Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts
Identifieur interne : 001787 ( PascalFrancis/Checkpoint ); précédent : 001786; suivant : 001788Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts
Auteurs : Shalom Michaeli [États-Unis] ; Gulin Öz [États-Unis] ; Dennis J. Sorce [États-Unis] ; Michael Garwood [États-Unis] ; Kamil Ugurbil [États-Unis] ; Stacv Majestic [États-Unis] ; Paul Tuite [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
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- Pascal (Inist)
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English descriptors
Abstract
Postmortem demonstration of increased iron in the substantia nigra (SN) is a well-appreciated finding in Parkinson's disease (PD). Iron facilitates generation of free radicals, which are thought to play a role in dopamine neuronal loss. To date, however, magnetic resonance imaging (MRI) has failed to show significant in vivo differences in SN iron levels in subjects with PD versus control subjects. This finding may be due to the limitations in tissue contrasts achievable with conventional T1- and T2-weighted MRI sequences that have been used. With the recent development of novel rotating frame transverse (T2p) and longitudinal (T1p) relaxation MRI methods that appear to be sensitive to iron and neuronal loss, respectively, we embarked on a study of 8 individuals with PD (Hoehn & Yahr, Stage II) and 8 age-matched control subjects. Using these techniques with a 4T MRI magnet, we assessed iron deposits and neuronal integrity in the SN. First, T2p MRI, which is reflective of iron-related dynamic dephasing mechanisms (e.g., chemical exchange and diffusion in the locally different magnetic susceptibilities), demonstrated a statistically significant difference between the PD and control group, while routine T2 MRI did not. Second, T1p measurements, which appear to reflect upon neuronal count, indicated neuronal loss in the SN in PD. We show here that sub-millimeter resolution T1p and T2p MRI relaxation methods can provide a noninvasive measure of iron content as well as evidence of neuronal loss in the midbrain of patients with PD.
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Sorce</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota Medical School</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Garwood, Michael" sort="Garwood, Michael" uniqKey="Garwood M" first="Michael" last="Garwood">Michael Garwood</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota Medical School</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Ugurbil, Kamil" sort="Ugurbil, Kamil" uniqKey="Ugurbil K" first="Kamil" last="Ugurbil">Kamil Ugurbil</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota Medical School</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Majestic, Stacv" sort="Majestic, Stacv" uniqKey="Majestic S" first="Stacv" last="Majestic">Stacv Majestic</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of Minnesota</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Tuite, Paul" sort="Tuite, Paul" uniqKey="Tuite P" first="Paul" last="Tuite">Paul Tuite</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of Minnesota</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0181690</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0181690 INIST</idno><idno type="RBID">Pascal:07-0181690</idno><idno type="wicri:Area/PascalFrancis/Corpus">001783</idno><idno type="wicri:Area/PascalFrancis/Curation">001538</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001787</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts</title><author><name sortKey="Michaeli, Shalom" sort="Michaeli, Shalom" uniqKey="Michaeli S" first="Shalom" last="Michaeli">Shalom Michaeli</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota Medical School</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Oz, Gulin" sort="Oz, Gulin" uniqKey="Oz G" first="Gulin" last="Öz">Gulin Öz</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota Medical School</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Sorce, Dennis J" sort="Sorce, Dennis J" uniqKey="Sorce D" first="Dennis J." last="Sorce">Dennis J. Sorce</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota Medical School</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Garwood, Michael" sort="Garwood, Michael" uniqKey="Garwood M" first="Michael" last="Garwood">Michael Garwood</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota Medical School</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Ugurbil, Kamil" sort="Ugurbil, Kamil" uniqKey="Ugurbil K" first="Kamil" last="Ugurbil">Kamil Ugurbil</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota Medical School</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Majestic, Stacv" sort="Majestic, Stacv" uniqKey="Majestic S" first="Stacv" last="Majestic">Stacv Majestic</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of Minnesota</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Tuite, Paul" sort="Tuite, Paul" uniqKey="Tuite P" first="Paul" last="Tuite">Paul Tuite</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of Minnesota</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Human</term><term>Iron</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Fer</term><term>Homme</term><term>Imagerie RMN</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Fer</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Postmortem demonstration of increased iron in the substantia nigra (SN) is a well-appreciated finding in Parkinson's disease (PD). Iron facilitates generation of free radicals, which are thought to play a role in dopamine neuronal loss. To date, however, magnetic resonance imaging (MRI) has failed to show significant in vivo differences in SN iron levels in subjects with PD versus control subjects. This finding may be due to the limitations in tissue contrasts achievable with conventional T<sub>1</sub>- and T<sub>2</sub>-weighted MRI sequences that have been used. With the recent development of novel rotating frame transverse (T<sub>2p</sub>) and longitudinal (T<sub>1p</sub>) relaxation MRI methods that appear to be sensitive to iron and neuronal loss, respectively, we embarked on a study of 8 individuals with PD (Hoehn & Yahr, Stage II) and 8 age-matched control subjects. Using these techniques with a 4T MRI magnet, we assessed iron deposits and neuronal integrity in the SN. First, T<sub>2p</sub> MRI, which is reflective of iron-related dynamic dephasing mechanisms (e.g., chemical exchange and diffusion in the locally different magnetic susceptibilities), demonstrated a statistically significant difference between the PD and control group, while routine T<sub>2</sub> MRI did not. Second, T<sub>1p</sub> measurements, which appear to reflect upon neuronal count, indicated neuronal loss in the SN in PD. We show here that sub-millimeter resolution T<sub>1p</sub> and T<sub>2p</sub> MRI relaxation methods can provide a noninvasive measure of iron content as well as evidence of neuronal loss in the midbrain of patients with PD.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>22</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts</s1></fA08><fA11 i1="01" i2="1"><s1>MICHAELI (Shalom)</s1></fA11><fA11 i1="02" i2="1"><s1>ÖZ (Gulin)</s1></fA11><fA11 i1="03" i2="1"><s1>SORCE (Dennis J.)</s1></fA11><fA11 i1="04" i2="1"><s1>GARWOOD (Michael)</s1></fA11><fA11 i1="05" i2="1"><s1>UGURBIL (Kamil)</s1></fA11><fA11 i1="06" i2="1"><s1>MAJESTIC (Stacv)</s1></fA11><fA11 i1="07" i2="1"><s1>TUITE (Paul)</s1></fA11><fA14 i1="01"><s1>Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota Medical School</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Neurology, University of Minnesota</s1><s2>Minneapolis, Minnesota</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA20><s1>334-340</s1></fA20><fA21><s1>2007</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000159377420070</s5></fA43><fA44><s0>0000</s0><s1>© 2007 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>40 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>07-0181690</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Postmortem demonstration of increased iron in the substantia nigra (SN) is a well-appreciated finding in Parkinson's disease (PD). Iron facilitates generation of free radicals, which are thought to play a role in dopamine neuronal loss. To date, however, magnetic resonance imaging (MRI) has failed to show significant in vivo differences in SN iron levels in subjects with PD versus control subjects. This finding may be due to the limitations in tissue contrasts achievable with conventional T<sub>1</sub>- and T<sub>2</sub>-weighted MRI sequences that have been used. With the recent development of novel rotating frame transverse (T<sub>2p</sub>) and longitudinal (T<sub>1p</sub>) relaxation MRI methods that appear to be sensitive to iron and neuronal loss, respectively, we embarked on a study of 8 individuals with PD (Hoehn & Yahr, Stage II) and 8 age-matched control subjects. Using these techniques with a 4T MRI magnet, we assessed iron deposits and neuronal integrity in the SN. First, T<sub>2p</sub> MRI, which is reflective of iron-related dynamic dephasing mechanisms (e.g., chemical exchange and diffusion in the locally different magnetic susceptibilities), demonstrated a statistically significant difference between the PD and control group, while routine T<sub>2</sub> MRI did not. Second, T<sub>1p</sub> measurements, which appear to reflect upon neuronal count, indicated neuronal loss in the SN in PD. We show here that sub-millimeter resolution T<sub>1p</sub> and T<sub>2p</sub> MRI relaxation methods can provide a noninvasive measure of iron content as well as evidence of neuronal loss in the midbrain of patients with PD.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC02 i1="03" i2="X"><s0>002B17F</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Fer</s0><s2>NC</s2><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Iron</s0><s2>NC</s2><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Hierro</s0><s2>NC</s2><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Homme</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Human</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Hombre</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Imagerie RMN</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Imaginería RMN</s0><s5>11</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>41</s5></fC07><fN21><s1>122</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Michaeli, Shalom" sort="Michaeli, Shalom" uniqKey="Michaeli S" first="Shalom" last="Michaeli">Shalom Michaeli</name></region><name sortKey="Garwood, Michael" sort="Garwood, Michael" uniqKey="Garwood M" first="Michael" last="Garwood">Michael Garwood</name><name sortKey="Majestic, Stacv" sort="Majestic, Stacv" uniqKey="Majestic S" first="Stacv" last="Majestic">Stacv Majestic</name><name sortKey="Oz, Gulin" sort="Oz, Gulin" uniqKey="Oz G" first="Gulin" last="Öz">Gulin Öz</name><name sortKey="Sorce, Dennis J" sort="Sorce, Dennis J" uniqKey="Sorce D" first="Dennis J." last="Sorce">Dennis J. Sorce</name><name sortKey="Tuite, Paul" sort="Tuite, Paul" uniqKey="Tuite P" first="Paul" last="Tuite">Paul Tuite</name><name sortKey="Ugurbil, Kamil" sort="Ugurbil, Kamil" uniqKey="Ugurbil K" first="Kamil" last="Ugurbil">Kamil Ugurbil</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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