Subthalamic Neuronal Responses to Cortical Stimulation
Identifieur interne : 000047 ( PascalFrancis/Checkpoint ); précédent : 000046; suivant : 000048Subthalamic Neuronal Responses to Cortical Stimulation
Auteurs : Marcus L. F. Janssen [Pays-Bas] ; Daphne G. M. Zwartjes [Pays-Bas] ; Yasin Temel [Pays-Bas] ; Vivianne Van Kranen-Mastenbroek [Pays-Bas] ; Annelien Duits [Pays-Bas] ; Lo J. Bour [Pays-Bas] ; Peter H. Veltink [Pays-Bas] ; Tjitske Heida [Pays-Bas] ; Veerle Visser-Vandewalle [Pays-Bas]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
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Abstract
Background: Deep brain stimulation of the subthalamic nucleus alleviates motor symptoms in Parkinson's disease patients. However, some patients suffer from cognitive and emotional changes. These side effects are most likely caused by current spread to the cognitive and limbic territories in the subthalamic nucleus. The aim of this study was to identify the motor part of the subthalamic nucleus to reduce stimulation-induced behavioral side effects, by using motor cortex stimulation. Methods: We describe the results of subthalamic nucleus neuronal responses to stimulation of the hand area of the motor cortex and evaluate the safety of this novel technique. Results: Responses differed between regions within the subthalamic nucleus. In the anterior and lateral electrode at dorsal levels of the subthalamic nucleus, an early excitation (˜5-4.5 ms) and subsequent inhibition (45-105 ms) were seen. The lateral electrode also showed a late excitation (˜125-160 ms). Focal seizures were observed following motor cortex stimulation. Conclusions: To prevent seizures the current density should be lowered, so that motor cortex stimulation-evoked responses can be safely used during deep brain stimulation surgery.
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Janssen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Maastricht Institute for Neuromodulative Development (MIND)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht Institute for Neuromodulative Development (MIND)</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>European Graduate School of Neuroscience (EURON)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>European Graduate School of Neuroscience (EURON)</wicri:noRegion></affiliation></author><author><name sortKey="Zwartjes, Daphne G M" sort="Zwartjes, Daphne G M" uniqKey="Zwartjes D" first="Daphne G. M." last="Zwartjes">Daphne G. M. Zwartjes</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>MIRA Institute for Biomedical Engineering and Technical Medicine, Department of Electrical Engineering, Mathematics and Computer Science, Biomedical Signals and Systems Group, University of Twente</s1><s2>Enschede</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Enschede</settlement><region nuts="2">Overijssel</region></placeName><orgName type="university">Université de Twente</orgName></affiliation></author><author><name sortKey="Temel, Yasin" sort="Temel, Yasin" uniqKey="Temel Y" first="Yasin" last="Temel">Yasin Temel</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Maastricht Institute for Neuromodulative Development (MIND)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht Institute for Neuromodulative Development (MIND)</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>European Graduate School of Neuroscience (EURON)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>European Graduate School of Neuroscience (EURON)</wicri:noRegion></affiliation></author><author><name sortKey="Kranen Mastenbroek, Vivianne Van" sort="Kranen Mastenbroek, Vivianne Van" uniqKey="Kranen Mastenbroek V" first="Vivianne Van" last="Kranen-Mastenbroek">Vivianne Van Kranen-Mastenbroek</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Maastricht Institute for Neuromodulative Development (MIND)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht Institute for Neuromodulative Development (MIND)</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurophysiology, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Duits, Annelien" sort="Duits, Annelien" uniqKey="Duits A" first="Annelien" last="Duits">Annelien Duits</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Maastricht Institute for Neuromodulative Development (MIND)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht Institute for Neuromodulative Development (MIND)</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Clinical Neuropsychology, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>5 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Bour, Lo J" sort="Bour, Lo J" uniqKey="Bour L" first="Lo J." last="Bour">Lo J. Bour</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Neurology/Clinical Neurophysiology, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Veltink, Peter H" sort="Veltink, Peter H" uniqKey="Veltink P" first="Peter H." last="Veltink">Peter H. Veltink</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>MIRA Institute for Biomedical Engineering and Technical Medicine, Department of Electrical Engineering, Mathematics and Computer Science, Biomedical Signals and Systems Group, University of Twente</s1><s2>Enschede</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Enschede</settlement><region nuts="2">Overijssel</region></placeName><orgName type="university">Université de Twente</orgName></affiliation></author><author><name sortKey="Heida, Tjitske" sort="Heida, Tjitske" uniqKey="Heida T" first="Tjitske" last="Heida">Tjitske Heida</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>MIRA Institute for Biomedical Engineering and Technical Medicine, Department of Electrical Engineering, Mathematics and Computer Science, Biomedical Signals and Systems Group, University of Twente</s1><s2>Enschede</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Enschede</settlement><region nuts="2">Overijssel</region></placeName><orgName type="university">Université de Twente</orgName></affiliation></author><author><name sortKey="Visser Vandewalle, Veerle" sort="Visser Vandewalle, Veerle" uniqKey="Visser Vandewalle V" first="Veerle" last="Visser-Vandewalle">Veerle Visser-Vandewalle</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Maastricht Institute for Neuromodulative Development (MIND)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht Institute for Neuromodulative Development (MIND)</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0198674</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0198674 INIST</idno><idno type="RBID">Pascal:12-0198674</idno><idno type="wicri:Area/PascalFrancis/Corpus">000225</idno><idno type="wicri:Area/PascalFrancis/Curation">002A89</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000047</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Subthalamic Neuronal Responses to Cortical Stimulation</title><author><name sortKey="Janssen, Marcus L F" sort="Janssen, Marcus L F" uniqKey="Janssen M" first="Marcus L. F." last="Janssen">Marcus L. F. Janssen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Maastricht Institute for Neuromodulative Development (MIND)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht Institute for Neuromodulative Development (MIND)</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>European Graduate School of Neuroscience (EURON)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>European Graduate School of Neuroscience (EURON)</wicri:noRegion></affiliation></author><author><name sortKey="Zwartjes, Daphne G M" sort="Zwartjes, Daphne G M" uniqKey="Zwartjes D" first="Daphne G. M." last="Zwartjes">Daphne G. M. Zwartjes</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>MIRA Institute for Biomedical Engineering and Technical Medicine, Department of Electrical Engineering, Mathematics and Computer Science, Biomedical Signals and Systems Group, University of Twente</s1><s2>Enschede</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Enschede</settlement><region nuts="2">Overijssel</region></placeName><orgName type="university">Université de Twente</orgName></affiliation></author><author><name sortKey="Temel, Yasin" sort="Temel, Yasin" uniqKey="Temel Y" first="Yasin" last="Temel">Yasin Temel</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Maastricht Institute for Neuromodulative Development (MIND)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht Institute for Neuromodulative Development (MIND)</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>European Graduate School of Neuroscience (EURON)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>European Graduate School of Neuroscience (EURON)</wicri:noRegion></affiliation></author><author><name sortKey="Kranen Mastenbroek, Vivianne Van" sort="Kranen Mastenbroek, Vivianne Van" uniqKey="Kranen Mastenbroek V" first="Vivianne Van" last="Kranen-Mastenbroek">Vivianne Van Kranen-Mastenbroek</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Maastricht Institute for Neuromodulative Development (MIND)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht Institute for Neuromodulative Development (MIND)</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurophysiology, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Duits, Annelien" sort="Duits, Annelien" uniqKey="Duits A" first="Annelien" last="Duits">Annelien Duits</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Maastricht Institute for Neuromodulative Development (MIND)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht Institute for Neuromodulative Development (MIND)</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Clinical Neuropsychology, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>5 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Bour, Lo J" sort="Bour, Lo J" uniqKey="Bour L" first="Lo J." last="Bour">Lo J. Bour</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Neurology/Clinical Neurophysiology, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Veltink, Peter H" sort="Veltink, Peter H" uniqKey="Veltink P" first="Peter H." last="Veltink">Peter H. Veltink</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>MIRA Institute for Biomedical Engineering and Technical Medicine, Department of Electrical Engineering, Mathematics and Computer Science, Biomedical Signals and Systems Group, University of Twente</s1><s2>Enschede</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Enschede</settlement><region nuts="2">Overijssel</region></placeName><orgName type="university">Université de Twente</orgName></affiliation></author><author><name sortKey="Heida, Tjitske" sort="Heida, Tjitske" uniqKey="Heida T" first="Tjitske" last="Heida">Tjitske Heida</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>MIRA Institute for Biomedical Engineering and Technical Medicine, Department of Electrical Engineering, Mathematics and Computer Science, Biomedical Signals and Systems Group, University of Twente</s1><s2>Enschede</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Enschede</settlement><region nuts="2">Overijssel</region></placeName><orgName type="university">Université de Twente</orgName></affiliation></author><author><name sortKey="Visser Vandewalle, Veerle" sort="Visser Vandewalle, Veerle" uniqKey="Visser Vandewalle V" first="Veerle" last="Visser-Vandewalle">Veerle Visser-Vandewalle</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Maastricht Institute for Neuromodulative Development (MIND)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Maastricht Institute for Neuromodulative Development (MIND)</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term><term>Nervous system diseases</term><term>Neurophysiology</term><term>Parkinson disease</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Neurophysiologie</term><term>Noyau sousthalamique</term><term>Stimulation cérébrale profonde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Deep brain stimulation of the subthalamic nucleus alleviates motor symptoms in Parkinson's disease patients. However, some patients suffer from cognitive and emotional changes. These side effects are most likely caused by current spread to the cognitive and limbic territories in the subthalamic nucleus. The aim of this study was to identify the motor part of the subthalamic nucleus to reduce stimulation-induced behavioral side effects, by using motor cortex stimulation. Methods: We describe the results of subthalamic nucleus neuronal responses to stimulation of the hand area of the motor cortex and evaluate the safety of this novel technique. Results: Responses differed between regions within the subthalamic nucleus. In the anterior and lateral electrode at dorsal levels of the subthalamic nucleus, an early excitation (˜5-4.5 ms) and subsequent inhibition (45-105 ms) were seen. The lateral electrode also showed a late excitation (˜125-160 ms). Focal seizures were observed following motor cortex stimulation. Conclusions: To prevent seizures the current density should be lowered, so that motor cortex stimulation-evoked responses can be safely used during deep brain stimulation surgery.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>27</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Subthalamic Neuronal Responses to Cortical Stimulation</s1></fA08><fA11 i1="01" i2="1"><s1>JANSSEN (Marcus L. F.)</s1></fA11><fA11 i1="02" i2="1"><s1>ZWARTJES (Daphne G. M.)</s1></fA11><fA11 i1="03" i2="1"><s1>TEMEL (Yasin)</s1></fA11><fA11 i1="04" i2="1"><s1>KRANEN-MASTENBROEK (Vivianne Van)</s1></fA11><fA11 i1="05" i2="1"><s1>DUITS (Annelien)</s1></fA11><fA11 i1="06" i2="1"><s1>BOUR (Lo J.)</s1></fA11><fA11 i1="07" i2="1"><s1>VELTINK (Peter H.)</s1></fA11><fA11 i1="08" i2="1"><s1>HEIDA (Tjitske)</s1></fA11><fA11 i1="09" i2="1"><s1>VISSER-VANDEWALLE (Veerle)</s1></fA11><fA14 i1="01"><s1>Department of Neuroscience, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Neurosurgery, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></fA14><fA14 i1="03"><s1>Maastricht Institute for Neuromodulative Development (MIND)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></fA14><fA14 i1="04"><s1>European Graduate School of Neuroscience (EURON)</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="05"><s1>MIRA Institute for Biomedical Engineering and Technical Medicine, Department of Electrical Engineering, Mathematics and Computer Science, Biomedical Signals and Systems Group, University of Twente</s1><s2>Enschede</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Neurophysiology, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>4 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Clinical Neuropsychology, Maastricht University Medical Center</s1><s2>Maastricht</s2><s3>NLD</s3><sZ>5 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Neurology/Clinical Neurophysiology, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>6 aut.</sZ></fA14><fA20><s1>435-438</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000506923350190</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>27 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0198674</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Background: Deep brain stimulation of the subthalamic nucleus alleviates motor symptoms in Parkinson's disease patients. However, some patients suffer from cognitive and emotional changes. These side effects are most likely caused by current spread to the cognitive and limbic territories in the subthalamic nucleus. The aim of this study was to identify the motor part of the subthalamic nucleus to reduce stimulation-induced behavioral side effects, by using motor cortex stimulation. Methods: We describe the results of subthalamic nucleus neuronal responses to stimulation of the hand area of the motor cortex and evaluate the safety of this novel technique. Results: Responses differed between regions within the subthalamic nucleus. In the anterior and lateral electrode at dorsal levels of the subthalamic nucleus, an early excitation (˜5-4.5 ms) and subsequent inhibition (45-105 ms) were seen. The lateral electrode also showed a late excitation (˜125-160 ms). Focal seizures were observed following motor cortex stimulation. Conclusions: To prevent seizures the current density should be lowered, so that motor cortex stimulation-evoked responses can be safely used during deep brain stimulation surgery.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B26I</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Neurophysiologie</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Neurophysiology</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Neurofisiología</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Noyau sousthalamique</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Subthalamic nucleus</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Núcleo subtalámico</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Stimulation cérébrale profonde</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Deep brain stimulation</s0><s4>CD</s4><s5>96</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Encéphale</s0><s5>42</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Encephalon</s0><s5>42</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Encéfalo</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>43</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system</s0><s5>43</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>43</s5></fC07><fN21><s1>156</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Septentrionale</li><li>Overijssel</li></region><settlement><li>Amsterdam</li><li>Enschede</li></settlement><orgName><li>Université de Twente</li></orgName></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Janssen, Marcus L F" sort="Janssen, Marcus L F" uniqKey="Janssen M" first="Marcus L. F." last="Janssen">Marcus L. F. Janssen</name></noRegion><name sortKey="Bour, Lo J" sort="Bour, Lo J" uniqKey="Bour L" first="Lo J." last="Bour">Lo J. Bour</name><name sortKey="Duits, Annelien" sort="Duits, Annelien" uniqKey="Duits A" first="Annelien" last="Duits">Annelien Duits</name><name sortKey="Duits, Annelien" sort="Duits, Annelien" uniqKey="Duits A" first="Annelien" last="Duits">Annelien Duits</name><name sortKey="Heida, Tjitske" sort="Heida, Tjitske" uniqKey="Heida T" first="Tjitske" last="Heida">Tjitske Heida</name><name sortKey="Janssen, Marcus L F" sort="Janssen, Marcus L F" uniqKey="Janssen M" first="Marcus L. F." last="Janssen">Marcus L. F. Janssen</name><name sortKey="Janssen, Marcus L F" sort="Janssen, Marcus L F" uniqKey="Janssen M" first="Marcus L. F." last="Janssen">Marcus L. F. Janssen</name><name sortKey="Janssen, Marcus L F" sort="Janssen, Marcus L F" uniqKey="Janssen M" first="Marcus L. F." last="Janssen">Marcus L. F. Janssen</name><name sortKey="Kranen Mastenbroek, Vivianne Van" sort="Kranen Mastenbroek, Vivianne Van" uniqKey="Kranen Mastenbroek V" first="Vivianne Van" last="Kranen-Mastenbroek">Vivianne Van Kranen-Mastenbroek</name><name sortKey="Kranen Mastenbroek, Vivianne Van" sort="Kranen Mastenbroek, Vivianne Van" uniqKey="Kranen Mastenbroek V" first="Vivianne Van" last="Kranen-Mastenbroek">Vivianne Van Kranen-Mastenbroek</name><name sortKey="Temel, Yasin" sort="Temel, Yasin" uniqKey="Temel Y" first="Yasin" last="Temel">Yasin Temel</name><name sortKey="Temel, Yasin" sort="Temel, Yasin" uniqKey="Temel Y" first="Yasin" last="Temel">Yasin Temel</name><name sortKey="Temel, Yasin" sort="Temel, Yasin" uniqKey="Temel Y" first="Yasin" last="Temel">Yasin Temel</name><name sortKey="Temel, Yasin" sort="Temel, Yasin" uniqKey="Temel Y" first="Yasin" last="Temel">Yasin Temel</name><name sortKey="Veltink, Peter H" sort="Veltink, Peter H" uniqKey="Veltink P" first="Peter H." last="Veltink">Peter H. Veltink</name><name sortKey="Visser Vandewalle, Veerle" sort="Visser Vandewalle, Veerle" uniqKey="Visser Vandewalle V" first="Veerle" last="Visser-Vandewalle">Veerle Visser-Vandewalle</name><name sortKey="Visser Vandewalle, Veerle" sort="Visser Vandewalle, Veerle" uniqKey="Visser Vandewalle V" first="Veerle" last="Visser-Vandewalle">Veerle Visser-Vandewalle</name><name sortKey="Zwartjes, Daphne G M" sort="Zwartjes, Daphne G M" uniqKey="Zwartjes D" first="Daphne G. M." last="Zwartjes">Daphne G. M. Zwartjes</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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