Cortical Hypometabolism Assessed by a Metabolic Ratio in Parkinson's Disease Primarily Reflects Cognitive Deterioration -[ 18F]FDG- PET
Identifieur interne : 000F28 ( PascalFrancis/Checkpoint ); précédent : 000F27; suivant : 000F29Cortical Hypometabolism Assessed by a Metabolic Ratio in Parkinson's Disease Primarily Reflects Cognitive Deterioration -[ 18F]FDG- PET
Auteurs : Inga Liepelt [Allemagne] ; Matthias Reimold [Allemagne] ; Walter Maetzler [Allemagne] ; Jana Godau [Allemagne] ; Gerald Reischl [Allemagne] ; Alexandra Gaenslen [Allemagne] ; Heinz Herbst [Allemagne] ; Daniela Berg [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
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Abstract
In Parkinson's disease patients with cognitive deterioration, regional cortical hypometabolism has been observed with [18F]fluorodeoxyglucose-positron emission tomography (FDG-PET). Our aim was to develop a robust method to subsume the overall degree of metabolic deterioration in Parkinson's disease by means of a single index and to investigate which of the clinical features correlates best with hypometabolism. Twenty-two Parkinson's patients (10 demented) and seven controls underwent FDG-PET. A metabolic index (mean relative uptake in typically affected regions) was calculated for each patient and compared with scores for cognition [Mini-mental State Examination (MMSE)], motor performance [Unified Parkinson's Disease Rating Scale (UPDRS III)] and behavior (Neuropsychiatric Inventory). In stepwise linear regression analysis, MMSE (P < 0.001) score showed the only significant effect. Estimated sensitivity and specificity for DSM-IV diagnosis of dementia were high for the metabolic index (MI), with 91 and 100%. Taken together, the presented data indicate that cerebral hypometabolism in Parkinson's disease is primarily associated with cognitive impairment.
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<front><div type="abstract" xml:lang="en">In Parkinson's disease patients with cognitive deterioration, regional cortical hypometabolism has been observed with [<sup>18</sup>
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<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Emission tomography</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Tomocentelleografía</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Tomographie par émission de positons</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Positron emission tomography</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Tomografía emisión positrones</s0>
<s5>12</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>257</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>District de Stuttgart</li>
<li>District de Tübingen</li>
</region>
<settlement><li>Stuttgart</li>
<li>Tübingen</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Liepelt, Inga" sort="Liepelt, Inga" uniqKey="Liepelt I" first="Inga" last="Liepelt">Inga Liepelt</name>
</region>
<name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name>
<name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name>
<name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name>
<name sortKey="Herbst, Heinz" sort="Herbst, Heinz" uniqKey="Herbst H" first="Heinz" last="Herbst">Heinz Herbst</name>
<name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name>
<name sortKey="Reimold, Matthias" sort="Reimold, Matthias" uniqKey="Reimold M" first="Matthias" last="Reimold">Matthias Reimold</name>
<name sortKey="Reischl, Gerald" sort="Reischl, Gerald" uniqKey="Reischl G" first="Gerald" last="Reischl">Gerald Reischl</name>
</country>
</tree>
</affiliations>
</record>
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