Anhidrosis in Multiple System Atrophy : A Preganglionic Sudomotor Dysfunction?
Identifieur interne : 001371 ( PascalFrancis/Checkpoint ); précédent : 001370; suivant : 001372Anhidrosis in Multiple System Atrophy : A Preganglionic Sudomotor Dysfunction?
Auteurs : Vincenzo Donadio [Italie] ; Maria Nolano [Italie] ; Mikael Elam [Suède] ; Pasquale Montagna [Italie] ; Vincenzo Provitera [Italie] ; Enrico Bugiardini [Italie] ; Agostino Baruzzi [Italie] ; Lucio Santoro [Italie] ; Rocco Liguori [Italie]Source :
- Movement disorders [ 0885-3185 ] ; 2008.
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Abstract
Anhidrosis occurs in the majority of multiple system atrophy (MSA) patients but the underlying site of lesion is not well established. We describe three patients with long-standing MSA and anhidrosis diagnosed on the basis of a thermoregulatory sweating test. In biopsies of anhidrotic skin, immunofluorescence analysis disclosed a well preserved postganglionic sudomotor innervation in all three patients supporting the hypothesis of a preganglionic nerve fiber lesion underlying their anhidrosis. Postganglionic sudomotor fiber integrity was also confirmed by normal electrodermal responses in one patient, whereas such responses and microneurographically detectable skin sympathetic nerve activity were absent in the other two MSA patients, suggesting a functional inactivity of structurally intact postganglionic sympathetic skin fibers.
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Foscolo 7</s1><s2>Bologna</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Provitera, Vincenzo" sort="Provitera, Vincenzo" uniqKey="Provitera V" first="Vincenzo" last="Provitera">Vincenzo Provitera</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Salvatore Maugeri Foundation, IRCCS, Via Bagni Vecchi</s1><s2>Telese Terme (BN)</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Telese Terme (BN)</wicri:noRegion></affiliation></author><author><name sortKey="Bugiardini, Enrico" sort="Bugiardini, Enrico" uniqKey="Bugiardini E" first="Enrico" last="Bugiardini">Enrico Bugiardini</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University of Bologna, Via U. Foscolo 7</s1><s2>Bologna</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Baruzzi, Agostino" sort="Baruzzi, Agostino" uniqKey="Baruzzi A" first="Agostino" last="Baruzzi">Agostino Baruzzi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University of Bologna, Via U. Foscolo 7</s1><s2>Bologna</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Santoro, Lucio" sort="Santoro, Lucio" uniqKey="Santoro L" first="Lucio" last="Santoro">Lucio Santoro</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, "Federico II" University of Naples</s1><s2>Naples</s2><s3>ITA</s3><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Liguori, Rocco" sort="Liguori, Rocco" uniqKey="Liguori R" first="Rocco" last="Liguori">Rocco Liguori</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University of Bologna, Via U. Foscolo 7</s1><s2>Bologna</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0251880</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0251880 INIST</idno><idno type="RBID">Pascal:08-0251880</idno><idno type="wicri:Area/PascalFrancis/Corpus">001254</idno><idno type="wicri:Area/PascalFrancis/Curation">001A65</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001371</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Anhidrosis in Multiple System Atrophy : A Preganglionic Sudomotor Dysfunction?</title><author><name sortKey="Donadio, Vincenzo" sort="Donadio, Vincenzo" uniqKey="Donadio V" first="Vincenzo" last="Donadio">Vincenzo Donadio</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University of Bologna, Via U. Foscolo 7</s1><s2>Bologna</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Nolano, Maria" sort="Nolano, Maria" uniqKey="Nolano M" first="Maria" last="Nolano">Maria Nolano</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Salvatore Maugeri Foundation, IRCCS, Via Bagni Vecchi</s1><s2>Telese Terme (BN)</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Telese Terme (BN)</wicri:noRegion></affiliation></author><author><name sortKey="Elam, Mikael" sort="Elam, Mikael" uniqKey="Elam M" first="Mikael" last="Elam">Mikael Elam</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Clinical Neurophysiology, Sahlgrenska University Hospital, Gotehorg University</s1><s2>Goteborg</s2><s3>SWE</s3><sZ>3 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Goteborg</wicri:noRegion></affiliation></author><author><name sortKey="Montagna, Pasquale" sort="Montagna, Pasquale" uniqKey="Montagna P" first="Pasquale" last="Montagna">Pasquale Montagna</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University of Bologna, Via U. Foscolo 7</s1><s2>Bologna</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Provitera, Vincenzo" sort="Provitera, Vincenzo" uniqKey="Provitera V" first="Vincenzo" last="Provitera">Vincenzo Provitera</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Salvatore Maugeri Foundation, IRCCS, Via Bagni Vecchi</s1><s2>Telese Terme (BN)</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Telese Terme (BN)</wicri:noRegion></affiliation></author><author><name sortKey="Bugiardini, Enrico" sort="Bugiardini, Enrico" uniqKey="Bugiardini E" first="Enrico" last="Bugiardini">Enrico Bugiardini</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University of Bologna, Via U. Foscolo 7</s1><s2>Bologna</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Baruzzi, Agostino" sort="Baruzzi, Agostino" uniqKey="Baruzzi A" first="Agostino" last="Baruzzi">Agostino Baruzzi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University of Bologna, Via U. Foscolo 7</s1><s2>Bologna</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Santoro, Lucio" sort="Santoro, Lucio" uniqKey="Santoro L" first="Lucio" last="Santoro">Lucio Santoro</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, "Federico II" University of Naples</s1><s2>Naples</s2><s3>ITA</s3><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Liguori, Rocco" sort="Liguori, Rocco" uniqKey="Liguori R" first="Rocco" last="Liguori">Rocco Liguori</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University of Bologna, Via U. Foscolo 7</s1><s2>Bologna</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anhidrosis</term><term>Biopsy</term><term>Dysfunction</term><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Skin</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anhidrose</term><term>Atrophie multisystématisée</term><term>Pathologie du système nerveux</term><term>Trouble fonctionnel</term><term>Peau</term><term>Biopsie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Anhidrosis occurs in the majority of multiple system atrophy (MSA) patients but the underlying site of lesion is not well established. We describe three patients with long-standing MSA and anhidrosis diagnosed on the basis of a thermoregulatory sweating test. In biopsies of anhidrotic skin, immunofluorescence analysis disclosed a well preserved postganglionic sudomotor innervation in all three patients supporting the hypothesis of a preganglionic nerve fiber lesion underlying their anhidrosis. Postganglionic sudomotor fiber integrity was also confirmed by normal electrodermal responses in one patient, whereas such responses and microneurographically detectable skin sympathetic nerve activity were absent in the other two MSA patients, suggesting a functional inactivity of structurally intact postganglionic sympathetic skin fibers.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>23</s2></fA05><fA06><s2>6</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Anhidrosis in Multiple System Atrophy : A Preganglionic Sudomotor Dysfunction?</s1></fA08><fA11 i1="01" i2="1"><s1>DONADIO (Vincenzo)</s1></fA11><fA11 i1="02" i2="1"><s1>NOLANO (Maria)</s1></fA11><fA11 i1="03" i2="1"><s1>ELAM (Mikael)</s1></fA11><fA11 i1="04" i2="1"><s1>MONTAGNA (Pasquale)</s1></fA11><fA11 i1="05" i2="1"><s1>PROVITERA (Vincenzo)</s1></fA11><fA11 i1="06" i2="1"><s1>BUGIARDINI (Enrico)</s1></fA11><fA11 i1="07" i2="1"><s1>BARUZZI (Agostino)</s1></fA11><fA11 i1="08" i2="1"><s1>SANTORO (Lucio)</s1></fA11><fA11 i1="09" i2="1"><s1>LIGUORI (Rocco)</s1></fA11><fA14 i1="01"><s1>Department of Neurological Sciences, University of Bologna, Via U. Foscolo 7</s1><s2>Bologna</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Neurology, Salvatore Maugeri Foundation, IRCCS, Via Bagni Vecchi</s1><s2>Telese Terme (BN)</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Clinical Neurophysiology, Sahlgrenska University Hospital, Gotehorg University</s1><s2>Goteborg</s2><s3>SWE</s3><sZ>3 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Neurology, "Federico II" University of Naples</s1><s2>Naples</s2><s3>ITA</s3><sZ>8 aut.</sZ></fA14><fA20><s1>885-888</s1></fA20><fA21><s1>2008</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000195888140180</s5></fA43><fA44><s0>0000</s0><s1>© 2008 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>15 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>08-0251880</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Anhidrosis occurs in the majority of multiple system atrophy (MSA) patients but the underlying site of lesion is not well established. We describe three patients with long-standing MSA and anhidrosis diagnosed on the basis of a thermoregulatory sweating test. In biopsies of anhidrotic skin, immunofluorescence analysis disclosed a well preserved postganglionic sudomotor innervation in all three patients supporting the hypothesis of a preganglionic nerve fiber lesion underlying their anhidrosis. Postganglionic sudomotor fiber integrity was also confirmed by normal electrodermal responses in one patient, whereas such responses and microneurographically detectable skin sympathetic nerve activity were absent in the other two MSA patients, suggesting a functional inactivity of structurally intact postganglionic sympathetic skin fibers.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17F</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Anhidrose</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Anhidrosis</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Anhidrosis</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Atrophie multisystématisée</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Multiple system atrophy</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Atrofia multisistematizada</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Trouble fonctionnel</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Dysfunction</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Trastorno funcional</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Peau</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Skin</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Piel</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Biopsie</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Biopsy</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Biopsia</s0><s5>11</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie des glandes sudoripares</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Sweat gland disease</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Glándula sudorípara patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de la peau</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Skin disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Piel patología</s0><s5>38</s5></fC07><fN21><s1>162</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Italie</li><li>Suède</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Donadio, Vincenzo" sort="Donadio, Vincenzo" uniqKey="Donadio V" first="Vincenzo" last="Donadio">Vincenzo Donadio</name></noRegion><name sortKey="Baruzzi, Agostino" sort="Baruzzi, Agostino" uniqKey="Baruzzi A" first="Agostino" last="Baruzzi">Agostino Baruzzi</name><name sortKey="Bugiardini, Enrico" sort="Bugiardini, Enrico" uniqKey="Bugiardini E" first="Enrico" last="Bugiardini">Enrico Bugiardini</name><name sortKey="Liguori, Rocco" sort="Liguori, Rocco" uniqKey="Liguori R" first="Rocco" last="Liguori">Rocco Liguori</name><name sortKey="Montagna, Pasquale" sort="Montagna, Pasquale" uniqKey="Montagna P" first="Pasquale" last="Montagna">Pasquale Montagna</name><name sortKey="Nolano, Maria" sort="Nolano, Maria" uniqKey="Nolano M" first="Maria" last="Nolano">Maria Nolano</name><name sortKey="Provitera, Vincenzo" sort="Provitera, Vincenzo" uniqKey="Provitera V" first="Vincenzo" last="Provitera">Vincenzo Provitera</name><name sortKey="Santoro, Lucio" sort="Santoro, Lucio" uniqKey="Santoro L" first="Lucio" last="Santoro">Lucio Santoro</name></country><country name="Suède"><noRegion><name sortKey="Elam, Mikael" sort="Elam, Mikael" uniqKey="Elam M" first="Mikael" last="Elam">Mikael Elam</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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