples "Parthenope,"/Naples/Italie (1 aut., 7 aut., 13 aut., 14 aut.); IDC, Hermitage Capodimonte/Naples/Italie (1 aut., 4 aut., 7 aut., 10 aut., 13 aut., 14 aut., 17 aut.); Audiology and Vestibology Unit, Department of Neuroscience, University of Naples Federico II/Naples/Italie (2 aut., 3 aut., 5 aut., 16 aut.); Department of Psychology, Second University of Naples/Caserta/Italie (4 aut.); Department of Neurological Sciences, University of Naples Federico II/Naples/Italie (6 aut., 8 aut., 9 aut., 10 aut., 11 aut., 12 aut.); Neurodegenerative Diseases Center, University of Salerno/Salerno/Italie (9 aut., 17 aut.); Department of Otolaryngology, University of Naples Federico II/Naples/Italie (15 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 12; Pp. 1530-1535; Bibl. 40 ref.</SO><LA>Anglais</LA><EA>The objective of this study was to evaluate hearing impairment in patients affected by Parkinson's disease compared with hearing scores observed in normal age- and sex-matched controls. One hundred eighteen consecutive patients with a clinical diagnosis of Parkinson's disease were screened. Severity of motor symptoms and staging were measured with the Unified Parkinson's Disease Rating Scale (section III) and the Hoehn and Yahr scale. Audiometric evaluation consisted of a comprehensive audiologic case history and questionnaire, visual otoscopic examination, acoustic immittance measures (tympanogram and acoustic reflexes), pure tone audiometry, and measurement of brain stem auditory-evoked potentials. Healthy age- and sex-matched subjects were selected as the control group. One hundred six of 118 patients were enrolled. Pure tone audiometry revealed age-dependent high-frequency hearing loss in patients with Parkinson's disease compared with both normative values and values for healthy age- and sex-matched controls (75/106 [71%],<sub> </sub>χ<sup>2</sup> = 5.959, P = .02; 92/106 [86.8%] vs 60/106 [56.6%], χ<sup>2</sup> = 23.804, P < .001, respectively). Pure tone audiometry scores correlated with Hoehn and Yahr scale scores (P < .05). Brain stem auditory-evoked potentials were normal in all patients. Our patients with Parkinson's disease showed age-dependent peripheral, unilateral, or bilateral hearing impairment. Whether these auditory deficits are intrinsic to Parkinson's disease or secondary to a more complex impaired processing of sensorial inputs occurring over the course of illness remains to be determined. Because α-synuclein is located predominately in the efferent neuronal system within the inner ear, it could affect susceptibility to noise-induced hearing loss or presbycusis. It is feasible that the natural aging process combined with neurodegenerative changes intrinsic to Parkinson's disease might interfere with cochlear transduction mechanisms, thus anticipating presbycusis.</EA><CC>002B17; 002B17G</CC><FD>Trouble de l'audition; Maladie de Parkinson; Pathologie du système nerveux; Phénotype; Son pur; Audiométrie</FD><FG>Pathologie ORL; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG><ED>Auditory disorder; Parkinson disease; Nervous system diseases; Phenotype; Pure tone; Audiometry</ED><EG>ENT disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG><SD>Trastorno auditivo; Parkinson enfermedad; Sistema nervioso patología; Fenotipo; Sonido puro; Audiometría</SD><LO>INIST-20953.354000502081650110</LO><ID>12-0423954</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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