Movement Disorders (revue)

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Association of Tef polymorphism with depression in Parkinson disease.

Identifieur interne : 003888 ( Ncbi/Merge ); précédent : 003887; suivant : 003889

Association of Tef polymorphism with depression in Parkinson disease.

Auteurs : Ping Hua [République populaire de Chine] ; Weiguo Liu ; Sheng-Han Kuo ; Yanyan Zhao ; Ling Chen ; Ning Zhang ; Chun Wang ; Suwan Guo ; Li Wang ; Hong Xiao ; Justin Y. Kwan ; Tianxia Wu

Source :

RBID : pubmed:23138696

English descriptors

Abstract

Circadian rhythm disturbance has been implicated in depression, and polymorphisms of circadian genes Cry1, Cry2, and Tef are associated with depression. However, the relationship between these genes and depression symptoms in Parkinson's disease (PD) has not been established.

DOI: 10.1002/mds.25195
PubMed: 23138696

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pubmed:23138696

Le document en format XML

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<name sortKey="Hua, Ping" sort="Hua, Ping" uniqKey="Hua P" first="Ping" last="Hua">Ping Hua</name>
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<nlm:affiliation>Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
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<name sortKey="Liu, Weiguo" sort="Liu, Weiguo" uniqKey="Liu W" first="Weiguo" last="Liu">Weiguo Liu</name>
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<name sortKey="Kuo, Sheng Han" sort="Kuo, Sheng Han" uniqKey="Kuo S" first="Sheng-Han" last="Kuo">Sheng-Han Kuo</name>
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<name sortKey="Zhao, Yanyan" sort="Zhao, Yanyan" uniqKey="Zhao Y" first="Yanyan" last="Zhao">Yanyan Zhao</name>
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<name sortKey="Chen, Ling" sort="Chen, Ling" uniqKey="Chen L" first="Ling" last="Chen">Ling Chen</name>
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<name sortKey="Zhang, Ning" sort="Zhang, Ning" uniqKey="Zhang N" first="Ning" last="Zhang">Ning Zhang</name>
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<name sortKey="Wang, Chun" sort="Wang, Chun" uniqKey="Wang C" first="Chun" last="Wang">Chun Wang</name>
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<name sortKey="Guo, Suwan" sort="Guo, Suwan" uniqKey="Guo S" first="Suwan" last="Guo">Suwan Guo</name>
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<name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name>
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<name sortKey="Xiao, Hong" sort="Xiao, Hong" uniqKey="Xiao H" first="Hong" last="Xiao">Hong Xiao</name>
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<name sortKey="Kwan, Justin Y" sort="Kwan, Justin Y" uniqKey="Kwan J" first="Justin Y" last="Kwan">Justin Y. Kwan</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<name sortKey="Liu, Weiguo" sort="Liu, Weiguo" uniqKey="Liu W" first="Weiguo" last="Liu">Weiguo Liu</name>
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<name sortKey="Kuo, Sheng Han" sort="Kuo, Sheng Han" uniqKey="Kuo S" first="Sheng-Han" last="Kuo">Sheng-Han Kuo</name>
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<name sortKey="Zhao, Yanyan" sort="Zhao, Yanyan" uniqKey="Zhao Y" first="Yanyan" last="Zhao">Yanyan Zhao</name>
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<name sortKey="Chen, Ling" sort="Chen, Ling" uniqKey="Chen L" first="Ling" last="Chen">Ling Chen</name>
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<name sortKey="Zhang, Ning" sort="Zhang, Ning" uniqKey="Zhang N" first="Ning" last="Zhang">Ning Zhang</name>
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<name sortKey="Wang, Chun" sort="Wang, Chun" uniqKey="Wang C" first="Chun" last="Wang">Chun Wang</name>
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<name sortKey="Guo, Suwan" sort="Guo, Suwan" uniqKey="Guo S" first="Suwan" last="Guo">Suwan Guo</name>
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<name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name>
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<name sortKey="Xiao, Hong" sort="Xiao, Hong" uniqKey="Xiao H" first="Hong" last="Xiao">Hong Xiao</name>
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<name sortKey="Kwan, Justin Y" sort="Kwan, Justin Y" uniqKey="Kwan J" first="Justin Y" last="Kwan">Justin Y. Kwan</name>
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<name sortKey="Wu, Tianxia" sort="Wu, Tianxia" uniqKey="Wu T" first="Tianxia" last="Wu">Tianxia Wu</name>
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<title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
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<term>Basic-Leucine Zipper Transcription Factors (genetics)</term>
<term>Cryptochromes (genetics)</term>
<term>Depression (etiology)</term>
<term>Depression (genetics)</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Association Studies</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Status Schedule</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>Basic-Leucine Zipper Transcription Factors</term>
<term>Cryptochromes</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en">
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en">
<term>Depression</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Depression</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
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<term>Aged</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Association Studies</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Status Schedule</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
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<front>
<div type="abstract" xml:lang="en">Circadian rhythm disturbance has been implicated in depression, and polymorphisms of circadian genes Cry1, Cry2, and Tef are associated with depression. However, the relationship between these genes and depression symptoms in Parkinson's disease (PD) has not been established.</div>
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<PMID Version="1">23138696</PMID>
<DateCreated>
<Year>2012</Year>
<Month>11</Month>
<Day>29</Day>
</DateCreated>
<DateCompleted>
<Year>2013</Year>
<Month>05</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised>
<Year>2014</Year>
<Month>05</Month>
<Day>08</Day>
</DateRevised>
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<ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>27</Volume>
<Issue>13</Issue>
<PubDate>
<Year>2012</Year>
<Month>Nov</Month>
</PubDate>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>Association of Tef polymorphism with depression in Parkinson disease.</ArticleTitle>
<Pagination>
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<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25195</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Circadian rhythm disturbance has been implicated in depression, and polymorphisms of circadian genes Cry1, Cry2, and Tef are associated with depression. However, the relationship between these genes and depression symptoms in Parkinson's disease (PD) has not been established.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Four hundred eight subjects with PD participated in this study. Demographics, UPDRS, Mini-Mental Status Examination (MMSE), and Hamilton Rating Scale for Depression (HAMD) were obtained in all subjects. Frequency of polymorphisms of Cry1 rs2287161, Cry2 rs10838524, and Tef rs738499 was determined, and the association between genetic polymorphisms of circadian genes and HAMD scores in patients with PD was examined.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Tef, but not Cry1 or Cry2, is associated with HAMD scores in patients with PD in a linear regression model after adjusting for clinical variables (P = 0.004).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The polymorphism of Tef rs738499 is associated with depression symptoms in PD.</AbstractText>
<CopyrightInformation>Copyright © 2012 Movement Disorder Society.</CopyrightInformation>
</Abstract>
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<ForeName>Ping</ForeName>
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