Conventional Magnetic Resonance Imaging in Confirmed Progressive Supranuclear Palsy and Multiple System Atrophy
Identifieur interne : 000013 ( PascalFrancis/Corpus ); précédent : 000012; suivant : 000014Conventional Magnetic Resonance Imaging in Confirmed Progressive Supranuclear Palsy and Multiple System Atrophy
Auteurs : Luke A. Massey ; Caroline Micallef ; Dominic C. Paviour ; Sean S. O'Sullivan ; Helen Ling ; David R. Williams ; Constantinos Kallis ; Janice L. Holton ; Tamas Revesz ; David J. Burn ; Tarek Yousry ; Med Habil ; Andrew J. Lees ; Nick C. Fox ; Hans R. J GerSource :
- Movement disorders [ 0885-3185 ] ; 2012.
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Abstract
Conventional magnetic resonance imaging (cMRI) is often used to aid the diagnosis of progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), but its ability to predict the histopathological diagnosis has not been systematically studied. cMRI from 48 neuropathologically confirmed cases, including PSP (n = 22), MSA (n = 13), Parkinson's disease (PD) (n = 7), and corticobasal degeneration (n = 6), and controls (n = 9) were assessed blinded to clinical details and systematically rated for reported abnormalities. Clinical diagnosis and macroscopic postmortem findings were retrospectively assessed. Radiological assessment of MRI was correct in 16 of 22 (72.7%) PSP cases and 10 of 13 (76.9%) MSA cases with substantial interrater agreement (Cohen's kappa 0.708; P <.001); no PSP case was misclassified as MSA or vice versa. MRI was less sensitive but more specific than clinical diagnosis in PSP and both more sensitive and specific than clinical diagnosis in MSA. The "hummingbird" and "morning glory" signs were highly specific for PSP, and "the middle cerebellar peduncle sign" and "hot cross bun" for MSA, but sensitivity was lower (up to 68.4%) and characteristic findings may not be present even at autopsy. cMRI, clinical diagnosis, and macroscopic examination at postmortem have similar sensitivity and specificity in predicting a neuropathological diagnosis. We have validated specific radiological signs in pathologically confirmed PSP and MSA. However, the low sensitivity of these and macroscopic findings at autopsy suggest a need for imaging techniques sensitive to microstructural abnormalities without regional atrophy.
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Format Inist (serveur)
| NO : | PASCAL 13-0063589 INIST |
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| ET : | Conventional Magnetic Resonance Imaging in Confirmed Progressive Supranuclear Palsy and Multiple System Atrophy |
| AU : | MASSEY (Luke A.); MICALLEF (Caroline); PAVIOUR (Dominic C.); O'SULLIVAN (Sean S.); LING (Helen); WILLIAMS (David R.); KALLIS (Constantinos); HOLTON (Janice L.); REVESZ (Tamas); BURN (David J.); YOUSRY (Tarek); HABIL (Med); LEES (Andrew J.); FOX (Nick C.); JÄGER (Hans R.) |
| AF : | Sara Koe PSP Research Centre, UCL Institute of Neurology, University College London/London/Royaume-Uni (1 aut., 3 aut., 5 aut., 8 aut., 9 aut., 13 aut.); Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, University College London/London/Royaume-Uni (1 aut., 4 aut., 5 aut., 8 aut., 9 aut., 13 aut.); Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, University College London/London/Royaume-Uni (1 aut., 4 aut., 5 aut., 13 aut.); Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery/London/Royaume-Uni (2 aut., 12 aut., 15 aut.); Van Cleef Roet Centre for Nervous Diseases, Monash University/Melbourne/Australie (6 aut.); Forensic Psychiatry Research Unit, Queen Mary, University of London/London/Royaume-Uni (7 aut.); Institute of Ageing, University of Newcastle/Newcastle upon Tyne/Royaume-Uni (10 aut.); Dementia Research Centre, UCL Institute of Neurology, University College London/London/Royaume-Uni (14 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 14; Pp. 1755-1762; Bibl. 39 ref. |
| LA : | Anglais |
| EA : | Conventional magnetic resonance imaging (cMRI) is often used to aid the diagnosis of progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), but its ability to predict the histopathological diagnosis has not been systematically studied. cMRI from 48 neuropathologically confirmed cases, including PSP (n = 22), MSA (n = 13), Parkinson's disease (PD) (n = 7), and corticobasal degeneration (n = 6), and controls (n = 9) were assessed blinded to clinical details and systematically rated for reported abnormalities. Clinical diagnosis and macroscopic postmortem findings were retrospectively assessed. Radiological assessment of MRI was correct in 16 of 22 (72.7%) PSP cases and 10 of 13 (76.9%) MSA cases with substantial interrater agreement (Cohen's kappa 0.708; P <.001); no PSP case was misclassified as MSA or vice versa. MRI was less sensitive but more specific than clinical diagnosis in PSP and both more sensitive and specific than clinical diagnosis in MSA. The "hummingbird" and "morning glory" signs were highly specific for PSP, and "the middle cerebellar peduncle sign" and "hot cross bun" for MSA, but sensitivity was lower (up to 68.4%) and characteristic findings may not be present even at autopsy. cMRI, clinical diagnosis, and macroscopic examination at postmortem have similar sensitivity and specificity in predicting a neuropathological diagnosis. We have validated specific radiological signs in pathologically confirmed PSP and MSA. However, the low sensitivity of these and macroscopic findings at autopsy suggest a need for imaging techniques sensitive to microstructural abnormalities without regional atrophy. |
| CC : | 002B17; 002B17F |
| FD : | Atrophie multisystématisée; Pathologie du système nerveux; Imagerie RMN; Ophtalmoplégie supranucléaire |
| FG : | Pathologie de l'encéphale; Maladie dégénérative; Syndrome oculomoteur; Pathologie de l'oeil; Pathologie du système nerveux central; Syndrome du tronc cérébral |
| ED : | Multiple system atrophy; Nervous system diseases; Nuclear magnetic resonance imaging; Supranuclear ophthalmoplegia |
| EG : | Cerebral disorder; Degenerative disease; Oculomotor syndrome; Eye disease; Central nervous system disease; Brain stem syndrome |
| SD : | Atrofia multisistematizada; Sistema nervioso patología; Imaginería RMN; Oftalmoplejía supranuclear |
| LO : | INIST-20953.354000503000040120 |
| ID : | 13-0063589 |
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Burn</name><affiliation><inist:fA14 i1="07"><s1>Institute of Ageing, University of Newcastle</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Yousry, Tarek" sort="Yousry, Tarek" uniqKey="Yousry T" first="Tarek" last="Yousry">Tarek Yousry</name></author><author><name sortKey="Habil, Med" sort="Habil, Med" uniqKey="Habil M" first="Med" last="Habil">Med Habil</name><affiliation><inist:fA14 i1="04"><s1>Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew J. Lees</name><affiliation><inist:fA14 i1="01"><s1>Sara Koe PSP Research Centre, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name><affiliation><inist:fA14 i1="08"><s1>Dementia Research Centre, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="J Ger, Hans R" sort="J Ger, Hans R" uniqKey="J Ger H" first="Hans R." last="J Ger">Hans R. J Ger</name><affiliation><inist:fA14 i1="04"><s1>Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0063589</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 13-0063589 INIST</idno><idno type="RBID">Pascal:13-0063589</idno><idno type="wicri:Area/PascalFrancis/Corpus">000013</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Conventional Magnetic Resonance Imaging in Confirmed Progressive Supranuclear Palsy and Multiple System Atrophy</title><author><name sortKey="Massey, Luke A" sort="Massey, Luke A" uniqKey="Massey L" first="Luke A." last="Massey">Luke A. Massey</name><affiliation><inist:fA14 i1="01"><s1>Sara Koe PSP Research Centre, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Micallef, Caroline" sort="Micallef, Caroline" uniqKey="Micallef C" first="Caroline" last="Micallef">Caroline Micallef</name><affiliation><inist:fA14 i1="04"><s1>Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Paviour, Dominic C" sort="Paviour, Dominic C" uniqKey="Paviour D" first="Dominic C." last="Paviour">Dominic C. Paviour</name><affiliation><inist:fA14 i1="01"><s1>Sara Koe PSP Research Centre, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="O Sullivan, Sean S" sort="O Sullivan, Sean S" uniqKey="O Sullivan S" first="Sean S." last="O'Sullivan">Sean S. O'Sullivan</name><affiliation><inist:fA14 i1="02"><s1>Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ling, Helen" sort="Ling, Helen" uniqKey="Ling H" first="Helen" last="Ling">Helen Ling</name><affiliation><inist:fA14 i1="01"><s1>Sara Koe PSP Research Centre, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R." last="Williams">David R. Williams</name><affiliation><inist:fA14 i1="05"><s1>Van Cleef Roet Centre for Nervous Diseases, Monash University</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kallis, Constantinos" sort="Kallis, Constantinos" uniqKey="Kallis C" first="Constantinos" last="Kallis">Constantinos Kallis</name><affiliation><inist:fA14 i1="06"><s1>Forensic Psychiatry Research Unit, Queen Mary, University of London</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Holton, Janice L" sort="Holton, Janice L" uniqKey="Holton J" first="Janice L." last="Holton">Janice L. Holton</name><affiliation><inist:fA14 i1="01"><s1>Sara Koe PSP Research Centre, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Revesz, Tamas" sort="Revesz, Tamas" uniqKey="Revesz T" first="Tamas" last="Revesz">Tamas Revesz</name><affiliation><inist:fA14 i1="01"><s1>Sara Koe PSP Research Centre, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name><affiliation><inist:fA14 i1="07"><s1>Institute of Ageing, University of Newcastle</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Yousry, Tarek" sort="Yousry, Tarek" uniqKey="Yousry T" first="Tarek" last="Yousry">Tarek Yousry</name></author><author><name sortKey="Habil, Med" sort="Habil, Med" uniqKey="Habil M" first="Med" last="Habil">Med Habil</name><affiliation><inist:fA14 i1="04"><s1>Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew J. Lees</name><affiliation><inist:fA14 i1="01"><s1>Sara Koe PSP Research Centre, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name><affiliation><inist:fA14 i1="08"><s1>Dementia Research Centre, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="J Ger, Hans R" sort="J Ger, Hans R" uniqKey="J Ger H" first="Hans R." last="J Ger">Hans R. J Ger</name><affiliation><inist:fA14 i1="04"><s1>Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Supranuclear ophthalmoplegia</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term><term>Pathologie du système nerveux</term><term>Imagerie RMN</term><term>Ophtalmoplégie supranucléaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Conventional magnetic resonance imaging (cMRI) is often used to aid the diagnosis of progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), but its ability to predict the histopathological diagnosis has not been systematically studied. cMRI from 48 neuropathologically confirmed cases, including PSP (n = 22), MSA (n = 13), Parkinson's disease (PD) (n = 7), and corticobasal degeneration (n = 6), and controls (n = 9) were assessed blinded to clinical details and systematically rated for reported abnormalities. Clinical diagnosis and macroscopic postmortem findings were retrospectively assessed. Radiological assessment of MRI was correct in 16 of 22 (72.7%) PSP cases and 10 of 13 (76.9%) MSA cases with substantial interrater agreement (Cohen's kappa 0.708; P <.001); no PSP case was misclassified as MSA or vice versa. MRI was less sensitive but more specific than clinical diagnosis in PSP and both more sensitive and specific than clinical diagnosis in MSA. The "hummingbird" and "morning glory" signs were highly specific for PSP, and "the middle cerebellar peduncle sign" and "hot cross bun" for MSA, but sensitivity was lower (up to 68.4%) and characteristic findings may not be present even at autopsy. cMRI, clinical diagnosis, and macroscopic examination at postmortem have similar sensitivity and specificity in predicting a neuropathological diagnosis. We have validated specific radiological signs in pathologically confirmed PSP and MSA. However, the low sensitivity of these and macroscopic findings at autopsy suggest a need for imaging techniques sensitive to microstructural abnormalities without regional atrophy.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>27</s2></fA05><fA06><s2>14</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Conventional Magnetic Resonance Imaging in Confirmed Progressive Supranuclear Palsy and Multiple System Atrophy</s1></fA08><fA11 i1="01" i2="1"><s1>MASSEY (Luke A.)</s1></fA11><fA11 i1="02" i2="1"><s1>MICALLEF (Caroline)</s1></fA11><fA11 i1="03" i2="1"><s1>PAVIOUR (Dominic C.)</s1></fA11><fA11 i1="04" i2="1"><s1>O'SULLIVAN (Sean S.)</s1></fA11><fA11 i1="05" i2="1"><s1>LING (Helen)</s1></fA11><fA11 i1="06" i2="1"><s1>WILLIAMS (David R.)</s1></fA11><fA11 i1="07" i2="1"><s1>KALLIS (Constantinos)</s1></fA11><fA11 i1="08" i2="1"><s1>HOLTON (Janice L.)</s1></fA11><fA11 i1="09" i2="1"><s1>REVESZ (Tamas)</s1></fA11><fA11 i1="10" i2="1"><s1>BURN (David J.)</s1></fA11><fA11 i1="11" i2="1"><s1>YOUSRY (Tarek)</s1></fA11><fA11 i1="12" i2="1"><s1>HABIL (Med)</s1></fA11><fA11 i1="13" i2="1"><s1>LEES (Andrew J.)</s1></fA11><fA11 i1="14" i2="1"><s1>FOX (Nick C.)</s1></fA11><fA11 i1="15" i2="1"><s1>JÄGER (Hans R.)</s1></fA11><fA14 i1="01"><s1>Sara Koe PSP Research Centre, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="02"><s1>Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="03"><s1>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="04"><s1>Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ></fA14><fA14 i1="05"><s1>Van Cleef Roet Centre for Nervous Diseases, Monash University</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ></fA14><fA14 i1="06"><s1>Forensic Psychiatry Research Unit, Queen Mary, University of London</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ></fA14><fA14 i1="07"><s1>Institute of Ageing, University of Newcastle</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>10 aut.</sZ></fA14><fA14 i1="08"><s1>Dementia Research Centre, UCL Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>14 aut.</sZ></fA14><fA20><s1>1755-1762</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000503000040120</s5></fA43><fA44><s0>0000</s0><s1>© 2013 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>39 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>13-0063589</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Conventional magnetic resonance imaging (cMRI) is often used to aid the diagnosis of progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), but its ability to predict the histopathological diagnosis has not been systematically studied. cMRI from 48 neuropathologically confirmed cases, including PSP (n = 22), MSA (n = 13), Parkinson's disease (PD) (n = 7), and corticobasal degeneration (n = 6), and controls (n = 9) were assessed blinded to clinical details and systematically rated for reported abnormalities. Clinical diagnosis and macroscopic postmortem findings were retrospectively assessed. Radiological assessment of MRI was correct in 16 of 22 (72.7%) PSP cases and 10 of 13 (76.9%) MSA cases with substantial interrater agreement (Cohen's kappa 0.708; P <.001); no PSP case was misclassified as MSA or vice versa. MRI was less sensitive but more specific than clinical diagnosis in PSP and both more sensitive and specific than clinical diagnosis in MSA. The "hummingbird" and "morning glory" signs were highly specific for PSP, and "the middle cerebellar peduncle sign" and "hot cross bun" for MSA, but sensitivity was lower (up to 68.4%) and characteristic findings may not be present even at autopsy. cMRI, clinical diagnosis, and macroscopic examination at postmortem have similar sensitivity and specificity in predicting a neuropathological diagnosis. We have validated specific radiological signs in pathologically confirmed PSP and MSA. However, the low sensitivity of these and macroscopic findings at autopsy suggest a need for imaging techniques sensitive to microstructural abnormalities without regional atrophy.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17F</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Atrophie multisystématisée</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Multiple system atrophy</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Atrofia multisistematizada</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Imagerie RMN</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Imaginería RMN</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Ophtalmoplégie supranucléaire</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Supranuclear ophthalmoplegia</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Oftalmoplejía supranuclear</s0><s5>10</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Syndrome oculomoteur</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Oculomotor syndrome</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Oculomotricidad síndrome</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie de l'oeil</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Eye disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Ojo patología</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Syndrome du tronc cérébral</s0><s5>43</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Brain stem syndrome</s0><s5>43</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Tallo encefalico sindrome</s0><s5>43</s5></fC07><fN21><s1>042</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 13-0063589 INIST</NO><ET>Conventional Magnetic Resonance Imaging in Confirmed Progressive Supranuclear Palsy and Multiple System Atrophy</ET><AU>MASSEY (Luke A.); MICALLEF (Caroline); PAVIOUR (Dominic C.); O'SULLIVAN (Sean S.); LING (Helen); WILLIAMS (David R.); KALLIS (Constantinos); HOLTON (Janice L.); REVESZ (Tamas); BURN (David J.); YOUSRY (Tarek); HABIL (Med); LEES (Andrew J.); FOX (Nick C.); JÄGER (Hans R.)</AU><AF>Sara Koe PSP Research Centre, UCL Institute of Neurology, University College London/London/Royaume-Uni (1 aut., 3 aut., 5 aut., 8 aut., 9 aut., 13 aut.); Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, University College London/London/Royaume-Uni (1 aut., 4 aut., 5 aut., 8 aut., 9 aut., 13 aut.); Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, University College London/London/Royaume-Uni (1 aut., 4 aut., 5 aut., 13 aut.); Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery/London/Royaume-Uni (2 aut., 12 aut., 15 aut.); Van Cleef Roet Centre for Nervous Diseases, Monash University/Melbourne/Australie (6 aut.); Forensic Psychiatry Research Unit, Queen Mary, University of London/London/Royaume-Uni (7 aut.); Institute of Ageing, University of Newcastle/Newcastle upon Tyne/Royaume-Uni (10 aut.); Dementia Research Centre, UCL Institute of Neurology, University College London/London/Royaume-Uni (14 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 14; Pp. 1755-1762; Bibl. 39 ref.</SO><LA>Anglais</LA><EA>Conventional magnetic resonance imaging (cMRI) is often used to aid the diagnosis of progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), but its ability to predict the histopathological diagnosis has not been systematically studied. cMRI from 48 neuropathologically confirmed cases, including PSP (n = 22), MSA (n = 13), Parkinson's disease (PD) (n = 7), and corticobasal degeneration (n = 6), and controls (n = 9) were assessed blinded to clinical details and systematically rated for reported abnormalities. Clinical diagnosis and macroscopic postmortem findings were retrospectively assessed. Radiological assessment of MRI was correct in 16 of 22 (72.7%) PSP cases and 10 of 13 (76.9%) MSA cases with substantial interrater agreement (Cohen's kappa 0.708; P <.001); no PSP case was misclassified as MSA or vice versa. MRI was less sensitive but more specific than clinical diagnosis in PSP and both more sensitive and specific than clinical diagnosis in MSA. The "hummingbird" and "morning glory" signs were highly specific for PSP, and "the middle cerebellar peduncle sign" and "hot cross bun" for MSA, but sensitivity was lower (up to 68.4%) and characteristic findings may not be present even at autopsy. cMRI, clinical diagnosis, and macroscopic examination at postmortem have similar sensitivity and specificity in predicting a neuropathological diagnosis. We have validated specific radiological signs in pathologically confirmed PSP and MSA. However, the low sensitivity of these and macroscopic findings at autopsy suggest a need for imaging techniques sensitive to microstructural abnormalities without regional atrophy.</EA><CC>002B17; 002B17F</CC><FD>Atrophie multisystématisée; Pathologie du système nerveux; Imagerie RMN; Ophtalmoplégie supranucléaire</FD><FG>Pathologie de l'encéphale; Maladie dégénérative; Syndrome oculomoteur; Pathologie de l'oeil; Pathologie du système nerveux central; Syndrome du tronc cérébral</FG><ED>Multiple system atrophy; Nervous system diseases; Nuclear magnetic resonance imaging; Supranuclear ophthalmoplegia</ED><EG>Cerebral disorder; Degenerative disease; Oculomotor syndrome; Eye disease; Central nervous system disease; Brain stem syndrome</EG><SD>Atrofia multisistematizada; Sistema nervioso patología; Imaginería RMN; Oftalmoplejía supranuclear</SD><LO>INIST-20953.354000503000040120</LO><ID>13-0063589</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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