MovDisordV3, PascalFrancis, Checkpoint, bibRecord, 002380

Parkinson's disease, subthalamic stimulation, and selection of candidates: A pathologic study

Identifieur interne : 002380 ( PascalFrancis/Checkpoint ); précédent : 002379; suivant : 002381

Parkinson's disease, subthalamic stimulation, and selection of candidates: A pathologic study

Auteurs : Bechir Jarraya [France] ; Anne-Marie Bonnet [France] ; Charles Duyckaerts [France] ; Jean-Luc Houetc [France] ; Philippe Cornu [France] ; Jean-Jacques Hauw [France] ; Yves Agid [France]

Source :

Movement disorders [ 0885-3185 ] ; 2003.

RBID : Pascal:04-0129063

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Stimulus électrique, Noyau sousthalamique, Critère sélection, Pronostic, Etude cas, Traitement instrumental, Indication, Personne âgée, Femelle.
Wicri :
- topic : Personne âgée.

English descriptors

KwdEn :
- Case study, Elderly, Electrical stimulus, Female, Indication, Instrumentation therapy, Parkinson disease, Prognosis, Selection criterion, Subthalamic nucleus.

Abstract

We report on a patient with Parkinson's disease (PD) who was moderately improved by stimulation of the subthalamic nucleus (STN) and died 2 years after electrode implantation. After neurosurgery, symptoms that had responded to levodopa treatment preoperatively continued to improve. Postural instability, dysarthria, and cognitive impairment continued to worsen, despite STN stimulation and levodopa treatment. Postmortem examination of the brain confirmed the diagnosis of PD and showed that the electrodes had been correctly positioned within the STN. The failure of STN stimulation in this patient confirms the importance of screening and excluding patients from surgery with evolving parkinsonian axial symptoms or cognitive impairment.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">We report on a patient with Parkinson's disease (PD) who was moderately improved by stimulation of the subthalamic nucleus (STN) and died 2 years after electrode implantation. After neurosurgery, symptoms that had responded to levodopa treatment preoperatively continued to improve. Postural instability, dysarthria, and cognitive impairment continued to worsen, despite STN stimulation and levodopa treatment. Postmortem examination of the brain confirmed the diagnosis of PD and showed that the electrodes had been correctly positioned within the STN. The failure of STN stimulation in this patient confirms the importance of screening and excluding patients from surgery with evolving parkinsonian axial symptoms or cognitive impairment.</div>
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<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Stimulation instrumentale</s0>
<s5>45</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Instrumental stimulation</s0>
<s5>45</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Estimulación instrumental</s0>
<s5>45</s5>
</fC07>
<fN21><s1>082</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
</settlement>
<orgName><li>Hôpital de la Salpêtrière</li>
</orgName>
</list>
<tree><country name="France"><noRegion><name sortKey="Jarraya, Bechir" sort="Jarraya, Bechir" uniqKey="Jarraya B" first="Bechir" last="Jarraya">Bechir Jarraya</name>
</noRegion>
<name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name>
<name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name>
<name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name>
<name sortKey="Hauw, Jean Jacques" sort="Hauw, Jean Jacques" uniqKey="Hauw J" first="Jean-Jacques" last="Hauw">Jean-Jacques Hauw</name>
<name sortKey="Houetc, Jean Luc" sort="Houetc, Jean Luc" uniqKey="Houetc J" first="Jean-Luc" last="Houetc">Jean-Luc Houetc</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Parkinson's disease, subthalamic stimulation, and selection of candidates: A pathologic study

Parkinson's disease, subthalamic stimulation, and selection of candidates: A pathologic study

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