Cortical motor activation in akinetic schizophrenic patients: A pilot functional MRI study
Identifieur interne : 002193 ( PascalFrancis/Checkpoint ); précédent : 002192; suivant : 002194Cortical motor activation in akinetic schizophrenic patients: A pilot functional MRI study
Auteurs : Pierre Payoux [France] ; Kader Boulanouar [France] ; Christine Sarramon [France] ; Nelly Fabre [France] ; Sylvie Descombes [France] ; Monique Galitsky [France] ; Claire Thalamas [France] ; Christine Brefel-Courbon [France] ; Umberto Sabatini [Italie] ; Claude Manelfe [France] ; Francois Chollet [France] ; Laurent Schmitt [France] ; Olivier Rascol [France]Source :
- Movement disorders [ 0885-3185 ] ; 2004.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
Abstract
Akinesia is associated with supplementary motor area (SMA) dysfunction in Parkinson's disease. We looked for a similar association in patients with schizophrenia. Using functional magnetic resonance imaging (fMRI), we compared motor activation in 6 akinetic neuroleptic-treated schizophrenic patients and 6 normal subjects. Schizophrenic patients had a defective activation in the SMA, left primary sensorimotor cortex, bilateral lateral premotor and inferior parietal cortices, whereas the right primary sensorimotor cortex and a mesial frontal area were hyperactive. SMA was hypoactive in akinetic schizophrenic patients, emphasizing the role of this area in motor slowness. Other abnormal signals likely reflect schizophrenia-related abnormal intracortical connections.
Affiliations:
- France, Italie
- Latium, Midi-Pyrénées
- Rome, Toulouse
- Université Toulouse III - Paul Sabatier, Université de Toulouse
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Pascal:04-0234531Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cortical motor activation in akinetic schizophrenic patients: A pilot functional MRI study</title>
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<author><name sortKey="Schmitt, Laurent" sort="Schmitt, Laurent" uniqKey="Schmitt L" first="Laurent" last="Schmitt">Laurent Schmitt</name>
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<placeName><settlement type="city">Toulouse</settlement>
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<orgName type="university" n="3">Université Toulouse III - Paul Sabatier</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Toulouse</orgName>
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<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
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<orgName type="institution" wicri:auto="newGroup">Université de Toulouse</orgName>
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<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Clinical Pharmacology, University Hospital of Toulouse</s1>
<s2>Toulouse</s2>
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<placeName><settlement type="city">Toulouse</settlement>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2004">2004</date>
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<front><div type="abstract" xml:lang="en">Akinesia is associated with supplementary motor area (SMA) dysfunction in Parkinson's disease. We looked for a similar association in patients with schizophrenia. Using functional magnetic resonance imaging (fMRI), we compared motor activation in 6 akinetic neuroleptic-treated schizophrenic patients and 6 normal subjects. Schizophrenic patients had a defective activation in the SMA, left primary sensorimotor cortex, bilateral lateral premotor and inferior parietal cortices, whereas the right primary sensorimotor cortex and a mesial frontal area were hyperactive. SMA was hypoactive in akinetic schizophrenic patients, emphasizing the role of this area in motor slowness. Other abnormal signals likely reflect schizophrenia-related abnormal intracortical connections.</div>
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