MovDisordV3, PascalFrancis, Checkpoint, bibRecord, 000D07

Serial Volumetric MRI in Parkinsonian Disorders

Identifieur interne : 000D07 ( PascalFrancis/Checkpoint ); précédent : 000D06; suivant : 000D08

Serial Volumetric MRI in Parkinsonian Disorders

Auteurs : Edward J. Wild [Royaume-Uni] ; Nick C. Fox [Royaume-Uni]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:10-0038100

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Démence à corps de Lewy, Atrophie multisystématisée, Pathologie du système nerveux, Imagerie RMN.

English descriptors

KwdEn :
- Lewy body dementia, Multiple system atrophy, Nervous system diseases, Nuclear magnetic resonance imaging, Parkinson disease.

Abstract

Tracking progression in neurodegenerative diseases is hampered by the limitations of the clinical rating scales, which are seldom linear, suffer from floor and ceiling effects, lack the ability to distinguish symptomatic change from disease modification, and are limited by imperfect intra- and inter-rater reliability. The promise of an era of neuroprotective therapies renders urgent the search for reliable measures of progression. Biomarkers have the potential to enhance several aspects of both therapeutic trials and clinical practice. MRI-based measures of cerebral volume can provide a surrogate for neuronal loss and several techniques have been applied to elucidate disease processes, aid diagnosis, and enable monitoring of progression in a variety of Parkinsonian disorders, including Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, progressive supranuclear palsy and Huntington's disease. We review the approaches to, and findings revealed by, serial volumetric MRI in these disorders.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Tracking progression in neurodegenerative diseases is hampered by the limitations of the clinical rating scales, which are seldom linear, suffer from floor and ceiling effects, lack the ability to distinguish symptomatic change from disease modification, and are limited by imperfect intra- and inter-rater reliability. The promise of an era of neuroprotective therapies renders urgent the search for reliable measures of progression. Biomarkers have the potential to enhance several aspects of both therapeutic trials and clinical practice. MRI-based measures of cerebral volume can provide a surrogate for neuronal loss and several techniques have been applied to elucidate disease processes, aid diagnosis, and enable monitoring of progression in a variety of Parkinsonian disorders, including Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, progressive supranuclear palsy and Huntington's disease. We review the approaches to, and findings revealed by, serial volumetric MRI in these disorders.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Serial Volumetric MRI in Parkinsonian Disorders

Serial Volumetric MRI in Parkinsonian Disorders

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri