Multicenter Study on Deep Brain Stimulation in Parkinson's Disease : An Independent Assessment of Reported Adverse Events at 4 Years
Identifieur interne : 001180 ( PascalFrancis/Checkpoint ); précédent : 001179; suivant : 001181Multicenter Study on Deep Brain Stimulation in Parkinson's Disease : An Independent Assessment of Reported Adverse Events at 4 Years
Auteurs : Marwan I. Hariz [Royaume-Uni, Suède] ; Stig Rehncrona [Suède] ; Niall P. Quinn [Royaume-Uni] ; Johannes D. Speelman [Pays-Bas] ; Carin Wensing [Pays-Bas]Source :
- Movement disorders [ 0885-3185 ] ; 2008.
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Abstract
Ongoing adverse events (AEs) at 4-years postsurgery in 69 patients with advanced Parkinson's disease (PD) who received deep brain stimulation (DBS) of the subthalamic nucleus (STN) (n = 49) or the internal globus pallidus (GPi) (n = 20), in the framework of a subset of eight centers of a multicenter study, were analyzed by an independent ad hoc committee. At baseline, the patients' age, sex, disease duration, and clinical condition were virtually identical, as was the duration of follow-up. There were 64 AEs reported in 53% of STN DBS patients and eight AEs reported in 35% of GPi DBS patients. Most of the AEs were not deemed severe and were reported to be present "both with and without stimulation." The majority of the AEs affected patients' cognitive, psychiatric and behavioral status, as well as speech, gait, and balance, and most of these AEs occurred in STN DBS patients. When comparing patients who exhibited AEs with those who did not, it was found that in the STN DBS group, the patients with AEs had a longer disease duration, as well as more gait disorders and psychiatric disturbances at baseline.
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Hariz</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery, University Hospital</s1><s2>Ume?</s2><s3>SWE</s3><sZ>1 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Ume?</wicri:noRegion></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurosurgery, University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>2 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Speelman, Johannes D" sort="Speelman, Johannes D" uniqKey="Speelman J" first="Johannes D." last="Speelman">Johannes D. 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Hariz</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery, University Hospital</s1><s2>Ume?</s2><s3>SWE</s3><sZ>1 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Ume?</wicri:noRegion></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurosurgery, University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>2 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Speelman, Johannes D" sort="Speelman, Johannes D" uniqKey="Speelman J" first="Johannes D." last="Speelman">Johannes D. Speelman</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurology, Academic Hospital</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Wensing, Carin" sort="Wensing, Carin" uniqKey="Wensing C" first="Carin" last="Wensing">Carin Wensing</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Bakken Research Centre</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>5 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Bakken Research Centre</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Complication</term><term>Deep brain stimulation</term><term>Multicenter study</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Etude multicentrique</term><term>Complication</term><term>Noyau sousthalamique</term><term>Stimulation cérébrale profonde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ongoing adverse events (AEs) at 4-years postsurgery in 69 patients with advanced Parkinson's disease (PD) who received deep brain stimulation (DBS) of the subthalamic nucleus (STN) (n = 49) or the internal globus pallidus (GPi) (n = 20), in the framework of a subset of eight centers of a multicenter study, were analyzed by an independent ad hoc committee. At baseline, the patients' age, sex, disease duration, and clinical condition were virtually identical, as was the duration of follow-up. There were 64 AEs reported in 53% of STN DBS patients and eight AEs reported in 35% of GPi DBS patients. Most of the AEs were not deemed severe and were reported to be present "both with and without stimulation." The majority of the AEs affected patients' cognitive, psychiatric and behavioral status, as well as speech, gait, and balance, and most of these AEs occurred in STN DBS patients. When comparing patients who exhibited AEs with those who did not, it was found that in the STN DBS group, the patients with AEs had a longer disease duration, as well as more gait disorders and psychiatric disturbances at baseline.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>23</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Multicenter Study on Deep Brain Stimulation in Parkinson's Disease : An Independent Assessment of Reported Adverse Events at 4 Years</s1></fA08><fA11 i1="01" i2="1"><s1>HARIZ (Marwan I.)</s1></fA11><fA11 i1="02" i2="1"><s1>REHNCRONA (Stig)</s1></fA11><fA11 i1="03" i2="1"><s1>QUINN (Niall P.)</s1></fA11><fA11 i1="04" i2="1"><s1>SPEELMAN (Johannes D.)</s1></fA11><fA11 i1="05" i2="1"><s1>WENSING (Carin)</s1></fA11><fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Neurosurgery, University Hospital</s1><s2>Ume?</s2><s3>SWE</s3><sZ>1 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Neurosurgery, University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>2 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Neurology, Academic Hospital</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>4 aut.</sZ></fA14><fA14 i1="05"><s1>Bakken Research Centre</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>5 aut.</sZ></fA14><fA17 i1="01" i2="1"><s1>Multicentre Advanced Parkinson's Disease Deep Brain Stimulation Group</s1><s3>GBR</s3></fA17><fA20><s1>416-421</s1></fA20><fA21><s1>2008</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000173639210140</s5></fA43><fA44><s0>0000</s0><s1>© 2008 INIST-CNRS. 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The majority of the AEs affected patients' cognitive, psychiatric and behavioral status, as well as speech, gait, and balance, and most of these AEs occurred in STN DBS patients. 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Hariz</name></region><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name></country><country name="Suède"><noRegion><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name></noRegion><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Speelman, Johannes D" sort="Speelman, Johannes D" uniqKey="Speelman J" first="Johannes D." last="Speelman">Johannes D. Speelman</name></region><name sortKey="Wensing, Carin" sort="Wensing, Carin" uniqKey="Wensing C" first="Carin" last="Wensing">Carin Wensing</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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