MovDisordV3, Ncbi, Merge, bibRecord, 004203

Effects of rasagiline on the progression of nonmotor scores of the MDS-UPDRS.

Identifieur interne : 004203 ( Ncbi/Merge ); précédent : 004202; suivant : 004204

Effects of rasagiline on the progression of nonmotor scores of the MDS-UPDRS.

Auteurs : Werner Poewe [Autriche] ; Robert A. Hauser ; Anthony Lang

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.

RBID : pubmed:25545629

Abstract

A draft version of part 1 (Non-Motor Aspects of Experiences of Daily Living; nM-EDL) of the MDS-UPDRS scale was employed as a secondary outcome in the ADAGIO study, which assessed the effect of rasagiline in early Parkinson's disease (PD) patients.

DOI: 10.1002/mds.26124
PubMed: 25545629

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Le document en format XML

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<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.</nlm:affiliation>
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<wicri:regionArea>Department of Neurology, Innsbruck Medical University, Innsbruck</wicri:regionArea>
<wicri:noRegion>Innsbruck</wicri:noRegion>
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<region nuts="2" type="region">Tyrol (Land)</region>
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<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A" last="Hauser">Robert A. Hauser</name>
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<author><name sortKey="Lang, Anthony" sort="Lang, Anthony" uniqKey="Lang A" first="Anthony" last="Lang">Anthony Lang</name>
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<author><name sortKey="Lang, Anthony" sort="Lang, Anthony" uniqKey="Lang A" first="Anthony" last="Lang">Anthony Lang</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<front><div type="abstract" xml:lang="en">A draft version of part 1 (Non-Motor Aspects of Experiences of Daily Living; nM-EDL) of the MDS-UPDRS scale was employed as a secondary outcome in the ADAGIO study, which assessed the effect of rasagiline in early Parkinson's disease (PD) patients.</div>
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<DateCreated><Year>2015</Year>
<Month>04</Month>
<Day>07</Day>
</DateCreated>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>30</Volume>
<Issue>4</Issue>
<PubDate><Year>2015</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>Effects of rasagiline on the progression of nonmotor scores of the MDS-UPDRS.</ArticleTitle>
<Pagination><MedlinePgn>589-92</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26124</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">A draft version of part 1 (Non-Motor Aspects of Experiences of Daily Living; nM-EDL) of the MDS-UPDRS scale was employed as a secondary outcome in the ADAGIO study, which assessed the effect of rasagiline in early Parkinson's disease (PD) patients.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">This analysis includes 1,150 untreated PD patients randomized to placebo or rasagiline 1 or 2 mg/day for 36 weeks in the placebo-controlled phase of ADAGIO who had draft-nM-EDL assessments at baseline and week 36.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Over the 9-month placebo-controlled phase of the study, nM-EDL scores significantly deteriorated from baseline in the placebo group only (0.34 ± 0.10 units; P < 0.001). Compared to the placebo group (n = 583), there was significantly less deterioration in the 1-mg/day rasagiline group (n = 280; treatment effect: -0.33 units; P < 0.05), whereas the treatment effect in the 2-mg/day rasagiline group (n = 287) was not statistically significant (-0.25 ± 0.17 units; P = 0.131).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The nM-EDL subscale appears sensitive to change in very early PD, and treatment with rasagiline 1 mg/day was associated with significantly less decline in nonmotor experiences of daily living versus placebo. Given that score changes were numerically small, the clinical implications of this effect remain unclear.</AbstractText>
<CopyrightInformation>© 2014 International Parkinson and Movement Disorder Society.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Poewe</LastName>
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<Author ValidYN="Y"><LastName>Lang</LastName>
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<Language>eng</Language>
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<Month>12</Month>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword>
<Keyword MajorTopicYN="N">nonmotor symptoms</Keyword>
<Keyword MajorTopicYN="N">rasagiline</Keyword>
<Keyword MajorTopicYN="N">treatment</Keyword>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Effects of rasagiline on the progression of nonmotor scores of the MDS-UPDRS.

Effects of rasagiline on the progression of nonmotor scores of the MDS-UPDRS.

Source :

Abstract

Links toward previous steps (curation, corpus...)

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Le document en format XML

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Pour générer des pages wiki