MovDisordV3, PascalFrancis, Checkpoint, bibRecord, 001606

Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease

Identifieur interne : 001606 ( PascalFrancis/Checkpoint ); précédent : 001605; suivant : 001607

Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease

Auteurs : XUEMEI HUANG [États-Unis] ; HONGLEI CHEN [États-Unis] ; William C. Miller [États-Unis] ; Richard B. Mailman [États-Unis] ; Jennifer L. Woodard [États-Unis] ; Peter C. Chen [États-Unis] ; DONG XIANG [États-Unis] ; Richard W. Murrow [États-Unis] ; Yi-Zhe Wang [États-Unis] ; Charles Poole [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0181697

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Lipoprotéine, Cholestérol, Apolipoprotéine E, Statine dérivé, Etude cas témoin.

English descriptors

KwdEn :
- Apolipoprotein E, Case control study, Cholesterol, Lipoprotein, Nervous system diseases, Parkinson disease, Statin derivative.

Abstract

The apolipoprotein E (APOE) e2 allele has been associated with both Parkinson's disease (PD) and lower low-density lipoprotein cholesterol (LDL-C). We tested the hypothesis that lower LDL-C may be associated with PD. This case-control study used fasting lipid profiles obtained from 124 PD cases and 112 controls. The PD cases were recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and the controls were recruited from the spouse populations of the same clinic. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol-lowering agents. Lower LDL-C concentrations were associated with a higher occurrence of PD. Compared with participants with the highest LDL-C (≥38 mg/dL), the OR was 2.2 (95% CI = 0.9-5.1) for participants with LDL-C of 115 to 137, 3.5 (95% CI = 1.6-8.1) for LDL-C of 93 to 114, and 2.6 (95% CI = 1.1-5.9) for LDL-C of ≤ 92. Interestingly, use of either cholesterol-lowering drugs, or statins alone, was related to lower PD occurrence. Thus, our data provide preliminary evidence that low LDL-C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence, either of which finding warrants further investigation.

Affiliations:

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease</title>
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<author><name sortKey="Dong Xiang" sort="Dong Xiang" uniqKey="Dong Xiang" last="Dong Xiang">DONG XIANG</name>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apolipoprotein E</term>
<term>Case control study</term>
<term>Cholesterol</term>
<term>Lipoprotein</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Statin derivative</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Parkinson maladie</term>
<term>Lipoprotéine</term>
<term>Cholestérol</term>
<term>Apolipoprotéine E</term>
<term>Statine dérivé</term>
<term>Etude cas témoin</term>
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<front><div type="abstract" xml:lang="en">The apolipoprotein E (APOE) e2 allele has been associated with both Parkinson's disease (PD) and lower low-density lipoprotein cholesterol (LDL-C). We tested the hypothesis that lower LDL-C may be associated with PD. This case-control study used fasting lipid profiles obtained from 124 PD cases and 112 controls. The PD cases were recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and the controls were recruited from the spouse populations of the same clinic. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol-lowering agents. Lower LDL-C concentrations were associated with a higher occurrence of PD. Compared with participants with the highest LDL-C (≥38 mg/dL), the OR was 2.2 (95% CI = 0.9-5.1) for participants with LDL-C of 115 to 137, 3.5 (95% CI = 1.6-8.1) for LDL-C of 93 to 114, and 2.6 (95% CI = 1.1-5.9) for LDL-C of ≤ 92. Interestingly, use of either cholesterol-lowering drugs, or statins alone, was related to lower PD occurrence. Thus, our data provide preliminary evidence that low LDL-C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence, either of which finding warrants further investigation.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease</s1>
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<fA11 i1="01" i2="1"><s1>XUEMEI HUANG</s1>
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<fA11 i1="02" i2="1"><s1>HONGLEI CHEN</s1>
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<fA11 i1="03" i2="1"><s1>MILLER (William C.)</s1>
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<fA11 i1="04" i2="1"><s1>MAILMAN (Richard B.)</s1>
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<fA11 i1="05" i2="1"><s1>WOODARD (Jennifer L.)</s1>
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<fA11 i1="06" i2="1"><s1>CHEN (Peter C.)</s1>
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<fA11 i1="07" i2="1"><s1>DONG XIANG</s1>
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<fA11 i1="08" i2="1"><s1>MURROW (Richard W.)</s1>
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<fA11 i1="09" i2="1"><s1>WANG (Yi-Zhe)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>POOLE (Charles)</s1>
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<fA14 i1="01"><s1>Department of Neurology, University of North Carolina School of Medicine</s1>
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</fA14>
<fA14 i1="02"><s1>National Institute of Environmental Health Sciences</s1>
<s2>Research Triangle Park, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Epidemiology, School of Public Health, University of North Carolina</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Pharmacology, Neuroscience Center, University of North Carolina School of Medicine</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Psychiatry, Neuroscience Center, University of North Carolina School of Medicine</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Medicinal Chemistry, Neuroscience Center, University of North Carolina School of Medicine</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA20><s1>377-381</s1>
</fA20>
<fA21><s1>2007</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000159377420140</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2007 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>30 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>07-0181697</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>The apolipoprotein E (APOE) e2 allele has been associated with both Parkinson's disease (PD) and lower low-density lipoprotein cholesterol (LDL-C). We tested the hypothesis that lower LDL-C may be associated with PD. This case-control study used fasting lipid profiles obtained from 124 PD cases and 112 controls. The PD cases were recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and the controls were recruited from the spouse populations of the same clinic. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol-lowering agents. Lower LDL-C concentrations were associated with a higher occurrence of PD. Compared with participants with the highest LDL-C (≥38 mg/dL), the OR was 2.2 (95% CI = 0.9-5.1) for participants with LDL-C of 115 to 137, 3.5 (95% CI = 1.6-8.1) for LDL-C of 93 to 114, and 2.6 (95% CI = 1.1-5.9) for LDL-C of ≤ 92. Interestingly, use of either cholesterol-lowering drugs, or statins alone, was related to lower PD occurrence. Thus, our data provide preliminary evidence that low LDL-C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence, either of which finding warrants further investigation.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B17A03</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Lipoprotéine</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Lipoprotein</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Lipoproteina</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Cholestérol</s0>
<s2>NK</s2>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Cholesterol</s0>
<s2>NK</s2>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Colesterol</s0>
<s2>NK</s2>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Apolipoprotéine E</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Apolipoprotein E</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Apolipoproteína E</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Statine dérivé</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Statin derivative</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Statina derivado</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Etude cas témoin</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Case control study</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Estudio caso control</s0>
<s5>13</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Lipide</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Lipids</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Lípido</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>41</s5>
</fC07>
<fN21><s1>122</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Xuemei Huang" sort="Xuemei Huang" uniqKey="Xuemei Huang" last="Xuemei Huang">XUEMEI HUANG</name>
</region>
<name sortKey="Chen, Peter C" sort="Chen, Peter C" uniqKey="Chen P" first="Peter C." last="Chen">Peter C. Chen</name>
<name sortKey="Dong Xiang" sort="Dong Xiang" uniqKey="Dong Xiang" last="Dong Xiang">DONG XIANG</name>
<name sortKey="Honglei Chen" sort="Honglei Chen" uniqKey="Honglei Chen" last="Honglei Chen">HONGLEI CHEN</name>
<name sortKey="Mailman, Richard B" sort="Mailman, Richard B" uniqKey="Mailman R" first="Richard B." last="Mailman">Richard B. Mailman</name>
<name sortKey="Mailman, Richard B" sort="Mailman, Richard B" uniqKey="Mailman R" first="Richard B." last="Mailman">Richard B. Mailman</name>
<name sortKey="Mailman, Richard B" sort="Mailman, Richard B" uniqKey="Mailman R" first="Richard B." last="Mailman">Richard B. Mailman</name>
<name sortKey="Mailman, Richard B" sort="Mailman, Richard B" uniqKey="Mailman R" first="Richard B." last="Mailman">Richard B. Mailman</name>
<name sortKey="Miller, William C" sort="Miller, William C" uniqKey="Miller W" first="William C." last="Miller">William C. Miller</name>
<name sortKey="Murrow, Richard W" sort="Murrow, Richard W" uniqKey="Murrow R" first="Richard W." last="Murrow">Richard W. Murrow</name>
<name sortKey="Poole, Charles" sort="Poole, Charles" uniqKey="Poole C" first="Charles" last="Poole">Charles Poole</name>
<name sortKey="Wang, Yi Zhe" sort="Wang, Yi Zhe" uniqKey="Wang Y" first="Yi-Zhe" last="Wang">Yi-Zhe Wang</name>
<name sortKey="Woodard, Jennifer L" sort="Woodard, Jennifer L" uniqKey="Woodard J" first="Jennifer L." last="Woodard">Jennifer L. Woodard</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease

Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease

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