Neuroanatomical Correlates of Apathy in Parkinson's Disease: A Magnetic Resonance Imaging Study Using Voxel-Based Morphometry
Identifieur interne : 000949 ( PascalFrancis/Checkpoint ); précédent : 000948; suivant : 000950Neuroanatomical Correlates of Apathy in Parkinson's Disease: A Magnetic Resonance Imaging Study Using Voxel-Based Morphometry
Auteurs : Jennifer S. A. M. Reijnders [Pays-Bas] ; Bart Scholtissen [Pays-Bas] ; Wim E. J. Weber [Pays-Bas] ; Pauline Aalten [Pays-Bas] ; Frans R. J. Verhey [Pays-Bas] ; Albert F. G. Leentjens [Pays-Bas]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
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Abstract
Apathy is generally defined as a disorder of motivation and is considered one of the most common neuropsychiatric disturbances in Parkinson's disease (PD). Only few studies addressed the neuroanatomical correlates of apathy in PD. The aim of this article was to determine the structural correlates of apathy in PD patients. Fifty-five PD patients underwent a neuropsychiatric and neuropsychological examination, and a 3 T magnetic resonance imaging scan was acquired. A voxel-based multiple regression analysis was used to calculate correlation between gray matter density and severity measures of apathy. Apathy correlates with decreased cognitive functioning and more depressive symptoms but not with more severe motor symptoms. High apathy scores were correlated with low gray matter density values in a number of cortical brain areas: the bilateral precentral gyrus (BA 4, 6), the bilateral inferior parietal gyrus (BA 40), the bilateral inferior frontal gyrus (BA 44, 47), the bilateral insula (BA 13), the right (posterior) cingulate gyrus (BA 24, 30, 31), and the right precuneus (BA 31). Apathy in PD correlates with reduced gray matter density in a number of brain regions. The involvement of the cingulate gyrus and inferior frontal gyrus is in line with the results of earlier studies addressing apathy in patients with Alzheimer's disease or depressive disorder. Further studies addressing the pathogenesis of apathy are needed.
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Reijnders</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, Maastricht University Medical Centre</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Scholtissen, Bart" sort="Scholtissen, Bart" uniqKey="Scholtissen B" first="Bart" last="Scholtissen">Bart Scholtissen</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Faculty of Psychology and Neuroscience, Maastricht University</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>2 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Weber, Wim E J" sort="Weber, Wim E J" uniqKey="Weber W" first="Wim E. J." last="Weber">Wim E. J. 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Leentjens</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, Maastricht University Medical Centre</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0491610</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0491610 INIST</idno><idno type="RBID">Pascal:10-0491610</idno><idno type="wicri:Area/PascalFrancis/Corpus">000833</idno><idno type="wicri:Area/PascalFrancis/Curation">002486</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000949</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Neuroanatomical Correlates of Apathy in Parkinson's Disease: A Magnetic Resonance Imaging Study Using Voxel-Based Morphometry</title><author><name sortKey="Reijnders, Jennifer S A M" sort="Reijnders, Jennifer S A M" uniqKey="Reijnders J" first="Jennifer S. A. M." last="Reijnders">Jennifer S. A. M. Reijnders</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, Maastricht University Medical Centre</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Scholtissen, Bart" sort="Scholtissen, Bart" uniqKey="Scholtissen B" first="Bart" last="Scholtissen">Bart Scholtissen</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Faculty of Psychology and Neuroscience, Maastricht University</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>2 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Weber, Wim E J" sort="Weber, Wim E J" uniqKey="Weber W" first="Wim E. J." last="Weber">Wim E. J. Weber</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Maastricht University Medical Centre</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Aalten, Pauline" sort="Aalten, Pauline" uniqKey="Aalten P" first="Pauline" last="Aalten">Pauline Aalten</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, Maastricht University Medical Centre</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Verhey, Frans R J" sort="Verhey, Frans R J" uniqKey="Verhey F" first="Frans R. J." last="Verhey">Frans R. J. Verhey</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, Maastricht University Medical Centre</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Leentjens, Albert F G" sort="Leentjens, Albert F G" uniqKey="Leentjens A" first="Albert F. G." last="Leentjens">Albert F. G. Leentjens</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, Maastricht University Medical Centre</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apathy</term><term>Morphometry</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson disease</term><term>Voxel</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Imagerie RMN</term><term>Voxel</term><term>Morphométrie</term><term>Apathie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Apathy is generally defined as a disorder of motivation and is considered one of the most common neuropsychiatric disturbances in Parkinson's disease (PD). Only few studies addressed the neuroanatomical correlates of apathy in PD. The aim of this article was to determine the structural correlates of apathy in PD patients. Fifty-five PD patients underwent a neuropsychiatric and neuropsychological examination, and a 3 T magnetic resonance imaging scan was acquired. A voxel-based multiple regression analysis was used to calculate correlation between gray matter density and severity measures of apathy. Apathy correlates with decreased cognitive functioning and more depressive symptoms but not with more severe motor symptoms. High apathy scores were correlated with low gray matter density values in a number of cortical brain areas: the bilateral precentral gyrus (BA 4, 6), the bilateral inferior parietal gyrus (BA 40), the bilateral inferior frontal gyrus (BA 44, 47), the bilateral insula (BA 13), the right (posterior) cingulate gyrus (BA 24, 30, 31), and the right precuneus (BA 31). Apathy in PD correlates with reduced gray matter density in a number of brain regions. The involvement of the cingulate gyrus and inferior frontal gyrus is in line with the results of earlier studies addressing apathy in patients with Alzheimer's disease or depressive disorder. Further studies addressing the pathogenesis of apathy are needed.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>25</s2></fA05><fA06><s2>14</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Neuroanatomical Correlates of Apathy in Parkinson's Disease: A Magnetic Resonance Imaging Study Using Voxel-Based Morphometry</s1></fA08><fA11 i1="01" i2="1"><s1>REIJNDERS (Jennifer S. A. M.)</s1></fA11><fA11 i1="02" i2="1"><s1>SCHOLTISSEN (Bart)</s1></fA11><fA11 i1="03" i2="1"><s1>WEBER (Wim E. J.)</s1></fA11><fA11 i1="04" i2="1"><s1>AALTEN (Pauline)</s1></fA11><fA11 i1="05" i2="1"><s1>VERHEY (Frans R. 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All rights reserved.</s1></fA44><fA45><s0>50 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>10-0491610</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Apathy is generally defined as a disorder of motivation and is considered one of the most common neuropsychiatric disturbances in Parkinson's disease (PD). Only few studies addressed the neuroanatomical correlates of apathy in PD. The aim of this article was to determine the structural correlates of apathy in PD patients. Fifty-five PD patients underwent a neuropsychiatric and neuropsychological examination, and a 3 T magnetic resonance imaging scan was acquired. A voxel-based multiple regression analysis was used to calculate correlation between gray matter density and severity measures of apathy. Apathy correlates with decreased cognitive functioning and more depressive symptoms but not with more severe motor symptoms. High apathy scores were correlated with low gray matter density values in a number of cortical brain areas: the bilateral precentral gyrus (BA 4, 6), the bilateral inferior parietal gyrus (BA 40), the bilateral inferior frontal gyrus (BA 44, 47), the bilateral insula (BA 13), the right (posterior) cingulate gyrus (BA 24, 30, 31), and the right precuneus (BA 31). Apathy in PD correlates with reduced gray matter density in a number of brain regions. The involvement of the cingulate gyrus and inferior frontal gyrus is in line with the results of earlier studies addressing apathy in patients with Alzheimer's disease or depressive disorder. 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A. M." last="Reijnders">Jennifer S. A. M. Reijnders</name></noRegion><name sortKey="Aalten, Pauline" sort="Aalten, Pauline" uniqKey="Aalten P" first="Pauline" last="Aalten">Pauline Aalten</name><name sortKey="Leentjens, Albert F G" sort="Leentjens, Albert F G" uniqKey="Leentjens A" first="Albert F. G." last="Leentjens">Albert F. G. Leentjens</name><name sortKey="Scholtissen, Bart" sort="Scholtissen, Bart" uniqKey="Scholtissen B" first="Bart" last="Scholtissen">Bart Scholtissen</name><name sortKey="Verhey, Frans R J" sort="Verhey, Frans R J" uniqKey="Verhey F" first="Frans R. J." last="Verhey">Frans R. J. Verhey</name><name sortKey="Weber, Wim E J" sort="Weber, Wim E J" uniqKey="Weber W" first="Wim E. J." last="Weber">Wim E. J. Weber</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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