Milestones in Research on the Pathophysiology of Parkinson's Disease
Identifieur interne : 000510 ( PascalFrancis/Checkpoint ); précédent : 000509; suivant : 000511Milestones in Research on the Pathophysiology of Parkinson's Disease
Auteurs : Thomas Wichmann [États-Unis] ; Mahlon R. Delong [États-Unis] ; Jorge Guridi [Espagne] ; Jose A. Obeso [Espagne]Source :
- Movement disorders [ 0885-3185 ] ; 2011.
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Abstract
Progress in our understanding of the mechanisms underlying the cardinal motor abnormalities of Parkinson's disease (PD), in particular akinesia and bradykinesia and their treatment, has been remarkable. Notable accomplishments include insights into the functional organization of the basal ganglia and their place in the motor system as components of a family of parallel cortico-subcortical circuits that subserve motor and nonmotor functions and the development of models of the intrinsic organization of the basal ganglia, including delineation of the so-called direct, indirect, and hyperdirect pathways. Studies in primate models of PD have provided insight into the alterations of neuronal activity that are responsible for the motor features of PD, revealing both altered tonic levels of discharge and significant disturbances of the patterns of discharge throughout the motor circuitry and have led to the formulation of circuit models of PD, providing testable hypotheses for research and stimulating the development of new therapies. Most importantly, the discovery that lesions of the subthalamic nucleus, a key node of the indirect pathway, abolish the cardinal features of PD contributed to the renaissance in the use of surgical approaches to treating patients with PD, including ablation and deep brain stimulation.
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Delong</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, School of Medicine, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Clinica Universidad de Navarra and Medical School, Neuroscience Area, CIMA, University of Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1><s2>Santander</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Clinica Universidad de Navarra and Medical School, Neuroscience Area, CIMA, University of Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1><s2>Santander</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0264658</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0264658 INIST</idno><idno type="RBID">Pascal:11-0264658</idno><idno type="wicri:Area/PascalFrancis/Corpus">000570</idno><idno type="wicri:Area/PascalFrancis/Curation">002748</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000510</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Milestones in Research on the Pathophysiology of Parkinson's Disease</title><author><name sortKey="Wichmann, Thomas" sort="Wichmann, Thomas" uniqKey="Wichmann T" first="Thomas" last="Wichmann">Thomas Wichmann</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, School of Medicine, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Yerkes National Primate Center at Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Delong, Mahlon R" sort="Delong, Mahlon R" uniqKey="Delong M" first="Mahlon R." last="Delong">Mahlon R. Delong</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, School of Medicine, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Clinica Universidad de Navarra and Medical School, Neuroscience Area, CIMA, University of Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1><s2>Santander</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Clinica Universidad de Navarra and Medical School, Neuroscience Area, CIMA, University of Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1><s2>Santander</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal ganglion</term><term>Deep brain stimulation</term><term>Dyskinesia</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Pathophysiology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Dyskinésie</term><term>Pathologie du système nerveux</term><term>Physiopathologie</term><term>Noyau gris central</term><term>Stimulation cérébrale profonde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Progress in our understanding of the mechanisms underlying the cardinal motor abnormalities of Parkinson's disease (PD), in particular akinesia and bradykinesia and their treatment, has been remarkable. Notable accomplishments include insights into the functional organization of the basal ganglia and their place in the motor system as components of a family of parallel cortico-subcortical circuits that subserve motor and nonmotor functions and the development of models of the intrinsic organization of the basal ganglia, including delineation of the so-called direct, indirect, and hyperdirect pathways. Studies in primate models of PD have provided insight into the alterations of neuronal activity that are responsible for the motor features of PD, revealing both altered tonic levels of discharge and significant disturbances of the patterns of discharge throughout the motor circuitry and have led to the formulation of circuit models of PD, providing testable hypotheses for research and stimulating the development of new therapies. Most importantly, the discovery that lesions of the subthalamic nucleus, a key node of the indirect pathway, abolish the cardinal features of PD contributed to the renaissance in the use of surgical approaches to treating patients with PD, including ablation and deep brain stimulation.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>26</s2></fA05><fA06><s2>6</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Milestones in Research on the Pathophysiology of Parkinson's Disease</s1></fA08><fA11 i1="01" i2="1"><s1>WICHMANN (Thomas)</s1></fA11><fA11 i1="02" i2="1"><s1>DELONG (Mahlon R.)</s1></fA11><fA11 i1="03" i2="1"><s1>GURIDI (Jorge)</s1></fA11><fA11 i1="04" i2="1"><s1>OBESO (Jose A.)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, School of Medicine, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></fA14><fA14 i1="02"><s1>Yerkes National Primate Center at Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Neurology, Clinica Universidad de Navarra and Medical School, Neuroscience Area, CIMA, University of Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Centros de Investigació Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1><s2>Santander</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></fA14><fA20><s1>1032-1041</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000191622890100</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>115 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0264658</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Progress in our understanding of the mechanisms underlying the cardinal motor abnormalities of Parkinson's disease (PD), in particular akinesia and bradykinesia and their treatment, has been remarkable. Notable accomplishments include insights into the functional organization of the basal ganglia and their place in the motor system as components of a family of parallel cortico-subcortical circuits that subserve motor and nonmotor functions and the development of models of the intrinsic organization of the basal ganglia, including delineation of the so-called direct, indirect, and hyperdirect pathways. Studies in primate models of PD have provided insight into the alterations of neuronal activity that are responsible for the motor features of PD, revealing both altered tonic levels of discharge and significant disturbances of the patterns of discharge throughout the motor circuitry and have led to the formulation of circuit models of PD, providing testable hypotheses for research and stimulating the development of new therapies. Most importantly, the discovery that lesions of the subthalamic nucleus, a key node of the indirect pathway, abolish the cardinal features of PD contributed to the renaissance in the use of surgical approaches to treating patients with PD, including ablation and deep brain stimulation.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Dyskinésie</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Dyskinesia</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Disquinesia</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Physiopathologie</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Pathophysiology</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Fisiopatología</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Noyau gris central</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Basal ganglion</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Núcleo basal</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Stimulation cérébrale profonde</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Deep brain stimulation</s0><s4>CD</s4><s5>96</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Encéphale</s0><s5>42</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Encephalon</s0><s5>42</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Encéfalo</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>43</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system</s0><s5>43</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>43</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Mouvement involontaire</s0><s5>44</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Involuntary movement</s0><s5>44</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Movimiento involuntario</s0><s5>44</s5></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Trouble neurologique</s0><s5>45</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Neurological disorder</s0><s5>45</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Trastorno neurológico</s0><s5>45</s5></fC07><fN21><s1>178</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Espagne</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Wichmann, Thomas" sort="Wichmann, Thomas" uniqKey="Wichmann T" first="Thomas" last="Wichmann">Thomas Wichmann</name></region><name sortKey="Delong, Mahlon R" sort="Delong, Mahlon R" uniqKey="Delong M" first="Mahlon R." last="Delong">Mahlon R. Delong</name><name sortKey="Wichmann, Thomas" sort="Wichmann, Thomas" uniqKey="Wichmann T" first="Thomas" last="Wichmann">Thomas Wichmann</name></country><country name="Espagne"><noRegion><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name></noRegion><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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