Progression of Parkinson's Disease as Evaluated by Hoehn and Yahr Stage Transition Times
Identifieur interne : 000887 ( PascalFrancis/Checkpoint ); précédent : 000886; suivant : 000888Progression of Parkinson's Disease as Evaluated by Hoehn and Yahr Stage Transition Times
Auteurs : YING JIAO ZHAO [Singapour] ; HWEE LIN WEE [Singapour] ; Yiong-Huak Chan [Singapour] ; SOO HOON SEAH [Singapour] ; WING LOK AU [Singapour] ; PUAY NGOH LAU [Singapour] ; Emmanuel Camara Pica [Singapour] ; SHU CHUEN LI [Australie] ; NAN LUO [Singapour] ; Louis C. S. Tan [Singapour]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
This study was carried out to evaluate progression in Parkinson's disease (PD) by analyzing time taken to transit from one Hoehn and Yahr (H&Y) stage to the next stage and to investigate the variables that would be associated with H&Y transition times using a large PD database that contained prospectively collected information. Data were obtained from the movement disorder database of the National Neuroscience Institute in Singapore. Kaplan-Meier (KM) survival analysis was adopted to investigate the time taken to progress through various H&Y stages. Cox regression analysis was used to examine the association between the baseline variables at the entry point of each H&Y stage and the progression to the next stage. A total of 695 patients (mean age: 65.2, male: 57.3%) were studied. Using KM analysis, the median time taken to transit from H&Y stage 1 to 2, 2 to 2.5, 2.5 to 3 were 20, 62, and 25 months, respectively ; whereas the median time taken to progress from stage 3 to 4 and 4 to 5 were 24 and 26 months, respectively. Cox regression analysis revealed that older age-at-diagnosis, longer PD duration, and higher Unified Parkinson's Disease Rating Scale (UPDRS) motor scores at baseline were associated with a significantly faster progression through various H&Y stages. Gender and ethnicity were not associated with disease progression. In conclusion, H&Y transition time is a useful measure of disease progression in PD and may be utilized in clinical studies evaluating therapeutic interventions and prognostic factors in PD.
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<front><div type="abstract" xml:lang="en">This study was carried out to evaluate progression in Parkinson's disease (PD) by analyzing time taken to transit from one Hoehn and Yahr (H&Y) stage to the next stage and to investigate the variables that would be associated with H&Y transition times using a large PD database that contained prospectively collected information. Data were obtained from the movement disorder database of the National Neuroscience Institute in Singapore. Kaplan-Meier (KM) survival analysis was adopted to investigate the time taken to progress through various H&Y stages. Cox regression analysis was used to examine the association between the baseline variables at the entry point of each H&Y stage and the progression to the next stage. A total of 695 patients (mean age: 65.2, male: 57.3%) were studied. Using KM analysis, the median time taken to transit from H&Y stage 1 to 2, 2 to 2.5, 2.5 to 3 were 20, 62, and 25 months, respectively ; whereas the median time taken to progress from stage 3 to 4 and 4 to 5 were 24 and 26 months, respectively. Cox regression analysis revealed that older age-at-diagnosis, longer PD duration, and higher Unified Parkinson's Disease Rating Scale (UPDRS) motor scores at baseline were associated with a significantly faster progression through various H&Y stages. Gender and ethnicity were not associated with disease progression. In conclusion, H&Y transition time is a useful measure of disease progression in PD and may be utilized in clinical studies evaluating therapeutic interventions and prognostic factors in PD.</div>
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<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>158</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Australie</li>
<li>Singapour</li>
</country>
<orgName><li>Université nationale de Singapour</li>
</orgName>
</list>
<tree><country name="Singapour"><noRegion><name sortKey="Ying Jiao Zhao" sort="Ying Jiao Zhao" uniqKey="Ying Jiao Zhao" last="Ying Jiao Zhao">YING JIAO ZHAO</name>
</noRegion>
<name sortKey="Camara Pica, Emmanuel" sort="Camara Pica, Emmanuel" uniqKey="Camara Pica E" first="Emmanuel" last="Camara Pica">Emmanuel Camara Pica</name>
<name sortKey="Chan, Yiong Huak" sort="Chan, Yiong Huak" uniqKey="Chan Y" first="Yiong-Huak" last="Chan">Yiong-Huak Chan</name>
<name sortKey="Hwee Lin Wee" sort="Hwee Lin Wee" uniqKey="Hwee Lin Wee" last="Hwee Lin Wee">HWEE LIN WEE</name>
<name sortKey="Nan Luo" sort="Nan Luo" uniqKey="Nan Luo" last="Nan Luo">NAN LUO</name>
<name sortKey="Nan Luo" sort="Nan Luo" uniqKey="Nan Luo" last="Nan Luo">NAN LUO</name>
<name sortKey="Puay Ngoh Lau" sort="Puay Ngoh Lau" uniqKey="Puay Ngoh Lau" last="Puay Ngoh Lau">PUAY NGOH LAU</name>
<name sortKey="Soo Hoon Seah" sort="Soo Hoon Seah" uniqKey="Soo Hoon Seah" last="Soo Hoon Seah">SOO HOON SEAH</name>
<name sortKey="Tan, Louis C S" sort="Tan, Louis C S" uniqKey="Tan L" first="Louis C. S." last="Tan">Louis C. S. Tan</name>
<name sortKey="Wing Lok Au" sort="Wing Lok Au" uniqKey="Wing Lok Au" last="Wing Lok Au">WING LOK AU</name>
</country>
<country name="Australie"><noRegion><name sortKey="Shu Chuen Li" sort="Shu Chuen Li" uniqKey="Shu Chuen Li" last="Shu Chuen Li">SHU CHUEN LI</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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