Gray Matter Correlates of Behavioral Severity in Progressive Supranuclear Palsy
Identifieur interne : 000586 ( PascalFrancis/Checkpoint ); précédent : 000585; suivant : 000587Gray Matter Correlates of Behavioral Severity in Progressive Supranuclear Palsy
Auteurs : Keith A. Josephs [États-Unis] ; Jennifer L. Whitwell [États-Unis] ; Scott D. Eggers [États-Unis] ; Matthew L. Senjem [États-Unis] ; Clifford R. Jr Jack [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2011.
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Abstract
Background: Behavioral changes occur in progressive supranuclear palsy. This study aimed to identify the anatomic correlate of behavioral severity in progressive supranuclear palsy. Methods: We performed standardized tests of behavioral severity (Frontal Behavioral Inventory), cognitive severity (Mini-Mental State Examination), motor severity (Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale Part III), and a 3.0-T volumetric head magnetic resonance imaging scan in 18 prospectively recruited subjects meeting National Institute of Neurological Diseases and Stroke-Society of Progressive Supranuclear Palsy criteria for probable progressive supranuclear palsy. Atlas-based parcellation was utilized to obtain regional gray matter volumes of frontal, temporal, and parietal lobe, and caudate and putamen, and voxel-based morphometry was used to assess voxel-level gray matter loss. We performed correlation analyses between total Frontal Behavioral Inventory score and gray matter volume, as well as assessed gray matter volume across three groups defined according to behavioral severity (mild, moderate, and severe) based on total Frontal Behavioral Inventory score. Results: Specific behaviors, with the exception of apathy that occurred in 83% of the subjects, were relatively infrequent. There was no association between Frontal Behavioral Inventory and cognitive or motor severity. Regions of the frontal lobe, particularly, the lateral posterior frontal cortex, significantly correlated with the total Frontal Behavioral Inventory score when using both regional volume and voxel-level analyses. The groupwise analyses also supported these findings. The presence of apathy correlated with atrophy of the putamen. Discussion: Behavioral severity in progressive supranuclear palsy appears to be associated with volume loss of frontostriatal regions, in particular, lateral posterior frontal lobe and putamen.
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Josephs</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Whitwell, Jennifer L" sort="Whitwell, Jennifer L" uniqKey="Whitwell J" first="Jennifer L." last="Whitwell">Jennifer L. Whitwell</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Radiology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Eggers, Scott D" sort="Eggers, Scott D" uniqKey="Eggers S" first="Scott D." last="Eggers">Scott D. Eggers</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Senjem, Matthew L" sort="Senjem, Matthew L" uniqKey="Senjem M" first="Matthew L." last="Senjem">Matthew L. Senjem</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Radiology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Radiology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apathy</term><term>Frontal</term><term>Inventory</term><term>Morphometry</term><term>Nervous system diseases</term><term>Supranuclear ophthalmoplegia</term><term>Voxel</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term><term>Ophtalmoplégie supranucléaire</term><term>Frontal</term><term>Inventaire</term><term>Voxel</term><term>Morphométrie</term><term>Apathie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Behavioral changes occur in progressive supranuclear palsy. This study aimed to identify the anatomic correlate of behavioral severity in progressive supranuclear palsy. Methods: We performed standardized tests of behavioral severity (Frontal Behavioral Inventory), cognitive severity (Mini-Mental State Examination), motor severity (Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale Part III), and a 3.0-T volumetric head magnetic resonance imaging scan in 18 prospectively recruited subjects meeting National Institute of Neurological Diseases and Stroke-Society of Progressive Supranuclear Palsy criteria for probable progressive supranuclear palsy. Atlas-based parcellation was utilized to obtain regional gray matter volumes of frontal, temporal, and parietal lobe, and caudate and putamen, and voxel-based morphometry was used to assess voxel-level gray matter loss. We performed correlation analyses between total Frontal Behavioral Inventory score and gray matter volume, as well as assessed gray matter volume across three groups defined according to behavioral severity (mild, moderate, and severe) based on total Frontal Behavioral Inventory score. Results: Specific behaviors, with the exception of apathy that occurred in 83% of the subjects, were relatively infrequent. There was no association between Frontal Behavioral Inventory and cognitive or motor severity. Regions of the frontal lobe, particularly, the lateral posterior frontal cortex, significantly correlated with the total Frontal Behavioral Inventory score when using both regional volume and voxel-level analyses. The groupwise analyses also supported these findings. The presence of apathy correlated with atrophy of the putamen. Discussion: Behavioral severity in progressive supranuclear palsy appears to be associated with volume loss of frontostriatal regions, in particular, lateral posterior frontal lobe and putamen.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>26</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Gray Matter Correlates of Behavioral Severity in Progressive Supranuclear Palsy</s1></fA08><fA11 i1="01" i2="1"><s1>JOSEPHS (Keith A.)</s1></fA11><fA11 i1="02" i2="1"><s1>WHITWELL (Jennifer L.)</s1></fA11><fA11 i1="03" i2="1"><s1>EGGERS (Scott D.)</s1></fA11><fA11 i1="04" i2="1"><s1>SENJEM (Matthew L.)</s1></fA11><fA11 i1="05" i2="1"><s1>JACK (Clifford R. JR)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Radiology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></fA14><fA20><s1>493-498</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000190875360180</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>50 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0211293</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Background: Behavioral changes occur in progressive supranuclear palsy. This study aimed to identify the anatomic correlate of behavioral severity in progressive supranuclear palsy. Methods: We performed standardized tests of behavioral severity (Frontal Behavioral Inventory), cognitive severity (Mini-Mental State Examination), motor severity (Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale Part III), and a 3.0-T volumetric head magnetic resonance imaging scan in 18 prospectively recruited subjects meeting National Institute of Neurological Diseases and Stroke-Society of Progressive Supranuclear Palsy criteria for probable progressive supranuclear palsy. Atlas-based parcellation was utilized to obtain regional gray matter volumes of frontal, temporal, and parietal lobe, and caudate and putamen, and voxel-based morphometry was used to assess voxel-level gray matter loss. We performed correlation analyses between total Frontal Behavioral Inventory score and gray matter volume, as well as assessed gray matter volume across three groups defined according to behavioral severity (mild, moderate, and severe) based on total Frontal Behavioral Inventory score. Results: Specific behaviors, with the exception of apathy that occurred in 83% of the subjects, were relatively infrequent. There was no association between Frontal Behavioral Inventory and cognitive or motor severity. Regions of the frontal lobe, particularly, the lateral posterior frontal cortex, significantly correlated with the total Frontal Behavioral Inventory score when using both regional volume and voxel-level analyses. The groupwise analyses also supported these findings. The presence of apathy correlated with atrophy of the putamen. 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Josephs</name></region><name sortKey="Eggers, Scott D" sort="Eggers, Scott D" uniqKey="Eggers S" first="Scott D." last="Eggers">Scott D. Eggers</name><name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name><name sortKey="Senjem, Matthew L" sort="Senjem, Matthew L" uniqKey="Senjem M" first="Matthew L." last="Senjem">Matthew L. Senjem</name><name sortKey="Whitwell, Jennifer L" sort="Whitwell, Jennifer L" uniqKey="Whitwell J" first="Jennifer L." last="Whitwell">Jennifer L. Whitwell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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