Decreased phasic EMG activity during Rapid eye movement sleep in treatment-naïve Parkinson's disease: Effects of treatment with levodopa and progression of illness
Identifieur interne : 002807 ( PascalFrancis/Checkpoint ); précédent : 002806; suivant : 002808Decreased phasic EMG activity during Rapid eye movement sleep in treatment-naïve Parkinson's disease: Effects of treatment with levodopa and progression of illness
Auteurs : Diego Garcia-Borreguero [Espagne] ; Ana B. Caminero [Espagne] ; Yolanda De La Llave [Espagne] ; Oscar Larrosa [Espagne] ; Soledad Barrio [Espagne] ; Juan J. Granizo [Espagne] ; Juan A. Pareja [Espagne]Source :
- Movement disorders [ 0885-3185 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
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Abstract
Rapid eye movement (REM) sleep behavior disorder (RBD) is frequently associated with Parkinson's disease (PD) and may anticipate its diagnosis by several years. We assessed the presence of motor dyscontrol during REM sleep in treatment-naïve PD patients and investigated the putative effect of levodopa (L-dopa) treatment on motor activity. Overnight sleep studies were performed on 15 previously untreated PD patients and 14 controls at baseline, again after a 3- to 9-month treatment period with a low dose of L-dopa, and 2 to 5 days after treatment discontinuation (in 8 patients). No differences in sleep parameters were observed across groups or treatment conditions. None of the patients met criteria for RBD at baseline, whereas 5 patients were symptomatic at the time of the second sleep study. A quantitative analysis of electromyographic (EMG) activity during REM sleep showed a lower phasic twitching activity in untreated PD than in controls. However, an increase in both phasic twitching and tonic activity was found after treatment with L-dopa. Discontinuation of treatment resulted in a return to pretreatment values of phasic but not of tonic EMG activity. Thus, the increase in phasic activity seems to depend on the effects of L-dopa, whereas the increase in tonic EMG activity during REM sleep might be caused by other factors such as the progression of disease. Potential implications for the understanding of the relationship between RBD and PD are discussed.
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Granizo</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department Epidemiology, Fundación Jiménez Diaz</s1><s2>Madrid</s2><s3>ESP</s3><sZ>6 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Pareja, Juan A" sort="Pareja, Juan A" uniqKey="Pareja J" first="Juan A." last="Pareja">Juan A. Pareja</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Hospital Rober International</s1><s2>Madrid</s2><s3>ESP</s3><sZ>7 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">02-0585144</idno><date when="2002">2002</date><idno type="stanalyst">PASCAL 02-0585144 INIST</idno><idno type="RBID">Pascal:02-0585144</idno><idno type="wicri:Area/PascalFrancis/Corpus">002606</idno><idno type="wicri:Area/PascalFrancis/Curation">000715</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002807</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Decreased phasic EMG activity during Rapid eye movement sleep in treatment-naïve Parkinson's disease: Effects of treatment with levodopa and progression of illness</title><author><name sortKey="Garcia Borreguero, Diego" sort="Garcia Borreguero, Diego" uniqKey="Garcia Borreguero D" first="Diego" last="Garcia-Borreguero">Diego Garcia-Borreguero</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Fundación Jiménez Diaz</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Caminero, Ana B" sort="Caminero, Ana B" uniqKey="Caminero A" first="Ana B." last="Caminero">Ana B. Caminero</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Hospital Nuestra Señora de Sonsoles</s1><s2>Ávila</s2><s3>ESP</s3><sZ>2 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Hospital Nuestra Señora de Sonsoles</wicri:noRegion></affiliation></author><author><name sortKey="De La Llave, Yolanda" sort="De La Llave, Yolanda" uniqKey="De La Llave Y" first="Yolanda" last="De La Llave">Yolanda De La Llave</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Fundación Jiménez Diaz</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Larrosa, Oscar" sort="Larrosa, Oscar" uniqKey="Larrosa O" first="Oscar" last="Larrosa">Oscar Larrosa</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Fundación Jiménez Diaz</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Barrio, Soledad" sort="Barrio, Soledad" uniqKey="Barrio S" first="Soledad" last="Barrio">Soledad Barrio</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Fundación Jiménez Diaz</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Granizo, Juan J" sort="Granizo, Juan J" uniqKey="Granizo J" first="Juan J." last="Granizo">Juan J. Granizo</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department Epidemiology, Fundación Jiménez Diaz</s1><s2>Madrid</s2><s3>ESP</s3><sZ>6 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Pareja, Juan A" sort="Pareja, Juan A" uniqKey="Pareja J" first="Juan A." last="Pareja">Juan A. Pareja</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Hospital Rober International</s1><s2>Madrid</s2><s3>ESP</s3><sZ>7 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson agent</term><term>Chemotherapy</term><term>Electromyography</term><term>Exploration</term><term>Human</term><term>Levodopa</term><term>Parkinson disease</term><term>Rapid eye movement sleep</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Sommeil paradoxal</term><term>Electromyographie</term><term>Lévodopa</term><term>Antiparkinsonien</term><term>Chimiothérapie</term><term>Exploration</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rapid eye movement (REM) sleep behavior disorder (RBD) is frequently associated with Parkinson's disease (PD) and may anticipate its diagnosis by several years. We assessed the presence of motor dyscontrol during REM sleep in treatment-naïve PD patients and investigated the putative effect of levodopa (L-dopa) treatment on motor activity. Overnight sleep studies were performed on 15 previously untreated PD patients and 14 controls at baseline, again after a 3- to 9-month treatment period with a low dose of L-dopa, and 2 to 5 days after treatment discontinuation (in 8 patients). No differences in sleep parameters were observed across groups or treatment conditions. None of the patients met criteria for RBD at baseline, whereas 5 patients were symptomatic at the time of the second sleep study. A quantitative analysis of electromyographic (EMG) activity during REM sleep showed a lower phasic twitching activity in untreated PD than in controls. However, an increase in both phasic twitching and tonic activity was found after treatment with L-dopa. Discontinuation of treatment resulted in a return to pretreatment values of phasic but not of tonic EMG activity. Thus, the increase in phasic activity seems to depend on the effects of L-dopa, whereas the increase in tonic EMG activity during REM sleep might be caused by other factors such as the progression of disease. Potential implications for the understanding of the relationship between RBD and PD are discussed.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>17</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Decreased phasic EMG activity during Rapid eye movement sleep in treatment-naïve Parkinson's disease: Effects of treatment with levodopa and progression of illness</s1></fA08><fA11 i1="01" i2="1"><s1>GARCIA-BORREGUERO (Diego)</s1></fA11><fA11 i1="02" i2="1"><s1>CAMINERO (Ana B.)</s1></fA11><fA11 i1="03" i2="1"><s1>DE LA LLAVE (Yolanda)</s1></fA11><fA11 i1="04" i2="1"><s1>LARROSA (Oscar)</s1></fA11><fA11 i1="05" i2="1"><s1>BARRIO (Soledad)</s1></fA11><fA11 i1="06" i2="1"><s1>GRANIZO (Juan J.)</s1></fA11><fA11 i1="07" i2="1"><s1>PAREJA (Juan A.)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, Fundación Jiménez Diaz</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="02"><s1>Hospital Nuestra Señora de Sonsoles</s1><s2>Ávila</s2><s3>ESP</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Department Epidemiology, Fundación Jiménez Diaz</s1><s2>Madrid</s2><s3>ESP</s3><sZ>6 aut.</sZ></fA14><fA14 i1="04"><s1>Hospital Rober International</s1><s2>Madrid</s2><s3>ESP</s3><sZ>7 aut.</sZ></fA14><fA20><s1>934-941</s1></fA20><fA21><s1>2002</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000105152380090</s5></fA43><fA44><s0>0000</s0><s1>© 2002 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>41 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>02-0585144</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Rapid eye movement (REM) sleep behavior disorder (RBD) is frequently associated with Parkinson's disease (PD) and may anticipate its diagnosis by several years. We assessed the presence of motor dyscontrol during REM sleep in treatment-naïve PD patients and investigated the putative effect of levodopa (L-dopa) treatment on motor activity. Overnight sleep studies were performed on 15 previously untreated PD patients and 14 controls at baseline, again after a 3- to 9-month treatment period with a low dose of L-dopa, and 2 to 5 days after treatment discontinuation (in 8 patients). No differences in sleep parameters were observed across groups or treatment conditions. None of the patients met criteria for RBD at baseline, whereas 5 patients were symptomatic at the time of the second sleep study. A quantitative analysis of electromyographic (EMG) activity during REM sleep showed a lower phasic twitching activity in untreated PD than in controls. However, an increase in both phasic twitching and tonic activity was found after treatment with L-dopa. Discontinuation of treatment resulted in a return to pretreatment values of phasic but not of tonic EMG activity. Thus, the increase in phasic activity seems to depend on the effects of L-dopa, whereas the increase in tonic EMG activity during REM sleep might be caused by other factors such as the progression of disease. Potential implications for the understanding of the relationship between RBD and PD are discussed.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Sommeil paradoxal</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Rapid eye movement sleep</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sueño paradojal</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Electromyographie</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Electromyography</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Electromiografía</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Lévodopa</s0><s2>NK</s2><s2>FR</s2><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Levodopa</s0><s2>NK</s2><s2>FR</s2><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Levodopa</s0><s2>NK</s2><s2>FR</s2><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Antiparkinsonien</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Antiparkinson agent</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Antiparkinsoniano</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Chimiothérapie</s0><s5>16</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Chemotherapy</s0><s5>16</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Quimioterapia</s0><s5>16</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Exploration</s0><s5>17</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Exploration</s0><s5>17</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Exploración</s0><s5>17</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Homme</s0><s5>20</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Human</s0><s5>20</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Hombre</s0><s5>20</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Electrodiagnostic</s0><s5>53</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Electrodiagnosis</s0><s5>53</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Electrodiagnóstico</s0><s5>53</s5></fC07><fN21><s1>343</s1></fN21><fN82><s1>PSI</s1></fN82></pA></standard></inist><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Garcia Borreguero, Diego" sort="Garcia Borreguero, Diego" uniqKey="Garcia Borreguero D" first="Diego" last="Garcia-Borreguero">Diego Garcia-Borreguero</name></region><name sortKey="Barrio, Soledad" sort="Barrio, Soledad" uniqKey="Barrio S" first="Soledad" last="Barrio">Soledad Barrio</name><name sortKey="Caminero, Ana B" sort="Caminero, Ana B" uniqKey="Caminero A" first="Ana B." last="Caminero">Ana B. Caminero</name><name sortKey="De La Llave, Yolanda" sort="De La Llave, Yolanda" uniqKey="De La Llave Y" first="Yolanda" last="De La Llave">Yolanda De La Llave</name><name sortKey="Granizo, Juan J" sort="Granizo, Juan J" uniqKey="Granizo J" first="Juan J." last="Granizo">Juan J. Granizo</name><name sortKey="Larrosa, Oscar" sort="Larrosa, Oscar" uniqKey="Larrosa O" first="Oscar" last="Larrosa">Oscar Larrosa</name><name sortKey="Pareja, Juan A" sort="Pareja, Juan A" uniqKey="Pareja J" first="Juan A." last="Pareja">Juan A. Pareja</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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