Nonlinear sensory cortex response to simultaneous tactile stimuli in Writer's cramp
Identifieur interne : 002677 ( PascalFrancis/Checkpoint ); précédent : 002676; suivant : 002678Nonlinear sensory cortex response to simultaneous tactile stimuli in Writer's cramp
Auteurs : Terence D. Sanger [États-Unis] ; Alvaro Pascual-Leone [États-Unis] ; Daniel Tarsy [États-Unis] ; Gottfried Schlaug [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2002.
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Abstract
Writer's cramp is a task-specific dystonia that leads to involuntary hand postures during writing. Abnormalities of sensory processing may play a pathophysiological role in this disorder. Electrophysiology studies in a monkey model of focal dystonia have revealed de-differentiation of sensory maps and the existence of single cells in hand regions of area 3b with enlarged receptive fields that extend to the surfaces of more than one digit. These changes may lead to abnormal processing of simultaneous sensory inputs. To study abnormal processing of simultaneous sensory information in adult humans with writer's cramp, we used functional magnetic resonance imaging to compare the response in primary sensory cortex with simultaneous tactile stimulation of the index and middle finger, with the response to stimulation of each finger alone. We tested five patients with writer's cramp and seven unaffected (normal) subjects. In the normal subjects, a linear combination of the activation patterns for individual finger stimulation predicts the pattern of activity for combined stimulation with 12% error. In writer's cramp patients, the linear combination predicted the combined stimulation pattern with 30% error. Results indicate a nonlinear interaction between the sensory cortical response to individual finger stimulation in writer's cramp. This altered interaction may contribute to the motor abnormalities.
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Sanger</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Child Neurology, Stanford University Medical Center</s1><s2>Stanford, California</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Pascual Leone, Alvaro" sort="Pascual Leone, Alvaro" uniqKey="Pascual Leone A" first="Alvaro" last="Pascual-Leone">Alvaro Pascual-Leone</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Behavioral Neurology Unit and Movement Disorders Center, Department of Neurology, Beth Israel Deaconess Medical Center</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Tarsy, Daniel" sort="Tarsy, Daniel" uniqKey="Tarsy D" first="Daniel" last="Tarsy">Daniel Tarsy</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Behavioral Neurology Unit and Movement Disorders Center, Department of Neurology, Beth Israel Deaconess Medical Center</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Schlaug, Gottfried" sort="Schlaug, Gottfried" uniqKey="Schlaug G" first="Gottfried" last="Schlaug">Gottfried Schlaug</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Neuroimaging Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activation</term><term>Adult</term><term>Exploration</term><term>Finger</term><term>Mechanical stimulus</term><term>Nuclear magnetic resonance imaging</term><term>Pathogenesis</term><term>Sensorimotor cortex</term><term>Upper limb</term><term>Writer cramp</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Crampe écrivain</term><term>Cortex sensorimoteur</term><term>Activation</term><term>Stimulus mécanique</term><term>Doigt</term><term>Membre supérieur</term><term>Imagerie RMN</term><term>Exploration</term><term>Pathogénie</term><term>Adulte</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Writer's cramp is a task-specific dystonia that leads to involuntary hand postures during writing. Abnormalities of sensory processing may play a pathophysiological role in this disorder. Electrophysiology studies in a monkey model of focal dystonia have revealed de-differentiation of sensory maps and the existence of single cells in hand regions of area 3b with enlarged receptive fields that extend to the surfaces of more than one digit. These changes may lead to abnormal processing of simultaneous sensory inputs. To study abnormal processing of simultaneous sensory information in adult humans with writer's cramp, we used functional magnetic resonance imaging to compare the response in primary sensory cortex with simultaneous tactile stimulation of the index and middle finger, with the response to stimulation of each finger alone. We tested five patients with writer's cramp and seven unaffected (normal) subjects. In the normal subjects, a linear combination of the activation patterns for individual finger stimulation predicts the pattern of activity for combined stimulation with 12% error. In writer's cramp patients, the linear combination predicted the combined stimulation pattern with 30% error. Results indicate a nonlinear interaction between the sensory cortical response to individual finger stimulation in writer's cramp. This altered interaction may contribute to the motor abnormalities.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>17</s2></fA05><fA06><s2>1</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Nonlinear sensory cortex response to simultaneous tactile stimuli in Writer's cramp</s1></fA08><fA11 i1="01" i2="1"><s1>SANGER (Terence D.)</s1></fA11><fA11 i1="02" i2="1"><s1>PASCUAL-LEONE (Alvaro)</s1></fA11><fA11 i1="03" i2="1"><s1>TARSY (Daniel)</s1></fA11><fA11 i1="04" i2="1"><s1>SCHLAUG (Gottfried)</s1></fA11><fA14 i1="01"><s1>Department of Child Neurology, Stanford University Medical Center</s1><s2>Stanford, California</s2><s3>USA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Behavioral Neurology Unit and Movement Disorders Center, Department of Neurology, Beth Israel Deaconess Medical Center</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="03"><s1>Neuroimaging Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ></fA14><fA20><s1>105-111</s1></fA20><fA21><s1>2002</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000100147290160</s5></fA43><fA44><s0>0000</s0><s1>© 2002 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>28 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>02-0204556</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Writer's cramp is a task-specific dystonia that leads to involuntary hand postures during writing. Abnormalities of sensory processing may play a pathophysiological role in this disorder. Electrophysiology studies in a monkey model of focal dystonia have revealed de-differentiation of sensory maps and the existence of single cells in hand regions of area 3b with enlarged receptive fields that extend to the surfaces of more than one digit. These changes may lead to abnormal processing of simultaneous sensory inputs. To study abnormal processing of simultaneous sensory information in adult humans with writer's cramp, we used functional magnetic resonance imaging to compare the response in primary sensory cortex with simultaneous tactile stimulation of the index and middle finger, with the response to stimulation of each finger alone. We tested five patients with writer's cramp and seven unaffected (normal) subjects. In the normal subjects, a linear combination of the activation patterns for individual finger stimulation predicts the pattern of activity for combined stimulation with 12% error. In writer's cramp patients, the linear combination predicted the combined stimulation pattern with 30% error. Results indicate a nonlinear interaction between the sensory cortical response to individual finger stimulation in writer's cramp. 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Sanger</name></region><name sortKey="Pascual Leone, Alvaro" sort="Pascual Leone, Alvaro" uniqKey="Pascual Leone A" first="Alvaro" last="Pascual-Leone">Alvaro Pascual-Leone</name><name sortKey="Schlaug, Gottfried" sort="Schlaug, Gottfried" uniqKey="Schlaug G" first="Gottfried" last="Schlaug">Gottfried Schlaug</name><name sortKey="Tarsy, Daniel" sort="Tarsy, Daniel" uniqKey="Tarsy D" first="Daniel" last="Tarsy">Daniel Tarsy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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