Ultrasound Treatment of Cutaneous Side-Effects of Infused Apomorphine : A Randomized Controlled Pilot Study
Identifieur interne : 000C68 ( PascalFrancis/Checkpoint ); précédent : 000C67; suivant : 000C69Ultrasound Treatment of Cutaneous Side-Effects of Infused Apomorphine : A Randomized Controlled Pilot Study
Auteurs : Leon Poltawski [Royaume-Uni] ; Hazel Edwards [Royaume-Uni] ; Amy Todd [Royaume-Uni] ; Tim Watson [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; Cherry Ann James [Royaume-Uni]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
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- Pascal (Inist)
English descriptors
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Abstract
Apomorphine hydrochloride is a dopamine agonist used in the treatment of advanced Parkinson's disease. Its administration by subcutaneous infusions is associated with the development of nodules that may interfere with absorption of the drug. This pilot study assessed the effectiveness of ultrasound (US) in the treatment of these nodules. Twelve participants were randomly assigned to receive a course of real or sham US on an area judged unsuitable for infusion. Following treatment, no significant change was observed in measures of tissue hardness and tenderness. However, 5 of 6 participants receiving real US rated the treated area suitable for infusion compared with the 1 of 6 receiving sham US. Sonographic appearance improved in both groups, but more substantially in the real US group. Power calculations suggest a total sample size of 30 would be required to establish statistical significance. A full-scale study of the effectiveness of therapeutic US in the treatment of apomorphine nodules is warranted.
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Hertfordshire</wicri:noRegion></affiliation></author><author><name sortKey="Todd, Amy" sort="Todd, Amy" uniqKey="Todd A" first="Amy" last="Todd">Amy Todd</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Physiotherapy, University of Hertfordshire</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Division of Physiotherapy, University of Hertfordshire</wicri:noRegion></affiliation></author><author><name sortKey="Watson, Tim" sort="Watson, Tim" uniqKey="Watson T" first="Tim" last="Watson">Tim Watson</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Health and Emergency Professions, University of Hertfordshire</s1><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>School of Health and Emergency Professions, University of Hertfordshire</wicri:noRegion></affiliation></author><author><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees (neurologue)</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Reta Lila Weston Institute of Neurological Studies, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author><author><name sortKey="James, Cherry Ann" sort="James, Cherry Ann" uniqKey="James C" first="Cherry Ann" last="James">Cherry Ann James</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>6 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wicri:level="1"><inist:fA14 i1="01"><s1>Division of Physiotherapy, University of Hertfordshire</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Division of Physiotherapy, University of Hertfordshire</wicri:noRegion></affiliation></author><author><name sortKey="Edwards, Hazel" sort="Edwards, Hazel" uniqKey="Edwards H" first="Hazel" last="Edwards">Hazel Edwards</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Radiography, University of Hertfordshire</s1><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Division of Radiography, University of Hertfordshire</wicri:noRegion></affiliation></author><author><name sortKey="Todd, Amy" sort="Todd, Amy" uniqKey="Todd A" first="Amy" last="Todd">Amy Todd</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Physiotherapy, University of Hertfordshire</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Division of Physiotherapy, University of Hertfordshire</wicri:noRegion></affiliation></author><author><name sortKey="Watson, Tim" sort="Watson, Tim" uniqKey="Watson T" first="Tim" last="Watson">Tim Watson</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Health and Emergency Professions, University of Hertfordshire</s1><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>School of Health and Emergency Professions, University of Hertfordshire</wicri:noRegion></affiliation></author><author><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees (neurologue)</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Reta Lila Weston Institute of Neurological Studies, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author><author><name sortKey="James, Cherry Ann" sort="James, Cherry Ann" uniqKey="James C" first="Cherry Ann" last="James">Cherry Ann James</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical trial</term><term>Nervous system diseases</term><term>Nodule</term><term>Parkinson disease</term><term>Skin</term><term>Treatment</term><term>Ultrasound</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Ultrason</term><term>Traitement</term><term>Peau</term><term>Apomorphine</term><term>Nodule</term><term>Essai clinique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Apomorphine hydrochloride is a dopamine agonist used in the treatment of advanced Parkinson's disease. Its administration by subcutaneous infusions is associated with the development of nodules that may interfere with absorption of the drug. This pilot study assessed the effectiveness of ultrasound (US) in the treatment of these nodules. Twelve participants were randomly assigned to receive a course of real or sham US on an area judged unsuitable for infusion. Following treatment, no significant change was observed in measures of tissue hardness and tenderness. However, 5 of 6 participants receiving real US rated the treated area suitable for infusion compared with the 1 of 6 receiving sham US. Sonographic appearance improved in both groups, but more substantially in the real US group. Power calculations suggest a total sample size of 30 would be required to establish statistical significance. A full-scale study of the effectiveness of therapeutic US in the treatment of apomorphine nodules is warranted.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>24</s2></fA05><fA06><s2>1</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Ultrasound Treatment of Cutaneous Side-Effects of Infused Apomorphine : A Randomized Controlled Pilot Study</s1></fA08><fA11 i1="01" i2="1"><s1>POLTAWSKI (Leon)</s1></fA11><fA11 i1="02" i2="1"><s1>EDWARDS (Hazel)</s1></fA11><fA11 i1="03" i2="1"><s1>TODD (Amy)</s1></fA11><fA11 i1="04" i2="1"><s1>WATSON (Tim)</s1></fA11><fA11 i1="05" i2="1"><s1>LEES (Andrew)</s1></fA11><fA11 i1="06" i2="1"><s1>JAMES (Cherry Ann)</s1></fA11><fA14 i1="01"><s1>Division of Physiotherapy, University of Hertfordshire</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>Division of Radiography, University of Hertfordshire</s1><s3>GBR</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>School of Health and Emergency Professions, University of Hertfordshire</s1><s3>GBR</s3><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Reta Lila Weston Institute of Neurological Studies, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ></fA14><fA20><s1>115-118</s1></fA20><fA21><s1>2009</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000186473060170</s5></fA43><fA44><s0>0000</s0><s1>© 2009 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>30 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>09-0094103</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Apomorphine hydrochloride is a dopamine agonist used in the treatment of advanced Parkinson's disease. Its administration by subcutaneous infusions is associated with the development of nodules that may interfere with absorption of the drug. This pilot study assessed the effectiveness of ultrasound (US) in the treatment of these nodules. Twelve participants were randomly assigned to receive a course of real or sham US on an area judged unsuitable for infusion. Following treatment, no significant change was observed in measures of tissue hardness and tenderness. However, 5 of 6 participants receiving real US rated the treated area suitable for infusion compared with the 1 of 6 receiving sham US. Sonographic appearance improved in both groups, but more substantially in the real US group. Power calculations suggest a total sample size of 30 would be required to establish statistical significance. A full-scale study of the effectiveness of therapeutic US in the treatment of apomorphine nodules is warranted.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B02Q</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Ultrason</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Ultrasound</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Ultrasonido</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Traitement</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Treatment</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Tratamiento</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Peau</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Skin</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Piel</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Apomorphine</s0><s2>NK</s2><s2>FR</s2><s5>12</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Nodule</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Nodule</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Nódulo</s0><s5>13</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Essai clinique</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Clinical trial</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Ensayo clínico</s0><s5>14</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>068</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Poltawski, Leon" sort="Poltawski, Leon" uniqKey="Poltawski L" first="Leon" last="Poltawski">Leon Poltawski</name></noRegion><name sortKey="Edwards, Hazel" sort="Edwards, Hazel" uniqKey="Edwards H" first="Hazel" last="Edwards">Hazel Edwards</name><name sortKey="James, Cherry Ann" sort="James, Cherry Ann" uniqKey="James C" first="Cherry Ann" last="James">Cherry Ann James</name><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees (neurologue)</name><name sortKey="Todd, Amy" sort="Todd, Amy" uniqKey="Todd A" first="Amy" last="Todd">Amy Todd</name><name sortKey="Watson, Tim" sort="Watson, Tim" uniqKey="Watson T" first="Tim" last="Watson">Tim Watson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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