MovDisordV3, PascalFrancis, Checkpoint, bibRecord, 001147

Parkinsonism and Dystonia Caused by the Illicit Use of Ephedrone : A Longitudinal Study

Identifieur interne : 001147 ( PascalFrancis/Checkpoint ); précédent : 001146; suivant : 001148

Parkinsonism and Dystonia Caused by the Illicit Use of Ephedrone : A Longitudinal Study

Auteurs : Marianna Selikhova [Royaume-Uni, Russie] ; Ljuda Fedoryshyn [Ukraine] ; Yuri Matviyenko [Ukraine] ; Irena Komnatska [Ukraine] ; Marianna Kyrylchuk [Ukraine] ; Lesrek Krolicki [Pologne] ; Andrzej Friedman [Pologne] ; Andrew Taylor [Royaume-Uni] ; H. Rolf J Ger [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; Yanush Sanotsky [Ukraine]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:09-0038026

Descripteurs français

Pascal (Inist)
- Parkinsonisme, Dystonie, Pathologie du système nerveux, Ephédrine, Pallidum.

English descriptors

KwdEn :
- Dystonia, Ephedrine, Nervous system diseases, Pallidum, Parkinsonism.

Abstract

A neurological syndrome characterized by levodopa unresponsive bradykinesia, retropulsion with falls backwards, dysarthria, gait disturbance, dystonia, and emotional lability was identified in 13 male opiate addicts following the prolonged intravenous use of ephedrone (methcathinone), a central nervous stimulant prepared from pseudoephedrine, potassium permanganate, and vinegar. The natural history, response to treatment, and clinical features has been studied, and MR and dopamine transporter SPECT brain imaging were carried out. Pubic hair was sampled for manganese. The clinical and radiological picture closely resembled previous reports of chronic manganese poisoning and increased mean manganese level in pubic hair observed for at least 1 year after cessation of ephedrone. Odor identification was intact. Cognitive assessment showed a mild executive dysfunction and a mild depression. DaTSCANs were all normal. The neurological syndrome bears some similarities to PSP but differs from Parkinson's disease. Delayed neurological progression despite discontinuation of ephedrone occurred in one-third of cases. Ephedrone poisoning should be considered as a possible cause of secondary Parkinsonism in young adults, particularly from Eastern Europe.

Affiliations:

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<front><div type="abstract" xml:lang="en">A neurological syndrome characterized by levodopa unresponsive bradykinesia, retropulsion with falls backwards, dysarthria, gait disturbance, dystonia, and emotional lability was identified in 13 male opiate addicts following the prolonged intravenous use of ephedrone (methcathinone), a central nervous stimulant prepared from pseudoephedrine, potassium permanganate, and vinegar. The natural history, response to treatment, and clinical features has been studied, and MR and dopamine transporter SPECT brain imaging were carried out. Pubic hair was sampled for manganese. The clinical and radiological picture closely resembled previous reports of chronic manganese poisoning and increased mean manganese level in pubic hair observed for at least 1 year after cessation of ephedrone. Odor identification was intact. Cognitive assessment showed a mild executive dysfunction and a mild depression. DaTSCANs were all normal. The neurological syndrome bears some similarities to PSP but differs from Parkinson's disease. Delayed neurological progression despite discontinuation of ephedrone occurred in one-third of cases. Ephedrone poisoning should be considered as a possible cause of secondary Parkinsonism in young adults, particularly from Eastern Europe.</div>
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<fA66 i1="01"><s0>USA</s0>
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<fC01 i1="01" l="ENG"><s0>A neurological syndrome characterized by levodopa unresponsive bradykinesia, retropulsion with falls backwards, dysarthria, gait disturbance, dystonia, and emotional lability was identified in 13 male opiate addicts following the prolonged intravenous use of ephedrone (methcathinone), a central nervous stimulant prepared from pseudoephedrine, potassium permanganate, and vinegar. The natural history, response to treatment, and clinical features has been studied, and MR and dopamine transporter SPECT brain imaging were carried out. Pubic hair was sampled for manganese. The clinical and radiological picture closely resembled previous reports of chronic manganese poisoning and increased mean manganese level in pubic hair observed for at least 1 year after cessation of ephedrone. Odor identification was intact. Cognitive assessment showed a mild executive dysfunction and a mild depression. DaTSCANs were all normal. The neurological syndrome bears some similarities to PSP but differs from Parkinson's disease. Delayed neurological progression despite discontinuation of ephedrone occurred in one-third of cases. Ephedrone poisoning should be considered as a possible cause of secondary Parkinsonism in young adults, particularly from Eastern Europe.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17H</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Parkinsonisme</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Parkinsonism</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Parkinson síndrome</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Dystonie</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Dystonia</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Distonía</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Ephédrine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Ephedrine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Pallidum</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Pallidum</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Pallidum</s0>
<s5>10</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Mouvement involontaire</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Involuntary movement</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Movimiento involuntario</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie du muscle strié</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Striated muscle disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Músculo estriado patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Noyau gris central</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Basal ganglion</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Núcleo basal</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>44</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>44</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>44</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>45</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>45</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>45</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>46</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>46</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>46</s5>
</fC07>
<fN21><s1>026</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Pologne</li>
<li>Royaume-Uni</li>
<li>Russie</li>
<li>Ukraine</li>
</country>
<region><li>Angleterre</li>
<li>District fédéral central</li>
<li>Grand Londres</li>
</region>
<settlement><li>Londres</li>
<li>Moscou</li>
</settlement>
<orgName><li>National Hospital for Neurology and Neurosurgery</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Selikhova, Marianna" sort="Selikhova, Marianna" uniqKey="Selikhova M" first="Marianna" last="Selikhova">Marianna Selikhova</name>
</noRegion>
<name sortKey="J Ger, H Rolf" sort="J Ger, H Rolf" uniqKey="J Ger H" first="H. Rolf" last="J Ger">H. Rolf J Ger</name>
<name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees (neurologue)</name>
<name sortKey="Taylor, Andrew" sort="Taylor, Andrew" uniqKey="Taylor A" first="Andrew" last="Taylor">Andrew Taylor</name>
</country>
<country name="Russie"><region name="District fédéral central"><name sortKey="Selikhova, Marianna" sort="Selikhova, Marianna" uniqKey="Selikhova M" first="Marianna" last="Selikhova">Marianna Selikhova</name>
</region>
</country>
<country name="Ukraine"><noRegion><name sortKey="Fedoryshyn, Ljuda" sort="Fedoryshyn, Ljuda" uniqKey="Fedoryshyn L" first="Ljuda" last="Fedoryshyn">Ljuda Fedoryshyn</name>
</noRegion>
<name sortKey="Komnatska, Irena" sort="Komnatska, Irena" uniqKey="Komnatska I" first="Irena" last="Komnatska">Irena Komnatska</name>
<name sortKey="Kyrylchuk, Marianna" sort="Kyrylchuk, Marianna" uniqKey="Kyrylchuk M" first="Marianna" last="Kyrylchuk">Marianna Kyrylchuk</name>
<name sortKey="Matviyenko, Yuri" sort="Matviyenko, Yuri" uniqKey="Matviyenko Y" first="Yuri" last="Matviyenko">Yuri Matviyenko</name>
<name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name>
</country>
<country name="Pologne"><noRegion><name sortKey="Krolicki, Lesrek" sort="Krolicki, Lesrek" uniqKey="Krolicki L" first="Lesrek" last="Krolicki">Lesrek Krolicki</name>
</noRegion>
<name sortKey="Friedman, Andrzej" sort="Friedman, Andrzej" uniqKey="Friedman A" first="Andrzej" last="Friedman">Andrzej Friedman</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Parkinsonism and Dystonia Caused by the Illicit Use of Ephedrone : A Longitudinal Study

Parkinsonism and Dystonia Caused by the Illicit Use of Ephedrone : A Longitudinal Study

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