Movement Disorders (revue)

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Dopamine Agonists and Delusional Jealousy in Parkinson's Disease: A Cross-Sectional Prevalence Study

Identifieur interne : 000032 ( PascalFrancis/Corpus ); précédent : 000031; suivant : 000033

Dopamine Agonists and Delusional Jealousy in Parkinson's Disease: A Cross-Sectional Prevalence Study

Auteurs : Michele Poletti ; Giulio Perugi ; Chiara Logi ; Anna Romano ; Paolo Del Dotto ; Roberto Ceravolo ; Giuseppe Rossi ; Pasquale Pepe ; Liliana Dell'Osso ; Ubaldo Bonuccelli

Source :

RBID : Pascal:13-0017947

Descripteurs français

English descriptors

Abstract

Background: Delusional jealousy (DJ) has been described in patients with Parkinson's disease (PD) on dopaminergic therapy, but a role for dopaminergic therapy in DJ has not been established. Methods: The current cross-sectional study on DJ investigated its association with dopaminergic therapies compared with their associations with hallucinations and its prevalence in PD patients. Eight hundred five consecutive patients with PD were enrolled between January 2009 and June 2010. Results: DJ was identified in 20 patients (2.48%) and hallucinations in 193 patients (23.98%). In the multivariate logistic regression analyses, dopamine agonists were significantly associated with DJ (odds ratio, 18.1; 95% CI, 3.0-infinity; P = .0002) but not with hallucinations (odds ratio, 0.73; 95% CI, 0.49-1.10; P = .133). Conclusions: These findings suggest that dopamine agonist treatment represents a risk factor for DJ in PD independent of the presence of a dementing disorder, and the presence of this additional nonmotor side effect should be investigated in this clinical population.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0885-3185
A03   1    @0 Mov. disord.
A05       @2 27
A06       @2 13
A08 01  1  ENG  @1 Dopamine Agonists and Delusional Jealousy in Parkinson's Disease: A Cross-Sectional Prevalence Study
A11 01  1    @1 POLETTI (Michele)
A11 02  1    @1 PERUGI (Giulio)
A11 03  1    @1 LOGI (Chiara)
A11 04  1    @1 ROMANO (Anna)
A11 05  1    @1 DEL DOTTO (Paolo)
A11 06  1    @1 CERAVOLO (Roberto)
A11 07  1    @1 ROSSI (Giuseppe)
A11 08  1    @1 PEPE (Pasquale)
A11 09  1    @1 DELL'OSSO (Liliana)
A11 10  1    @1 BONUCCELLI (Ubaldo)
A14 01      @1 Department of Neuroscience, University of Pisa @2 Pisa @3 ITA @Z 1 aut. @Z 6 aut. @Z 10 aut.
A14 02      @1 Department of Psychiatry, University of Pisa @2 Pisa @3 ITA @Z 2 aut. @Z 4 aut. @Z 9 aut.
A14 03      @1 Neurology Unit, Hospital of Viareggio, USL 12 @2 Toscana @3 ITA @Z 3 aut. @Z 5 aut.
A14 04      @1 Unit of Epidemiology and Biostatistics, Institute of Clinical Physiology, National Research Council @2 Pisa @3 ITA @Z 7 aut. @Z 8 aut.
A20       @1 1679-1682
A21       @1 2012
A23 01      @0 ENG
A43 01      @1 INIST @2 20953 @5 354000505459050200
A44       @0 0000 @1 © 2013 INIST-CNRS. All rights reserved.
A45       @0 32 ref.
A47 01  1    @0 13-0017947
A60       @1 P @3 CC
A61       @0 A
A64 01  1    @0 Movement disorders
A66 01      @0 USA
C01 01    ENG  @0 Background: Delusional jealousy (DJ) has been described in patients with Parkinson's disease (PD) on dopaminergic therapy, but a role for dopaminergic therapy in DJ has not been established. Methods: The current cross-sectional study on DJ investigated its association with dopaminergic therapies compared with their associations with hallucinations and its prevalence in PD patients. Eight hundred five consecutive patients with PD were enrolled between January 2009 and June 2010. Results: DJ was identified in 20 patients (2.48%) and hallucinations in 193 patients (23.98%). In the multivariate logistic regression analyses, dopamine agonists were significantly associated with DJ (odds ratio, 18.1; 95% CI, 3.0-infinity; P = .0002) but not with hallucinations (odds ratio, 0.73; 95% CI, 0.49-1.10; P = .133). Conclusions: These findings suggest that dopamine agonist treatment represents a risk factor for DJ in PD independent of the presence of a dementing disorder, and the presence of this additional nonmotor side effect should be investigated in this clinical population.
C02 01  X    @0 002B17
C02 02  X    @0 002B17G
C03 01  X  FRE  @0 Délire @5 01
C03 01  X  ENG  @0 Delusion @5 01
C03 01  X  SPA  @0 Delirio @5 01
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C03 02  X  ENG  @0 Parkinson disease @2 NM @5 02
C03 02  X  SPA  @0 Parkinson enfermedad @2 NM @5 02
C03 03  X  FRE  @0 Démence @5 03
C03 03  X  ENG  @0 Dementia @5 03
C03 03  X  SPA  @0 Demencia @5 03
C03 04  X  FRE  @0 Pathologie du système nerveux @5 04
C03 04  X  ENG  @0 Nervous system diseases @5 04
C03 04  X  SPA  @0 Sistema nervioso patología @5 04
C03 05  X  FRE  @0 Stimulant dopaminergique @5 09
C03 05  X  ENG  @0 Dopamine agonist @5 09
C03 05  X  SPA  @0 Estimulante dopaminérgico @5 09
C03 06  X  FRE  @0 Etude transversale @5 10
C03 06  X  ENG  @0 Cross sectional study @5 10
C03 06  X  SPA  @0 Estudio transversal @5 10
C03 07  X  FRE  @0 Prévalence @5 11
C03 07  X  ENG  @0 Prevalence @5 11
C03 07  X  SPA  @0 Prevalencia @5 11
C03 08  X  FRE  @0 Lévodopa @2 NK @2 FR @5 12
C03 08  X  ENG  @0 Levodopa @2 NK @2 FR @5 12
C03 08  X  SPA  @0 Levodopa @2 NK @2 FR @5 12
C07 01  X  FRE  @0 Pathologie de l'encéphale @5 37
C07 01  X  ENG  @0 Cerebral disorder @5 37
C07 01  X  SPA  @0 Encéfalo patología @5 37
C07 02  X  FRE  @0 Syndrome extrapyramidal @5 38
C07 02  X  ENG  @0 Extrapyramidal syndrome @5 38
C07 02  X  SPA  @0 Extrapiramidal síndrome @5 38
C07 03  X  FRE  @0 Maladie dégénérative @5 39
C07 03  X  ENG  @0 Degenerative disease @5 39
C07 03  X  SPA  @0 Enfermedad degenerativa @5 39
C07 04  X  FRE  @0 Pathologie du système nerveux central @5 40
C07 04  X  ENG  @0 Central nervous system disease @5 40
C07 04  X  SPA  @0 Sistema nervosio central patología @5 40
N21       @1 007
N44 01      @1 OTO
N82       @1 OTO

Format Inist (serveur)

NO : PASCAL 13-0017947 INIST
ET : Dopamine Agonists and Delusional Jealousy in Parkinson's Disease: A Cross-Sectional Prevalence Study
AU : POLETTI (Michele); PERUGI (Giulio); LOGI (Chiara); ROMANO (Anna); DEL DOTTO (Paolo); CERAVOLO (Roberto); ROSSI (Giuseppe); PEPE (Pasquale); DELL'OSSO (Liliana); BONUCCELLI (Ubaldo)
AF : Department of Neuroscience, University of Pisa/Pisa/Italie (1 aut., 6 aut., 10 aut.); Department of Psychiatry, University of Pisa/Pisa/Italie (2 aut., 4 aut., 9 aut.); Neurology Unit, Hospital of Viareggio, USL 12/Toscana/Italie (3 aut., 5 aut.); Unit of Epidemiology and Biostatistics, Institute of Clinical Physiology, National Research Council/Pisa/Italie (7 aut., 8 aut.)
DT : Publication en série; Courte communication, note brève; Niveau analytique
SO : Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 13; Pp. 1679-1682; Bibl. 32 ref.
LA : Anglais
EA : Background: Delusional jealousy (DJ) has been described in patients with Parkinson's disease (PD) on dopaminergic therapy, but a role for dopaminergic therapy in DJ has not been established. Methods: The current cross-sectional study on DJ investigated its association with dopaminergic therapies compared with their associations with hallucinations and its prevalence in PD patients. Eight hundred five consecutive patients with PD were enrolled between January 2009 and June 2010. Results: DJ was identified in 20 patients (2.48%) and hallucinations in 193 patients (23.98%). In the multivariate logistic regression analyses, dopamine agonists were significantly associated with DJ (odds ratio, 18.1; 95% CI, 3.0-infinity; P = .0002) but not with hallucinations (odds ratio, 0.73; 95% CI, 0.49-1.10; P = .133). Conclusions: These findings suggest that dopamine agonist treatment represents a risk factor for DJ in PD independent of the presence of a dementing disorder, and the presence of this additional nonmotor side effect should be investigated in this clinical population.
CC : 002B17; 002B17G
FD : Délire; Maladie de Parkinson; Démence; Pathologie du système nerveux; Stimulant dopaminergique; Etude transversale; Prévalence; Lévodopa
FG : Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED : Delusion; Parkinson disease; Dementia; Nervous system diseases; Dopamine agonist; Cross sectional study; Prevalence; Levodopa
EG : Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD : Delirio; Parkinson enfermedad; Demencia; Sistema nervioso patología; Estimulante dopaminérgico; Estudio transversal; Prevalencia; Levodopa
LO : INIST-20953.354000505459050200
ID : 13-0017947

Links to Exploration step

Pascal:13-0017947

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<div type="abstract" xml:lang="en">Background: Delusional jealousy (DJ) has been described in patients with Parkinson's disease (PD) on dopaminergic therapy, but a role for dopaminergic therapy in DJ has not been established. Methods: The current cross-sectional study on DJ investigated its association with dopaminergic therapies compared with their associations with hallucinations and its prevalence in PD patients. Eight hundred five consecutive patients with PD were enrolled between January 2009 and June 2010. Results: DJ was identified in 20 patients (2.48%) and hallucinations in 193 patients (23.98%). In the multivariate logistic regression analyses, dopamine agonists were significantly associated with DJ (odds ratio, 18.1; 95% CI, 3.0-infinity; P = .0002) but not with hallucinations (odds ratio, 0.73; 95% CI, 0.49-1.10; P = .133). Conclusions: These findings suggest that dopamine agonist treatment represents a risk factor for DJ in PD independent of the presence of a dementing disorder, and the presence of this additional nonmotor side effect should be investigated in this clinical population.</div>
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<fA11 i1="10" i2="1">
<s1>BONUCCELLI (Ubaldo)</s1>
</fA11>
<fA14 i1="01">
<s1>Department of Neuroscience, University of Pisa</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="02">
<s1>Department of Psychiatry, University of Pisa</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="03">
<s1>Neurology Unit, Hospital of Viareggio, USL 12</s1>
<s2>Toscana</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="04">
<s1>Unit of Epidemiology and Biostatistics, Institute of Clinical Physiology, National Research Council</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA20>
<s1>1679-1682</s1>
</fA20>
<fA21>
<s1>2012</s1>
</fA21>
<fA23 i1="01">
<s0>ENG</s0>
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<fA43 i1="01">
<s1>INIST</s1>
<s2>20953</s2>
<s5>354000505459050200</s5>
</fA43>
<fA44>
<s0>0000</s0>
<s1>© 2013 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45>
<s0>32 ref.</s0>
</fA45>
<fA47 i1="01" i2="1">
<s0>13-0017947</s0>
</fA47>
<fA60>
<s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>Movement disorders</s0>
</fA64>
<fA66 i1="01">
<s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>Background: Delusional jealousy (DJ) has been described in patients with Parkinson's disease (PD) on dopaminergic therapy, but a role for dopaminergic therapy in DJ has not been established. Methods: The current cross-sectional study on DJ investigated its association with dopaminergic therapies compared with their associations with hallucinations and its prevalence in PD patients. Eight hundred five consecutive patients with PD were enrolled between January 2009 and June 2010. Results: DJ was identified in 20 patients (2.48%) and hallucinations in 193 patients (23.98%). In the multivariate logistic regression analyses, dopamine agonists were significantly associated with DJ (odds ratio, 18.1; 95% CI, 3.0-infinity; P = .0002) but not with hallucinations (odds ratio, 0.73; 95% CI, 0.49-1.10; P = .133). Conclusions: These findings suggest that dopamine agonist treatment represents a risk factor for DJ in PD independent of the presence of a dementing disorder, and the presence of this additional nonmotor side effect should be investigated in this clinical population.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X">
<s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Délire</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Delusion</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Delirio</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Démence</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Dementia</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Demencia</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Pathologie du système nerveux</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Nervous system diseases</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Sistema nervioso patología</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Stimulant dopaminergique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Dopamine agonist</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Estimulante dopaminérgico</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Etude transversale</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Cross sectional study</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Estudio transversal</s0>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Prévalence</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Prevalence</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Prevalencia</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Lévodopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG">
<s0>Levodopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Levodopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>12</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Pathologie du système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21>
<s1>007</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
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<server>
<NO>PASCAL 13-0017947 INIST</NO>
<ET>Dopamine Agonists and Delusional Jealousy in Parkinson's Disease: A Cross-Sectional Prevalence Study</ET>
<AU>POLETTI (Michele); PERUGI (Giulio); LOGI (Chiara); ROMANO (Anna); DEL DOTTO (Paolo); CERAVOLO (Roberto); ROSSI (Giuseppe); PEPE (Pasquale); DELL'OSSO (Liliana); BONUCCELLI (Ubaldo)</AU>
<AF>Department of Neuroscience, University of Pisa/Pisa/Italie (1 aut., 6 aut., 10 aut.); Department of Psychiatry, University of Pisa/Pisa/Italie (2 aut., 4 aut., 9 aut.); Neurology Unit, Hospital of Viareggio, USL 12/Toscana/Italie (3 aut., 5 aut.); Unit of Epidemiology and Biostatistics, Institute of Clinical Physiology, National Research Council/Pisa/Italie (7 aut., 8 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 13; Pp. 1679-1682; Bibl. 32 ref.</SO>
<LA>Anglais</LA>
<EA>Background: Delusional jealousy (DJ) has been described in patients with Parkinson's disease (PD) on dopaminergic therapy, but a role for dopaminergic therapy in DJ has not been established. Methods: The current cross-sectional study on DJ investigated its association with dopaminergic therapies compared with their associations with hallucinations and its prevalence in PD patients. Eight hundred five consecutive patients with PD were enrolled between January 2009 and June 2010. Results: DJ was identified in 20 patients (2.48%) and hallucinations in 193 patients (23.98%). In the multivariate logistic regression analyses, dopamine agonists were significantly associated with DJ (odds ratio, 18.1; 95% CI, 3.0-infinity; P = .0002) but not with hallucinations (odds ratio, 0.73; 95% CI, 0.49-1.10; P = .133). Conclusions: These findings suggest that dopamine agonist treatment represents a risk factor for DJ in PD independent of the presence of a dementing disorder, and the presence of this additional nonmotor side effect should be investigated in this clinical population.</EA>
<CC>002B17; 002B17G</CC>
<FD>Délire; Maladie de Parkinson; Démence; Pathologie du système nerveux; Stimulant dopaminergique; Etude transversale; Prévalence; Lévodopa</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG>
<ED>Delusion; Parkinson disease; Dementia; Nervous system diseases; Dopamine agonist; Cross sectional study; Prevalence; Levodopa</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Delirio; Parkinson enfermedad; Demencia; Sistema nervioso patología; Estimulante dopaminérgico; Estudio transversal; Prevalencia; Levodopa</SD>
<LO>INIST-20953.354000505459050200</LO>
<ID>13-0017947</ID>
</server>
</inist>
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