Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation
Identifieur interne : 001891 ( PascalFrancis/Checkpoint ); précédent : 001890; suivant : 001892Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation
Auteurs : Ioannis U. Isaias [Italie] ; Riccardo Benti [Italie] ; Stefano Goldwurm [Italie] ; Michela Zini [Italie] ; Roberto Cilia [Italie] ; Paolo Gerundini [Italie] ; Alessio Di Fonzo [Pays-Bas, Italie] ; Vincenzo Bonifati [Pays-Bas, Italie] ; Gianni Pezzoli [Italie] ; Angelo Antonini [Italie]Source :
- Movement disorders [ 0885-3185 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
We measured striatal dopamine transporter binding using [123]ioflupane and SPECT in patients with Parkinson's disease associated with the LRRK2 (PARK8) Gly2019Ser gene mutation (LRRK2-PD) and in gene-negative patients with idiopathic Parkinson's disease (IPD) of comparable disease duration and severity. The LRRK2-PD group consisted of a total of 10 patients (3 sporadic) with mean age 62 ± 14 years, disease duration 9 ± 3 years, and UPDRS III motor score 21.60 ± 6.65. The control IPD group consisted of 15 patients with mean age 59 ± 9 years, disease duration 9 ± 5 years, and UPDRS III motor score 23.80 ± 8.69. [123I]ioflupane-specific uptake ratios were calculated for caudate nucleus and putamen using the occipital cortex as reference region. We found no differences between the LRRK2-PD group and IPD in all items studied. In particular, putamen and caudate uptake values as well as side asymmetry indexes and putamen/caudate ratios all revealed comparable between-group values. We conclude that in these patients carrying the LRRK2 Gly2019Ser mutation, the neurodegenerative process results in a pattern of nigrostriatal dopaminergic dysfunction similar to that observed in IPD.
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
Pascal:06-0435083Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation</title><author><name sortKey="Isaias, Ioannis U" sort="Isaias, Ioannis U" uniqKey="Isaias I" first="Ioannis U." last="Isaias">Ioannis U. Isaias</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centro Parkinson, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS-Ospedale Maggiore, Institute of Nuclear Medicine</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, University of Milano-Bicocca</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Benti, Riccardo" sort="Benti, Riccardo" uniqKey="Benti R" first="Riccardo" last="Benti">Riccardo Benti</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS-Ospedale Maggiore, Institute of Nuclear Medicine</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centro Parkinson, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Zini, Michela" sort="Zini, Michela" uniqKey="Zini M" first="Michela" last="Zini">Michela Zini</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centro Parkinson, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, University of Milano-Bicocca</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centro Parkinson, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, University of Milano-Bicocca</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Gerundini, Paolo" sort="Gerundini, Paolo" uniqKey="Gerundini P" first="Paolo" last="Gerundini">Paolo Gerundini</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS-Ospedale Maggiore, Institute of Nuclear Medicine</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Di Fonzo, Alessio" sort="Di Fonzo, Alessio" uniqKey="Di Fonzo A" first="Alessio" last="Di Fonzo">Alessio Di Fonzo</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Erasmus MC Rotterdam</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Centro Dino Ferrari, Department of Neurological Sciences, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>7 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Erasmus MC Rotterdam</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Neurological Sciences, "La Sapienza" University</s1><s2>Rome</s2><s3>ITA</s3><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centro Parkinson, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centro Parkinson, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0435083</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0435083 INIST</idno><idno type="RBID">Pascal:06-0435083</idno><idno type="wicri:Area/PascalFrancis/Corpus">001A55</idno><idno type="wicri:Area/PascalFrancis/Curation">001266</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001891</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation</title><author><name sortKey="Isaias, Ioannis U" sort="Isaias, Ioannis U" uniqKey="Isaias I" first="Ioannis U." last="Isaias">Ioannis U. Isaias</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centro Parkinson, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS-Ospedale Maggiore, Institute of Nuclear Medicine</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, University of Milano-Bicocca</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Benti, Riccardo" sort="Benti, Riccardo" uniqKey="Benti R" first="Riccardo" last="Benti">Riccardo Benti</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS-Ospedale Maggiore, Institute of Nuclear Medicine</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centro Parkinson, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Zini, Michela" sort="Zini, Michela" uniqKey="Zini M" first="Michela" last="Zini">Michela Zini</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centro Parkinson, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, University of Milano-Bicocca</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centro Parkinson, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, University of Milano-Bicocca</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Gerundini, Paolo" sort="Gerundini, Paolo" uniqKey="Gerundini P" first="Paolo" last="Gerundini">Paolo Gerundini</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS-Ospedale Maggiore, Institute of Nuclear Medicine</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Di Fonzo, Alessio" sort="Di Fonzo, Alessio" uniqKey="Di Fonzo A" first="Alessio" last="Di Fonzo">Alessio Di Fonzo</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Erasmus MC Rotterdam</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Centro Dino Ferrari, Department of Neurological Sciences, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>7 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Erasmus MC Rotterdam</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Neurological Sciences, "La Sapienza" University</s1><s2>Rome</s2><s3>ITA</s3><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centro Parkinson, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centro Parkinson, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dopamine</term><term>Ioflupane(123I)</term><term>Mutation</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Photon</term><term>Single photon emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Dopamine</term><term>Mutation</term><term>Ioflupane(123I)</term><term>Tomoscintigraphie émission monophotonique</term><term>Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We measured striatal dopamine transporter binding using [<sup>123</sup>]ioflupane and SPECT in patients with Parkinson's disease associated with the LRRK2 (PARK8) Gly2019Ser gene mutation (LRRK2-PD) and in gene-negative patients with idiopathic Parkinson's disease (IPD) of comparable disease duration and severity. The LRRK2-PD group consisted of a total of 10 patients (3 sporadic) with mean age 62 ± 14 years, disease duration 9 ± 3 years, and UPDRS III motor score 21.60 ± 6.65. The control IPD group consisted of 15 patients with mean age 59 ± 9 years, disease duration 9 ± 5 years, and UPDRS III motor score 23.80 ± 8.69. [<sup>123</sup>I]ioflupane-specific uptake ratios were calculated for caudate nucleus and putamen using the occipital cortex as reference region. We found no differences between the LRRK2-PD group and IPD in all items studied. In particular, putamen and caudate uptake values as well as side asymmetry indexes and putamen/caudate ratios all revealed comparable between-group values. We conclude that in these patients carrying the LRRK2 Gly2019Ser mutation, the neurodegenerative process results in a pattern of nigrostriatal dopaminergic dysfunction similar to that observed in IPD.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>21</s2></fA05><fA06><s2>8</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation</s1></fA08><fA11 i1="01" i2="1"><s1>ISAIAS (Ioannis U.)</s1></fA11><fA11 i1="02" i2="1"><s1>BENTI (Riccardo)</s1></fA11><fA11 i1="03" i2="1"><s1>GOLDWURM (Stefano)</s1></fA11><fA11 i1="04" i2="1"><s1>ZINI (Michela)</s1></fA11><fA11 i1="05" i2="1"><s1>CILIA (Roberto)</s1></fA11><fA11 i1="06" i2="1"><s1>GERUNDINI (Paolo)</s1></fA11><fA11 i1="07" i2="1"><s1>DI FONZO (Alessio)</s1></fA11><fA11 i1="08" i2="1"><s1>BONIFATI (Vincenzo)</s1></fA11><fA11 i1="09" i2="1"><s1>PEZZOLI (Gianni)</s1></fA11><fA11 i1="10" i2="1"><s1>ANTONINI (Angelo)</s1></fA11><fA14 i1="01"><s1>Centro Parkinson, Istituti Clinici di Perfezionamento</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="02"><s1>IRCCS-Ospedale Maggiore, Institute of Nuclear Medicine</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Neurology, University of Milano-Bicocca</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="04"><s1>Erasmus MC Rotterdam</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="05"><s1>Centro Dino Ferrari, Department of Neurological Sciences, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>7 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Neurological Sciences, "La Sapienza" University</s1><s2>Rome</s2><s3>ITA</s3><sZ>8 aut.</sZ></fA14><fA20><s1>1144-1147</s1></fA20><fA21><s1>2006</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000142193570140</s5></fA43><fA44><s0>0000</s0><s1>© 2006 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>24 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>06-0435083</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>We measured striatal dopamine transporter binding using [<sup>123</sup>]ioflupane and SPECT in patients with Parkinson's disease associated with the LRRK2 (PARK8) Gly2019Ser gene mutation (LRRK2-PD) and in gene-negative patients with idiopathic Parkinson's disease (IPD) of comparable disease duration and severity. The LRRK2-PD group consisted of a total of 10 patients (3 sporadic) with mean age 62 ± 14 years, disease duration 9 ± 3 years, and UPDRS III motor score 21.60 ± 6.65. The control IPD group consisted of 15 patients with mean age 59 ± 9 years, disease duration 9 ± 5 years, and UPDRS III motor score 23.80 ± 8.69. [<sup>123</sup>I]ioflupane-specific uptake ratios were calculated for caudate nucleus and putamen using the occipital cortex as reference region. We found no differences between the LRRK2-PD group and IPD in all items studied. In particular, putamen and caudate uptake values as well as side asymmetry indexes and putamen/caudate ratios all revealed comparable between-group values. We conclude that in these patients carrying the LRRK2 Gly2019Ser mutation, the neurodegenerative process results in a pattern of nigrostriatal dopaminergic dysfunction similar to that observed in IPD.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC02 i1="03" i2="X"><s0>002B17A03</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Dopamine</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Dopamine</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Dopamina</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Mutation</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Mutation</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Mutación</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Ioflupane(123I)</s0><s2>NK</s2><s2>FR</s2><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Ioflupane(123I)</s0><s2>NK</s2><s2>FR</s2><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Ioflupano(123I)</s0><s2>NK</s2><s2>FR</s2><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Tomoscintigraphie émission monophotonique</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Single photon emission tomography</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Tomografía emisión fotón único</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Photon</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Photon</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Fotón</s0><s5>13</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Catécholamine</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Catecholamine</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Catecolamina</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Neurotransmetteur</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Neurotransmitter</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Neurotransmisor</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>42</s5></fC07><fN21><s1>289</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Italie</li><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li><li>Latium</li><li>Lombardie</li></region><settlement><li>Milan</li><li>Rome</li><li>Rotterdam</li></settlement></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Isaias, Ioannis U" sort="Isaias, Ioannis U" uniqKey="Isaias I" first="Ioannis U." last="Isaias">Ioannis U. Isaias</name></region><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><name sortKey="Benti, Riccardo" sort="Benti, Riccardo" uniqKey="Benti R" first="Riccardo" last="Benti">Riccardo Benti</name><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name><name sortKey="Di Fonzo, Alessio" sort="Di Fonzo, Alessio" uniqKey="Di Fonzo A" first="Alessio" last="Di Fonzo">Alessio Di Fonzo</name><name sortKey="Gerundini, Paolo" sort="Gerundini, Paolo" uniqKey="Gerundini P" first="Paolo" last="Gerundini">Paolo Gerundini</name><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name><name sortKey="Isaias, Ioannis U" sort="Isaias, Ioannis U" uniqKey="Isaias I" first="Ioannis U." last="Isaias">Ioannis U. Isaias</name><name sortKey="Isaias, Ioannis U" sort="Isaias, Ioannis U" uniqKey="Isaias I" first="Ioannis U." last="Isaias">Ioannis U. Isaias</name><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><name sortKey="Zini, Michela" sort="Zini, Michela" uniqKey="Zini M" first="Michela" last="Zini">Michela Zini</name><name sortKey="Zini, Michela" sort="Zini, Michela" uniqKey="Zini M" first="Michela" last="Zini">Michela Zini</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Di Fonzo, Alessio" sort="Di Fonzo, Alessio" uniqKey="Di Fonzo A" first="Alessio" last="Di Fonzo">Alessio Di Fonzo</name></region><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001891 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 001891 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= PascalFrancis
|étape= Checkpoint
|type= RBID
|clé= Pascal:06-0435083
|texte= Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation
}}
| This area was generated with Dilib version V0.6.23. |  |