Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease
Identifieur interne : 000661 ( PascalFrancis/Checkpoint ); précédent : 000660; suivant : 000662Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease
Auteurs : GUANGWEI DU [États-Unis] ; Mechelle M. Lewis [États-Unis] ; Martin Styner [États-Unis] ; Michele L. Shaffer [États-Unis] ; SUMAN SEN [États-Unis] ; Qing X. Yang [États-Unis] ; XUEMEI HUANG [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2011.
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Abstract
Recent magnetic resonance imaging studies suggest an increased transverse relaxation rate and reduced diffusion tensor imaging fractional anisotropy values in the substantia nigra in Parkinson's disease. The transverse relaxation rate and fractional anisotropy changes may reflect different aspects of Parkinson's disease-related pathological processes (ie, tissue iron deposition and microstructure disorganization). This study investigated the combined changes of transverse relaxation rate and fractional anisotropy in the substantia nigra in Parkinson's disease. High-resolution magnetic resonance imaging (T2-weighted, T2*, and diffusion tensor imaging) were obtained from 16 Parkinson's disease patients and 16 controls. Bilateral substantia nigras were delineated manually on T2-weighted images and coregistered to transverse relaxation rate and fractional anisotropy maps. The mean transverse relaxation rate and fractional anisotropy values in each substantia nigra were then calculated and compared between Parkinson's disease subjects and controls. Logistic regression, followed by receiver operating characteristic curve analysis, was employed to investigate the sensitivity and specificity of the combined measures for differentiating Parkinson's disease subjects from controls. Compared with controls, Parkinson's disease subjects demonstrated increased transverse relaxation rate (P <.0001) and reduced fractional anisotropy (P = .0365) in the substantia nigra. There was no significant correlation between transverse relaxation rate and fractional anisotropy values. Logistic regression analyses indicated that the combined use of transverse relaxation rate and fractional anisotropy values provides excellent discrimination between Parkinson's disease subjects and controls (c-statistic = 0.996) compared with transverse relaxation rate (c-statistic = 0.930) or fractional anisotropy (c-statistic = 0.742) alone. This study shows that the combined use of transverse relaxation rate and fractional anisotropy measures in the substantia nigra of Parkinson's disease enhances sensitivity and specificity in differentiating Parkinson's disease from controls. Further studies are warranted to evaluate the pathophysiological correlations of these magnetic resonance imaging measurements and their effectiveness in assisting in diagnosing Parkinson's disease and following its progression.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Combined R2<sup>*</sup> and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease</title><author><name sortKey="Guangwei Du" sort="Guangwei Du" uniqKey="Guangwei Du" last="Guangwei Du">GUANGWEI DU</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. Lewis</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Pharmacology, Pennsylvania State University-Milton S. 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Shaffer</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Suman Sen" sort="Suman Sen" uniqKey="Suman Sen" last="Suman Sen">SUMAN SEN</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Yang, Qing X" sort="Yang, Qing X" uniqKey="Yang Q" first="Qing X." last="Yang">Qing X. Yang</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Bioengineering, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Xuemei Huang" sort="Xuemei Huang" uniqKey="Xuemei Huang" last="Xuemei Huang">XUEMEI HUANG</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0380254</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0380254 INIST</idno><idno type="RBID">Pascal:11-0380254</idno><idno type="wicri:Area/PascalFrancis/Corpus">000491</idno><idno type="wicri:Area/PascalFrancis/Curation">002827</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000661</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Combined R2<sup>*</sup> and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease</title><author><name sortKey="Guangwei Du" sort="Guangwei Du" uniqKey="Guangwei Du" last="Guangwei Du">GUANGWEI DU</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. Lewis</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Styner, Martin" sort="Styner, Martin" uniqKey="Styner M" first="Martin" last="Styner">Martin Styner</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Computer Science, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Psychiatry, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Shaffer, Michele L" sort="Shaffer, Michele L" uniqKey="Shaffer M" first="Michele L." last="Shaffer">Michele L. Shaffer</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Suman Sen" sort="Suman Sen" uniqKey="Suman Sen" last="Suman Sen">SUMAN SEN</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Yang, Qing X" sort="Yang, Qing X" uniqKey="Yang Q" first="Qing X." last="Yang">Qing X. Yang</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Bioengineering, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Xuemei Huang" sort="Xuemei Huang" uniqKey="Xuemei Huang" last="Xuemei Huang">XUEMEI HUANG</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Diffusion tensor imaging</term><term>Locus niger</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson disease</term><term>Relaxation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Imagerie du tenseur de diffusion</term><term>Locus niger</term><term>Relaxation</term><term>Imagerie RMN</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent magnetic resonance imaging studies suggest an increased transverse relaxation rate and reduced diffusion tensor imaging fractional anisotropy values in the substantia nigra in Parkinson's disease. The transverse relaxation rate and fractional anisotropy changes may reflect different aspects of Parkinson's disease-related pathological processes (ie, tissue iron deposition and microstructure disorganization). This study investigated the combined changes of transverse relaxation rate and fractional anisotropy in the substantia nigra in Parkinson's disease. High-resolution magnetic resonance imaging (T2-weighted, T2<sup>*</sup>, and diffusion tensor imaging) were obtained from 16 Parkinson's disease patients and 16 controls. Bilateral substantia nigras were delineated manually on T2-weighted images and coregistered to transverse relaxation rate and fractional anisotropy maps. The mean transverse relaxation rate and fractional anisotropy values in each substantia nigra were then calculated and compared between Parkinson's disease subjects and controls. Logistic regression, followed by receiver operating characteristic curve analysis, was employed to investigate the sensitivity and specificity of the combined measures for differentiating Parkinson's disease subjects from controls. Compared with controls, Parkinson's disease subjects demonstrated increased transverse relaxation rate (P <.0001) and reduced fractional anisotropy (P = .0365) in the substantia nigra. There was no significant correlation between transverse relaxation rate and fractional anisotropy values. Logistic regression analyses indicated that the combined use of transverse relaxation rate and fractional anisotropy values provides excellent discrimination between Parkinson's disease subjects and controls (c-statistic = 0.996) compared with transverse relaxation rate (c-statistic = 0.930) or fractional anisotropy (c-statistic = 0.742) alone. This study shows that the combined use of transverse relaxation rate and fractional anisotropy measures in the substantia nigra of Parkinson's disease enhances sensitivity and specificity in differentiating Parkinson's disease from controls. Further studies are warranted to evaluate the pathophysiological correlations of these magnetic resonance imaging measurements and their effectiveness in assisting in diagnosing Parkinson's disease and following its progression.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>26</s2></fA05><fA06><s2>9</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Combined R2<sup>*</sup> and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease</s1></fA08><fA11 i1="01" i2="1"><s1>GUANGWEI DU</s1></fA11><fA11 i1="02" i2="1"><s1>LEWIS (Mechelle M.)</s1></fA11><fA11 i1="03" i2="1"><s1>STYNER (Martin)</s1></fA11><fA11 i1="04" i2="1"><s1>SHAFFER (Michele L.)</s1></fA11><fA11 i1="05" i2="1"><s1>SUMAN SEN</s1></fA11><fA11 i1="06" i2="1"><s1>YANG (Qing X.)</s1></fA11><fA11 i1="07" i2="1"><s1>XUEMEI HUANG</s1></fA11><fA14 i1="01"><s1>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Computer Science, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>3 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Psychiatry, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>3 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>4 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Bioengineering, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>6 aut.</sZ></fA14><fA14 i1="09"><s1>Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center</s1><s2>Hershey, Pennsylvania</s2><s3>USA</s3><sZ>7 aut.</sZ></fA14><fA20><s1>1627-1632</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000508939410060</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>24 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0380254</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Recent magnetic resonance imaging studies suggest an increased transverse relaxation rate and reduced diffusion tensor imaging fractional anisotropy values in the substantia nigra in Parkinson's disease. The transverse relaxation rate and fractional anisotropy changes may reflect different aspects of Parkinson's disease-related pathological processes (ie, tissue iron deposition and microstructure disorganization). This study investigated the combined changes of transverse relaxation rate and fractional anisotropy in the substantia nigra in Parkinson's disease. High-resolution magnetic resonance imaging (T2-weighted, T2<sup>*</sup>, and diffusion tensor imaging) were obtained from 16 Parkinson's disease patients and 16 controls. Bilateral substantia nigras were delineated manually on T2-weighted images and coregistered to transverse relaxation rate and fractional anisotropy maps. The mean transverse relaxation rate and fractional anisotropy values in each substantia nigra were then calculated and compared between Parkinson's disease subjects and controls. Logistic regression, followed by receiver operating characteristic curve analysis, was employed to investigate the sensitivity and specificity of the combined measures for differentiating Parkinson's disease subjects from controls. Compared with controls, Parkinson's disease subjects demonstrated increased transverse relaxation rate (P <.0001) and reduced fractional anisotropy (P = .0365) in the substantia nigra. There was no significant correlation between transverse relaxation rate and fractional anisotropy values. Logistic regression analyses indicated that the combined use of transverse relaxation rate and fractional anisotropy values provides excellent discrimination between Parkinson's disease subjects and controls (c-statistic = 0.996) compared with transverse relaxation rate (c-statistic = 0.930) or fractional anisotropy (c-statistic = 0.742) alone. This study shows that the combined use of transverse relaxation rate and fractional anisotropy measures in the substantia nigra of Parkinson's disease enhances sensitivity and specificity in differentiating Parkinson's disease from controls. Further studies are warranted to evaluate the pathophysiological correlations of these magnetic resonance imaging measurements and their effectiveness in assisting in diagnosing Parkinson's disease and following its progression.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Imagerie du tenseur de diffusion</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Diffusion tensor imaging</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Imágen de tensor de difusión</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Locus niger</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Locus niger</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Locus níger</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Relaxation</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Relaxation</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Relajación</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Imagerie RMN</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Imaginería RMN</s0><s5>12</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Encephalon</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>42</s5></fC07><fN21><s1>262</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Guangwei Du" sort="Guangwei Du" uniqKey="Guangwei Du" last="Guangwei Du">GUANGWEI DU</name></region><name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. 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