The value of putaminal diffusion imaging versus 18-fluorodeoxyglucose positron emission tomography for the differential diagnosis of the Parkinson variant of multiple system atrophy.
Identifieur interne : 003E25 ( Ncbi/Merge ); précédent : 003E24; suivant : 003E26The value of putaminal diffusion imaging versus 18-fluorodeoxyglucose positron emission tomography for the differential diagnosis of the Parkinson variant of multiple system atrophy.
Auteurs : Simon Baudrexel [Allemagne] ; Carola Seifried ; Bianca Penndorf ; Johannes C. Klein ; Marcus Middendorp ; Helmuth Steinmetz ; Frank Grünwald ; Rüdiger HilkerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Diagnosis, Differential, Diffusion Magnetic Resonance Imaging (methods), Female, Fluorodeoxyglucose F18 (diagnostic use), Humans, Male, Middle Aged, Multiple System Atrophy (pathology), Multiple System Atrophy (radionuclide imaging), Parkinsonian Disorders (pathology), Parkinsonian Disorders (radionuclide imaging), Positron-Emission Tomography (methods), Putamen (pathology).
- MESH :
- chemical , diagnostic use : Fluorodeoxyglucose F18.
- methods : Diffusion Magnetic Resonance Imaging, Positron-Emission Tomography.
- pathology : Multiple System Atrophy, Parkinsonian Disorders, Putamen.
- radionuclide imaging : Multiple System Atrophy, Parkinsonian Disorders.
- Aged, Aged, 80 and over, Diagnosis, Differential, Female, Humans, Male, Middle Aged.
Abstract
Differentiating the Parkinson variant of multiple system atrophy (MSA-P) from idiopathic Parkinson's disease (PD) and other forms of atypical parkinsonism can be difficult because symptoms overlap considerably. 18-Fluorodeoxyglucose positron emission tomography (FDG-PET) is a powerful imaging technique that can assist in the diagnosis of MSA-P via detection of putaminal and cerebellar hypometabolism. Recent studies suggest that diffusion-weighted imaging (DWI) might be of similar diagnostic value, as it can detect microstructural damage in the putamen by means of an increased mean diffusivity (MD). The aim of this study was a direct comparison of DWI and FDG-PET by using both methods on the same subject cohort. To this end, combined DWI and FDG-PET were employed in patients with MSA-P (n = 11), PD (n = 13), progressive supranuclear palsy (n = 8), and in 6 control subjects. MD values and FDG uptake ratios were derived from volumetric parcellations of the putamen and subjected to further analysis of covariance (ANCOVA) and receiver operating characteristics analyses. MSA-P was found to be associated with an increased posterior putaminal MD (P < 0.001 in all subgroup comparisons) that correlated strongly with local reductions in FDG uptake (r = -0.85, P = 0.002). DWI discriminated patients with MSA-P from other subgroups nearly as accurately as FDG-PET (area under the curve = 0.89 vs 0.95, P = 0.27 [pooled data]). Our data suggest a close association between the amount of putaminal microstructural damage and a reduced energy metabolism in patients with MSA-P. The clinical use of DWI for the differential diagnosis of MSA-P is encouraged.
DOI: 10.1002/mds.25749
PubMed: 24243813
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Klein</name></author><author><name sortKey="Middendorp, Marcus" sort="Middendorp, Marcus" uniqKey="Middendorp M" first="Marcus" last="Middendorp">Marcus Middendorp</name></author><author><name sortKey="Steinmetz, Helmuth" sort="Steinmetz, Helmuth" uniqKey="Steinmetz H" first="Helmuth" last="Steinmetz">Helmuth Steinmetz</name></author><author><name sortKey="Grunwald, Frank" sort="Grunwald, Frank" uniqKey="Grunwald F" first="Frank" last="Grünwald">Frank Grünwald</name></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24243813</idno><idno type="pmid">24243813</idno><idno type="doi">10.1002/mds.25749</idno><idno type="wicri:Area/PubMed/Corpus">000672</idno><idno type="wicri:Area/PubMed/Curation">000672</idno><idno type="wicri:Area/PubMed/Checkpoint">000380</idno><idno type="wicri:Area/Ncbi/Merge">003E25</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The value of putaminal diffusion imaging versus 18-fluorodeoxyglucose positron emission tomography for the differential diagnosis of the Parkinson variant of multiple system atrophy.</title><author><name sortKey="Baudrexel, Simon" sort="Baudrexel, Simon" uniqKey="Baudrexel S" first="Simon" last="Baudrexel">Simon Baudrexel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany; Brain Imaging Center, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany; Brain Imaging Center, Goethe University Frankfurt am Main, Frankfurt am Main</wicri:regionArea><wicri:noRegion>Frankfurt am Main</wicri:noRegion><wicri:noRegion>Frankfurt am Main</wicri:noRegion><wicri:noRegion>Frankfurt am Main</wicri:noRegion></affiliation></author><author><name sortKey="Seifried, Carola" sort="Seifried, Carola" uniqKey="Seifried C" first="Carola" last="Seifried">Carola Seifried</name></author><author><name sortKey="Penndorf, Bianca" sort="Penndorf, Bianca" uniqKey="Penndorf B" first="Bianca" last="Penndorf">Bianca Penndorf</name></author><author><name sortKey="Klein, Johannes C" sort="Klein, Johannes C" uniqKey="Klein J" first="Johannes C" last="Klein">Johannes C. Klein</name></author><author><name sortKey="Middendorp, Marcus" sort="Middendorp, Marcus" uniqKey="Middendorp M" first="Marcus" last="Middendorp">Marcus Middendorp</name></author><author><name sortKey="Steinmetz, Helmuth" sort="Steinmetz, Helmuth" uniqKey="Steinmetz H" first="Helmuth" last="Steinmetz">Helmuth Steinmetz</name></author><author><name sortKey="Grunwald, Frank" sort="Grunwald, Frank" uniqKey="Grunwald F" first="Frank" last="Grünwald">Frank Grünwald</name></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Diagnosis, Differential</term><term>Diffusion Magnetic Resonance Imaging (methods)</term><term>Female</term><term>Fluorodeoxyglucose F18 (diagnostic use)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (pathology)</term><term>Multiple System Atrophy (radionuclide imaging)</term><term>Parkinsonian Disorders (pathology)</term><term>Parkinsonian Disorders (radionuclide imaging)</term><term>Positron-Emission Tomography (methods)</term><term>Putamen (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Fluorodeoxyglucose F18</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diffusion Magnetic Resonance Imaging</term><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinsonian Disorders</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Differentiating the Parkinson variant of multiple system atrophy (MSA-P) from idiopathic Parkinson's disease (PD) and other forms of atypical parkinsonism can be difficult because symptoms overlap considerably. 18-Fluorodeoxyglucose positron emission tomography (FDG-PET) is a powerful imaging technique that can assist in the diagnosis of MSA-P via detection of putaminal and cerebellar hypometabolism. Recent studies suggest that diffusion-weighted imaging (DWI) might be of similar diagnostic value, as it can detect microstructural damage in the putamen by means of an increased mean diffusivity (MD). The aim of this study was a direct comparison of DWI and FDG-PET by using both methods on the same subject cohort. To this end, combined DWI and FDG-PET were employed in patients with MSA-P (n = 11), PD (n = 13), progressive supranuclear palsy (n = 8), and in 6 control subjects. MD values and FDG uptake ratios were derived from volumetric parcellations of the putamen and subjected to further analysis of covariance (ANCOVA) and receiver operating characteristics analyses. MSA-P was found to be associated with an increased posterior putaminal MD (P < 0.001 in all subgroup comparisons) that correlated strongly with local reductions in FDG uptake (r = -0.85, P = 0.002). DWI discriminated patients with MSA-P from other subgroups nearly as accurately as FDG-PET (area under the curve = 0.89 vs 0.95, P = 0.27 [pooled data]). Our data suggest a close association between the amount of putaminal microstructural damage and a reduced energy metabolism in patients with MSA-P. The clinical use of DWI for the differential diagnosis of MSA-P is encouraged.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24243813</PMID><DateCreated><Year>2014</Year><Month>03</Month><Day>18</Day></DateCreated><DateCompleted><Year>2014</Year><Month>12</Month><Day>01</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>3</Issue><PubDate><Year>2014</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>The value of putaminal diffusion imaging versus 18-fluorodeoxyglucose positron emission tomography for the differential diagnosis of the Parkinson variant of multiple system atrophy.</ArticleTitle><Pagination><MedlinePgn>380-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25749</ELocationID><Abstract><AbstractText>Differentiating the Parkinson variant of multiple system atrophy (MSA-P) from idiopathic Parkinson's disease (PD) and other forms of atypical parkinsonism can be difficult because symptoms overlap considerably. 18-Fluorodeoxyglucose positron emission tomography (FDG-PET) is a powerful imaging technique that can assist in the diagnosis of MSA-P via detection of putaminal and cerebellar hypometabolism. Recent studies suggest that diffusion-weighted imaging (DWI) might be of similar diagnostic value, as it can detect microstructural damage in the putamen by means of an increased mean diffusivity (MD). The aim of this study was a direct comparison of DWI and FDG-PET by using both methods on the same subject cohort. To this end, combined DWI and FDG-PET were employed in patients with MSA-P (n = 11), PD (n = 13), progressive supranuclear palsy (n = 8), and in 6 control subjects. MD values and FDG uptake ratios were derived from volumetric parcellations of the putamen and subjected to further analysis of covariance (ANCOVA) and receiver operating characteristics analyses. MSA-P was found to be associated with an increased posterior putaminal MD (P < 0.001 in all subgroup comparisons) that correlated strongly with local reductions in FDG uptake (r = -0.85, P = 0.002). DWI discriminated patients with MSA-P from other subgroups nearly as accurately as FDG-PET (area under the curve = 0.89 vs 0.95, P = 0.27 [pooled data]). Our data suggest a close association between the amount of putaminal microstructural damage and a reduced energy metabolism in patients with MSA-P. The clinical use of DWI for the differential diagnosis of MSA-P is encouraged.</AbstractText><CopyrightInformation>© 2013 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Baudrexel</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany; Brain Imaging Center, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seifried</LastName><ForeName>Carola</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Penndorf</LastName><ForeName>Bianca</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Klein</LastName><ForeName>Johannes C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Middendorp</LastName><ForeName>Marcus</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Steinmetz</LastName><ForeName>Helmuth</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Grünwald</LastName><ForeName>Frank</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Hilker</LastName><ForeName>Rüdiger</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>11</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0Z5B2CJX4D</RegistryNumber><NameOfSubstance UI="D019788">Fluorodeoxyglucose F18</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D003937">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D038524">Diffusion Magnetic Resonance Imaging</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019788">Fluorodeoxyglucose F18</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000176">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019578">Multiple System Atrophy</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020734">Parkinsonian Disorders</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D049268">Positron-Emission Tomography</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011699">Putamen</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">PET</Keyword><Keyword MajorTopicYN="N">diffusion-weighted imaging</Keyword><Keyword MajorTopicYN="N">mean diffusivity</Keyword><Keyword MajorTopicYN="N">multiple system atrophy</Keyword><Keyword MajorTopicYN="N">volumetry</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>2</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>10</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>10</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2013</Year><Month>11</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>11</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>11</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24243813</ArticleId><ArticleId IdType="doi">10.1002/mds.25749</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Grunwald, Frank" sort="Grunwald, Frank" uniqKey="Grunwald F" first="Frank" last="Grünwald">Frank Grünwald</name><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name><name sortKey="Klein, Johannes C" sort="Klein, Johannes C" uniqKey="Klein J" first="Johannes C" last="Klein">Johannes C. Klein</name><name sortKey="Middendorp, Marcus" sort="Middendorp, Marcus" uniqKey="Middendorp M" first="Marcus" last="Middendorp">Marcus Middendorp</name><name sortKey="Penndorf, Bianca" sort="Penndorf, Bianca" uniqKey="Penndorf B" first="Bianca" last="Penndorf">Bianca Penndorf</name><name sortKey="Seifried, Carola" sort="Seifried, Carola" uniqKey="Seifried C" first="Carola" last="Seifried">Carola Seifried</name><name sortKey="Steinmetz, Helmuth" sort="Steinmetz, Helmuth" uniqKey="Steinmetz H" first="Helmuth" last="Steinmetz">Helmuth Steinmetz</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Baudrexel, Simon" sort="Baudrexel, Simon" uniqKey="Baudrexel S" first="Simon" last="Baudrexel">Simon Baudrexel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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