Power-law temporal autocorrelation of activity reflects severity of parkinsonism
Identifieur interne : 001529 ( PascalFrancis/Checkpoint ); précédent : 001528; suivant : 001530Power-law temporal autocorrelation of activity reflects severity of parkinsonism
Auteurs : WEIDONG PAN [Japon] ; Kyoko Ohashi [Japon, États-Unis] ; Yoshiharu Yamamoto [Japon] ; Shin Kwak [Japon]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
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Abstract
We aimed to obtain a reliable, objective scale representing disease severity for appropriate management of patients with Parkinson's disease (PD). Nineteen patients with PD at the Department of Neurology, Tokyo University Hospital, were classified into mild (n = 10) or severe groups (n = 9) depending on their Hoehn-Yahr scores, and wore accelerometers on their wrists for more than 6 consecutive days. During this time we monitored their subjective assessments of symptom severity and analyzed the power-law exponents (a) for local maxima and minima of fluctuations in the activity time series. Statistical comparisons were made between the severe and mild groups and of individual patients on "good condition" and "bad condition" days, as well as between days before and after antiparkinsonism medication. In all patients, the a for local maxima was always lower when parkinsonism was mild than when severe. Presence of tremor did not influence the a for local maxima. As the lower a value for local maxima of fluctuations in activity records reflects more frequent switching behavior from low to high physical activities or the severity of akinesia, actigraph monitoring of parkinsonism, and analysis of its power-law correlation may provide useful objective information for controlling parkinsonism in outpatient clinics and for evaluating new antiparkinsonism drugs.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Power-law temporal autocorrelation of activity reflects severity of parkinsonism</title><author><name sortKey="Weidong Pan" sort="Weidong Pan" uniqKey="Weidong Pan" last="Weidong Pan">WEIDONG PAN</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, The University of Tokyo</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Ohashi, Kyoko" sort="Ohashi, Kyoko" uniqKey="Ohashi K" first="Kyoko" last="Ohashi">Kyoko Ohashi</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Developmental Biopsychiatry Research Program, McLean Hospital/Harvard Medical School</s1><s2>Belmont, Massachusetts</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Yamamoto, Yoshiharu" sort="Yamamoto, Yoshiharu" uniqKey="Yamamoto Y" first="Yoshiharu" last="Yamamoto">Yoshiharu Yamamoto</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Kwak, Shin" sort="Kwak, Shin" uniqKey="Kwak S" first="Shin" last="Kwak">Shin Kwak</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, The University of Tokyo</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0391082</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0391082 INIST</idno><idno type="RBID">Pascal:07-0391082</idno><idno type="wicri:Area/PascalFrancis/Corpus">001614</idno><idno type="wicri:Area/PascalFrancis/Curation">001707</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001529</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Power-law temporal autocorrelation of activity reflects severity of parkinsonism</title><author><name sortKey="Weidong Pan" sort="Weidong Pan" uniqKey="Weidong Pan" last="Weidong Pan">WEIDONG PAN</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, The University of Tokyo</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Ohashi, Kyoko" sort="Ohashi, Kyoko" uniqKey="Ohashi K" first="Kyoko" last="Ohashi">Kyoko Ohashi</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Developmental Biopsychiatry Research Program, McLean Hospital/Harvard Medical School</s1><s2>Belmont, Massachusetts</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Yamamoto, Yoshiharu" sort="Yamamoto, Yoshiharu" uniqKey="Yamamoto Y" first="Yoshiharu" last="Yamamoto">Yoshiharu Yamamoto</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Kwak, Shin" sort="Kwak, Shin" uniqKey="Kwak S" first="Shin" last="Kwak">Shin Kwak</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, The University of Tokyo</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Akinesia</term><term>Autocorrelation</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Parkinsonism</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinsonisme</term><term>Parkinson maladie</term><term>Akinésie</term><term>Autocorrélation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We aimed to obtain a reliable, objective scale representing disease severity for appropriate management of patients with Parkinson's disease (PD). Nineteen patients with PD at the Department of Neurology, Tokyo University Hospital, were classified into mild (n = 10) or severe groups (n = 9) depending on their Hoehn-Yahr scores, and wore accelerometers on their wrists for more than 6 consecutive days. During this time we monitored their subjective assessments of symptom severity and analyzed the power-law exponents (a) for local maxima and minima of fluctuations in the activity time series. Statistical comparisons were made between the severe and mild groups and of individual patients on "good condition" and "bad condition" days, as well as between days before and after antiparkinsonism medication. In all patients, the a for local maxima was always lower when parkinsonism was mild than when severe. Presence of tremor did not influence the a for local maxima. As the lower a value for local maxima of fluctuations in activity records reflects more frequent switching behavior from low to high physical activities or the severity of akinesia, actigraph monitoring of parkinsonism, and analysis of its power-law correlation may provide useful objective information for controlling parkinsonism in outpatient clinics and for evaluating new antiparkinsonism drugs.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>22</s2></fA05><fA06><s2>9</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Power-law temporal autocorrelation of activity reflects severity of parkinsonism</s1></fA08><fA11 i1="01" i2="1"><s1>WEIDONG PAN</s1></fA11><fA11 i1="02" i2="1"><s1>OHASHI (Kyoko)</s1></fA11><fA11 i1="03" i2="1"><s1>YAMAMOTO (Yoshiharu)</s1></fA11><fA11 i1="04" i2="1"><s1>KWAK (Shin)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, Graduate School of Medicine, The University of Tokyo</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="02"><s1>Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="03"><s1>Developmental Biopsychiatry Research Program, McLean Hospital/Harvard Medical School</s1><s2>Belmont, Massachusetts</s2><s3>USA</s3><sZ>2 aut.</sZ></fA14><fA20><s1>1308-1313</s1></fA20><fA21><s1>2007</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000146732490150</s5></fA43><fA44><s0>0000</s0><s1>© 2007 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>21 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>07-0391082</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>We aimed to obtain a reliable, objective scale representing disease severity for appropriate management of patients with Parkinson's disease (PD). Nineteen patients with PD at the Department of Neurology, Tokyo University Hospital, were classified into mild (n = 10) or severe groups (n = 9) depending on their Hoehn-Yahr scores, and wore accelerometers on their wrists for more than 6 consecutive days. During this time we monitored their subjective assessments of symptom severity and analyzed the power-law exponents (a) for local maxima and minima of fluctuations in the activity time series. Statistical comparisons were made between the severe and mild groups and of individual patients on "good condition" and "bad condition" days, as well as between days before and after antiparkinsonism medication. In all patients, the a for local maxima was always lower when parkinsonism was mild than when severe. Presence of tremor did not influence the a for local maxima. As the lower a value for local maxima of fluctuations in activity records reflects more frequent switching behavior from low to high physical activities or the severity of akinesia, actigraph monitoring of parkinsonism, and analysis of its power-law correlation may provide useful objective information for controlling parkinsonism in outpatient clinics and for evaluating new antiparkinsonism drugs.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17A03</s0></fC02><fC02 i1="03" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Parkinsonisme</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkinsonism</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkinson síndrome</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Akinésie</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Akinesia</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Aquinesia</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Autocorrélation</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Autocorrelation</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Autocorrelación</s0><s5>09</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Trouble moteur</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Motor system disorder</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Trastorno motor</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Trouble neurologique</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Neurological disorder</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Trastorno neurológico</s0><s5>42</s5></fC07><fN21><s1>253</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Massachusetts</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Weidong Pan" sort="Weidong Pan" uniqKey="Weidong Pan" last="Weidong Pan">WEIDONG PAN</name></noRegion><name sortKey="Kwak, Shin" sort="Kwak, Shin" uniqKey="Kwak S" first="Shin" last="Kwak">Shin Kwak</name><name sortKey="Ohashi, Kyoko" sort="Ohashi, Kyoko" uniqKey="Ohashi K" first="Kyoko" last="Ohashi">Kyoko Ohashi</name><name sortKey="Yamamoto, Yoshiharu" sort="Yamamoto, Yoshiharu" uniqKey="Yamamoto Y" first="Yoshiharu" last="Yamamoto">Yoshiharu Yamamoto</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Ohashi, Kyoko" sort="Ohashi, Kyoko" uniqKey="Ohashi K" first="Kyoko" last="Ohashi">Kyoko Ohashi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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