What’s special about task in dystonia? A voxel-based morphometry and diffusion weighted imaging study
Identifieur interne : 004025 ( Ncbi/Merge ); précédent : 004024; suivant : 004026What’s special about task in dystonia? A voxel-based morphometry and diffusion weighted imaging study
Auteurs : Ritesh A. Ramdhani [États-Unis] ; Veena Kumar [États-Unis] ; Miodrag Velickovic [États-Unis] ; Steven J. Frucht [États-Unis] ; Michele Tagliati [États-Unis] ; Kristina Simonyan [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Blepharospasm, Dystonic Disorders, Torticollis.
- pathology : Brain.
- Adult, Aged, Analysis of Variance, Brain Mapping, Diffusion Magnetic Resonance Imaging, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Young Adult.
Abstract
Numerous brain imaging studies have demonstrated structural changes in the basal ganglia, thalamus, sensorimotor cortex and cerebellum across different forms of primary dystonia. However, our understanding of brain abnormalities contributing to the clinically well-described phenomenon of task-specificity in dystonia remained limited.
We used high-resolution MRI with voxel-based morphometry and diffusion tensor imaging with tract-based spatial statistics of fractional anisotropy to examine gray and white matter organization in two task-specific dystonia forms, writer’s cramp and laryngeal dystonia, and two non-task-specific dystonia forms, cervical dystonia and blepharospasm.
A direct comparison between the both dystonia forms revealed that characteristic gray matter volumetric changes in task-specific dystonia involve the brain regions responsible for sensorimotor control during writing and speaking, such as primary somatosensory cortex, middle frontal gyrus, superior/inferior temporal gyrus, middle/posterior cingulate cortex, occipital cortex as well as the striatum and cerebellum (lobules VI-VIIa). These gray matter changes were accompanied by white matter abnormalities in the premotor cortex, middle/inferior frontal gyrus, genu of the corpus callosum, anterior limb/genu of the internal capsule, and putamen. Conversely, gray matter volumetric changes in non-task-specific group were limited to the left cerebellum (lobule VIIa) only, while white matter alterations were found to underlie the primary sensorimotor cortex, inferior parietal lobule and middle cingulate gyrus.
Distinct microstructural patterns in task-specific and non-task-specific dystonias may represent neuroimaging markers and provide evidence that these two dystonia subclasses likely follow divergent pathophysiological mechanisms precipitated by different triggers.
Url:
DOI: 10.1002/mds.25934
PubMed: 24925463
PubMed Central: 4139455
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<term>Blepharospasm (diagnosis)</term>
<term>Brain (pathology)</term>
<term>Brain Mapping</term>
<term>Diffusion Magnetic Resonance Imaging</term>
<term>Dystonic Disorders (diagnosis)</term>
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<term>Middle Aged</term>
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<term>Young Adult</term>
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<term>Aged</term>
<term>Analysis of Variance</term>
<term>Brain Mapping</term>
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<term>Female</term>
<term>Functional Laterality</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Numerous brain imaging studies have demonstrated structural changes in the basal ganglia, thalamus, sensorimotor cortex and cerebellum across different forms of primary dystonia. However, our understanding of brain abnormalities contributing to the clinically well-described phenomenon of task-specificity in dystonia remained limited.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We used high-resolution MRI with voxel-based morphometry and diffusion tensor imaging with tract-based spatial statistics of fractional anisotropy to examine gray and white matter organization in two task-specific dystonia forms, writer’s cramp and laryngeal dystonia, and two non-task-specific dystonia forms, cervical dystonia and blepharospasm.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">A direct comparison between the both dystonia forms revealed that characteristic gray matter volumetric changes in task-specific dystonia involve the brain regions responsible for sensorimotor control during writing and speaking, such as primary somatosensory cortex, middle frontal gyrus, superior/inferior temporal gyrus, middle/posterior cingulate cortex, occipital cortex as well as the striatum and cerebellum (lobules VI-VIIa). These gray matter changes were accompanied by white matter abnormalities in the premotor cortex, middle/inferior frontal gyrus, genu of the corpus callosum, anterior limb/genu of the internal capsule, and putamen. Conversely, gray matter volumetric changes in non-task-specific group were limited to the left cerebellum (lobule VIIa) only, while white matter alterations were found to underlie the primary sensorimotor cortex, inferior parietal lobule and middle cingulate gyrus.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Distinct microstructural patterns in task-specific and non-task-specific dystonias may represent neuroimaging markers and provide evidence that these two dystonia subclasses likely follow divergent pathophysiological mechanisms precipitated by different triggers.</p>
</sec>
</div>
</front>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Numerous brain imaging studies have demonstrated structural changes in the basal ganglia, thalamus, sensorimotor cortex and cerebellum across different forms of primary dystonia. However, our understanding of brain abnormalities contributing to the clinically well-described phenomenon of task-specificity in dystonia remained limited.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We used high-resolution MRI with voxel-based morphometry and diffusion tensor imaging with tract-based spatial statistics of fractional anisotropy to examine gray and white matter organization in two task-specific dystonia forms, writer’s cramp and laryngeal dystonia, and two non-task-specific dystonia forms, cervical dystonia and blepharospasm.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">A direct comparison between the both dystonia forms revealed that characteristic gray matter volumetric changes in task-specific dystonia involve the brain regions responsible for sensorimotor control during writing and speaking, such as primary somatosensory cortex, middle frontal gyrus, superior/inferior temporal gyrus, middle/posterior cingulate cortex, occipital cortex as well as the striatum and cerebellum (lobules VI-VIIa). These gray matter changes were accompanied by white matter abnormalities in the premotor cortex, middle/inferior frontal gyrus, genu of the corpus callosum, anterior limb/genu of the internal capsule, and putamen. Conversely, gray matter volumetric changes in non-task-specific group were limited to the left cerebellum (lobule VIIa) only, while white matter alterations were found to underlie the primary sensorimotor cortex, inferior parietal lobule and middle cingulate gyrus.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Distinct microstructural patterns in task-specific and non-task-specific dystonias may represent neuroimaging markers and provide evidence that these two dystonia subclasses likely follow divergent pathophysiological mechanisms precipitated by different triggers.</p>
</sec>
</div>
</front>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">What's special about task in dystonia? A voxel-based morphometry and diffusion weighted imaging study.</title>
<author><name sortKey="Ramdhani, Ritesh A" sort="Ramdhani, Ritesh A" uniqKey="Ramdhani R" first="Ritesh A" last="Ramdhani">Ritesh A. Ramdhani</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kumar, Veena" sort="Kumar, Veena" uniqKey="Kumar V" first="Veena" last="Kumar">Veena Kumar</name>
</author>
<author><name sortKey="Velickovic, Miodrag" sort="Velickovic, Miodrag" uniqKey="Velickovic M" first="Miodrag" last="Velickovic">Miodrag Velickovic</name>
</author>
<author><name sortKey="Frucht, Steven J" sort="Frucht, Steven J" uniqKey="Frucht S" first="Steven J" last="Frucht">Steven J. Frucht</name>
</author>
<author><name sortKey="Tagliati, Michele" sort="Tagliati, Michele" uniqKey="Tagliati M" first="Michele" last="Tagliati">Michele Tagliati</name>
</author>
<author><name sortKey="Simonyan, Kristina" sort="Simonyan, Kristina" uniqKey="Simonyan K" first="Kristina" last="Simonyan">Kristina Simonyan</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24925463</idno>
<idno type="pmid">24925463</idno>
<idno type="doi">10.1002/mds.25934</idno>
<idno type="wicri:Area/PubMed/Corpus">000474</idno>
<idno type="wicri:Area/PubMed/Curation">000474</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000359</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">What's special about task in dystonia? A voxel-based morphometry and diffusion weighted imaging study.</title>
<author><name sortKey="Ramdhani, Ritesh A" sort="Ramdhani, Ritesh A" uniqKey="Ramdhani R" first="Ritesh A" last="Ramdhani">Ritesh A. Ramdhani</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kumar, Veena" sort="Kumar, Veena" uniqKey="Kumar V" first="Veena" last="Kumar">Veena Kumar</name>
</author>
<author><name sortKey="Velickovic, Miodrag" sort="Velickovic, Miodrag" uniqKey="Velickovic M" first="Miodrag" last="Velickovic">Miodrag Velickovic</name>
</author>
<author><name sortKey="Frucht, Steven J" sort="Frucht, Steven J" uniqKey="Frucht S" first="Steven J" last="Frucht">Steven J. Frucht</name>
</author>
<author><name sortKey="Tagliati, Michele" sort="Tagliati, Michele" uniqKey="Tagliati M" first="Michele" last="Tagliati">Michele Tagliati</name>
</author>
<author><name sortKey="Simonyan, Kristina" sort="Simonyan, Kristina" uniqKey="Simonyan K" first="Kristina" last="Simonyan">Kristina Simonyan</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Analysis of Variance</term>
<term>Blepharospasm (diagnosis)</term>
<term>Brain (pathology)</term>
<term>Brain Mapping</term>
<term>Diffusion Magnetic Resonance Imaging</term>
<term>Dystonic Disorders (diagnosis)</term>
<term>Female</term>
<term>Functional Laterality</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Torticollis (diagnosis)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Blepharospasm</term>
<term>Dystonic Disorders</term>
<term>Torticollis</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Analysis of Variance</term>
<term>Brain Mapping</term>
<term>Diffusion Magnetic Resonance Imaging</term>
<term>Female</term>
<term>Functional Laterality</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Young Adult</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Numerous brain imaging studies have demonstrated structural changes in the basal ganglia, thalamus, sensorimotor cortex, and cerebellum across different forms of primary dystonia. However, our understanding of brain abnormalities contributing to the clinically well-described phenomenon of task specificity in dystonia remained limited. We used high-resolution magnetic resonance imaging (MRI) with voxel-based morphometry and diffusion weighted imaging with tract-based spatial statistics of fractional anisotropy to examine gray and white matter organization in two task-specific dystonia forms, writer's cramp and laryngeal dystonia, and two non-task-specific dystonia forms, cervical dystonia and blepharospasm. A direct comparison between both dystonia forms indicated that characteristic gray matter volumetric changes in task-specific dystonia involve the brain regions responsible for sensorimotor control during writing and speaking, such as primary somatosensory cortex, middle frontal gyrus, superior/inferior temporal gyrus, middle/posterior cingulate cortex, and occipital cortex as well as the striatum and cerebellum (lobules VI-VIIa). These gray matter changes were accompanied by white matter abnormalities in the premotor cortex, middle/inferior frontal gyrus, genu of the corpus callosum, anterior limb/genu of the internal capsule, and putamen. Conversely, gray matter volumetric changes in the non-task-specific group were limited to the left cerebellum (lobule VIIa) only, whereas white matter alterations were found to underlie the primary sensorimotor cortex, inferior parietal lobule, and middle cingulate gyrus. Distinct microstructural patterns in task-specific and non-task-specific dystonias may represent neuroimaging markers and provide evidence that these two dystonia subclasses likely follow divergent pathophysiological mechanisms precipitated by different triggers.</div>
</front>
</TEI>
</pubmed>
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