Impact of Apathy on Health-Related Quality of Life in Recently Diagnosed Parkinson's Disease: The ANIMO Study
Identifieur interne : 000166 ( PascalFrancis/Checkpoint ); précédent : 000165; suivant : 000167Impact of Apathy on Health-Related Quality of Life in Recently Diagnosed Parkinson's Disease: The ANIMO Study
Auteurs : Julián Benito-Leon [Espagne] ; Esther Cubo [Espagne] ; Carlos Coronell [Espagne]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
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- Pascal (Inist)
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- geographic : Espagne.
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Abstract
The impact of apathy on health-related quality of life (HRQOL) in recently diagnosed Parkinson's disease (PD) has not been systematically investigated. The objective of this cross-sectional survey (ANIMO study) was to examine the contribution of apathy to HRQOL in a Spanish sample of recently diagnosed PD patients. PD patients, diagnosed within 2 years of inclusion, were recruited at 102 outpatient clinics in 82 communities throughout Spain. Apathy was quantified using the Lille Apathy Rating Scale and HRQOL with the EuroQol-5D questionnaire. A mean EuroQol-5D index score of 0.89 obtained from population references in Spain was used as the cutoff for this study. The relationship between apathy and the dichotomized EuroQol-5D index score (<0.89 [lower HRQOL] vs ≥0.89 [reference]) was examined using multiple logistic regression analysis, adjusting for sociodemographic and clinical variables. We consecutively recruited 557 patients (60.3% men) with a mean age of 68.8 ± 9.7 years. Apathy was diagnosed in 291 (52.2%) and was related to problems in each of the EuroQoL dimensions. Apathetic PD patients showed EuroQol-5D index scores significantly lower than those without apathy (0.64 vs 0.83). In an adjusted model, apathetic PD patients were 2.49 times more likely to have lower HRQOL than nonapathetic patients (odds ratio, 2.49; 95% confidence interval, 1.49-4.15, P < 0.01). Apathy is very common in those with recently diagnosed PD and is one of the major clinical determinants of HRQOL in this disease. It should be one of the primary concerns among clinicians who provide treatment to individuals affected by PD.
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de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Medicine, Faculty of Medicine, Complutense University</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Cubo, Esther" sort="Cubo, Esther" uniqKey="Cubo E" first="Esther" last="Cubo">Esther Cubo</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Hospital "General Yagüe</s1><s2>Burgos</s2><s3>ESP</s3><sZ>2 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Burgos</wicri:noRegion></affiliation></author><author><name sortKey="Coronell, Carlos" sort="Coronell, Carlos" uniqKey="Coronell C" first="Carlos" last="Coronell">Carlos Coronell</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Medical Advising Department, Boehringer 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Benito-Leon</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital "12 de Octubre"</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Medicine, Faculty of Medicine, Complutense University</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Cubo, Esther" sort="Cubo, Esther" uniqKey="Cubo E" first="Esther" last="Cubo">Esther Cubo</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Hospital "General Yagüe</s1><s2>Burgos</s2><s3>ESP</s3><sZ>2 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Burgos</wicri:noRegion></affiliation></author><author><name sortKey="Coronell, Carlos" sort="Coronell, Carlos" uniqKey="Coronell C" first="Carlos" last="Coronell">Carlos Coronell</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Medical Advising Department, Boehringer Ingelheim España</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>3 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apathy</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Quality of life</term><term>Spain</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Qualité de vie</term><term>Espagne</term><term>Apathie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The impact of apathy on health-related quality of life (HRQOL) in recently diagnosed Parkinson's disease (PD) has not been systematically investigated. The objective of this cross-sectional survey (ANIMO study) was to examine the contribution of apathy to HRQOL in a Spanish sample of recently diagnosed PD patients. PD patients, diagnosed within 2 years of inclusion, were recruited at 102 outpatient clinics in 82 communities throughout Spain. Apathy was quantified using the Lille Apathy Rating Scale and HRQOL with the EuroQol-5D questionnaire. A mean EuroQol-5D index score of 0.89 obtained from population references in Spain was used as the cutoff for this study. The relationship between apathy and the dichotomized EuroQol-5D index score (<0.89 [lower HRQOL] vs ≥0.89 [reference]) was examined using multiple logistic regression analysis, adjusting for sociodemographic and clinical variables. We consecutively recruited 557 patients (60.3% men) with a mean age of 68.8 ± 9.7 years. Apathy was diagnosed in 291 (52.2%) and was related to problems in each of the EuroQoL dimensions. Apathetic PD patients showed EuroQol-5D index scores significantly lower than those without apathy (0.64 vs 0.83). In an adjusted model, apathetic PD patients were 2.49 times more likely to have lower HRQOL than nonapathetic patients (odds ratio, 2.49; 95% confidence interval, 1.49-4.15, P < 0.01). Apathy is very common in those with recently diagnosed PD and is one of the major clinical determinants of HRQOL in this disease. It should be one of the primary concerns among clinicians who provide treatment to individuals affected by PD.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>27</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Impact of Apathy on Health-Related Quality of Life in Recently Diagnosed Parkinson's Disease: The ANIMO Study</s1></fA08><fA11 i1="01" i2="1"><s1>BENITO-LEON (Julián)</s1></fA11><fA11 i1="02" i2="1"><s1>CUBO (Esther)</s1></fA11><fA11 i1="03" i2="1"><s1>CORONELL (Carlos)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, University Hospital "12 de Octubre"</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Medicine, Faculty of Medicine, Complutense University</s1><s2>Madrid</s2><s3>ESP</s3><sZ>1 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Neurology, Hospital "General Yagüe</s1><s2>Burgos</s2><s3>ESP</s3><sZ>2 aut.</sZ></fA14><fA14 i1="05"><s1>Medical Advising Department, Boehringer Ingelheim España</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>3 aut.</sZ></fA14><fA20><s1>211-218</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000508698420080</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. 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