MovDisordV3, Ncbi, Merge, bibRecord, 004435

Appendectomy may delay Parkinson's disease Onset.

Identifieur interne : 004435 ( Ncbi/Merge ); précédent : 004434; suivant : 004436

Appendectomy may delay Parkinson's disease Onset.

Auteurs : Alexandre Mendes [Portugal] ; Alexandra Gonçalves [Portugal] ; Nuno Vila-Chã [Portugal] ; Inês Moreira [Portugal] ; Joana Fernandes [Portugal] ; Joana Damásio [Portugal] ; Armando Teixeira-Pinto [Portugal] ; Ricardo Taipa [Portugal] ; Ant Nio Bastos Lima [Portugal] ; Sara Cavaco [Portugal]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.

RBID : pubmed:26228745

Abstract

Alpha-synuclein (α-Syn) is particularly abundant in the vermiform appendix, which makes this structure an anatomical candidate for the initiation of Parkinson's disease (PD) pathology. We hypothesized that history of appendectomy might affect PD clinical onset.

DOI: 10.1002/mds.26311
PubMed: 26228745

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pubmed:26228745

Le document en format XML

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<author><name sortKey="Teixeira Pinto, Armando" sort="Teixeira Pinto, Armando" uniqKey="Teixeira Pinto A" first="Armando" last="Teixeira-Pinto">Armando Teixeira-Pinto</name>
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<author><name sortKey="Cavaco, Sara" sort="Cavaco, Sara" uniqKey="Cavaco S" first="Sara" last="Cavaco">Sara Cavaco</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<front><div type="abstract" xml:lang="en">Alpha-synuclein (α-Syn) is particularly abundant in the vermiform appendix, which makes this structure an anatomical candidate for the initiation of Parkinson's disease (PD) pathology. We hypothesized that history of appendectomy might affect PD clinical onset.</div>
</front>
</TEI>
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<DateCreated><Year>2015</Year>
<Month>09</Month>
<Day>03</Day>
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<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>30</Volume>
<Issue>10</Issue>
<PubDate><Year>2015</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>Appendectomy may delay Parkinson's disease Onset.</ArticleTitle>
<Pagination><MedlinePgn>1404-7</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26311</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Alpha-synuclein (α-Syn) is particularly abundant in the vermiform appendix, which makes this structure an anatomical candidate for the initiation of Parkinson's disease (PD) pathology. We hypothesized that history of appendectomy might affect PD clinical onset.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">A total of 295 PD patients enrolled in a comprehensive observational study were asked about past history of appendectomy. Cox's regression, with a time-dependent covariate, explored the effects of appendectomy on age at PD onset.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Thirty-four patients (11.5%) had appendectomy before PD onset. There was no significant effect of appendectomy on age at PD onset for the entire cohort (P = 0.153). However, among patients with late onset (≥55 years), we found evidence that those with past appendectomy had more years of life without PD symptoms than patients without appendectomy (P = 0.040). No association was found for the young-onset group (P = 0.663).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">An apparent relationship was observed between appendectomy and PD onset in the late PD cohort.</AbstractText>
<CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mendes</LastName>
<ForeName>Alexandre</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Serviço de Neurologia, Centro Hospitalar do Porto, Porto, Portugal.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Unidade Multidisciplinar de Investigação Biomedica, Instituto Ciências Biomedicas Abel Salazar, Universidade do Porto, Porto, Portugal.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Gonçalves</LastName>
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<AffiliationInfo><Affiliation>Serviço de Neurologia, Centro Hospitalar do Porto, Porto, Portugal.</Affiliation>
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<AffiliationInfo><Affiliation>Unidade Multidisciplinar de Investigação Biomedica, Instituto Ciências Biomedicas Abel Salazar, Universidade do Porto, Porto, Portugal.</Affiliation>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Unidade Multidisciplinar de Investigação Biomedica, Instituto Ciências Biomedicas Abel Salazar, Universidade do Porto, Porto, Portugal.</Affiliation>
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<Initials>A</Initials>
<AffiliationInfo><Affiliation>CINTESIS, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Screening and Test Evaluation Program, Sydney School of Public Health, University of Sydney, Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Serviço de Neuropatologia, Centro Hospitalar do Porto, Porto, Portugal.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Lima</LastName>
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<Initials>AB</Initials>
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<Author ValidYN="Y"><LastName>Cavaco</LastName>
<ForeName>Sara</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Serviço de Neurologia, Centro Hospitalar do Porto, Porto, Portugal.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Unidade Multidisciplinar de Investigação Biomedica, Instituto Ciências Biomedicas Abel Salazar, Universidade do Porto, Porto, Portugal.</Affiliation>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Appendectomy may delay Parkinson's disease Onset.

Appendectomy may delay Parkinson's disease Onset.

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