Disclosure of research results in genetic studies of Parkinson's disease caused by LRRK2 mutations.
Identifieur interne : 004344 ( Ncbi/Merge ); précédent : 004343; suivant : 004345Disclosure of research results in genetic studies of Parkinson's disease caused by LRRK2 mutations.
Auteurs : Claustre Pont-Sunyer [Espagne] ; Susan Bressman [États-Unis] ; Deborah Raymond [États-Unis] ; Amanda Glickman [États-Unis] ; Eduardo Tolosa [Espagne] ; Rachel Saunders-Pullman [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
With the advent of large genetic studies examining both symptomatic and asymptomatic individuals, whether and how to disclose genetic research results have become pressing questions. The need is particularly acute in the case of LRRK2 research: Movement centers worldwide are recruiting cohorts of individuals with Parkinson's disease (PD) and their family members, including asymptomatic carriers. Clinical features and treatment are complex and evolving, and disclosure policies vary at different sites and have been modified during the course of some studies. We present the major ethical principles of autonomy, beneficence, nonmaleficence, and honesty that should guide disclosure policies in studies of families with LRRK2 mutations. We make recommendations regarding genetic counseling, policies of either active or passive disclosure, responsibilities of funders to budget for genetic counseling, clinical genetic testing where locally required for disclosure, and aspects of study design to avoid mandatory disclosure whenever feasible. © 2015 International Parkinson and Movement Disorder Society.
DOI: 10.1002/mds.26250
PubMed: 25952684
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sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Raymond, Deborah" sort="Raymond, Deborah" uniqKey="Raymond D" first="Deborah" last="Raymond">Deborah Raymond</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New 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The need is particularly acute in the case of LRRK2 research: Movement centers worldwide are recruiting cohorts of individuals with Parkinson's disease (PD) and their family members, including asymptomatic carriers. Clinical features and treatment are complex and evolving, and disclosure policies vary at different sites and have been modified during the course of some studies. We present the major ethical principles of autonomy, beneficence, nonmaleficence, and honesty that should guide disclosure policies in studies of families with LRRK2 mutations. We make recommendations regarding genetic counseling, policies of either active or passive disclosure, responsibilities of funders to budget for genetic counseling, clinical genetic testing where locally required for disclosure, and aspects of study design to avoid mandatory disclosure whenever feasible. © 2015 International Parkinson and Movement Disorder Society.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">25952684</PMID><DateCreated><Year>2015</Year><Month>06</Month><Day>23</Day></DateCreated><DateRevised><Year>2015</Year><Month>06</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>7</Issue><PubDate><Year>2015</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Disclosure of research results in genetic studies of Parkinson's disease caused by LRRK2 mutations.</ArticleTitle><Pagination><MedlinePgn>904-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26250</ELocationID><Abstract><AbstractText>With the advent of large genetic studies examining both symptomatic and asymptomatic individuals, whether and how to disclose genetic research results have become pressing questions. The need is particularly acute in the case of LRRK2 research: Movement centers worldwide are recruiting cohorts of individuals with Parkinson's disease (PD) and their family members, including asymptomatic carriers. Clinical features and treatment are complex and evolving, and disclosure policies vary at different sites and have been modified during the course of some studies. We present the major ethical principles of autonomy, beneficence, nonmaleficence, and honesty that should guide disclosure policies in studies of families with LRRK2 mutations. We make recommendations regarding genetic counseling, policies of either active or passive disclosure, responsibilities of funders to budget for genetic counseling, clinical genetic testing where locally required for disclosure, and aspects of study design to avoid mandatory disclosure whenever feasible. © 2015 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pont-Sunyer</LastName><ForeName>Claustre</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Parkinson Disease and Movement Disorders Unit, Neurology Service, IDIBAPS, CIBERNED, Universitat de Barcelona, Hospital Clínic, Barcelona, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bressman</LastName><ForeName>Susan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, NY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, Icahn School of Medicine, Mount Sinai Medical Center, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raymond</LastName><ForeName>Deborah</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Glickman</LastName><ForeName>Amanda</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tolosa</LastName><ForeName>Eduardo</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Parkinson Disease and Movement Disorders Unit, Neurology Service, IDIBAPS, CIBERNED, Universitat de Barcelona, Hospital Clínic, Barcelona, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saunders-Pullman</LastName><ForeName>Rachel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, NY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, Icahn School of Medicine, Mount Sinai Medical Center, New York, NY, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>K02 NS073836</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>NS073836</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., 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Fall;10(3):221-7</RefSource><PMID Version="1">17020475</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2006 Oct 24;67(8):1518-9</RefSource><PMID Version="1">17060595</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2006 Nov 28;67(10):1786-91</RefSource><PMID Version="1">17050822</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Health Psychol. 2008 Jan;27(1):100-9</RefSource><PMID Version="1">18230020</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2008 Feb 12;70(7):521-7</RefSource><PMID Version="1">17914064</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2008 Jul;7(7):583-90</RefSource><PMID Version="1">18539534</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Neurol. 2009 Aug;16(8):957-60</RefSource><PMID Version="1">19473361</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2009 Oct 22;361(17):1651-61</RefSource><PMID Version="1">19846850</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2010 Sep 21;75(12):1118-9</RefSource><PMID Version="1">20855856</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Genet. 2011 Feb;27(2):41-7</RefSource><PMID Version="1">21190750</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurologia. 2011 Apr;26(3):143-9</RefSource><PMID Version="1">21163230</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2011 Aug;17(7):501-8</RefSource><PMID Version="1">21641266</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2011 Sep;26(11):2144-5</RefSource><PMID Version="1">21714003</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Sci. 2011 Nov 15;310(1-2):17-20</RefSource><PMID Version="1">21704337</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2011 Aug 15;26(10):1875-80</RefSource><PMID Version="1">21611978</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Semin Neurol. 2011 Nov;31(5):431-2</RefSource><PMID Version="1">22266880</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Semin Neurol. 2011 Nov;31(5):542-52</RefSource><PMID Version="1">22266891</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Drug Discov. 2012 Sep;11(9):657-60</RefSource><PMID Version="1">22935790</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2013 Jan;19(1):129-31</RefSource><PMID Version="1">22940477</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2013 Nov 10;31(32):4165-6</RefSource><PMID Version="1">24101049</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2014 May;35(5):1125-31</RefSource><PMID Version="1">24355527</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Med. 2014 Aug;16(8):644-5</RefSource><PMID Version="1">25093570</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Genet Couns. 2015 Apr;24(2):238-46</RefSource><PMID Version="1">25127731</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Public Health. 1989 Nov;79(11):1544-8</RefSource><PMID Version="1">2817169</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuron. 2004 Nov 18;44(4):595-600</RefSource><PMID Version="1">15541308</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2005 Nov;58(5):784-7</RefSource><PMID Version="1">16240353</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Adv Neurol. 2005;96:226-39</RefSource><PMID Version="1">16383222</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2006 Jan 26;354(4):424-5</RefSource><PMID Version="1">16436782</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2006 Mar;63(3):377-82</RefSource><PMID Version="1">16533964</PMID></CommentsCorrections></CommentsCorrectionsList><OtherID Source="NLM">NIHMS680065 [Available on 06/01/16]</OtherID><OtherID Source="NLM">PMC4478096 [Available on 06/01/16]</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">LRRK2 mutation</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">clinical research</Keyword><Keyword MajorTopicYN="N">disclosure</Keyword><Keyword MajorTopicYN="N">ethics</Keyword><Keyword MajorTopicYN="N">genetic 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