Dopamine Agonists Restore Cortical Plasticity in Patients with Idiopathic Restless Legs Syndrome
Identifieur interne : 000F08 ( PascalFrancis/Checkpoint ); précédent : 000F07; suivant : 000F09Dopamine Agonists Restore Cortical Plasticity in Patients with Idiopathic Restless Legs Syndrome
Auteurs : Vincenzo Rizzo [Italie] ; Irene Arico [Italie] ; Claudia Mastroeni [Italie] ; Francesca Morgante [Italie] ; Giovanna Liotta [Italie] ; Paolo Girlanda [Italie] ; Rosalia Silvestri [Italie] ; Angelo Quartarone [Italie]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
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Abstract
In the present work, we aimed at assessing whether patients with idiopathic restless legs syndrome (RLS) showed alterations of sensory-motor plasticity, an indirect probe for motor learning, within the motor cortex (Ml). Previous findings suggest that learning in human Ml occurs through LTP-like mechanisms. To test our hypothesis, we employed the paired associative stimulation (PAS) protocol by transcranial magnetic stimulation (TMS), which is able to induce LTP-like effects in the motor cortex of normal subjects. Twelve patients with idiopathic RLS and 10 age- and sex-matched control subjects were recruited. PAS protocol consisted of 0.05 Hz electrical median nerve stimulation (90 stimuli), paired with 0.05 Hz TMS (90 stimuli) over the hot spot for stimulating the abductor pollicis brevis (APB) muscle given 25 milliseconds after the onset of the electrical stimulus. Corticospinal excitability recorded in APB muscle, as indexed by MEP obtained after single stimulus, was tested before and up to 30 minutes after PAS protocol. Eight of 12 patients were studied before and after 4 weeks of dopaminergic treatment. PAS protocol increased significantly corticospinal excitability as long as 30 minutes in healthy subjects. On the contrary, PAS protocol did not change the amplitude of MEPs in patients with idiopathic RLS without treatment. PAS associative plasticity was restored after 4 weeks of dopaminergic treatment. Our data demonstrated that associative sensory-motor plasticity, an indirect probe for motor learning, is impaired in idiopathic RLS patients but may be reverted to normal after dopaminergic treatment.
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type="wicri:Area/PascalFrancis/Curation">001E13</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000F08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Dopamine Agonists Restore Cortical Plasticity in Patients with Idiopathic Restless Legs Syndrome</title><author><name sortKey="Rizzo, Vincenzo" sort="Rizzo, Vincenzo" uniqKey="Rizzo V" first="Vincenzo" last="Rizzo">Vincenzo Rizzo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1><s2>Messina</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Arico, Irene" sort="Arico, Irene" uniqKey="Arico I" first="Irene" last="Arico">Irene Arico</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1><s2>Messina</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Mastroeni, Claudia" sort="Mastroeni, Claudia" uniqKey="Mastroeni C" first="Claudia" last="Mastroeni">Claudia Mastroeni</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1><s2>Messina</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1><s2>Messina</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Liotta, Giovanna" sort="Liotta, Giovanna" uniqKey="Liotta G" first="Giovanna" last="Liotta">Giovanna Liotta</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1><s2>Messina</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Girlanda, Paolo" sort="Girlanda, Paolo" uniqKey="Girlanda P" first="Paolo" last="Girlanda">Paolo Girlanda</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1><s2>Messina</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Silvestri, Rosalia" sort="Silvestri, Rosalia" uniqKey="Silvestri R" first="Rosalia" last="Silvestri">Rosalia Silvestri</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1><s2>Messina</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Quartarone, Angelo" sort="Quartarone, Angelo" uniqKey="Quartarone A" first="Angelo" last="Quartarone">Angelo Quartarone</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1><s2>Messina</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Messina</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dopamine agonist</term><term>Human</term><term>Idiopathic</term><term>Nervous system diseases</term><term>Plasticity</term><term>Restless legs syndrome</term><term>Transcranial magnetic stimulation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Syndrome des jambes sans repos</term><term>Pathologie du système nerveux</term><term>Stimulant dopaminergique</term><term>Plasticité</term><term>Homme</term><term>Idiopathique</term><term>Stimulation magnétique transcrânienne</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the present work, we aimed at assessing whether patients with idiopathic restless legs syndrome (RLS) showed alterations of sensory-motor plasticity, an indirect probe for motor learning, within the motor cortex (Ml). Previous findings suggest that learning in human Ml occurs through LTP-like mechanisms. To test our hypothesis, we employed the paired associative stimulation (PAS) protocol by transcranial magnetic stimulation (TMS), which is able to induce LTP-like effects in the motor cortex of normal subjects. Twelve patients with idiopathic RLS and 10 age- and sex-matched control subjects were recruited. PAS protocol consisted of 0.05 Hz electrical median nerve stimulation (90 stimuli), paired with 0.05 Hz TMS (90 stimuli) over the hot spot for stimulating the abductor pollicis brevis (APB) muscle given 25 milliseconds after the onset of the electrical stimulus. Corticospinal excitability recorded in APB muscle, as indexed by MEP obtained after single stimulus, was tested before and up to 30 minutes after PAS protocol. Eight of 12 patients were studied before and after 4 weeks of dopaminergic treatment. PAS protocol increased significantly corticospinal excitability as long as 30 minutes in healthy subjects. On the contrary, PAS protocol did not change the amplitude of MEPs in patients with idiopathic RLS without treatment. PAS associative plasticity was restored after 4 weeks of dopaminergic treatment. Our data demonstrated that associative sensory-motor plasticity, an indirect probe for motor learning, is impaired in idiopathic RLS patients but may be reverted to normal after dopaminergic treatment.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>24</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Dopamine Agonists Restore Cortical Plasticity in Patients with Idiopathic Restless Legs Syndrome</s1></fA08><fA11 i1="01" i2="1"><s1>RIZZO (Vincenzo)</s1></fA11><fA11 i1="02" i2="1"><s1>ARICO (Irene)</s1></fA11><fA11 i1="03" i2="1"><s1>MASTROENI (Claudia)</s1></fA11><fA11 i1="04" i2="1"><s1>MORGANTE (Francesca)</s1></fA11><fA11 i1="05" i2="1"><s1>LIOTTA (Giovanna)</s1></fA11><fA11 i1="06" i2="1"><s1>GIRLANDA (Paolo)</s1></fA11><fA11 i1="07" i2="1"><s1>SILVESTRI (Rosalia)</s1></fA11><fA11 i1="08" i2="1"><s1>QUARTARONE (Angelo)</s1></fA11><fA14 i1="01"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1><s2>Messina</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></fA14><fA20><s1>710-715</s1></fA20><fA21><s1>2009</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000186090170120</s5></fA43><fA44><s0>0000</s0><s1>© 2009 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>31 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>09-0218158</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>In the present work, we aimed at assessing whether patients with idiopathic restless legs syndrome (RLS) showed alterations of sensory-motor plasticity, an indirect probe for motor learning, within the motor cortex (Ml). Previous findings suggest that learning in human Ml occurs through LTP-like mechanisms. To test our hypothesis, we employed the paired associative stimulation (PAS) protocol by transcranial magnetic stimulation (TMS), which is able to induce LTP-like effects in the motor cortex of normal subjects. Twelve patients with idiopathic RLS and 10 age- and sex-matched control subjects were recruited. PAS protocol consisted of 0.05 Hz electrical median nerve stimulation (90 stimuli), paired with 0.05 Hz TMS (90 stimuli) over the hot spot for stimulating the abductor pollicis brevis (APB) muscle given 25 milliseconds after the onset of the electrical stimulus. Corticospinal excitability recorded in APB muscle, as indexed by MEP obtained after single stimulus, was tested before and up to 30 minutes after PAS protocol. Eight of 12 patients were studied before and after 4 weeks of dopaminergic treatment. PAS protocol increased significantly corticospinal excitability as long as 30 minutes in healthy subjects. On the contrary, PAS protocol did not change the amplitude of MEPs in patients with idiopathic RLS without treatment. PAS associative plasticity was restored after 4 weeks of dopaminergic treatment. Our data demonstrated that associative sensory-motor plasticity, an indirect probe for motor learning, is impaired in idiopathic RLS patients but may be reverted to normal after dopaminergic treatment.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17F</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Syndrome des jambes sans repos</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Restless legs syndrome</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Acroparestesia nocturna</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Stimulant dopaminergique</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Dopamine agonist</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Estimulante dopaminérgico</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Plasticité</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Plasticity</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Plasticidad</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Human</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Idiopathique</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Idiopathic</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Idiopático</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Stimulation magnétique transcrânienne</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Transcranial magnetic stimulation</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Estimulación magnética transcraneal</s0><s5>13</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Trouble neurologique</s0><s5>38</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Neurological disorder</s0><s5>38</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Trastorno neurológico</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Trouble de la sensibilité</s0><s5>39</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Sensitivity disorder</s0><s5>39</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Trastorno sensibilidad</s0><s5>39</s5></fC07><fN21><s1>159</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Rizzo, Vincenzo" sort="Rizzo, Vincenzo" uniqKey="Rizzo V" first="Vincenzo" last="Rizzo">Vincenzo Rizzo</name></noRegion><name sortKey="Arico, Irene" sort="Arico, Irene" uniqKey="Arico I" first="Irene" last="Arico">Irene Arico</name><name sortKey="Girlanda, Paolo" sort="Girlanda, Paolo" uniqKey="Girlanda P" first="Paolo" last="Girlanda">Paolo Girlanda</name><name sortKey="Liotta, Giovanna" sort="Liotta, Giovanna" uniqKey="Liotta G" first="Giovanna" last="Liotta">Giovanna Liotta</name><name sortKey="Mastroeni, Claudia" sort="Mastroeni, Claudia" uniqKey="Mastroeni C" first="Claudia" last="Mastroeni">Claudia Mastroeni</name><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name><name sortKey="Quartarone, Angelo" sort="Quartarone, Angelo" uniqKey="Quartarone A" first="Angelo" last="Quartarone">Angelo Quartarone</name><name sortKey="Silvestri, Rosalia" sort="Silvestri, Rosalia" uniqKey="Silvestri R" first="Rosalia" last="Silvestri">Rosalia Silvestri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|flux= PascalFrancis
|étape= Checkpoint
|type= RBID
|clé= Pascal:09-0218158
|texte= Dopamine Agonists Restore Cortical Plasticity in Patients with Idiopathic Restless Legs Syndrome
}}
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