Corticobasal degeneration and Parkinson's disease assessed by HmPaO spect : The utility of factorial discriminant analysis
Identifieur interne : 001E88 ( PascalFrancis/Checkpoint ); précédent : 001E87; suivant : 001E89Corticobasal degeneration and Parkinson's disease assessed by HmPaO spect : The utility of factorial discriminant analysis
Auteurs : Alexandre Kreisler [France] ; Luc Defebvre [France] ; Pascal Lecouffe [France] ; Alain Duhamel [France] ; Pierre Charpentier [France] ; Marc Steinling [France] ; Alain Destée [France]Source :
- Movement disorders [ 0885-3185 ] ; 2005.
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Abstract
The diagnosis of corticobasal degeneration (CBD) is difficult despite the existence of some typical clinical features. Single photon emission computerized tomography (SPECT) in CBD presents an original pattern (with asymmetric hypoperfusion in pre- and retrorolandic regions) that could facilitate the differential diagnosis of CBD relative to the other degenerative parkinsonian syndromes. The objective of our study was to compare the regional cerebral blood flow measurements studied by SPECT in both CBD and Parkinson's disease (PD) using a multivariate procedure. Twenty-one patients with probable CBD and 20 patients with probable PD underwent brain 99mTc HmPaO SPECT. We used factorial discriminant analysis (FDA) to study the relative fixation of 26 regions of interest (ROIs) drawn on two transverse slices, together with the asymmetry indexes of 13 pairs of ROIs. FDA performed using the full set of parameters classified all the patients correctly. In order to classify the patients more easily, a predictive score using a selection of parameters was established. The most discriminating ROIs were the temporoinsular, temporoparietal, and frontal medial regions. We believe that this semiautomatic classification may be a precious tool for reinforcing the current clinical differential diagnosis of CBD and PD.
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type="wicri:source">INIST</idno><idno type="inist">06-0077734</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 06-0077734 INIST</idno><idno type="RBID">Pascal:06-0077734</idno><idno type="wicri:Area/PascalFrancis/Corpus">001D12</idno><idno type="wicri:Area/PascalFrancis/Curation">001009</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001E88</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Corticobasal degeneration and Parkinson's disease assessed by HmPaO spect : The utility of factorial discriminant analysis</title><author><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre Kreisler</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Regional and University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Regional and University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Lecouffe, Pascal" sort="Lecouffe, Pascal" uniqKey="Lecouffe P" first="Pascal" last="Lecouffe">Pascal Lecouffe</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Nuclear Medicine, Regional and University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Biostatistics, Regional and University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Charpentier, Pierre" sort="Charpentier, Pierre" uniqKey="Charpentier P" first="Pierre" last="Charpentier">Pierre Charpentier</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Regional and University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Steinling, Marc" sort="Steinling, Marc" uniqKey="Steinling M" first="Marc" last="Steinling">Marc Steinling</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Nuclear Medicine, Regional and University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destee">Alain Destée</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Regional and University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Degeneration</term><term>Discriminant analysis</term><term>Functional imaging</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Photon</term><term>Single photon emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Dégénérescence</term><term>Parkinson maladie</term><term>Tomoscintigraphie émission monophotonique</term><term>Photon</term><term>Analyse discriminante</term><term>Imagerie fonctionnelle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The diagnosis of corticobasal degeneration (CBD) is difficult despite the existence of some typical clinical features. Single photon emission computerized tomography (SPECT) in CBD presents an original pattern (with asymmetric hypoperfusion in pre- and retrorolandic regions) that could facilitate the differential diagnosis of CBD relative to the other degenerative parkinsonian syndromes. The objective of our study was to compare the regional cerebral blood flow measurements studied by SPECT in both CBD and Parkinson's disease (PD) using a multivariate procedure. Twenty-one patients with probable CBD and 20 patients with probable PD underwent brain <sup>99m</sup>Tc HmPaO SPECT. We used factorial discriminant analysis (FDA) to study the relative fixation of 26 regions of interest (ROIs) drawn on two transverse slices, together with the asymmetry indexes of 13 pairs of ROIs. FDA performed using the full set of parameters classified all the patients correctly. In order to classify the patients more easily, a predictive score using a selection of parameters was established. The most discriminating ROIs were the temporoinsular, temporoparietal, and frontal medial regions. We believe that this semiautomatic classification may be a precious tool for reinforcing the current clinical differential diagnosis of CBD and PD.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>20</s2></fA05><fA06><s2>11</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Corticobasal degeneration and Parkinson's disease assessed by HmPaO spect : The utility of factorial discriminant analysis</s1></fA08><fA11 i1="01" i2="1"><s1>KREISLER (Alexandre)</s1></fA11><fA11 i1="02" i2="1"><s1>DEFEBVRE (Luc)</s1></fA11><fA11 i1="03" i2="1"><s1>LECOUFFE (Pascal)</s1></fA11><fA11 i1="04" i2="1"><s1>DUHAMEL (Alain)</s1></fA11><fA11 i1="05" i2="1"><s1>CHARPENTIER (Pierre)</s1></fA11><fA11 i1="06" i2="1"><s1>STEINLING (Marc)</s1></fA11><fA11 i1="07" i2="1"><s1>DESTEE (Alain)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, Regional and University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Nuclear Medicine, Regional and University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Biostatistics, Regional and University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>4 aut.</sZ></fA14><fA20><s1>1431-1438</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000134570810060</s5></fA43><fA44><s0>0000</s0><s1>© 2006 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>36 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>06-0077734</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>The diagnosis of corticobasal degeneration (CBD) is difficult despite the existence of some typical clinical features. Single photon emission computerized tomography (SPECT) in CBD presents an original pattern (with asymmetric hypoperfusion in pre- and retrorolandic regions) that could facilitate the differential diagnosis of CBD relative to the other degenerative parkinsonian syndromes. The objective of our study was to compare the regional cerebral blood flow measurements studied by SPECT in both CBD and Parkinson's disease (PD) using a multivariate procedure. Twenty-one patients with probable CBD and 20 patients with probable PD underwent brain <sup>99m</sup>Tc HmPaO SPECT. We used factorial discriminant analysis (FDA) to study the relative fixation of 26 regions of interest (ROIs) drawn on two transverse slices, together with the asymmetry indexes of 13 pairs of ROIs. FDA performed using the full set of parameters classified all the patients correctly. In order to classify the patients more easily, a predictive score using a selection of parameters was established. The most discriminating ROIs were the temporoinsular, temporoparietal, and frontal medial regions. We believe that this semiautomatic classification may be a precious tool for reinforcing the current clinical differential diagnosis of CBD and PD.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC02 i1="03" i2="X"><s0>002B17A03</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Dégénérescence</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Degeneration</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Degeneración</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Tomoscintigraphie émission monophotonique</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Single photon emission tomography</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Tomografía emisión fotón único</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Photon</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Photon</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Fotón</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Analyse discriminante</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Discriminant analysis</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Análisis discriminante</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Imagerie fonctionnelle</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Functional imaging</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Imaginería funcional</s0><s5>12</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>044</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>France</li></country><region><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement><orgName><li>Université Lille 2</li><li>Université Lille Nord de France</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre Kreisler</name></noRegion><name sortKey="Charpentier, Pierre" sort="Charpentier, Pierre" uniqKey="Charpentier P" first="Pierre" last="Charpentier">Pierre Charpentier</name><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destee">Alain Destée</name><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name><name sortKey="Lecouffe, Pascal" sort="Lecouffe, Pascal" uniqKey="Lecouffe P" first="Pascal" last="Lecouffe">Pascal Lecouffe</name><name sortKey="Steinling, Marc" sort="Steinling, Marc" uniqKey="Steinling M" first="Marc" last="Steinling">Marc Steinling</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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