Cortical Hypometabolism Assessed by a Metabolic Ratio in Parkinson's Disease Primarily Reflects Cognitive Deterioration -[ 18F]FDG- PET
Identifieur interne : 000F28 ( PascalFrancis/Checkpoint ); précédent : 000F27; suivant : 000F29Cortical Hypometabolism Assessed by a Metabolic Ratio in Parkinson's Disease Primarily Reflects Cognitive Deterioration -[ 18F]FDG- PET
Auteurs : Inga Liepelt [Allemagne] ; Matthias Reimold [Allemagne] ; Walter Maetzler [Allemagne] ; Jana Godau [Allemagne] ; Gerald Reischl [Allemagne] ; Alexandra Gaenslen [Allemagne] ; Heinz Herbst [Allemagne] ; Daniela Berg [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
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Abstract
In Parkinson's disease patients with cognitive deterioration, regional cortical hypometabolism has been observed with [18F]fluorodeoxyglucose-positron emission tomography (FDG-PET). Our aim was to develop a robust method to subsume the overall degree of metabolic deterioration in Parkinson's disease by means of a single index and to investigate which of the clinical features correlates best with hypometabolism. Twenty-two Parkinson's patients (10 demented) and seven controls underwent FDG-PET. A metabolic index (mean relative uptake in typically affected regions) was calculated for each patient and compared with scores for cognition [Mini-mental State Examination (MMSE)], motor performance [Unified Parkinson's Disease Rating Scale (UPDRS III)] and behavior (Neuropsychiatric Inventory). In stepwise linear regression analysis, MMSE (P < 0.001) score showed the only significant effect. Estimated sensitivity and specificity for DSM-IV diagnosis of dementia were high for the metabolic index (MI), with 91 and 100%. Taken together, the presented data indicate that cerebral hypometabolism in Parkinson's disease is primarily associated with cognitive impairment.
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Research, Department of Neurodegenerative Diseases, University of Tuebingen</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Reimold, Matthias" sort="Reimold, Matthias" uniqKey="Reimold M" first="Matthias" last="Reimold">Matthias Reimold</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Nuclear Medicine and PET Center, University of Tuebingen</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>2 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Reischl, Gerald" sort="Reischl, Gerald" uniqKey="Reischl G" first="Gerald" last="Reischl">Gerald Reischl</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Radiopharmacy, PET Center, University of Tuebingen</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Herbst, Heinz" sort="Herbst, Heinz" uniqKey="Herbst H" first="Heinz" last="Herbst">Heinz Herbst</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Neurology Practice</s1><s2>Stuttgart</s2><s3>DEU</s3><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dementia</term><term>Deterioration</term><term>Emission tomography</term><term>Metabolic diseases</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Positron emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Démence</term><term>Pathologie du système nerveux</term><term>Maladie métabolique</term><term>Détérioration</term><term>Tomoscintigraphie</term><term>Tomographie par émission de positons</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Parkinson's disease patients with cognitive deterioration, regional cortical hypometabolism has been observed with [<sup>18</sup>F]fluorodeoxyglucose-positron emission tomography (FDG-PET). Our aim was to develop a robust method to subsume the overall degree of metabolic deterioration in Parkinson's disease by means of a single index and to investigate which of the clinical features correlates best with hypometabolism. Twenty-two Parkinson's patients (10 demented) and seven controls underwent FDG-PET. A metabolic index (mean relative uptake in typically affected regions) was calculated for each patient and compared with scores for cognition [Mini-mental State Examination (MMSE)], motor performance [Unified Parkinson's Disease Rating Scale (UPDRS III)] and behavior (Neuropsychiatric Inventory). In stepwise linear regression analysis, MMSE (P < 0.001) score showed the only significant effect. Estimated sensitivity and specificity for DSM-IV diagnosis of dementia were high for the metabolic index (MI), with 91 and 100%. Taken together, the presented data indicate that cerebral hypometabolism in Parkinson's disease is primarily associated with cognitive impairment.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>24</s2></fA05><fA06><s2>10</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Cortical Hypometabolism Assessed by a Metabolic Ratio in Parkinson's Disease Primarily Reflects Cognitive Deterioration -[ <sup>18</sup>F]FDG- PET</s1></fA08><fA11 i1="01" i2="1"><s1>LIEPELT (Inga)</s1></fA11><fA11 i1="02" i2="1"><s1>REIMOLD (Matthias)</s1></fA11><fA11 i1="03" i2="1"><s1>MAETZLER (Walter)</s1></fA11><fA11 i1="04" i2="1"><s1>GODAU (Jana)</s1></fA11><fA11 i1="05" i2="1"><s1>REISCHL (Gerald)</s1></fA11><fA11 i1="06" i2="1"><s1>GAENSLEN (Alexandra)</s1></fA11><fA11 i1="07" i2="1"><s1>HERBST (Heinz)</s1></fA11><fA11 i1="08" i2="1"><s1>BERG (Daniela)</s1></fA11><fA14 i1="01"><s1>Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Nuclear Medicine and PET Center, University of Tuebingen</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Radiopharmacy, PET Center, University of Tuebingen</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>5 aut.</sZ></fA14><fA14 i1="04"><s1>Neurology Practice</s1><s2>Stuttgart</s2><s3>DEU</s3><sZ>7 aut.</sZ></fA14><fA20><s1>1504-1511</s1></fA20><fA21><s1>2009</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000187543670120</s5></fA43><fA44><s0>0000</s0><s1>© 2009 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>41 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>09-0358927</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>In Parkinson's disease patients with cognitive deterioration, regional cortical hypometabolism has been observed with [<sup>18</sup>F]fluorodeoxyglucose-positron emission tomography (FDG-PET). Our aim was to develop a robust method to subsume the overall degree of metabolic deterioration in Parkinson's disease by means of a single index and to investigate which of the clinical features correlates best with hypometabolism. Twenty-two Parkinson's patients (10 demented) and seven controls underwent FDG-PET. A metabolic index (mean relative uptake in typically affected regions) was calculated for each patient and compared with scores for cognition [Mini-mental State Examination (MMSE)], motor performance [Unified Parkinson's Disease Rating Scale (UPDRS III)] and behavior (Neuropsychiatric Inventory). In stepwise linear regression analysis, MMSE (P < 0.001) score showed the only significant effect. Estimated sensitivity and specificity for DSM-IV diagnosis of dementia were high for the metabolic index (MI), with 91 and 100%. Taken together, the presented data indicate that cerebral hypometabolism in Parkinson's disease is primarily associated with cognitive impairment.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Démence</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Dementia</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Demencia</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Maladie métabolique</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Metabolic diseases</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Metabolismo patología</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Détérioration</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Deterioration</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Deterioración</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Tomoscintigraphie</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Emission tomography</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Tomocentelleografía</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Tomographie par émission de positons</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Positron emission tomography</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Tomografía emisión positrones</s0><s5>12</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>257</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Stuttgart</li><li>District de Tübingen</li></region><settlement><li>Stuttgart</li><li>Tübingen</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Liepelt, Inga" sort="Liepelt, Inga" uniqKey="Liepelt I" first="Inga" last="Liepelt">Inga Liepelt</name></region><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name><name sortKey="Herbst, Heinz" sort="Herbst, Heinz" uniqKey="Herbst H" first="Heinz" last="Herbst">Heinz Herbst</name><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><name sortKey="Reimold, Matthias" sort="Reimold, Matthias" uniqKey="Reimold M" first="Matthias" last="Reimold">Matthias Reimold</name><name sortKey="Reischl, Gerald" sort="Reischl, Gerald" uniqKey="Reischl G" first="Gerald" last="Reischl">Gerald Reischl</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Cortical Hypometabolism Assessed by a Metabolic Ratio in Parkinson's Disease Primarily Reflects Cognitive Deterioration -[ 18F]FDG- PET
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