Movement Disorders (revue)

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Eye Symptoms in Relatives of Patients with Primary Adult-Onset Dystonia

Identifieur interne : 000195 ( PascalFrancis/Checkpoint ); précédent : 000194; suivant : 000196

Eye Symptoms in Relatives of Patients with Primary Adult-Onset Dystonia

Auteurs : Giovanni Defazio [Italie] ; Giovanni Abbruzzese [Italie] ; Maria Stella Aniello [Italie] ; Roberta Di Fede [Italie] ; Marcello Esposito [Italie] ; Giovanni Fabbrini [Italie] ; Paolo Girlanda [Italie] ; Rocco Liguori [Italie] ; Lucio Marinelli [Italie] ; Davide Martino [Italie] ; Francesca Morgante [Italie] ; Lucio Santoro [Italie] ; Michele Tinazzi [Italie] ; Alfredo Berardelli [Italie]

Source :

RBID : Pascal:12-0113821

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English descriptors

Abstract

Methods: Using a validated questionnaire, we screened eye symptoms (burning sensation, grittiness, dry eye) in 333 first-degree relatives of 140 probands with different forms of primary adult-onset dystonia, 208 healthy subjects, and 293 patients with primary blepharospasm. Results: The rate of eye symptoms was similar in the relatives of focal dystonia patients and in healthy subjects (adjusted HR, 1.1; 95% CI, 0.7-1.7; P = .69), thus suggesting a common origin of eye symptoms in both groups. A higher rate was observed in blepharospasm patients (adjusted HR, 2; 95% CI, 1.4-2.9; P<.0001). Relatives of focal dystonia patients who developed blepharospasm were more likely to have preceding eye symptoms than were relatives who developed focal dystonia other than blepharospasm (BSP) or relatives who did not develop dystonia. Conclusions: Eye symptoms reported by relatives of patients with focal dystonia probably result from eye diseases and are not part of the clinical spectrum of blepharospasm.


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Pascal:12-0113821

Le document en format XML

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<title xml:lang="en" level="a">Eye Symptoms in Relatives of Patients with Primary Adult-Onset Dystonia</title>
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<s2>Rome</s2>
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<s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1>
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<name sortKey="Liguori, Rocco" sort="Liguori, Rocco" uniqKey="Liguori R" first="Rocco" last="Liguori">Rocco Liguori</name>
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<name sortKey="Martino, Davide" sort="Martino, Davide" uniqKey="Martino D" first="Davide" last="Martino">Davide Martino</name>
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<name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name>
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<name sortKey="Santoro, Lucio" sort="Santoro, Lucio" uniqKey="Santoro L" first="Lucio" last="Santoro">Lucio Santoro</name>
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<name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name>
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<country>Italie</country>
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<name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name>
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<s2>Rome</s2>
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<settlement type="city">Rome</settlement>
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<title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint>
<date when="2012">2012</date>
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<title level="j" type="main">Movement disorders</title>
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<idno type="ISSN">0885-3185</idno>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Blepharospasm</term>
<term>Dystonia</term>
<term>Eye</term>
<term>Human</term>
<term>Nervous system diseases</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Dystonie</term>
<term>Blépharospasme</term>
<term>Pathologie du système nerveux</term>
<term>Oeil</term>
<term>Homme</term>
</keywords>
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<term>Homme</term>
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<div type="abstract" xml:lang="en">Methods: Using a validated questionnaire, we screened eye symptoms (burning sensation, grittiness, dry eye) in 333 first-degree relatives of 140 probands with different forms of primary adult-onset dystonia, 208 healthy subjects, and 293 patients with primary blepharospasm. Results: The rate of eye symptoms was similar in the relatives of focal dystonia patients and in healthy subjects (adjusted HR, 1.1; 95% CI, 0.7-1.7; P = .69), thus suggesting a common origin of eye symptoms in both groups. A higher rate was observed in blepharospasm patients (adjusted HR, 2; 95% CI, 1.4-2.9; P<.0001). Relatives of focal dystonia patients who developed blepharospasm were more likely to have preceding eye symptoms than were relatives who developed focal dystonia other than blepharospasm (BSP) or relatives who did not develop dystonia. Conclusions: Eye symptoms reported by relatives of patients with focal dystonia probably result from eye diseases and are not part of the clinical spectrum of blepharospasm.</div>
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<s1>DI FEDE (Roberta)</s1>
</fA11>
<fA11 i1="05" i2="1">
<s1>ESPOSITO (Marcello)</s1>
</fA11>
<fA11 i1="06" i2="1">
<s1>FABBRINI (Giovanni)</s1>
</fA11>
<fA11 i1="07" i2="1">
<s1>GIRLANDA (Paolo)</s1>
</fA11>
<fA11 i1="08" i2="1">
<s1>LIGUORI (Rocco)</s1>
</fA11>
<fA11 i1="09" i2="1">
<s1>MARINELLI (Lucio)</s1>
</fA11>
<fA11 i1="10" i2="1">
<s1>MARTINO (Davide)</s1>
</fA11>
<fA11 i1="11" i2="1">
<s1>MORGANTE (Francesca)</s1>
</fA11>
<fA11 i1="12" i2="1">
<s1>SANTORO (Lucio)</s1>
</fA11>
<fA11 i1="13" i2="1">
<s1>TINAZZI (Michele)</s1>
</fA11>
<fA11 i1="14" i2="1">
<s1>BERARDELLI (Alfredo)</s1>
</fA11>
<fA14 i1="01">
<s1>Department of Neurosciences and Sensory Organs, School of Motor Sciences, "Aldo Moro" University of Bari</s1>
<s2>Bari</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="02">
<s1>Department of Neurosciences, Ophthalmology and Genetics, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="03">
<s1>Department of Neurology, Second University of Naples</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>5 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="04">
<s1>Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed Institute (Pozzilli IS)</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>14 aut.</sZ>
</fA14>
<fA14 i1="05">
<s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1>
<s2>Messina</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="06">
<s1>Department of Neurology and Psychiatry Sapienza University of Rome, and IRCSS NEUROMED Institute (Pozzilli IS)</s1>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="07">
<s1>Department of Neurological and Vision Sciences, University of Verona</s1>
<s2>Verona</s2>
<s3>ITA</s3>
<sZ>13 aut.</sZ>
</fA14>
<fA20>
<s1>305-307</s1>
</fA20>
<fA21>
<s1>2012</s1>
</fA21>
<fA23 i1="01">
<s0>ENG</s0>
</fA23>
<fA43 i1="01">
<s1>INIST</s1>
<s2>20953</s2>
<s5>354000508698420230</s5>
</fA43>
<fA44>
<s0>0000</s0>
<s1>© 2012 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45>
<s0>15 ref.</s0>
</fA45>
<fA47 i1="01" i2="1">
<s0>12-0113821</s0>
</fA47>
<fA60>
<s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>Movement disorders</s0>
</fA64>
<fA66 i1="01">
<s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>Methods: Using a validated questionnaire, we screened eye symptoms (burning sensation, grittiness, dry eye) in 333 first-degree relatives of 140 probands with different forms of primary adult-onset dystonia, 208 healthy subjects, and 293 patients with primary blepharospasm. Results: The rate of eye symptoms was similar in the relatives of focal dystonia patients and in healthy subjects (adjusted HR, 1.1; 95% CI, 0.7-1.7; P = .69), thus suggesting a common origin of eye symptoms in both groups. A higher rate was observed in blepharospasm patients (adjusted HR, 2; 95% CI, 1.4-2.9; P<.0001). Relatives of focal dystonia patients who developed blepharospasm were more likely to have preceding eye symptoms than were relatives who developed focal dystonia other than blepharospasm (BSP) or relatives who did not develop dystonia. Conclusions: Eye symptoms reported by relatives of patients with focal dystonia probably result from eye diseases and are not part of the clinical spectrum of blepharospasm.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X">
<s0>002B17H</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Dystonie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Dystonia</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Distonía</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Blépharospasme</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Blepharospasm</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Blefaroespasmo</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Pathologie du système nerveux</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Nervous system diseases</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Sistema nervioso patología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Oeil</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Eye</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Ojo</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Homme</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Human</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Hombre</s0>
<s5>10</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Appareil visuel</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Visual system</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Aparato visual</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Mouvement involontaire</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Involuntary movement</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Movimiento involuntario</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Pathologie du muscle strié</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Striated muscle disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Músculo estriado patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Trouble neurologique</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Neurological disorder</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Trastorno neurológico</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE">
<s0>Pathologie de l'oeil</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG">
<s0>Eye disease</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA">
<s0>Ojo patología</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE">
<s0>Pathologie de la paupière</s0>
<s5>44</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG">
<s0>Eyelid disease</s0>
<s5>44</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA">
<s0>Párpado patología</s0>
<s5>44</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE">
<s0>Pathologie de l'encéphale</s0>
<s5>45</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG">
<s0>Cerebral disorder</s0>
<s5>45</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA">
<s0>Encéfalo patología</s0>
<s5>45</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE">
<s0>Pathologie du système nerveux central</s0>
<s5>46</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>46</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>46</s5>
</fC07>
<fN21>
<s1>086</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations>
<list>
<country>
<li>Italie</li>
</country>
<region>
<li>Latium</li>
</region>
<settlement>
<li>Rome</li>
</settlement>
</list>
<tree>
<country name="Italie">
<noRegion>
<name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name>
</noRegion>
<name sortKey="Abbruzzese, Giovanni" sort="Abbruzzese, Giovanni" uniqKey="Abbruzzese G" first="Giovanni" last="Abbruzzese">Giovanni Abbruzzese</name>
<name sortKey="Aniello, Maria Stella" sort="Aniello, Maria Stella" uniqKey="Aniello M" first="Maria Stella" last="Aniello">Maria Stella Aniello</name>
<name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name>
<name sortKey="Di Fede, Roberta" sort="Di Fede, Roberta" uniqKey="Di Fede R" first="Roberta" last="Di Fede">Roberta Di Fede</name>
<name sortKey="Esposito, Marcello" sort="Esposito, Marcello" uniqKey="Esposito M" first="Marcello" last="Esposito">Marcello Esposito</name>
<name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name>
<name sortKey="Girlanda, Paolo" sort="Girlanda, Paolo" uniqKey="Girlanda P" first="Paolo" last="Girlanda">Paolo Girlanda</name>
<name sortKey="Liguori, Rocco" sort="Liguori, Rocco" uniqKey="Liguori R" first="Rocco" last="Liguori">Rocco Liguori</name>
<name sortKey="Marinelli, Lucio" sort="Marinelli, Lucio" uniqKey="Marinelli L" first="Lucio" last="Marinelli">Lucio Marinelli</name>
<name sortKey="Martino, Davide" sort="Martino, Davide" uniqKey="Martino D" first="Davide" last="Martino">Davide Martino</name>
<name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name>
<name sortKey="Santoro, Lucio" sort="Santoro, Lucio" uniqKey="Santoro L" first="Lucio" last="Santoro">Lucio Santoro</name>
<name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name>
</country>
</tree>
</affiliations>
</record>

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