MovDisordV3, Ncbi, Merge, bibRecord, 004291

Automated neuromelanin imaging as a diagnostic biomarker for Parkinson's disease.

Identifieur interne : 004291 ( Ncbi/Merge ); précédent : 004290; suivant : 004292

Automated neuromelanin imaging as a diagnostic biomarker for Parkinson's disease.

Auteurs : Gabriel Castellanos [Espagne] ; María A. Fernández-Seara [Espagne] ; Oswaldo Lorenzo-Betancor [Espagne] ; Sara Ortega-Cubero [Espagne] ; Marc Puigvert [Espagne] ; Javier Uranga [Espagne] ; Marta Vidorreta [Espagne] ; Jaione Irigoyen [Espagne] ; Elena Lorenzo [Espagne] ; Arrate Mu Oz-Barrutia [Espagne] ; Carlos Ortiz-De-Solorzano [Espagne] ; Pau Pastor [Espagne] ; María A. Pastor [Espagne]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.

RBID : pubmed:25772492

Abstract

We aimed to analyze the diagnostic accuracy of an automated segmentation and quantification method of the SNc and locus coeruleus (LC) volumes based on neuromelanin (NM)-sensitive MRI (NM-MRI) in patients with idiopathic (iPD) and monogenic (iPD) Parkinson's disease (PD).

DOI: 10.1002/mds.26201
PubMed: 25772492

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<author><name sortKey="Mu Oz Barrutia, Arrate" sort="Mu Oz Barrutia, Arrate" uniqKey="Mu Oz Barrutia A" first="Arrate" last="Mu Oz-Barrutia">Arrate Mu Oz-Barrutia</name>
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<author><name sortKey="Ortiz De Solorzano, Carlos" sort="Ortiz De Solorzano, Carlos" uniqKey="Ortiz De Solorzano C" first="Carlos" last="Ortiz-De-Solorzano">Carlos Ortiz-De-Solorzano</name>
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<author><name sortKey="Irigoyen, Jaione" sort="Irigoyen, Jaione" uniqKey="Irigoyen J" first="Jaione" last="Irigoyen">Jaione Irigoyen</name>
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<author><name sortKey="Mu Oz Barrutia, Arrate" sort="Mu Oz Barrutia, Arrate" uniqKey="Mu Oz Barrutia A" first="Arrate" last="Mu Oz-Barrutia">Arrate Mu Oz-Barrutia</name>
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<author><name sortKey="Ortiz De Solorzano, Carlos" sort="Ortiz De Solorzano, Carlos" uniqKey="Ortiz De Solorzano C" first="Carlos" last="Ortiz-De-Solorzano">Carlos Ortiz-De-Solorzano</name>
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<author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
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<author><name sortKey="Pastor, Maria A" sort="Pastor, Maria A" uniqKey="Pastor M" first="María A" last="Pastor">María A. Pastor</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<front><div type="abstract" xml:lang="en">We aimed to analyze the diagnostic accuracy of an automated segmentation and quantification method of the SNc and locus coeruleus (LC) volumes based on neuromelanin (NM)-sensitive MRI (NM-MRI) in patients with idiopathic (iPD) and monogenic (iPD) Parkinson's disease (PD).</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">25772492</PMID>
<DateCreated><Year>2015</Year>
<Month>06</Month>
<Day>23</Day>
</DateCreated>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>30</Volume>
<Issue>7</Issue>
<PubDate><Year>2015</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Automated neuromelanin imaging as a diagnostic biomarker for Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>945-52</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26201</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">We aimed to analyze the diagnostic accuracy of an automated segmentation and quantification method of the SNc and locus coeruleus (LC) volumes based on neuromelanin (NM)-sensitive MRI (NM-MRI) in patients with idiopathic (iPD) and monogenic (iPD) Parkinson's disease (PD).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Thirty-six patients (23 idiopathic and 13 monogenic PARKIN or LRRK2 mutations) and 37 age-matched healthy controls underwent 3T-NM-MRI. SNc and LC volumetry were performed using fully automated multi-image atlas segmentation. The diagnostic performance to differentiate PD from controls was measured using the area under the curve (AUC) and likelihood ratios based on receiver operating characteristic (ROC) analyses.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">We found a significant reduction of SNc and LC volumes in patients, when compared to controls. ROC analysis showed better diagnostic accuracy when using SNc volume than LC volume. Significant differences between ipsilateral and contralateral SNc volumes, in relation to the more clinically affected side, were found in patients with iPD (P = 0.007). Contralateral atrophy in the SNc showed the highest power to discriminate PD subjects from controls (AUC, 0.93-0.94; sensitivity, 91%-92%; specificity, 89%; positive likelihood ratio: 8.4-8.5; negative likelihood ratio: 0.09-0.1 at a single cut-off point). Interval likelihood ratios for contralateral SNc volume improved the diagnostic accuracy of volumetric measurements.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">SNc and LC volumetry based on NM-MRI resulting from the automated segmentation and quantification technique can yield high diagnostic accuracy for differentiating PD from health and might be an unbiased disease biomarker. © 2015 International Parkinson and Movement Disorder Society.</AbstractText>
<CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Castellanos</LastName>
<ForeName>Gabriel</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Neuroimaging Laboratory, University of Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fernández-Seara</LastName>
<ForeName>María A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Neuroimaging Laboratory, University of Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lorenzo-Betancor</LastName>
<ForeName>Oswaldo</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Neurogenetics Laboratory, University of Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ortega-Cubero</LastName>
<ForeName>Sara</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Neurogenetics Laboratory, University of Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Puigvert</LastName>
<ForeName>Marc</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Pulmonary Department, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Uranga</LastName>
<ForeName>Javier</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Cancer Imaging Laboratory, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vidorreta</LastName>
<ForeName>Marta</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Neuroimaging Laboratory, University of Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Irigoyen</LastName>
<ForeName>Jaione</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Neuroimaging Laboratory, University of Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Neurogenetics Laboratory, University of Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lorenzo</LastName>
<ForeName>Elena</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Neurogenetics Laboratory, University of Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Muñoz-Barrutia</LastName>
<ForeName>Arrate</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Cancer Imaging Laboratory, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Bioengineering and Aerospace Engineering Department, University Carlos III of Madrid and Gregorio Marañon Health Research Institute, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ortiz-de-Solorzano</LastName>
<ForeName>Carlos</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Cancer Imaging Laboratory, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pastor</LastName>
<ForeName>Pau</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Neurogenetics Laboratory, University of Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Hospital Universitari Mutua de Terrassa, University of Barcelona, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pastor</LastName>
<ForeName>María A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Neuroimaging Laboratory, University of Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>03</Month>
<Day>15</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's</Keyword>
<Keyword MajorTopicYN="N">diagnosis</Keyword>
<Keyword MajorTopicYN="N">magnetic resonance imaging</Keyword>
<Keyword MajorTopicYN="N">neuromelanin</Keyword>
<Keyword MajorTopicYN="N">substantia nigra</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
<Month>10</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2015</Year>
<Month>1</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>2</Month>
<Day>9</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year>
<Month>3</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>3</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>3</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2015</Year>
<Month>3</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">25772492</ArticleId>
<ArticleId IdType="doi">10.1002/mds.26201</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Espagne</li>
</country>
</list>
<tree><country name="Espagne"><noRegion><name sortKey="Castellanos, Gabriel" sort="Castellanos, Gabriel" uniqKey="Castellanos G" first="Gabriel" last="Castellanos">Gabriel Castellanos</name>
</noRegion>
<name sortKey="Fernandez Seara, Maria A" sort="Fernandez Seara, Maria A" uniqKey="Fernandez Seara M" first="María A" last="Fernández-Seara">María A. Fernández-Seara</name>
<name sortKey="Irigoyen, Jaione" sort="Irigoyen, Jaione" uniqKey="Irigoyen J" first="Jaione" last="Irigoyen">Jaione Irigoyen</name>
<name sortKey="Lorenzo Betancor, Oswaldo" sort="Lorenzo Betancor, Oswaldo" uniqKey="Lorenzo Betancor O" first="Oswaldo" last="Lorenzo-Betancor">Oswaldo Lorenzo-Betancor</name>
<name sortKey="Lorenzo, Elena" sort="Lorenzo, Elena" uniqKey="Lorenzo E" first="Elena" last="Lorenzo">Elena Lorenzo</name>
<name sortKey="Mu Oz Barrutia, Arrate" sort="Mu Oz Barrutia, Arrate" uniqKey="Mu Oz Barrutia A" first="Arrate" last="Mu Oz-Barrutia">Arrate Mu Oz-Barrutia</name>
<name sortKey="Ortega Cubero, Sara" sort="Ortega Cubero, Sara" uniqKey="Ortega Cubero S" first="Sara" last="Ortega-Cubero">Sara Ortega-Cubero</name>
<name sortKey="Ortiz De Solorzano, Carlos" sort="Ortiz De Solorzano, Carlos" uniqKey="Ortiz De Solorzano C" first="Carlos" last="Ortiz-De-Solorzano">Carlos Ortiz-De-Solorzano</name>
<name sortKey="Pastor, Maria A" sort="Pastor, Maria A" uniqKey="Pastor M" first="María A" last="Pastor">María A. Pastor</name>
<name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
<name sortKey="Puigvert, Marc" sort="Puigvert, Marc" uniqKey="Puigvert M" first="Marc" last="Puigvert">Marc Puigvert</name>
<name sortKey="Uranga, Javier" sort="Uranga, Javier" uniqKey="Uranga J" first="Javier" last="Uranga">Javier Uranga</name>
<name sortKey="Vidorreta, Marta" sort="Vidorreta, Marta" uniqKey="Vidorreta M" first="Marta" last="Vidorreta">Marta Vidorreta</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Automated neuromelanin imaging as a diagnostic biomarker for Parkinson's disease.

Automated neuromelanin imaging as a diagnostic biomarker for Parkinson's disease.

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