Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation
Identifieur interne : 001891 ( PascalFrancis/Checkpoint ); précédent : 001890; suivant : 001892Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation
Auteurs : Ioannis U. Isaias [Italie] ; Riccardo Benti [Italie] ; Stefano Goldwurm [Italie] ; Michela Zini [Italie] ; Roberto Cilia [Italie] ; Paolo Gerundini [Italie] ; Alessio Di Fonzo [Pays-Bas, Italie] ; Vincenzo Bonifati [Pays-Bas, Italie] ; Gianni Pezzoli [Italie] ; Angelo Antonini [Italie]Source :
- Movement disorders [ 0885-3185 ] ; 2006.
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Abstract
We measured striatal dopamine transporter binding using [123]ioflupane and SPECT in patients with Parkinson's disease associated with the LRRK2 (PARK8) Gly2019Ser gene mutation (LRRK2-PD) and in gene-negative patients with idiopathic Parkinson's disease (IPD) of comparable disease duration and severity. The LRRK2-PD group consisted of a total of 10 patients (3 sporadic) with mean age 62 ± 14 years, disease duration 9 ± 3 years, and UPDRS III motor score 21.60 ± 6.65. The control IPD group consisted of 15 patients with mean age 59 ± 9 years, disease duration 9 ± 5 years, and UPDRS III motor score 23.80 ± 8.69. [123I]ioflupane-specific uptake ratios were calculated for caudate nucleus and putamen using the occipital cortex as reference region. We found no differences between the LRRK2-PD group and IPD in all items studied. In particular, putamen and caudate uptake values as well as side asymmetry indexes and putamen/caudate ratios all revealed comparable between-group values. We conclude that in these patients carrying the LRRK2 Gly2019Ser mutation, the neurodegenerative process results in a pattern of nigrostriatal dopaminergic dysfunction similar to that observed in IPD.
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation</title>
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<author><name sortKey="Zini, Michela" sort="Zini, Michela" uniqKey="Zini M" first="Michela" last="Zini">Michela Zini</name>
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<series><title level="j" type="main">Movement disorders</title>
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<term>Single photon emission tomography</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Parkinson maladie</term>
<term>Dopamine</term>
<term>Mutation</term>
<term>Ioflupane(123I)</term>
<term>Tomoscintigraphie émission monophotonique</term>
<term>Photon</term>
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<front><div type="abstract" xml:lang="en">We measured striatal dopamine transporter binding using [<sup>123</sup>
]ioflupane and SPECT in patients with Parkinson's disease associated with the LRRK2 (PARK8) Gly2019Ser gene mutation (LRRK2-PD) and in gene-negative patients with idiopathic Parkinson's disease (IPD) of comparable disease duration and severity. The LRRK2-PD group consisted of a total of 10 patients (3 sporadic) with mean age 62 ± 14 years, disease duration 9 ± 3 years, and UPDRS III motor score 21.60 ± 6.65. The control IPD group consisted of 15 patients with mean age 59 ± 9 years, disease duration 9 ± 5 years, and UPDRS III motor score 23.80 ± 8.69. [<sup>123</sup>
I]ioflupane-specific uptake ratios were calculated for caudate nucleus and putamen using the occipital cortex as reference region. We found no differences between the LRRK2-PD group and IPD in all items studied. In particular, putamen and caudate uptake values as well as side asymmetry indexes and putamen/caudate ratios all revealed comparable between-group values. We conclude that in these patients carrying the LRRK2 Gly2019Ser mutation, the neurodegenerative process results in a pattern of nigrostriatal dopaminergic dysfunction similar to that observed in IPD.</div>
</front>
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</fA03>
<fA05><s2>21</s2>
</fA05>
<fA06><s2>8</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>ISAIAS (Ioannis U.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>BENTI (Riccardo)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>GOLDWURM (Stefano)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>ZINI (Michela)</s1>
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<fA11 i1="05" i2="1"><s1>CILIA (Roberto)</s1>
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<fA11 i1="06" i2="1"><s1>GERUNDINI (Paolo)</s1>
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<fA11 i1="07" i2="1"><s1>DI FONZO (Alessio)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>BONIFATI (Vincenzo)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>PEZZOLI (Gianni)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>ANTONINI (Angelo)</s1>
</fA11>
<fA14 i1="01"><s1>Centro Parkinson, Istituti Clinici di Perfezionamento</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>IRCCS-Ospedale Maggiore, Institute of Nuclear Medicine</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Neurology, University of Milano-Bicocca</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Erasmus MC Rotterdam</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Centro Dino Ferrari, Department of Neurological Sciences, University of Milan</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Neurological Sciences, "La Sapienza" University</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA20><s1>1144-1147</s1>
</fA20>
<fA21><s1>2006</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000142193570140</s5>
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<fA44><s0>0000</s0>
<s1>© 2006 INIST-CNRS. All rights reserved.</s1>
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<fA45><s0>24 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>06-0435083</s0>
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<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>We measured striatal dopamine transporter binding using [<sup>123</sup>
]ioflupane and SPECT in patients with Parkinson's disease associated with the LRRK2 (PARK8) Gly2019Ser gene mutation (LRRK2-PD) and in gene-negative patients with idiopathic Parkinson's disease (IPD) of comparable disease duration and severity. The LRRK2-PD group consisted of a total of 10 patients (3 sporadic) with mean age 62 ± 14 years, disease duration 9 ± 3 years, and UPDRS III motor score 21.60 ± 6.65. The control IPD group consisted of 15 patients with mean age 59 ± 9 years, disease duration 9 ± 5 years, and UPDRS III motor score 23.80 ± 8.69. [<sup>123</sup>
I]ioflupane-specific uptake ratios were calculated for caudate nucleus and putamen using the occipital cortex as reference region. We found no differences between the LRRK2-PD group and IPD in all items studied. In particular, putamen and caudate uptake values as well as side asymmetry indexes and putamen/caudate ratios all revealed comparable between-group values. We conclude that in these patients carrying the LRRK2 Gly2019Ser mutation, the neurodegenerative process results in a pattern of nigrostriatal dopaminergic dysfunction similar to that observed in IPD.</s0>
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<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B17A03</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>01</s5>
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<s5>02</s5>
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<s2>FR</s2>
<s5>09</s5>
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<fC03 i1="03" i2="X" l="ENG"><s0>Dopamine</s0>
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<s5>09</s5>
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<fC03 i1="03" i2="X" l="SPA"><s0>Dopamina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>09</s5>
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<fC03 i1="04" i2="X" l="FRE"><s0>Mutation</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Mutation</s0>
<s5>10</s5>
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<fC03 i1="04" i2="X" l="SPA"><s0>Mutación</s0>
<s5>10</s5>
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<s2>NK</s2>
<s2>FR</s2>
<s5>11</s5>
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<s5>11</s5>
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<fC03 i1="06" i2="X" l="FRE"><s0>Tomoscintigraphie émission monophotonique</s0>
<s5>12</s5>
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<fC03 i1="06" i2="X" l="ENG"><s0>Single photon emission tomography</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Tomografía emisión fotón único</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Photon</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Photon</s0>
<s5>13</s5>
</fC03>
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<s5>13</s5>
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<s5>37</s5>
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<s5>37</s5>
</fC07>
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<s5>37</s5>
</fC07>
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<s5>38</s5>
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<s5>38</s5>
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<s5>38</s5>
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<s5>39</s5>
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<s5>39</s5>
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<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
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<s5>40</s5>
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<fN21><s1>289</s1>
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