MovDisordV3, PascalFrancis, Checkpoint, bibRecord, 000267

Bilateral Subthalamic Nucleus Stimulation for Generalized Dystonia after Bilateral Pallidotomy

Identifieur interne : 000267 ( PascalFrancis/Checkpoint ); précédent : 000266; suivant : 000268

Bilateral Subthalamic Nucleus Stimulation for Generalized Dystonia after Bilateral Pallidotomy

Auteurs : Erich Talamoni [Brésil] ; Wuilker Knoner Campos [Brésil] ; Mauricio Mandel [Brésil] ; Eduardo Joaquim Lopes Alho [Brésil, Allemagne] ; Manoel Jacobsen Teixeira [Brésil]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0423942

Descripteurs français

Pascal (Inist)
- Dystonie, Pathologie du système nerveux, Noyau sousthalamique, Thalamotomie, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Deep brain stimulation, Dystonia, Nervous system diseases, Subthalamic nucleus, Thalamotomy.

Abstract

Background: Thalamotomies and pallidotomies were commonly performed before the deep brain stimulation (DBS) era. Although ablative procedures can lead to significant dystonia improvement, longer periods of analysis reveal disease progression and functional deterioration. Today, the same patients seek additional treatment possibilities. Methods: Four patients with generalized dystonia who previously had undergone bilateral pallidotomy came to our service seeking additional treatment because of dystonic symptom progression. Bilateral subthalamic nucleus DBS (B-STN-DBS) was the treatment of choice. The patients were evaluated with the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and the Unified Dystonia Rating Scale (UDRS) before and 2 years after surgery. Results: All patients showed significant functional improvement, averaging 65.3% in BFMDRS (P = .014) and 69.2% in UDRS (P = .025). Conclusions: These results suggest that B-STN-DBS may be an interesting treatment option for generalized dystonia, even for patients who have already undergone bilateral pallidotomy.

Affiliations:

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<front><div type="abstract" xml:lang="en">Background: Thalamotomies and pallidotomies were commonly performed before the deep brain stimulation (DBS) era. Although ablative procedures can lead to significant dystonia improvement, longer periods of analysis reveal disease progression and functional deterioration. Today, the same patients seek additional treatment possibilities. Methods: Four patients with generalized dystonia who previously had undergone bilateral pallidotomy came to our service seeking additional treatment because of dystonic symptom progression. Bilateral subthalamic nucleus DBS (B-STN-DBS) was the treatment of choice. The patients were evaluated with the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and the Unified Dystonia Rating Scale (UDRS) before and 2 years after surgery. Results: All patients showed significant functional improvement, averaging 65.3% in BFMDRS (P = .014) and 69.2% in UDRS (P = .025). Conclusions: These results suggest that B-STN-DBS may be an interesting treatment option for generalized dystonia, even for patients who have already undergone bilateral pallidotomy.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Bilateral Subthalamic Nucleus Stimulation for Generalized Dystonia after Bilateral Pallidotomy

Bilateral Subthalamic Nucleus Stimulation for Generalized Dystonia after Bilateral Pallidotomy

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