Direct economic impact of Parkinson's disease: A research survey in the United Kingdom
Identifieur interne : 002487 ( PascalFrancis/Checkpoint ); précédent : 002486; suivant : 002488Direct economic impact of Parkinson's disease: A research survey in the United Kingdom
Auteurs : Leslie Findley [Royaume-Uni] ; Manjit Aujla [Royaume-Uni] ; Peter G. Bain [Royaume-Uni] ; Mary Baker [Royaume-Uni] ; Catherine Beech [Royaume-Uni] ; Clive Bowman [Royaume-Uni] ; Jeremy Holmes [Royaume-Uni] ; Wendy K. Kingdom [Royaume-Uni] ; Douglas G. Macmahon [Royaume-Uni] ; Viv Peto [Royaume-Uni] ; Jeremy R. Playfer [Royaume-Uni]Source :
- Movement disorders [ 0885-3185 ] ; 2003.
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Abstract
The direct costs of care were evaluated prospectively in a sample of people with Parkinson's disease (PD) in the United Kingdom in 1998. The subjects were drawn from a random sample of general practitioner practices within a representative sample of 36 Regional Health Authorities and the equivalent. A total of 444 resource use questionnaires with usable data were returned (response rate, 59%). The total mean annual cost of care per patient for all patients by age was £5,993 (?9,554, n = 432). Hoehn and Yahr stage significantly (P < 0.001) influenced expenditure by stage as follows: 0 and I, £2,971 (?4,736, n = 110); II, £3,065 (?4,886, n = 89); III, £6,183 (?9,857, n = 120); IV, £10,134 (?16,155, n = 87); V, £18,358 (?29,265, n = 17). National Health Service costs accounted for approximately 38% and social services for 34% of the direct costs of care. Drug expenditure accounted for 24% of overall costs in the <65 years age group and 10% in patients aged >85 years. A move from home to residential care was associated with an approximately 500% cost increase. In conclusion, PD imposes significant direct costs on public services and on individuals. These costs should be taken into account when allocating public funds.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Direct economic impact of Parkinson's disease: A research survey in the United Kingdom</title><author><name sortKey="Findley, Leslie" sort="Findley, Leslie" uniqKey="Findley L" first="Leslie" last="Findley">Leslie Findley</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Oldchurch Hospital</s1><s2>Romford</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Oldchurch Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Aujla, Manjit" sort="Aujla, Manjit" uniqKey="Aujla M" first="Manjit" last="Aujla">Manjit Aujla</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>DuPont, Pharmaceuticals, Ltd.</s1><s2>Stevenage</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Stevenage</wicri:noRegion></affiliation></author><author><name sortKey="Bain, Peter G" sort="Bain, Peter G" uniqKey="Bain P" first="Peter G." last="Bain">Peter G. Bain</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Imperial College, Charing Cross Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Baker, Mary" sort="Baker, Mary" uniqKey="Baker M" first="Mary" last="Baker">Mary Baker</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Eurupean Parkinson's Disease Association</s1><s2>London</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Beech, Catherine" sort="Beech, Catherine" uniqKey="Beech C" first="Catherine" last="Beech">Catherine Beech</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>DuPont, Pharmaceuticals, Ltd.</s1><s2>Stevenage</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Stevenage</wicri:noRegion></affiliation></author><author><name sortKey="Bowman, Clive" sort="Bowman, Clive" uniqKey="Bowman C" first="Clive" last="Bowman">Clive Bowman</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>International Institute on Health and Ageing, University of Bristol</s1><s2>Bristol</s2><s3>GBR</s3><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Holmes, Jeremy" sort="Holmes, Jeremy" uniqKey="Holmes J" first="Jeremy" last="Holmes">Jeremy Holmes</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Beaufort International Health Economics</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kingdom, Wendy K" sort="Kingdom, Wendy K" uniqKey="Kingdom W" first="Wendy K." last="Kingdom">Wendy K. Kingdom</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>DuPont, Pharmaceuticals, Ltd.</s1><s2>Stevenage</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Stevenage</wicri:noRegion></affiliation></author><author><name sortKey="Macmahon, Douglas G" sort="Macmahon, Douglas G" uniqKey="Macmahon D" first="Douglas G." last="Macmahon">Douglas G. Macmahon</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Camborne-Redruth Community Hospital</s1><s2>Redruth</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Camborne-Redruth Community Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Peto, Viv" sort="Peto, Viv" uniqKey="Peto V" first="Viv" last="Peto">Viv Peto</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Health Services Research Unit, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Playfer, Jeremy R" sort="Playfer, Jeremy R" uniqKey="Playfer J" first="Jeremy R." last="Playfer">Jeremy R. Playfer</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Royal Liverpool University Hospital</s1><s2>Liverpool</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Royal Liverpool University Hospital</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">04-0095610</idno><date when="2003">2003</date><idno type="stanalyst">PASCAL 04-0095610 INIST</idno><idno type="RBID">Pascal:04-0095610</idno><idno type="wicri:Area/PascalFrancis/Corpus">002357</idno><idno type="wicri:Area/PascalFrancis/Curation">000964</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002487</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Direct economic impact of Parkinson's disease: A research survey in the United Kingdom</title><author><name sortKey="Findley, Leslie" sort="Findley, Leslie" uniqKey="Findley L" first="Leslie" last="Findley">Leslie Findley</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Oldchurch Hospital</s1><s2>Romford</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Oldchurch Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Aujla, Manjit" sort="Aujla, Manjit" uniqKey="Aujla M" first="Manjit" last="Aujla">Manjit Aujla</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>DuPont, Pharmaceuticals, Ltd.</s1><s2>Stevenage</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Stevenage</wicri:noRegion></affiliation></author><author><name sortKey="Bain, Peter G" sort="Bain, Peter G" uniqKey="Bain P" first="Peter G." last="Bain">Peter G. Bain</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Imperial College, Charing Cross Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Baker, Mary" sort="Baker, Mary" uniqKey="Baker M" first="Mary" last="Baker">Mary Baker</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Eurupean Parkinson's Disease Association</s1><s2>London</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Beech, Catherine" sort="Beech, Catherine" uniqKey="Beech C" first="Catherine" last="Beech">Catherine Beech</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>DuPont, Pharmaceuticals, Ltd.</s1><s2>Stevenage</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Stevenage</wicri:noRegion></affiliation></author><author><name sortKey="Bowman, Clive" sort="Bowman, Clive" uniqKey="Bowman C" first="Clive" last="Bowman">Clive Bowman</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>International Institute on Health and Ageing, University of Bristol</s1><s2>Bristol</s2><s3>GBR</s3><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Holmes, Jeremy" sort="Holmes, Jeremy" uniqKey="Holmes J" first="Jeremy" last="Holmes">Jeremy Holmes</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Beaufort International Health Economics</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kingdom, Wendy K" sort="Kingdom, Wendy K" uniqKey="Kingdom W" first="Wendy K." last="Kingdom">Wendy K. Kingdom</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>DuPont, Pharmaceuticals, Ltd.</s1><s2>Stevenage</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Stevenage</wicri:noRegion></affiliation></author><author><name sortKey="Macmahon, Douglas G" sort="Macmahon, Douglas G" uniqKey="Macmahon D" first="Douglas G." last="Macmahon">Douglas G. Macmahon</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Camborne-Redruth Community Hospital</s1><s2>Redruth</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Camborne-Redruth Community Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Peto, Viv" sort="Peto, Viv" uniqKey="Peto V" first="Viv" last="Peto">Viv Peto</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Health Services Research Unit, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Playfer, Jeremy R" sort="Playfer, Jeremy R" uniqKey="Playfer J" first="Jeremy R." last="Playfer">Jeremy R. Playfer</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Royal Liverpool University Hospital</s1><s2>Liverpool</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Royal Liverpool University Hospital</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cost analysis</term><term>Costs</term><term>Economic impact</term><term>Health economy</term><term>Human</term><term>Parkinson disease</term><term>United Kingdom</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Royaume Uni</term><term>Analyse coût</term><term>Coût</term><term>Impact économique</term><term>Economie santé</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The direct costs of care were evaluated prospectively in a sample of people with Parkinson's disease (PD) in the United Kingdom in 1998. The subjects were drawn from a random sample of general practitioner practices within a representative sample of 36 Regional Health Authorities and the equivalent. A total of 444 resource use questionnaires with usable data were returned (response rate, 59%). The total mean annual cost of care per patient for all patients by age was £5,993 (?9,554, n = 432). Hoehn and Yahr stage significantly (P < 0.001) influenced expenditure by stage as follows: 0 and I, £2,971 (?4,736, n = 110); II, £3,065 (?4,886, n = 89); III, £6,183 (?9,857, n = 120); IV, £10,134 (?16,155, n = 87); V, £18,358 (?29,265, n = 17). National Health Service costs accounted for approximately 38% and social services for 34% of the direct costs of care. Drug expenditure accounted for 24% of overall costs in the <65 years age group and 10% in patients aged >85 years. A move from home to residential care was associated with an approximately 500% cost increase. In conclusion, PD imposes significant direct costs on public services and on individuals. These costs should be taken into account when allocating public funds.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>18</s2></fA05><fA06><s2>10</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Direct economic impact of Parkinson's disease: A research survey in the United Kingdom</s1></fA08><fA11 i1="01" i2="1"><s1>FINDLEY (Leslie)</s1></fA11><fA11 i1="02" i2="1"><s1>AUJLA (Manjit)</s1></fA11><fA11 i1="03" i2="1"><s1>BAIN (Peter G.)</s1></fA11><fA11 i1="04" i2="1"><s1>BAKER (Mary)</s1></fA11><fA11 i1="05" i2="1"><s1>BEECH (Catherine)</s1></fA11><fA11 i1="06" i2="1"><s1>BOWMAN (Clive)</s1></fA11><fA11 i1="07" i2="1"><s1>HOLMES (Jeremy)</s1></fA11><fA11 i1="08" i2="1"><s1>KINGDOM (Wendy K.)</s1></fA11><fA11 i1="09" i2="1"><s1>MACMAHON (Douglas G.)</s1></fA11><fA11 i1="10" i2="1"><s1>PETO (Viv)</s1></fA11><fA11 i1="11" i2="1"><s1>PLAYFER (Jeremy R.)</s1></fA11><fA14 i1="01"><s1>Oldchurch Hospital</s1><s2>Romford</s2><s3>GBR</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>DuPont, Pharmaceuticals, Ltd.</s1><s2>Stevenage</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="03"><s1>Imperial College, Charing Cross Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></fA14><fA14 i1="04"><s1>Eurupean Parkinson's Disease Association</s1><s2>London</s2><s3>GBR</s3><sZ>4 aut.</sZ></fA14><fA14 i1="05"><s1>International Institute on Health and Ageing, University of Bristol</s1><s2>Bristol</s2><s3>GBR</s3><sZ>6 aut.</sZ></fA14><fA14 i1="06"><s1>Beaufort International Health Economics</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ></fA14><fA14 i1="07"><s1>Camborne-Redruth Community Hospital</s1><s2>Redruth</s2><s3>GBR</s3><sZ>9 aut.</sZ></fA14><fA14 i1="08"><s1>Health Services Research Unit, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>10 aut.</sZ></fA14><fA14 i1="09"><s1>Royal Liverpool University Hospital</s1><s2>Liverpool</s2><s3>GBR</s3><sZ>11 aut.</sZ></fA14><fA20><s1>1139-1145</s1></fA20><fA21><s1>2003</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000113383090060</s5></fA43><fA44><s0>0000</s0><s1>© 2004 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>21 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>04-0095610</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>The direct costs of care were evaluated prospectively in a sample of people with Parkinson's disease (PD) in the United Kingdom in 1998. The subjects were drawn from a random sample of general practitioner practices within a representative sample of 36 Regional Health Authorities and the equivalent. A total of 444 resource use questionnaires with usable data were returned (response rate, 59%). The total mean annual cost of care per patient for all patients by age was £5,993 (?9,554, n = 432). Hoehn and Yahr stage significantly (P < 0.001) influenced expenditure by stage as follows: 0 and I, £2,971 (?4,736, n = 110); II, £3,065 (?4,886, n = 89); III, £6,183 (?9,857, n = 120); IV, £10,134 (?16,155, n = 87); V, £18,358 (?29,265, n = 17). National Health Service costs accounted for approximately 38% and social services for 34% of the direct costs of care. Drug expenditure accounted for 24% of overall costs in the <65 years age group and 10% in patients aged >85 years. A move from home to residential care was associated with an approximately 500% cost increase. In conclusion, PD imposes significant direct costs on public services and on individuals. These costs should be taken into account when allocating public funds.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Royaume Uni</s0><s2>NG</s2><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>United Kingdom</s0><s2>NG</s2><s5>04</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Reino Unido</s0><s2>NG</s2><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Analyse coût</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Cost analysis</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Análisis costo</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Coût</s0><s5>08</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Costs</s0><s5>08</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Coste</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Impact économique</s0><s5>17</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Economic impact</s0><s5>17</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Impacto económico</s0><s5>17</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Economie santé</s0><s5>18</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Health economy</s0><s5>18</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Economía salud</s0><s5>18</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Homme</s0><s5>20</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Human</s0><s5>20</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Hombre</s0><s5>20</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Europe</s0><s2>NG</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Europe</s0><s2>NG</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Europa</s0><s2>NG</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>37</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>38</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>39</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>40</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>41</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Santé publique</s0><s5>45</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Public health</s0><s5>45</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Salud pública</s0><s5>45</s5></fC07><fN21><s1>061</s1></fN21><fN82><s1>PSI</s1></fN82></pA></standard></inist><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Oxfordshire</li></region><settlement><li>Londres</li><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Findley, Leslie" sort="Findley, Leslie" uniqKey="Findley L" first="Leslie" last="Findley">Leslie Findley</name></noRegion><name sortKey="Aujla, Manjit" sort="Aujla, Manjit" uniqKey="Aujla M" first="Manjit" last="Aujla">Manjit Aujla</name><name sortKey="Bain, Peter G" sort="Bain, Peter G" uniqKey="Bain P" first="Peter G." last="Bain">Peter G. Bain</name><name sortKey="Baker, Mary" sort="Baker, Mary" uniqKey="Baker M" first="Mary" last="Baker">Mary Baker</name><name sortKey="Beech, Catherine" sort="Beech, Catherine" uniqKey="Beech C" first="Catherine" last="Beech">Catherine Beech</name><name sortKey="Bowman, Clive" sort="Bowman, Clive" uniqKey="Bowman C" first="Clive" last="Bowman">Clive Bowman</name><name sortKey="Holmes, Jeremy" sort="Holmes, Jeremy" uniqKey="Holmes J" first="Jeremy" last="Holmes">Jeremy Holmes</name><name sortKey="Kingdom, Wendy K" sort="Kingdom, Wendy K" uniqKey="Kingdom W" first="Wendy K." last="Kingdom">Wendy K. Kingdom</name><name sortKey="Macmahon, Douglas G" sort="Macmahon, Douglas G" uniqKey="Macmahon D" first="Douglas G." last="Macmahon">Douglas G. Macmahon</name><name sortKey="Peto, Viv" sort="Peto, Viv" uniqKey="Peto V" first="Viv" last="Peto">Viv Peto</name><name sortKey="Playfer, Jeremy R" sort="Playfer, Jeremy R" uniqKey="Playfer J" first="Jeremy R." last="Playfer">Jeremy R. 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