Is Dominant-Side Onset Associated With a Better Motor Compensation in Parkinson's Disease?
Identifieur interne : 004494 ( Ncbi/Merge ); précédent : 004493; suivant : 004495Is Dominant-Side Onset Associated With a Better Motor Compensation in Parkinson's Disease?
Auteurs : Jee H. Ham [Corée du Sud] ; Jae J. Lee [Corée du Sud] ; Jae S. Kim [Corée du Sud] ; Phil H. Lee [Corée du Sud] ; Young H. Sohn [Corée du Sud]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Unilateral onset and persistent asymmetry of motor signs are unique features of PD. The dominant hemisphere may have more efficient motor networks with greater neural reserve to cope with pathological changes. Therefore, this study compared dominant-side onset and non-dominant-side onset PD to evaluate whether dominant-side onset patients have greater neural reserve and fewer motor deficits despite similar pathological changes.
DOI: 10.1002/mds.26418
PubMed: 26408124
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Is Dominant-Side Onset Associated With a Better Motor Compensation in Parkinson's Disease?</title><author><name sortKey="Ham, Jee H" sort="Ham, Jee H" uniqKey="Ham J" first="Jee H" last="Ham">Jee H. Ham</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Jae J" sort="Lee, Jae J" uniqKey="Lee J" first="Jae J" last="Lee">Jae J. Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Jae S" sort="Kim, Jae S" uniqKey="Kim J" first="Jae S" last="Kim">Jae S. Kim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Phil H" sort="Lee, Phil H" uniqKey="Lee P" first="Phil H" last="Lee">Phil H. Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H" last="Sohn">Young H. Sohn</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="doi">10.1002/mds.26418</idno><idno type="RBID">pubmed:26408124</idno><idno type="pmid">26408124</idno><idno type="wicri:Area/PubMed/Corpus">000024</idno><idno type="wicri:Area/PubMed/Curation">000024</idno><idno type="wicri:Area/PubMed/Checkpoint">000201</idno><idno type="wicri:Area/Ncbi/Merge">004494</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Is Dominant-Side Onset Associated With a Better Motor Compensation in Parkinson's Disease?</title><author><name sortKey="Ham, Jee H" sort="Ham, Jee H" uniqKey="Ham J" first="Jee H" last="Ham">Jee H. Ham</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Jae J" sort="Lee, Jae J" uniqKey="Lee J" first="Jae J" last="Lee">Jae J. Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Jae S" sort="Kim, Jae S" uniqKey="Kim J" first="Jae S" last="Kim">Jae S. Kim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Phil H" sort="Lee, Phil H" uniqKey="Lee P" first="Phil H" last="Lee">Phil H. Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H" last="Sohn">Young H. Sohn</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Unilateral onset and persistent asymmetry of motor signs are unique features of PD. The dominant hemisphere may have more efficient motor networks with greater neural reserve to cope with pathological changes. Therefore, this study compared dominant-side onset and non-dominant-side onset PD to evaluate whether dominant-side onset patients have greater neural reserve and fewer motor deficits despite similar pathological changes.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26408124</PMID><DateCreated><Year>2015</Year><Month>9</Month><Day>26</Day></DateCreated><DateRevised><Year>2015</Year><Month>9</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2015</Year><Month>Sep</Month><Day>26</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Is Dominant-Side Onset Associated With a Better Motor Compensation in Parkinson's Disease?</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><ELocationID EIdType="doi">10.1002/mds.26418</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Unilateral onset and persistent asymmetry of motor signs are unique features of PD. The dominant hemisphere may have more efficient motor networks with greater neural reserve to cope with pathological changes. Therefore, this study compared dominant-side onset and non-dominant-side onset PD to evaluate whether dominant-side onset patients have greater neural reserve and fewer motor deficits despite similar pathological changes.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We included the data of 157 consecutive, de novo PD patients with documented right-handedness who underwent dopamine transporter PET scans for an initial diagnostic workup. Among them, 118 patients with significant asymmetric motor deficits were selected for the analyses.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Dominant-side patients (i.e., the majority of motor deficits on the right side) showed significantly fewer motor deficits (i.e., the part III score of the UPDRS) than non-dominant-side patients (18.0 ± 8.1 and 22.9 ± 10.1, respectively; P = 0.005). Other variables, including symptom duration and striatal dopaminergic activities, were similar between the two groups. A general linear model showed that this difference in motor deficits remained statistically significant after controlling for patient age, sex, symptom duration, and striatal dopaminergic activity in the posterior putamen (P = 0.013).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">These results suggest that dominant-side patients have greater neural reserve, allowing them to better cope with PD-related pathological changes (i.e., fewer motor deficits despite similar dopamine reduction) compared to non-dominant-side patients. © 2015 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList><Author><LastName>Ham</LastName><ForeName>Jee H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author><LastName>Lee</LastName><ForeName>Jae J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author><LastName>Kim</LastName><ForeName>Jae S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author><LastName>Lee</LastName><ForeName>Phil H</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author><LastName>Sohn</LastName><ForeName>Young H</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>9</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">PET</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">dopamine transporter</Keyword><Keyword MajorTopicYN="N">hand dominance</Keyword><Keyword MajorTopicYN="N">neural reserve</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>2</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>8</Month><Day>3</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>8</Month><Day>4</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>9</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.26418</ArticleId><ArticleId IdType="pubmed">26408124</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Ham, Jee H" sort="Ham, Jee H" uniqKey="Ham J" first="Jee H" last="Ham">Jee H. Ham</name></noRegion><name sortKey="Kim, Jae S" sort="Kim, Jae S" uniqKey="Kim J" first="Jae S" last="Kim">Jae S. Kim</name><name sortKey="Lee, Jae J" sort="Lee, Jae J" uniqKey="Lee J" first="Jae J" last="Lee">Jae J. Lee</name><name sortKey="Lee, Phil H" sort="Lee, Phil H" uniqKey="Lee P" first="Phil H" last="Lee">Phil H. Lee</name><name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H" last="Sohn">Young H. Sohn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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