Progressive retinal structure abnormalities in multiple system atrophy.
Identifieur interne : 004478 ( Ncbi/Merge ); précédent : 004477; suivant : 004479Progressive retinal structure abnormalities in multiple system atrophy.
Auteurs : Carlos E. Mendoza-Santiesteban [États-Unis] ; Jose-Alberto Palma [États-Unis] ; Jose Martinez [États-Unis] ; Lucy Norcliffe-Kaufmann [États-Unis] ; Thomas R. Hedges [États-Unis] ; Horacio Kaufmann [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Objective measures of disease progression that can be used as endpoints in clinical trials of MSA are necessary. We studied retinal thickness in patients with MSA and assessed changes over time to determine its usefulness as an imaging biomarker of disease progression.
DOI: 10.1002/mds.26360
PubMed: 26359930
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Mendoza-Santiesteban</name><affiliation wicri:level="2"><nlm:affiliation>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Palma, Jose Alberto" sort="Palma, Jose Alberto" uniqKey="Palma J" first="Jose-Alberto" last="Palma">Jose-Alberto Palma</name><affiliation wicri:level="2"><nlm:affiliation>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Martinez, Jose" sort="Martinez, Jose" uniqKey="Martinez J" first="Jose" last="Martinez">Jose Martinez</name><affiliation wicri:level="2"><nlm:affiliation>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Norcliffe Kaufmann, Lucy" sort="Norcliffe Kaufmann, Lucy" uniqKey="Norcliffe Kaufmann L" first="Lucy" last="Norcliffe-Kaufmann">Lucy Norcliffe-Kaufmann</name><affiliation wicri:level="2"><nlm:affiliation>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hedges, Thomas R" sort="Hedges, Thomas R" uniqKey="Hedges T" first="Thomas R" last="Hedges">Thomas R. Hedges</name><affiliation wicri:level="2"><nlm:affiliation>New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kaufmann, Horacio" sort="Kaufmann, Horacio" uniqKey="Kaufmann H" first="Horacio" last="Kaufmann">Horacio Kaufmann</name><affiliation wicri:level="2"><nlm:affiliation>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective measures of disease progression that can be used as endpoints in clinical trials of MSA are necessary. We studied retinal thickness in patients with MSA and assessed changes over time to determine its usefulness as an imaging biomarker of disease progression.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26359930</PMID><DateCreated><Year>2015</Year><Month>9</Month><Day>11</Day></DateCreated><DateRevised><Year>2015</Year><Month>9</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2015</Year><Month>Sep</Month><Day>11</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Progressive retinal structure abnormalities in multiple system atrophy.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><ELocationID EIdType="doi">10.1002/mds.26360</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Objective measures of disease progression that can be used as endpoints in clinical trials of MSA are necessary. We studied retinal thickness in patients with MSA and assessed changes over time to determine its usefulness as an imaging biomarker of disease progression.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This was a cross-sectional study including 24 patients with MSA, 20 with PD, and 35 controls, followed by a longitudinal study of 13 MSA patients. Patients were evaluated with high-definition optical coherence tomography and the Unified Multiple System Atrophy Rating Scale. Evaluations were performed at baseline and at consecutive follow-up visits for up to 26 months.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">MSA subjects had normal visual acuity and color discrimination. Compared to controls, retinal nerve fiber layer (P = 0.008 and P = 0.001) and ganglion cell complex (P = 0.013 and P = 0.001) thicknesses were reduced in MSA and PD. No significant differences between MSA and PD were found. Over time, in patients with MSA, there was a significant reduction of the retinal nerve fiber layer and ganglion cell complex thicknesses, with estimated annual average losses of 3.7 and 1.8 μm, respectively.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Visually asymptomatic MSA patients exhibit progressive reductions in the thickness of the retinal nerve fiber layer and, to a lesser extent, in the macular ganglion cell complex, which can be quantified by high-definition optical coherence tomography. Specific patterns of retinal nerve fiber damage could be a useful imaging biomarker of disease progression in future clinical trials. © 2015 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2015 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList><Author><LastName>Mendoza-Santiesteban</LastName><ForeName>Carlos E</ForeName><Initials>CE</Initials><AffiliationInfo><Affiliation>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Palma</LastName><ForeName>Jose-Alberto</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Martinez</LastName><ForeName>Jose</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Norcliffe-Kaufmann</LastName><ForeName>Lucy</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Hedges</LastName><ForeName>Thomas R</ForeName><Initials>TR</Initials><Suffix>3rd</Suffix><AffiliationInfo><Affiliation>New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Kaufmann</LastName><ForeName>Horacio</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><GrantList><Grant><GrantID>U54 NS065736</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>9</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson disease</Keyword><Keyword MajorTopicYN="N">ganglion cell complex</Keyword><Keyword MajorTopicYN="N">multiple system atrophy</Keyword><Keyword MajorTopicYN="N">optical coherence tomography</Keyword><Keyword MajorTopicYN="N">retinal nerve fiber layer</Keyword><Keyword MajorTopicYN="N">unified multiple system atrophy rating scale</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>2</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>7</Month><Day>6</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>7</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>9</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2017</Year><Month>3</Month><Day>11</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.26360</ArticleId><ArticleId IdType="pubmed">26359930</ArticleId><ArticleId IdType="pmc">PMC4568758</ArticleId><ArticleId IdType="mid">NIHMS708965</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Mendoza Santiesteban, Carlos E" sort="Mendoza Santiesteban, Carlos E" uniqKey="Mendoza Santiesteban C" first="Carlos E" last="Mendoza-Santiesteban">Carlos E. Mendoza-Santiesteban</name></region><name sortKey="Hedges, Thomas R" sort="Hedges, Thomas R" uniqKey="Hedges T" first="Thomas R" last="Hedges">Thomas R. Hedges</name><name sortKey="Kaufmann, Horacio" sort="Kaufmann, Horacio" uniqKey="Kaufmann H" first="Horacio" last="Kaufmann">Horacio Kaufmann</name><name sortKey="Martinez, Jose" sort="Martinez, Jose" uniqKey="Martinez J" first="Jose" last="Martinez">Jose Martinez</name><name sortKey="Norcliffe Kaufmann, Lucy" sort="Norcliffe Kaufmann, Lucy" uniqKey="Norcliffe Kaufmann L" first="Lucy" last="Norcliffe-Kaufmann">Lucy Norcliffe-Kaufmann</name><name sortKey="Palma, Jose Alberto" sort="Palma, Jose Alberto" uniqKey="Palma J" first="Jose-Alberto" last="Palma">Jose-Alberto Palma</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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