Parkinsonism and Motor Neuron Diseases: Twenty-Seven Patients with Diverse Overlap Syndromes
Identifieur interne : 000910 ( PascalFrancis/Checkpoint ); précédent : 000909; suivant : 000911Parkinsonism and Motor Neuron Diseases: Twenty-Seven Patients with Diverse Overlap Syndromes
Auteurs : Rebecca M. Wolf Gilbert [États-Unis] ; Stanley Fahn [États-Unis] ; Hiroshi Mitsumoto [États-Unis] ; Lewis P. Rowland [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
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Abstract
It has long been recognized that signs of motor neuron disease (MND) may accompany clinical evidence of parkinsonism in different neurodegenerative conditions. By using the Columbia University Division of Movement Disorders database, we reviewed data from 5,500 cases of parkinsonism and recorded the presence of upper motor neuron (UMN) dysfunction, lower motor neuron (LMN) dysfunction, or both. Among the 27 patients so identified, we counted those with autonomic dysfunction, cerebellar dysfunction, or dementia. Among the 27 cases, seven had UMN signs and LMN signs as well as parkinsonism and were diagnosed with amyotrophic lateral sclerosis (ALS)-parkinsonism (Brait-Fahn disease). Three of the seven had dementia that was not deemed to be frontotemporal dementia (FTD). Six other patients had no LMN signs but had UMN signs and parkinsonism and were classified as having primary lateral sclerosis (PLS)-parkinsonism. Four patients had both UMN and LMN signs with parkinsonism as well as the characteristic dementia of FTD; they were diagnosed with FTD-parkinsonism-ALS. Seven patients had MND, parkinsonism, and autonomic or cerebellar dysfunction, a combination compatible with multiple system atrophy (MSA). Three patients had syndromes compatible with hereditary spastic paraplegia (HSP). In sum, we found that MND occurs in association with diverse parkinsonian syndromes; some are heritable, others sporadic and causes are uncertain. Having MND may be a risk factor for parkinsonism. A prospective study may elucidate this possibility.
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Wolf Gilbert</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, NYU Langone Medical Center</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, Columbia University Medical Center</s1><s2>New York, New York</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mitsumoto, Hiroshi" sort="Mitsumoto, Hiroshi" uniqKey="Mitsumoto H" first="Hiroshi" last="Mitsumoto">Hiroshi Mitsumoto</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, Columbia University Medical Center</s1><s2>New York, New York</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Rowland, Lewis P" sort="Rowland, Lewis P" uniqKey="Rowland L" first="Lewis P." last="Rowland">Lewis P. 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Wolf Gilbert</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, NYU Langone Medical Center</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, Columbia University Medical Center</s1><s2>New York, New York</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mitsumoto, Hiroshi" sort="Mitsumoto, Hiroshi" uniqKey="Mitsumoto H" first="Hiroshi" last="Mitsumoto">Hiroshi Mitsumoto</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, Columbia University Medical Center</s1><s2>New York, New York</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Rowland, Lewis P" sort="Rowland, Lewis P" uniqKey="Rowland L" first="Lewis P." last="Rowland">Lewis P. Rowland</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, Columbia University Medical Center</s1><s2>New York, New York</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amyotrophic lateral sclerosis</term><term>Autoimmune disease</term><term>Frontotemporal dementia</term><term>Human</term><term>Motor neuron disease</term><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Parkinsonism</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinsonisme</term><term>Maladie du neurone moteur</term><term>Maladie autoimmune</term><term>Sclérose latérale amyotrophique</term><term>Démence frontotemporale</term><term>Atrophie multisystématisée</term><term>Pathologie du système nerveux</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It has long been recognized that signs of motor neuron disease (MND) may accompany clinical evidence of parkinsonism in different neurodegenerative conditions. By using the Columbia University Division of Movement Disorders database, we reviewed data from 5,500 cases of parkinsonism and recorded the presence of upper motor neuron (UMN) dysfunction, lower motor neuron (LMN) dysfunction, or both. Among the 27 patients so identified, we counted those with autonomic dysfunction, cerebellar dysfunction, or dementia. Among the 27 cases, seven had UMN signs and LMN signs as well as parkinsonism and were diagnosed with amyotrophic lateral sclerosis (ALS)-parkinsonism (Brait-Fahn disease). Three of the seven had dementia that was not deemed to be frontotemporal dementia (FTD). Six other patients had no LMN signs but had UMN signs and parkinsonism and were classified as having primary lateral sclerosis (PLS)-parkinsonism. Four patients had both UMN and LMN signs with parkinsonism as well as the characteristic dementia of FTD; they were diagnosed with FTD-parkinsonism-ALS. Seven patients had MND, parkinsonism, and autonomic or cerebellar dysfunction, a combination compatible with multiple system atrophy (MSA). Three patients had syndromes compatible with hereditary spastic paraplegia (HSP). In sum, we found that MND occurs in association with diverse parkinsonian syndromes; some are heritable, others sporadic and causes are uncertain. Having MND may be a risk factor for parkinsonism. A prospective study may elucidate this possibility.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>25</s2></fA05><fA06><s2>12</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Parkinsonism and Motor Neuron Diseases: Twenty-Seven Patients with Diverse Overlap Syndromes</s1></fA08><fA11 i1="01" i2="1"><s1>WOLF GILBERT (Rebecca M.)</s1></fA11><fA11 i1="02" i2="1"><s1>FAHN (Stanley)</s1></fA11><fA11 i1="03" i2="1"><s1>MITSUMOTO (Hiroshi)</s1></fA11><fA11 i1="04" i2="1"><s1>ROWLAND (Lewis P.)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, NYU Langone Medical Center</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Neurology, Columbia University Medical Center</s1><s2>New York, New York</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></fA14><fA20><s1>1868-1875</s1></fA20><fA21><s1>2010</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000194841700130</s5></fA43><fA44><s0>0000</s0><s1>© 2010 INIST-CNRS. 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Three of the seven had dementia that was not deemed to be frontotemporal dementia (FTD). Six other patients had no LMN signs but had UMN signs and parkinsonism and were classified as having primary lateral sclerosis (PLS)-parkinsonism. Four patients had both UMN and LMN signs with parkinsonism as well as the characteristic dementia of FTD; they were diagnosed with FTD-parkinsonism-ALS. Seven patients had MND, parkinsonism, and autonomic or cerebellar dysfunction, a combination compatible with multiple system atrophy (MSA). Three patients had syndromes compatible with hereditary spastic paraplegia (HSP). In sum, we found that MND occurs in association with diverse parkinsonian syndromes; some are heritable, others sporadic and causes are uncertain. Having MND may be a risk factor for parkinsonism. 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Wolf Gilbert</name></region><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name><name sortKey="Mitsumoto, Hiroshi" sort="Mitsumoto, Hiroshi" uniqKey="Mitsumoto H" first="Hiroshi" last="Mitsumoto">Hiroshi Mitsumoto</name><name sortKey="Rowland, Lewis P" sort="Rowland, Lewis P" uniqKey="Rowland L" first="Lewis P." last="Rowland">Lewis P. Rowland</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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