Efficacy of pramipexole in restless legs syndrome : A six-week, multicenter, randomized, double-blind study (effect-RLS study)
Identifieur interne : 001688 ( PascalFrancis/Checkpoint ); précédent : 001687; suivant : 001689Efficacy of pramipexole in restless legs syndrome : A six-week, multicenter, randomized, double-blind study (effect-RLS study)
Auteurs : Wolfgang H. Oertel [Allemagne] ; Karin Stiasny-Kolster [Allemagne] ; Bettina Bergtholdt [Allemagne] ; Yngve Hallström [Suède] ; Jaan Albo [Suède] ; Lena Leissner [Suède] ; Thomas Schindler [Allemagne] ; Juergen Koester [Allemagne] ; Juergen Reess [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
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Abstract
We evaluated the efficacy of pramipexole versus placebo in restless legs syndrome (RLS) for 6 weeks. Overall, 345 patients were randomly assigned in a 1:2 ratio to receive either placebo (n = 115) or pramipexole (n = 230) with a starting dose of 0.125 mg/day. The dose was individually optimized according to the Patient Global Impression (PGI) assessment, up to a maximum of 0.75 mg/day. The primary endpoint consisted of two assessments: the change from baseline in the International RLS Study Group Rating Scale (IRLS) and the proportion of patients with Clinical Global Impressions-Improvement (CGI-I) assessments of "much/very much improved" (CGI-I responders) at week 6. Secondary endpoints included PGI and IRLS responder rates. Patient demographics and baseline characteristics were comparable between treatment groups. At baseline, mean IRLS scores were 24.9 (placebo) and 24.7 (pramipexole), representing severely affected patients. After 6 weeks, adjusted mean reductions (±SE) in IRLS score were 5.7 (±0.9) for placebo (median dose 0.47 mg/day) and 12.3 (±0.6) for pramipexole (median dose 0.35 mg/day; P < 0.0001). CGI-I responder rates were 32.5% (placebo) and 62.9% (pramipexole) (P < 0.0001). For all secondary endpoints, pramipexole showed superior results. Pramipexole was well tolerated throughout the study.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Efficacy of pramipexole in restless legs syndrome : A six-week, multicenter, randomized, double-blind study (effect-RLS study)</title><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Philipps-University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Philipps-University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Bergtholdt, Bettina" sort="Bergtholdt, Bettina" uniqKey="Bergtholdt B" first="Bettina" last="Bergtholdt">Bettina Bergtholdt</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Emovis GmbH</s1><s2>Berlin</s2><s3>DEU</s3><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Hallstrom, Yngve" sort="Hallstrom, Yngve" uniqKey="Hallstrom Y" first="Yngve" last="Hallström">Yngve Hallström</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Neuro Center</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>4 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Albo, Jaan" sort="Albo, Jaan" uniqKey="Albo J" first="Jaan" last="Albo">Jaan Albo</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Läkarhuset Vallingby</s1><s2>Vällingby</s2><s3>SWE</s3><sZ>5 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Läkarhuset Vallingby</wicri:noRegion></affiliation></author><author><name sortKey="Leissner, Lena" sort="Leissner, Lena" uniqKey="Leissner L" first="Lena" last="Leissner">Lena Leissner</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurologiska Kliniken</s1><s2>Örebro</s2><s3>SWE</s3><sZ>6 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Neurologiska Kliniken</wicri:noRegion></affiliation></author><author><name sortKey="Schindler, Thomas" sort="Schindler, Thomas" uniqKey="Schindler T" first="Thomas" last="Schindler">Thomas Schindler</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Boehringer Ingelheim Pharma GmbH & Co. KG</s1><s3>DEU</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Boehringer Ingelheim Pharma GmbH & Co. KG</wicri:noRegion><wicri:noRegion>Boehringer Ingelheim Pharma GmbH & Co. KG</wicri:noRegion></affiliation></author><author><name sortKey="Koester, Juergen" sort="Koester, Juergen" uniqKey="Koester J" first="Juergen" last="Koester">Juergen Koester</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Boehringer Ingelheim Pharma GmbH & Co. KG</s1><s3>DEU</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Boehringer Ingelheim Pharma GmbH & Co. KG</wicri:noRegion><wicri:noRegion>Boehringer Ingelheim Pharma GmbH & Co. KG</wicri:noRegion></affiliation></author><author><name sortKey="Reess, Juergen" sort="Reess, Juergen" uniqKey="Reess J" first="Juergen" last="Reess">Juergen Reess</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Boehringer Ingelheim Pharma GmbH & Co. KG</s1><s3>DEU</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Boehringer Ingelheim Pharma GmbH & Co. KG</wicri:noRegion><wicri:noRegion>Boehringer Ingelheim Pharma GmbH & Co. KG</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0133246</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0133246 INIST</idno><idno type="RBID">Pascal:07-0133246</idno><idno type="wicri:Area/PascalFrancis/Corpus">001806</idno><idno type="wicri:Area/PascalFrancis/Curation">001515</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001688</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Efficacy of pramipexole in restless legs syndrome : A six-week, multicenter, randomized, double-blind study (effect-RLS study)</title><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Philipps-University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Philipps-University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Bergtholdt, Bettina" sort="Bergtholdt, Bettina" uniqKey="Bergtholdt B" first="Bettina" last="Bergtholdt">Bettina Bergtholdt</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Emovis GmbH</s1><s2>Berlin</s2><s3>DEU</s3><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Hallstrom, Yngve" sort="Hallstrom, Yngve" uniqKey="Hallstrom Y" first="Yngve" last="Hallström">Yngve Hallström</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Neuro Center</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>4 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Albo, Jaan" sort="Albo, Jaan" uniqKey="Albo J" first="Jaan" last="Albo">Jaan Albo</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Läkarhuset Vallingby</s1><s2>Vällingby</s2><s3>SWE</s3><sZ>5 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Läkarhuset Vallingby</wicri:noRegion></affiliation></author><author><name sortKey="Leissner, Lena" sort="Leissner, Lena" uniqKey="Leissner L" first="Lena" last="Leissner">Lena Leissner</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurologiska Kliniken</s1><s2>Örebro</s2><s3>SWE</s3><sZ>6 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Neurologiska Kliniken</wicri:noRegion></affiliation></author><author><name sortKey="Schindler, Thomas" sort="Schindler, Thomas" uniqKey="Schindler T" first="Thomas" last="Schindler">Thomas Schindler</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Boehringer Ingelheim Pharma GmbH & Co. KG</s1><s3>DEU</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Boehringer Ingelheim Pharma GmbH & Co. KG</wicri:noRegion><wicri:noRegion>Boehringer Ingelheim Pharma GmbH & Co. KG</wicri:noRegion></affiliation></author><author><name sortKey="Koester, Juergen" sort="Koester, Juergen" uniqKey="Koester J" first="Juergen" last="Koester">Juergen Koester</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Boehringer Ingelheim Pharma GmbH & Co. KG</s1><s3>DEU</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Boehringer Ingelheim Pharma GmbH & Co. KG</wicri:noRegion><wicri:noRegion>Boehringer Ingelheim Pharma GmbH & Co. KG</wicri:noRegion></affiliation></author><author><name sortKey="Reess, Juergen" sort="Reess, Juergen" uniqKey="Reess J" first="Juergen" last="Reess">Juergen Reess</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Boehringer Ingelheim Pharma GmbH & Co. KG</s1><s3>DEU</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Boehringer Ingelheim Pharma GmbH & Co. KG</wicri:noRegion><wicri:noRegion>Boehringer Ingelheim Pharma GmbH & Co. KG</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical trial</term><term>Dopamine agonist</term><term>Double blind study</term><term>Multicenter study</term><term>Nervous system diseases</term><term>Pramipexole</term><term>Restless legs syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Impatience membre inférieur syndrome</term><term>Pramipexole</term><term>Etude multicentrique</term><term>Etude double insu</term><term>Essai clinique</term><term>Stimulant dopaminergique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We evaluated the efficacy of pramipexole versus placebo in restless legs syndrome (RLS) for 6 weeks. Overall, 345 patients were randomly assigned in a 1:2 ratio to receive either placebo (n = 115) or pramipexole (n = 230) with a starting dose of 0.125 mg/day. The dose was individually optimized according to the Patient Global Impression (PGI) assessment, up to a maximum of 0.75 mg/day. The primary endpoint consisted of two assessments: the change from baseline in the International RLS Study Group Rating Scale (IRLS) and the proportion of patients with Clinical Global Impressions-Improvement (CGI-I) assessments of "much/very much improved" (CGI-I responders) at week 6. Secondary endpoints included PGI and IRLS responder rates. Patient demographics and baseline characteristics were comparable between treatment groups. At baseline, mean IRLS scores were 24.9 (placebo) and 24.7 (pramipexole), representing severely affected patients. After 6 weeks, adjusted mean reductions (±SE) in IRLS score were 5.7 (±0.9) for placebo (median dose 0.47 mg/day) and 12.3 (±0.6) for pramipexole (median dose 0.35 mg/day; P < 0.0001). CGI-I responder rates were 32.5% (placebo) and 62.9% (pramipexole) (P < 0.0001). For all secondary endpoints, pramipexole showed superior results. Pramipexole was well tolerated throughout the study.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>22</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Efficacy of pramipexole in restless legs syndrome : A six-week, multicenter, randomized, double-blind study (effect-RLS study)</s1></fA08><fA11 i1="01" i2="1"><s1>OERTEL (Wolfgang H.)</s1></fA11><fA11 i1="02" i2="1"><s1>STIASNY-KOLSTER (Karin)</s1></fA11><fA11 i1="03" i2="1"><s1>BERGTHOLDT (Bettina)</s1></fA11><fA11 i1="04" i2="1"><s1>HALLSTRÖM (Yngve)</s1></fA11><fA11 i1="05" i2="1"><s1>ALBO (Jaan)</s1></fA11><fA11 i1="06" i2="1"><s1>LEISSNER (Lena)</s1></fA11><fA11 i1="07" i2="1"><s1>SCHINDLER (Thomas)</s1></fA11><fA11 i1="08" i2="1"><s1>KOESTER (Juergen)</s1></fA11><fA11 i1="09" i2="1"><s1>REESS (Juergen)</s1></fA11><fA14 i1="01"><s1>Philipps-University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></fA14><fA14 i1="02"><s1>Emovis GmbH</s1><s2>Berlin</s2><s3>DEU</s3><sZ>3 aut.</sZ></fA14><fA14 i1="03"><s1>Neuro Center</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Läkarhuset Vallingby</s1><s2>Vällingby</s2><s3>SWE</s3><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Neurologiska Kliniken</s1><s2>Örebro</s2><s3>SWE</s3><sZ>6 aut.</sZ></fA14><fA14 i1="06"><s1>Boehringer Ingelheim Pharma GmbH & Co. KG</s1><s3>DEU</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></fA14><fA17 i1="01" i2="1"><s1>Pramipexole RLS Study Group</s1><s3>INC</s3></fA17><fA20><s1>213-219</s1></fA20><fA21><s1>2007</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000145528070110</s5></fA43><fA44><s0>0000</s0><s1>© 2007 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>14 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>07-0133246</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>We evaluated the efficacy of pramipexole versus placebo in restless legs syndrome (RLS) for 6 weeks. Overall, 345 patients were randomly assigned in a 1:2 ratio to receive either placebo (n = 115) or pramipexole (n = 230) with a starting dose of 0.125 mg/day. The dose was individually optimized according to the Patient Global Impression (PGI) assessment, up to a maximum of 0.75 mg/day. The primary endpoint consisted of two assessments: the change from baseline in the International RLS Study Group Rating Scale (IRLS) and the proportion of patients with Clinical Global Impressions-Improvement (CGI-I) assessments of "much/very much improved" (CGI-I responders) at week 6. Secondary endpoints included PGI and IRLS responder rates. Patient demographics and baseline characteristics were comparable between treatment groups. At baseline, mean IRLS scores were 24.9 (placebo) and 24.7 (pramipexole), representing severely affected patients. After 6 weeks, adjusted mean reductions (±SE) in IRLS score were 5.7 (±0.9) for placebo (median dose 0.47 mg/day) and 12.3 (±0.6) for pramipexole (median dose 0.35 mg/day; P < 0.0001). CGI-I responder rates were 32.5% (placebo) and 62.9% (pramipexole) (P < 0.0001). For all secondary endpoints, pramipexole showed superior results. Pramipexole was well tolerated throughout the study.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B02Q</s0></fC02><fC02 i1="03" i2="X"><s0>002B17D</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Impatience membre inférieur syndrome</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Restless legs syndrome</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Acroparestesia nocturna</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pramipexole</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Pramipexole</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Pramipexol</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Etude multicentrique</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Multicenter study</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Estudio multicéntrico</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Etude double insu</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Double blind study</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Estudio doble ciego</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Essai clinique</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Clinical trial</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Ensayo clínico</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Stimulant dopaminergique</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Dopamine agonist</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Estimulante dopaminérgico</s0><s5>13</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Trouble neurologique</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Neurological disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Trastorno neurológico</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Trouble sensibilité</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Sensitivity disorder</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Trastorno sensibilidad</s0><s5>38</s5></fC07><fN21><s1>085</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Allemagne</li><li>Suède</li></country><region><li>Berlin</li><li>District de Giessen</li><li>Hesse (Land)</li><li>Svealand</li></region><settlement><li>Berlin</li><li>Marbourg</li><li>Stockholm</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name></region><name sortKey="Bergtholdt, Bettina" sort="Bergtholdt, Bettina" uniqKey="Bergtholdt B" first="Bettina" last="Bergtholdt">Bettina Bergtholdt</name><name sortKey="Koester, Juergen" sort="Koester, Juergen" uniqKey="Koester J" first="Juergen" last="Koester">Juergen Koester</name><name sortKey="Reess, Juergen" sort="Reess, Juergen" uniqKey="Reess J" first="Juergen" last="Reess">Juergen Reess</name><name sortKey="Schindler, Thomas" sort="Schindler, Thomas" uniqKey="Schindler T" first="Thomas" last="Schindler">Thomas Schindler</name><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name></country><country name="Suède"><region name="Svealand"><name sortKey="Hallstrom, Yngve" sort="Hallstrom, Yngve" uniqKey="Hallstrom Y" first="Yngve" last="Hallström">Yngve Hallström</name></region><name sortKey="Albo, Jaan" sort="Albo, Jaan" uniqKey="Albo J" first="Jaan" last="Albo">Jaan Albo</name><name sortKey="Leissner, Lena" sort="Leissner, Lena" uniqKey="Leissner L" first="Lena" last="Leissner">Lena Leissner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Efficacy of pramipexole in restless legs syndrome : A six-week, multicenter, randomized, double-blind study (effect-RLS study)
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