Loss of Dopamine Transporter Binding and Clinical Symptoms in Dementia With Lewy Bodies.
Identifieur interne : 004421 ( Ncbi/Merge ); précédent : 004420; suivant : 004422Loss of Dopamine Transporter Binding and Clinical Symptoms in Dementia With Lewy Bodies.
Auteurs : Françoise J. Siepel [Norvège] ; Ingvild Dalen [Norvège] ; Renate Grüner [Norvège] ; Jan Booij [Pays-Bas] ; Kolbj Rn S. Br Nnick [Norvège] ; Tirza C. Buter [Norvège] ; Dag Aarsland [Norvège]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Little is known about the underlying mechanisms of clinical symptoms in dementia with Lewy bodies. The aim of this study was to explore the association between loss of striatal dopamine transporter binding and symptoms in dementia with Lewy bodies.
DOI: 10.1002/mds.26327
PubMed: 26207978
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Siepel</name><affiliation wicri:level="1"><nlm:affiliation>Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Center for Age-Related Medicine, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Dalen, Ingvild" sort="Dalen, Ingvild" uniqKey="Dalen I" first="Ingvild" last="Dalen">Ingvild Dalen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Research, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Research, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Gruner, Renate" sort="Gruner, Renate" uniqKey="Gruner R" first="Renate" last="Grüner">Renate Grüner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Haukeland University Hospital, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Radiology, Haukeland University Hospital, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Booij, Jan" sort="Booij, Jan" uniqKey="Booij J" first="Jan" last="Booij">Jan Booij</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Nuclear Medicine, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Br Nnick, Kolbj Rn S" sort="Br Nnick, Kolbj Rn S" uniqKey="Br Nnick K" first="Kolbj Rn S" last="Br Nnick">Kolbj Rn S. Br Nnick</name><affiliation wicri:level="1"><nlm:affiliation>TIPS-Regional Center for Clinical Research in Psychosis, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>TIPS-Regional Center for Clinical Research in Psychosis, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Buter, Tirza C" sort="Buter, Tirza C" uniqKey="Buter T" first="Tirza C" last="Buter">Tirza C. Buter</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Nuclear Medicine, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><affiliation wicri:level="1"><nlm:affiliation>Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Center for Age-Related Medicine, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Little is known about the underlying mechanisms of clinical symptoms in dementia with Lewy bodies. The aim of this study was to explore the association between loss of striatal dopamine transporter binding and symptoms in dementia with Lewy bodies.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26207978</PMID><DateCreated><Year>2015</Year><Month>7</Month><Day>24</Day></DateCreated><DateRevised><Year>2015</Year><Month>7</Month><Day>26</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2015</Year><Month>Jul</Month><Day>24</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Loss of Dopamine Transporter Binding and Clinical Symptoms in Dementia With Lewy Bodies.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><ELocationID EIdType="doi">10.1002/mds.26327</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Little is known about the underlying mechanisms of clinical symptoms in dementia with Lewy bodies. The aim of this study was to explore the association between loss of striatal dopamine transporter binding and symptoms in dementia with Lewy bodies.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Thirty-five patients with dementia with Lewy bodies underwent single-photon emission computerized tomography brain imaging with N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane ([(123) I]FP-CIT). Associations between striatal binding ratios and motor (UPDRS), psychiatric (Neuropsychiatric Inventory; [NPI]), and cognitive (Mini-Mental State Examination [MMSE] and neuropsychological tests) symptoms were assessed by linear regression analysis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The explorative analysis showed that the motor UPDRS was negatively associated with putamen dopamine transporter binding, whereas no association with striatal dopamine transporter binding was found for total NPI, hallucinations, apathy, depression, anxiety, and MMSE scores. However, in post-hoc analysis, executive impairment was positively associated with dopamine transporter loss after adjustment of age and gender.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Dopamine deficiency in patients with dementia with Lewy bodies was associated with severity of motor symptoms, but did not correlate significantly with ratings of neurobehavioral disturbances or overall cognition. © 2015 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList><Author><LastName>Siepel</LastName><ForeName>Françoise J</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.</Affiliation></AffiliationInfo></Author><Author><LastName>Dalen</LastName><ForeName>Ingvild</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Research, Stavanger University Hospital, Stavanger, Norway.</Affiliation></AffiliationInfo></Author><Author><LastName>Grüner</LastName><ForeName>Renate</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Radiology, Haukeland University Hospital, Bergen, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Physics and Technology, University of Bergen, Bergen, Norway.</Affiliation></AffiliationInfo></Author><Author><LastName>Booij</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author><LastName>Brønnick</LastName><ForeName>Kolbjørn S</ForeName><Initials>KS</Initials><AffiliationInfo><Affiliation>TIPS-Regional Center for Clinical Research in Psychosis, Stavanger University Hospital, Stavanger, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Social Sciences, University of Stavanger, Stavanger, Norway.</Affiliation></AffiliationInfo></Author><Author><LastName>Buter</LastName><ForeName>Tirza C</ForeName><Initials>TC</Initials><AffiliationInfo><Affiliation>Department of Nuclear Medicine, Stavanger University Hospital, Stavanger, Norway.</Affiliation></AffiliationInfo></Author><Author><LastName>Aarsland</LastName><ForeName>Dag</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurobiology, Care Sciences and Society (NVS), Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institute, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>7</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Lewy body</Keyword><Keyword MajorTopicYN="N">SPECT</Keyword><Keyword MajorTopicYN="N">[123I]FP-CIT</Keyword><Keyword MajorTopicYN="N">dementia</Keyword><Keyword MajorTopicYN="N">dopamine transporter</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>12</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>6</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>6</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>7</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>7</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>7</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.26327</ArticleId><ArticleId IdType="pubmed">26207978</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Norvège</li><li>Pays-Bas</li></country><region><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li></settlement></list><tree><country name="Norvège"><noRegion><name sortKey="Siepel, Francoise J" sort="Siepel, Francoise J" uniqKey="Siepel F" first="Françoise J" last="Siepel">Françoise J. Siepel</name></noRegion><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><name sortKey="Br Nnick, Kolbj Rn S" sort="Br Nnick, Kolbj Rn S" uniqKey="Br Nnick K" first="Kolbj Rn S" last="Br Nnick">Kolbj Rn S. Br Nnick</name><name sortKey="Buter, Tirza C" sort="Buter, Tirza C" uniqKey="Buter T" first="Tirza C" last="Buter">Tirza C. Buter</name><name sortKey="Dalen, Ingvild" sort="Dalen, Ingvild" uniqKey="Dalen I" first="Ingvild" last="Dalen">Ingvild Dalen</name><name sortKey="Gruner, Renate" sort="Gruner, Renate" uniqKey="Gruner R" first="Renate" last="Grüner">Renate Grüner</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Booij, Jan" sort="Booij, Jan" uniqKey="Booij J" first="Jan" last="Booij">Jan Booij</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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