Pergolide compared with bromocriptine in Parkinson's disease: a multicenter, crossover, controlled study.
Identifieur interne : 004821 ( Ncbi/Merge ); précédent : 004820; suivant : 004822Pergolide compared with bromocriptine in Parkinson's disease: a multicenter, crossover, controlled study.
Auteurs : G. Pezzoli [Italie] ; E. Martignoni ; C. Pacchetti ; V A Angeleri ; P. Lamberti ; A. Muratorio ; U. Bonuccelli ; M. De Mari ; N. Foschi ; E. CossuttaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1994.
English descriptors
- KwdEn :
- Aged, Bromocriptine (adverse effects), Bromocriptine (therapeutic use), Cross-Over Studies, Disability Evaluation, Dose-Response Relationship, Drug, Drug Therapy, Combination, Humans, Infant, Levodopa (adverse effects), Levodopa (therapeutic use), Male, Middle Aged, Neurologic Examination (drug effects), Parkinson Disease (drug therapy), Pergolide (adverse effects), Pergolide (therapeutic use), Single-Blind Method, Treatment Outcome.
- MESH :
- chemical , adverse effects : Bromocriptine, Levodopa, Pergolide.
- chemical , therapeutic use : Bromocriptine, Levodopa, Pergolide.
- drug effects : Neurologic Examination.
- drug therapy : Parkinson Disease.
- Aged, Cross-Over Studies, Disability Evaluation, Dose-Response Relationship, Drug, Drug Therapy, Combination, Humans, Infant, Male, Middle Aged, Single-Blind Method, Treatment Outcome.
Abstract
We compared the efficacy and safety of pergolide and bromocriptine in 57 patients with Parkinson's disease (PD) with a declining response to levodopa therapy in a single-blind, crossover study. Patients were placed randomly on the sequence bromocriptine-pergolide (12 + 12 weeks) or vice versa. Regular evaluations using the New York University Parkinson's Disease Scale were performed by a clinician blinded to treatment assignment. Patients' and clinicians' impressions also were recorded. The average daily dose of pergolide was 2.3 +/0- 0.8 mg, and that of bromocriptine was 24.2 +/- 8.4 mg. Significantly greater efficacy was demonstrated by both drugs as adjunctive therapy to levodopa compared with previous treatment of levodopa alone (pergolide, p = 0.0001; bromocriptine, p = 0.0005; Wilcoxon t test). Pergolide was more effective than bromocriptine in daily living scores (p = 0.020) and motor scores (p = 0.038). No difference in dyskinesias, dystonias, and psychosis was observed. Adverse events were more frequent in bromocriptine-treated patients. Most patients and physicians preferred pergolide to bromocriptine. Pergolide as adjunctive therapy to levodopa was more effective than bromocriptine in this short-term trial.
DOI: 10.1002/mds.870090409
PubMed: 7969210
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pubmed:7969210Le document en format XML
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<author><name sortKey="Angeleri, V A" sort="Angeleri, V A" uniqKey="Angeleri V" first="V A" last="Angeleri">V A Angeleri</name>
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<author><name sortKey="De Mari, M" sort="De Mari, M" uniqKey="De Mari M" first="M" last="De Mari">M. De Mari</name>
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<term>Disability Evaluation</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drug Therapy, Combination</term>
<term>Humans</term>
<term>Infant</term>
<term>Levodopa (adverse effects)</term>
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<term>Male</term>
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<term>Pergolide (therapeutic use)</term>
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<front><div type="abstract" xml:lang="en">We compared the efficacy and safety of pergolide and bromocriptine in 57 patients with Parkinson's disease (PD) with a declining response to levodopa therapy in a single-blind, crossover study. Patients were placed randomly on the sequence bromocriptine-pergolide (12 + 12 weeks) or vice versa. Regular evaluations using the New York University Parkinson's Disease Scale were performed by a clinician blinded to treatment assignment. Patients' and clinicians' impressions also were recorded. The average daily dose of pergolide was 2.3 +/0- 0.8 mg, and that of bromocriptine was 24.2 +/- 8.4 mg. Significantly greater efficacy was demonstrated by both drugs as adjunctive therapy to levodopa compared with previous treatment of levodopa alone (pergolide, p = 0.0001; bromocriptine, p = 0.0005; Wilcoxon t test). Pergolide was more effective than bromocriptine in daily living scores (p = 0.020) and motor scores (p = 0.038). No difference in dyskinesias, dystonias, and psychosis was observed. Adverse events were more frequent in bromocriptine-treated patients. Most patients and physicians preferred pergolide to bromocriptine. Pergolide as adjunctive therapy to levodopa was more effective than bromocriptine in this short-term trial.</div>
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<Abstract><AbstractText>We compared the efficacy and safety of pergolide and bromocriptine in 57 patients with Parkinson's disease (PD) with a declining response to levodopa therapy in a single-blind, crossover study. Patients were placed randomly on the sequence bromocriptine-pergolide (12 + 12 weeks) or vice versa. Regular evaluations using the New York University Parkinson's Disease Scale were performed by a clinician blinded to treatment assignment. Patients' and clinicians' impressions also were recorded. The average daily dose of pergolide was 2.3 +/0- 0.8 mg, and that of bromocriptine was 24.2 +/- 8.4 mg. Significantly greater efficacy was demonstrated by both drugs as adjunctive therapy to levodopa compared with previous treatment of levodopa alone (pergolide, p = 0.0001; bromocriptine, p = 0.0005; Wilcoxon t test). Pergolide was more effective than bromocriptine in daily living scores (p = 0.020) and motor scores (p = 0.038). No difference in dyskinesias, dystonias, and psychosis was observed. Adverse events were more frequent in bromocriptine-treated patients. Most patients and physicians preferred pergolide to bromocriptine. Pergolide as adjunctive therapy to levodopa was more effective than bromocriptine in this short-term trial.</AbstractText>
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