Parkin disease in a brazilian kindred : Manifesting heterozygotes and clinical follow-up over 10 years
Identifieur interne : 001D63 ( PascalFrancis/Checkpoint ); précédent : 001D62; suivant : 001D64Parkin disease in a brazilian kindred : Manifesting heterozygotes and clinical follow-up over 10 years
Auteurs : Naheed L. Khan [Royaume-Uni] ; Wagner Horta [Brésil] ; Louise Eunson [Royaume-Uni] ; Elizabeth Graham [Royaume-Uni] ; Janel O. Johnson [États-Unis] ; SHANNON CHANG [États-Unis] ; Mary Davis [Royaume-Uni] ; Andrew Singleton [États-Unis] ; Nicholas W. Wood [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni]Source :
- Movement disorders [ 0885-3185 ] ; 2005.
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- Pascal (Inist)
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Abstract
We report on a large Brazilian kindred with young-onset parkinsonism due to either a homozygous or heterozygous mutation in parkin. A total of 6 members were affected: 5 were homozygous and 1 heterozygous for a deletion in exon 4. Two other heterozygotes also had extra-pyramidal signs. All affected subjects showed characteristic features of parkin disease with foot dystonia and an excellent response to levodopa complicated by motor fluctuations and dyskinesia within 3 years of therapy. Careful clinical follow-up over 10 years showed the phenotype was similar in all the homozygotes with asymmetrical limb bradykinesia and early walking difficulties. Some acceleration of disability was observed in some of the cases as they entered the third decade of illness, but dementia was absent.
Affiliations:
- Brésil, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Maryland
- Londres
- National Hospital for Neurology and Neurosurgery
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Khan</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience, Institute of Neurology</s1><s2>Queen Square, London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Horta, Wagner" sort="Horta, Wagner" uniqKey="Horta W" first="Wagner" last="Horta">Wagner Horta</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Hospital Universitario Walter Cantidio, Neurology Service and Movement Disorders Department, Federal University of Ceara</s1><s2>Fortaleza, Ceara</s2><s3>BRA</s3><sZ>2 aut.</sZ></inist:fA14><country>Brésil</country><wicri:noRegion>Fortaleza, Ceara</wicri:noRegion></affiliation></author><author><name sortKey="Eunson, Louise" sort="Eunson, Louise" uniqKey="Eunson L" first="Louise" last="Eunson">Louise Eunson</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience, Institute of Neurology</s1><s2>Queen Square, London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Graham, Elizabeth" sort="Graham, Elizabeth" uniqKey="Graham E" first="Elizabeth" last="Graham">Elizabeth Graham</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience, Institute of Neurology</s1><s2>Queen Square, London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Johnson, Janel O" sort="Johnson, Janel O" uniqKey="Johnson J" first="Janel O." last="Johnson">Janel O. Johnson</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Shannon Chang" sort="Shannon Chang" uniqKey="Shannon Chang" last="Shannon Chang">SHANNON CHANG</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Davis, Mary" sort="Davis, Mary" uniqKey="Davis M" first="Mary" last="Davis">Mary Davis</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience, Institute of Neurology</s1><s2>Queen Square, London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas W." last="Wood">Nicholas W. Wood</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience, Institute of Neurology</s1><s2>Queen Square, London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience, Institute of Neurology</s1><s2>Queen Square, London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Reta Lila Weston Unit of Neurological Studies, Royal Free Hospital and University College Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0262070</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0262070 INIST</idno><idno type="RBID">Pascal:05-0262070</idno><idno type="wicri:Area/PascalFrancis/Corpus">001F04</idno><idno type="wicri:Area/PascalFrancis/Curation">000E17</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001D63</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Parkin disease in a brazilian kindred : Manifesting heterozygotes and clinical follow-up over 10 years</title><author><name sortKey="Khan, Naheed L" sort="Khan, Naheed L" uniqKey="Khan N" first="Naheed L." last="Khan">Naheed L. Khan</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience, Institute of Neurology</s1><s2>Queen Square, London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Horta, Wagner" sort="Horta, Wagner" uniqKey="Horta W" first="Wagner" last="Horta">Wagner Horta</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Hospital Universitario Walter Cantidio, Neurology Service and Movement Disorders Department, Federal University of Ceara</s1><s2>Fortaleza, Ceara</s2><s3>BRA</s3><sZ>2 aut.</sZ></inist:fA14><country>Brésil</country><wicri:noRegion>Fortaleza, Ceara</wicri:noRegion></affiliation></author><author><name sortKey="Eunson, Louise" sort="Eunson, Louise" uniqKey="Eunson L" first="Louise" last="Eunson">Louise Eunson</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience, Institute of Neurology</s1><s2>Queen Square, London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Graham, Elizabeth" sort="Graham, Elizabeth" uniqKey="Graham E" first="Elizabeth" last="Graham">Elizabeth Graham</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience, Institute of Neurology</s1><s2>Queen Square, London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Johnson, Janel O" sort="Johnson, Janel O" uniqKey="Johnson J" first="Janel O." last="Johnson">Janel O. Johnson</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Shannon Chang" sort="Shannon Chang" uniqKey="Shannon Chang" last="Shannon Chang">SHANNON CHANG</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Davis, Mary" sort="Davis, Mary" uniqKey="Davis M" first="Mary" last="Davis">Mary Davis</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience, Institute of Neurology</s1><s2>Queen Square, London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas W." last="Wood">Nicholas W. Wood</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience, Institute of Neurology</s1><s2>Queen Square, London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience, Institute of Neurology</s1><s2>Queen Square, London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Reta Lila Weston Unit of Neurological Studies, Royal Free Hospital and University College Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carrier</term><term>Nervous system diseases</term><term>Parkin</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkine</term><term>Porteur</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report on a large Brazilian kindred with young-onset parkinsonism due to either a homozygous or heterozygous mutation in parkin. A total of 6 members were affected: 5 were homozygous and 1 heterozygous for a deletion in exon 4. Two other heterozygotes also had extra-pyramidal signs. All affected subjects showed characteristic features of parkin disease with foot dystonia and an excellent response to levodopa complicated by motor fluctuations and dyskinesia within 3 years of therapy. Careful clinical follow-up over 10 years showed the phenotype was similar in all the homozygotes with asymmetrical limb bradykinesia and early walking difficulties. Some acceleration of disability was observed in some of the cases as they entered the third decade of illness, but dementia was absent.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>20</s2></fA05><fA06><s2>4</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Parkin disease in a brazilian kindred : Manifesting heterozygotes and clinical follow-up over 10 years</s1></fA08><fA11 i1="01" i2="1"><s1>KHAN (Naheed L.)</s1></fA11><fA11 i1="02" i2="1"><s1>HORTA (Wagner)</s1></fA11><fA11 i1="03" i2="1"><s1>EUNSON (Louise)</s1></fA11><fA11 i1="04" i2="1"><s1>GRAHAM (Elizabeth)</s1></fA11><fA11 i1="05" i2="1"><s1>JOHNSON (Janel O.)</s1></fA11><fA11 i1="06" i2="1"><s1>SHANNON CHANG</s1></fA11><fA11 i1="07" i2="1"><s1>DAVIS (Mary)</s1></fA11><fA11 i1="08" i2="1"><s1>SINGLETON (Andrew)</s1></fA11><fA11 i1="09" i2="1"><s1>WOOD (Nicholas W.)</s1></fA11><fA11 i1="10" i2="1"><s1>LEES (Andrew J.)</s1></fA11><fA14 i1="01"><s1>Department of Molecular Neuroscience, Institute of Neurology</s1><s2>Queen Square, London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="02"><s1>Hospital Universitario Walter Cantidio, Neurology Service and Movement Disorders Department, Federal University of Ceara</s1><s2>Fortaleza, Ceara</s2><s3>BRA</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="04"><s1>Reta Lila Weston Unit of Neurological Studies, Royal Free Hospital and University College Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ></fA14><fA20><s1>479-484</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000124582390130</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. 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Some acceleration of disability was observed in some of the cases as they entered the third decade of illness, but dementia was absent.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC02 i1="03" i2="X"><s0>002B17A03</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Parkine</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkin</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkin</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Porteur</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Carrier</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Portador</s0><s5>03</s5></fC03><fN21><s1>185</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Brésil</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Maryland</li></region><settlement><li>Londres</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Khan, Naheed L" sort="Khan, Naheed L" uniqKey="Khan N" first="Naheed L." last="Khan">Naheed L. Khan</name></region><name sortKey="Davis, Mary" sort="Davis, Mary" uniqKey="Davis M" first="Mary" last="Davis">Mary Davis</name><name sortKey="Eunson, Louise" sort="Eunson, Louise" uniqKey="Eunson L" first="Louise" last="Eunson">Louise Eunson</name><name sortKey="Graham, Elizabeth" sort="Graham, Elizabeth" uniqKey="Graham E" first="Elizabeth" last="Graham">Elizabeth Graham</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas W." last="Wood">Nicholas W. Wood</name></country><country name="Brésil"><noRegion><name sortKey="Horta, Wagner" sort="Horta, Wagner" uniqKey="Horta W" first="Wagner" last="Horta">Wagner Horta</name></noRegion></country><country name="États-Unis"><region name="Maryland"><name sortKey="Johnson, Janel O" sort="Johnson, Janel O" uniqKey="Johnson J" first="Janel O." last="Johnson">Janel O. Johnson</name></region><name sortKey="Shannon Chang" sort="Shannon Chang" uniqKey="Shannon Chang" last="Shannon Chang">SHANNON CHANG</name><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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