MovDisordV3, PascalFrancis, Checkpoint, bibRecord, 002835

Case-control study of estrogen receptor gene polymorphisms in Parkinson's disease

Identifieur interne : 002835 ( PascalFrancis/Checkpoint ); précédent : 002834; suivant : 002836

Case-control study of estrogen receptor gene polymorphisms in Parkinson's disease

Auteurs : Demetrius M. Maraganore [États-Unis] ; Matthew J. Fairer [États-Unis] ; Shannon K. Mcdonnell [États-Unis] ; Alexis Elbaz [États-Unis] ; Daniel J. Schaid [États-Unis] ; John A. Hardy [États-Unis] ; Walter A. Rocca [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:02-0369132

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Polymorphisme, Gène, Récepteur oestrogène, Génotype, Etude cas témoin, Facteur risque, Adulte.
Wicri :
- topic : Adulte.

English descriptors

KwdEn :
- Adult, Case control study, Estrogen receptor, Gene, Genotype, Parkinson disease, Polymorphism, Risk factor.

Abstract

We investigated the association of Parkinson's disease (PD) with two estrogen receptor gene polymorphisms. In a sample of 319 unrelated PD cases and 196 control subjects including both men and women, we observed no association of PD with the estrogen receptor genotypes derived from Xbal and Pvull digests. Analyses restricted to women or to cases and controls of European origin yielded similar findings. Further analyses stratified by age at examination or by family history did not show associations. While exogenous and endogenous estrogen may modify the risk of PD in women, the two estrogen receptor gene polymorphisms considered here do not seem to contribute to PD susceptibility.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">We investigated the association of Parkinson's disease (PD) with two estrogen receptor gene polymorphisms. In a sample of 319 unrelated PD cases and 196 control subjects including both men and women, we observed no association of PD with the estrogen receptor genotypes derived from Xbal and Pvull digests. Analyses restricted to women or to cases and controls of European origin yielded similar findings. Further analyses stratified by age at examination or by family history did not show associations. While exogenous and endogenous estrogen may modify the risk of PD in women, the two estrogen receptor gene polymorphisms considered here do not seem to contribute to PD susceptibility.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Case-control study of estrogen receptor gene polymorphisms in Parkinson's disease

Case-control study of estrogen receptor gene polymorphisms in Parkinson's disease

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