Progressive Parkinsonism, Oculomotor Abnormalities and Autonomic Dysfunction: Clinicopathological Case
Identifieur interne : 000439 ( PascalFrancis/Checkpoint ); précédent : 000438; suivant : 000440Progressive Parkinsonism, Oculomotor Abnormalities and Autonomic Dysfunction: Clinicopathological Case
Auteurs : Giovanni Fabbrini [Italie] ; Marcello Merello [Argentine] ; Andrew H. Evans [Australie] ; Andrew Lees (neurologue) [Royaume-Uni] ; Janice Holton [Royaume-Uni] ; David R. Williams [Royaume-Uni, Australie]Source :
- Movement disorders [ 0885-3185 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
A 59-year-old woman presented with asymmetric parkinsonism that was not-responsive to Levodopa therapy. She developed early falls, postural instability, and moderately severe autonomic dysfunction. Eye movement abnormalities were reported 2 years after her first symptoms, and she eventually developed anterocollis. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.
Affiliations:
- Argentine, Australie, Italie, Royaume-Uni
- Angleterre, Grand Londres
- Londres
- National Hospital for Neurology and Neurosurgery
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Evans</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Royal Melbourne Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London</wicri:noRegion><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Queen Square Brain Bank for Neurological Disorders, University College London</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Queen Square Brain Bank for Neurological Disorders, University College London</wicri:noRegion><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author><author><name sortKey="Holton, Janice" sort="Holton, Janice" uniqKey="Holton J" first="Janice" last="Holton">Janice Holton</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Queen Square Brain Bank for Neurological Disorders, University College London</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Queen Square Brain Bank for Neurological Disorders, University College London</wicri:noRegion></affiliation></author><author><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R." last="Williams">David R. Williams</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Queen Square Brain Bank for Neurological Disorders, University College London</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Queen Square Brain Bank for Neurological Disorders, University College London</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Faculty of Medicine (Neurosciences), Van Cleef Roet Centre for Nervous Diseases, Monash University</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Melbourne, Victoria</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0211271</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0211271 INIST</idno><idno type="RBID">Pascal:11-0211271</idno><idno type="wicri:Area/PascalFrancis/Corpus">000693</idno><idno type="wicri:Area/PascalFrancis/Curation">002625</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000439</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Progressive Parkinsonism, Oculomotor Abnormalities and Autonomic Dysfunction: Clinicopathological Case</title><author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome</s1><s3>ITA</s3><sZ>1 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome</wicri:noRegion></affiliation></author><author><name sortKey="Merello, Marcello" sort="Merello, Marcello" uniqKey="Merello M" first="Marcello" last="Merello">Marcello Merello</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI)</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>2 aut.</sZ></inist:fA14><country>Argentine</country><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Evans, Andrew H" sort="Evans, Andrew H" uniqKey="Evans A" first="Andrew H." last="Evans">Andrew H. Evans</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Royal Melbourne Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London</wicri:noRegion><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Queen Square Brain Bank for Neurological Disorders, University College London</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Queen Square Brain Bank for Neurological Disorders, University College London</wicri:noRegion><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author><author><name sortKey="Holton, Janice" sort="Holton, Janice" uniqKey="Holton J" first="Janice" last="Holton">Janice Holton</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Queen Square Brain Bank for Neurological Disorders, University College London</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Queen Square Brain Bank for Neurological Disorders, University College London</wicri:noRegion></affiliation></author><author><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R." last="Williams">David R. Williams</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Queen Square Brain Bank for Neurological Disorders, University College London</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Queen Square Brain Bank for Neurological Disorders, University College London</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Faculty of Medicine (Neurosciences), Van Cleef Roet Centre for Nervous Diseases, Monash University</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Melbourne, Victoria</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dysfunction</term><term>Nervous system diseases</term><term>Parkinsonism</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinsonisme</term><term>Pathologie du système nerveux</term><term>Trouble fonctionnel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A 59-year-old woman presented with asymmetric parkinsonism that was not-responsive to Levodopa therapy. She developed early falls, postural instability, and moderately severe autonomic dysfunction. Eye movement abnormalities were reported 2 years after her first symptoms, and she eventually developed anterocollis. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>26</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Progressive Parkinsonism, Oculomotor Abnormalities and Autonomic Dysfunction: Clinicopathological Case</s1></fA08><fA11 i1="01" i2="1"><s1>FABBRINI (Giovanni)</s1></fA11><fA11 i1="02" i2="1"><s1>MERELLO (Marcello)</s1></fA11><fA11 i1="03" i2="1"><s1>EVANS (Andrew H.)</s1></fA11><fA11 i1="04" i2="1"><s1>LEES (Andrew J.)</s1></fA11><fA11 i1="05" i2="1"><s1>HOLTON (Janice)</s1></fA11><fA11 i1="06" i2="1"><s1>WILLIAMS (David R.)</s1></fA11><fA14 i1="01"><s1>Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome</s1><s3>ITA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI)</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Neurology, Royal Melbourne Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>3 aut.</sZ></fA14><fA14 i1="04"><s1>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="05"><s1>Queen Square Brain Bank for Neurological Disorders, University College London</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="06"><s1>Faculty of Medicine (Neurosciences), Van Cleef Roet Centre for Nervous Diseases, Monash University</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>6 aut.</sZ></fA14><fA20><s1>424-429</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000190875360080</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>31 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0211271</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>A 59-year-old woman presented with asymmetric parkinsonism that was not-responsive to Levodopa therapy. She developed early falls, postural instability, and moderately severe autonomic dysfunction. Eye movement abnormalities were reported 2 years after her first symptoms, and she eventually developed anterocollis. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17E</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinsonisme</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinsonism</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson síndrome</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Trouble fonctionnel</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Dysfunction</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Trastorno funcional</s0><s5>09</s5></fC03><fN21><s1>143</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Argentine</li><li>Australie</li><li>Italie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name></noRegion></country><country name="Argentine"><noRegion><name sortKey="Merello, Marcello" sort="Merello, Marcello" uniqKey="Merello M" first="Marcello" last="Merello">Marcello Merello</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Evans, Andrew H" sort="Evans, Andrew H" uniqKey="Evans A" first="Andrew H." last="Evans">Andrew H. Evans</name></noRegion><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R." last="Williams">David R. Williams</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name></region><name sortKey="Holton, Janice" sort="Holton, Janice" uniqKey="Holton J" first="Janice" last="Holton">Janice Holton</name><name sortKey="Holton, Janice" sort="Holton, Janice" uniqKey="Holton J" first="Janice" last="Holton">Janice Holton</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R." last="Williams">David R. Williams</name><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R." last="Williams">David R. 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