L-dopa increases α-synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro.
Identifieur interne : 004396 ( Ncbi/Merge ); précédent : 004395; suivant : 004397L-dopa increases α-synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro.
Auteurs : Ina Schmitt [Allemagne] ; Oliver Kaut [Allemagne] ; Hassan Khazneh [Allemagne] ; Laura Deboni [Allemagne] ; Ashar Ahmad [Allemagne] ; Daniela Berg [Allemagne] ; Christine Klein [Allemagne] ; Holger Fröhlich [Allemagne] ; Ullrich Wüllner [Allemagne]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Increasing gene dosages of α-synuclein induce familial Parkinson's disease (PD); thus, the hypothesis has been put forward that regulation of gene expression, in particular altered α-synuclein gene methylation, might be associated with sporadic PD and could be used as a biological marker.
DOI: 10.1002/mds.26319
PubMed: 26173746
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<front><div type="abstract" xml:lang="en">Increasing gene dosages of α-synuclein induce familial Parkinson's disease (PD); thus, the hypothesis has been put forward that regulation of gene expression, in particular altered α-synuclein gene methylation, might be associated with sporadic PD and could be used as a biological marker.</div>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Increasing gene dosages of α-synuclein induce familial Parkinson's disease (PD); thus, the hypothesis has been put forward that regulation of gene expression, in particular altered α-synuclein gene methylation, might be associated with sporadic PD and could be used as a biological marker.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We performed a thorough analysis of α-synuclein methylation in bisulfite-treated DNA from peripheral blood of 490 sporadic PD patients and 485 healthy controls and in addition analyzed the effect of levodopa (l-dopa) on α-synuclein methylation and expression in cultured mononuclear cells.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">α-Synuclein was hypomethylated in sporadic PD patients, correlated with sex, age, and a polymorphism in the analyzed sequence stretch (rs3756063). α-Synuclein methylation separated healthy individuals from sporadic PD with a specificity of 74% (male) and 78% (female), respectively. α-Synuclein methylation was increased in sporadic PD patients with higher l-dopa dosage, and l-dopa specifically induced methylation of α-synuclein intron 1 in cultured mononuclear cells.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">α-Synuclein methylation levels depended on disease status, sex, age, and the genotype of rs3756063. The pharmacological action of l-dopa was not limited to the dopamine precursor function but included epigenetic off-target effects. The hypomethylation of α-synuclein in sporadic PD patients' blood already observed in previous studies was probably underestimated because of effect of l-dopa, which was not known previously. The analysis of α-synuclein methylation can help to identify nonparkinsonian individuals with reasonable specificity, which offers a valuable tool for researchers and clinicians. © 2015 International Parkinson and Movement Disorder Society.</AbstractText>
<CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList><Author><LastName>Schmitt</LastName>
<ForeName>Ina</ForeName>
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<AffiliationInfo><Affiliation>Department of Neurology, UKB, Bonn, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Neurology, UKB, Bonn, Germany.</Affiliation>
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<Author><LastName>Khazneh</LastName>
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</AffiliationInfo>
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<Author><LastName>deBoni</LastName>
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<Author><LastName>Ahmad</LastName>
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<Initials>D</Initials>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Tübingen, Germany.</Affiliation>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">DNA methylation</Keyword>
<Keyword MajorTopicYN="N">Parkinson's disease</Keyword>
<Keyword MajorTopicYN="N">blood</Keyword>
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