Behavioral models of Parkinson's disease in rodents : A new look at an old problem
Identifieur interne : 001C18 ( PascalFrancis/Checkpoint ); précédent : 001C17; suivant : 001C19Behavioral models of Parkinson's disease in rodents : A new look at an old problem
Auteurs : Gloria E. Meredith [États-Unis] ; UN JUNG KANG [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The circuitry important for voluntary movement is influenced by dopamine from the substantia nigra and regulated by the nigrostriatal system. The basal ganglia influence the pyramidal tract and other motor systems, such as the mesopontine nuclei and the rubrospinal tract. Although the neuroanatomical substrates underlying motor control are similar for humans and rodents, the behavioral repertoire mediated by those circuits is not. The principal aim of this review is to evaluate how injury to dopamine-mediated pathways in rodents gives rise to motor dysfunction that mimics human Parkinsonism. We will examine the behavioral tests in common use with rodent models of Parkinson's disease and critically evaluate the appropriateness of each test for detecting motor impairment. We will show how tests of motor performance must be guided by a thorough understanding of the clinical symptoms accompanying the disease, the circuitry mediating dopamine deficits in rodents, and familiarity with the rodent behavioral repertoire. We will explain how investigations in rodents of skilled forepaw actions, including placing, grooming, or foot faults, have clear correlates in Parkinson's disease, and are, therefore, the most sensitive ways of detecting motor impairment following dopamine loss from the basal ganglia of rodents.
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
Pascal:06-0538574Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Behavioral models of Parkinson's disease in rodents : A new look at an old problem</title><author><name sortKey="Meredith, Gloria E" sort="Meredith, Gloria E" uniqKey="Meredith G" first="Gloria E." last="Meredith">Gloria E. Meredith</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science</s1><s2>North Chicago, Illinois</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Un Jung Kang" sort="Un Jung Kang" uniqKey="Un Jung Kang" last="Un Jung Kang">UN JUNG KANG</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Departments of Neurology and Neurohiology, Pharmacology, and Physiology, The University of Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0538574</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0538574 INIST</idno><idno type="RBID">Pascal:06-0538574</idno><idno type="wicri:Area/PascalFrancis/Corpus">001968</idno><idno type="wicri:Area/PascalFrancis/Curation">001353</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001C18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Behavioral models of Parkinson's disease in rodents : A new look at an old problem</title><author><name sortKey="Meredith, Gloria E" sort="Meredith, Gloria E" uniqKey="Meredith G" first="Gloria E." last="Meredith">Gloria E. Meredith</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science</s1><s2>North Chicago, Illinois</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Un Jung Kang" sort="Un Jung Kang" uniqKey="Un Jung Kang" last="Un Jung Kang">UN JUNG KANG</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Departments of Neurology and Neurohiology, Pharmacology, and Physiology, The University of Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Grid</term><term>Locomotion</term><term>Models</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Rodentia</term><term>Rotation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Modèle</term><term>Rodentia</term><term>Animal</term><term>Locomotion</term><term>Grille</term><term>Rotation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The circuitry important for voluntary movement is influenced by dopamine from the substantia nigra and regulated by the nigrostriatal system. The basal ganglia influence the pyramidal tract and other motor systems, such as the mesopontine nuclei and the rubrospinal tract. Although the neuroanatomical substrates underlying motor control are similar for humans and rodents, the behavioral repertoire mediated by those circuits is not. The principal aim of this review is to evaluate how injury to dopamine-mediated pathways in rodents gives rise to motor dysfunction that mimics human Parkinsonism. We will examine the behavioral tests in common use with rodent models of Parkinson's disease and critically evaluate the appropriateness of each test for detecting motor impairment. We will show how tests of motor performance must be guided by a thorough understanding of the clinical symptoms accompanying the disease, the circuitry mediating dopamine deficits in rodents, and familiarity with the rodent behavioral repertoire. We will explain how investigations in rodents of skilled forepaw actions, including placing, grooming, or foot faults, have clear correlates in Parkinson's disease, and are, therefore, the most sensitive ways of detecting motor impairment following dopamine loss from the basal ganglia of rodents.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>21</s2></fA05><fA06><s2>10</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Behavioral models of Parkinson's disease in rodents : A new look at an old problem</s1></fA08><fA11 i1="01" i2="1"><s1>MEREDITH (Gloria E.)</s1></fA11><fA11 i1="02" i2="1"><s1>UN JUNG KANG</s1></fA11><fA14 i1="01"><s1>Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science</s1><s2>North Chicago, Illinois</s2><s3>USA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Departments of Neurology and Neurohiology, Pharmacology, and Physiology, The University of Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>2 aut.</sZ></fA14><fA20><s1>1595-1606</s1></fA20><fA21><s1>2006</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000158877800040</s5></fA43><fA44><s0>0000</s0><s1>© 2006 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>119 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>06-0538574</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>The circuitry important for voluntary movement is influenced by dopamine from the substantia nigra and regulated by the nigrostriatal system. The basal ganglia influence the pyramidal tract and other motor systems, such as the mesopontine nuclei and the rubrospinal tract. Although the neuroanatomical substrates underlying motor control are similar for humans and rodents, the behavioral repertoire mediated by those circuits is not. The principal aim of this review is to evaluate how injury to dopamine-mediated pathways in rodents gives rise to motor dysfunction that mimics human Parkinsonism. We will examine the behavioral tests in common use with rodent models of Parkinson's disease and critically evaluate the appropriateness of each test for detecting motor impairment. We will show how tests of motor performance must be guided by a thorough understanding of the clinical symptoms accompanying the disease, the circuitry mediating dopamine deficits in rodents, and familiarity with the rodent behavioral repertoire. We will explain how investigations in rodents of skilled forepaw actions, including placing, grooming, or foot faults, have clear correlates in Parkinson's disease, and are, therefore, the most sensitive ways of detecting motor impairment following dopamine loss from the basal ganglia of rodents.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC02 i1="03" i2="X"><s0>002B17A03</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Modèle</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Models</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Modelo</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Rodentia</s0><s2>NS</s2><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Rodentia</s0><s2>NS</s2><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Rodentia</s0><s2>NS</s2><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Animal</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Animal</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Animal</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Locomotion</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Locomotion</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Locomoción</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Grille</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Grid</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Rejilla</s0><s5>13</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Rotation</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Rotation</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Rotación</s0><s5>14</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>37</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>40</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>353</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Meredith, Gloria E" sort="Meredith, Gloria E" uniqKey="Meredith G" first="Gloria E." last="Meredith">Gloria E. Meredith</name></region><name sortKey="Un Jung Kang" sort="Un Jung Kang" uniqKey="Un Jung Kang" last="Un Jung Kang">UN JUNG KANG</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C18 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 001C18 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= PascalFrancis
|étape= Checkpoint
|type= RBID
|clé= Pascal:06-0538574
|texte= Behavioral models of Parkinson's disease in rodents : A new look at an old problem
}}
| This area was generated with Dilib version V0.6.23. |  |