Pathological Laughter in Gilles de la Tourette Syndrome: An Unusual Phonic Tic
Identifieur interne : 000907 ( PascalFrancis/Checkpoint ); précédent : 000906; suivant : 000908Pathological Laughter in Gilles de la Tourette Syndrome: An Unusual Phonic Tic
Auteurs : Andrea E. Cavanna [Royaume-Uni] ; Fizzah Ali [Royaume-Uni] ; James F. Leckman [États-Unis] ; Mary M. Robertson [Royaume-Uni]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
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Abstract
Patients with Gilles de la Tourette syndrome (GTS) can display socially inappropriate behaviors as part of their multiform tic phenomenology. Pathological laughter (PL), defined as the presence of episodic and contextually inappropriate outbursts of laughter, has been detailed as a symptom of various psychiatric and neurological conditions. We present a case series of eight subjects diagnosed with GTS who reported PL as part of their tic repertoire. All subjects experienced PL as a simple phonic tic, accompanied by characteristic premonitory urges and significant impairment in social interactions. In addition, all patients presented with multiple tic-related symptoms (mainly self-injurious behaviors and echolalia, n = 7; palilalia, n = 6; coprolalia/mental coprolalia, n = 5), and six patients had comorbid conditions (in particular obsessive-compulsive disorder/behaviors, n = 7; attention-deficit hyperactivity disorder, n = 4). We suggest that the pathophysiological mechanisms underlying the expression of PL as a tic could involve a dissociation between frontostriatal and limbic networks.
Affiliations:
- Royaume-Uni, États-Unis
- Angleterre, Connecticut, Grand Londres, Midlands de l'Ouest
- Birmingham, Londres
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Cavanna</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neuropsychiatry, University of Birmingham and BSMHFT</s1><s2>Birmingham</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Mental Health Sciences, UCL</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ali, Fizzah" sort="Ali, Fizzah" uniqKey="Ali F" first="Fizzah" last="Ali">Fizzah Ali</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neuropsychiatry, University of Birmingham and BSMHFT</s1><s2>Birmingham</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Leckman, James F" sort="Leckman, James F" uniqKey="Leckman J" first="James F." last="Leckman">James F. 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Cavanna</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neuropsychiatry, University of Birmingham and BSMHFT</s1><s2>Birmingham</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Mental Health Sciences, UCL</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ali, Fizzah" sort="Ali, Fizzah" uniqKey="Ali F" first="Fizzah" last="Ali">Fizzah Ali</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neuropsychiatry, University of Birmingham and BSMHFT</s1><s2>Birmingham</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Leckman, James F" sort="Leckman, James F" uniqKey="Leckman J" first="James F." last="Leckman">James F. Leckman</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Pediatrics, Child Study Center, Yale University</s1><s2>New Haven, Connecticut</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Robertson, Mary M" sort="Robertson, Mary M" uniqKey="Robertson M" first="Mary M." last="Robertson">Mary M. Robertson</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Mental Health Sciences, UCL</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, St George's Hospital and Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gilles de la Tourette syndrome</term><term>Laughter</term><term>Nervous system diseases</term><term>Tic</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Syndrome de Gilles de la Tourette</term><term>Tic</term><term>Pathologie du système nerveux</term><term>Rire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with Gilles de la Tourette syndrome (GTS) can display socially inappropriate behaviors as part of their multiform tic phenomenology. Pathological laughter (PL), defined as the presence of episodic and contextually inappropriate outbursts of laughter, has been detailed as a symptom of various psychiatric and neurological conditions. We present a case series of eight subjects diagnosed with GTS who reported PL as part of their tic repertoire. All subjects experienced PL as a simple phonic tic, accompanied by characteristic premonitory urges and significant impairment in social interactions. In addition, all patients presented with multiple tic-related symptoms (mainly self-injurious behaviors and echolalia, n = 7; palilalia, n = 6; coprolalia/mental coprolalia, n = 5), and six patients had comorbid conditions (in particular obsessive-compulsive disorder/behaviors, n = 7; attention-deficit hyperactivity disorder, n = 4). We suggest that the pathophysiological mechanisms underlying the expression of PL as a tic could involve a dissociation between frontostriatal and limbic networks.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>25</s2></fA05><fA06><s2>13</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Pathological Laughter in Gilles de la Tourette Syndrome: An Unusual Phonic Tic</s1></fA08><fA11 i1="01" i2="1"><s1>CAVANNA (Andrea E.)</s1></fA11><fA11 i1="02" i2="1"><s1>ALI (Fizzah)</s1></fA11><fA11 i1="03" i2="1"><s1>LECKMAN (James F.)</s1></fA11><fA11 i1="04" i2="1"><s1>ROBERTSON (Mary M.)</s1></fA11><fA14 i1="01"><s1>Department of Neuropsychiatry, University of Birmingham and BSMHFT</s1><s2>Birmingham</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></fA14><fA14 i1="02"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Mental Health Sciences, UCL</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Pediatrics, Child Study Center, Yale University</s1><s2>New Haven, Connecticut</s2><s3>USA</s3><sZ>3 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Neurology, St George's Hospital and Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>4 aut.</sZ></fA14><fA20><s1>2233-2239</s1></fA20><fA21><s1>2010</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000193258110330</s5></fA43><fA44><s0>0000</s0><s1>© 2010 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>56 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>10-0474379</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Patients with Gilles de la Tourette syndrome (GTS) can display socially inappropriate behaviors as part of their multiform tic phenomenology. Pathological laughter (PL), defined as the presence of episodic and contextually inappropriate outbursts of laughter, has been detailed as a symptom of various psychiatric and neurological conditions. We present a case series of eight subjects diagnosed with GTS who reported PL as part of their tic repertoire. All subjects experienced PL as a simple phonic tic, accompanied by characteristic premonitory urges and significant impairment in social interactions. In addition, all patients presented with multiple tic-related symptoms (mainly self-injurious behaviors and echolalia, n = 7; palilalia, n = 6; coprolalia/mental coprolalia, n = 5), and six patients had comorbid conditions (in particular obsessive-compulsive disorder/behaviors, n = 7; attention-deficit hyperactivity disorder, n = 4). 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Cavanna</name></region><name sortKey="Ali, Fizzah" sort="Ali, Fizzah" uniqKey="Ali F" first="Fizzah" last="Ali">Fizzah Ali</name><name sortKey="Cavanna, Andrea E" sort="Cavanna, Andrea E" uniqKey="Cavanna A" first="Andrea E." last="Cavanna">Andrea E. Cavanna</name><name sortKey="Cavanna, Andrea E" sort="Cavanna, Andrea E" uniqKey="Cavanna A" first="Andrea E." last="Cavanna">Andrea E. Cavanna</name><name sortKey="Robertson, Mary M" sort="Robertson, Mary M" uniqKey="Robertson M" first="Mary M." last="Robertson">Mary M. Robertson</name><name sortKey="Robertson, Mary M" sort="Robertson, Mary M" uniqKey="Robertson M" first="Mary M." last="Robertson">Mary M. Robertson</name></country><country name="États-Unis"><region name="Connecticut"><name sortKey="Leckman, James F" sort="Leckman, James F" uniqKey="Leckman J" first="James F." last="Leckman">James F. Leckman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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