Movement Disorders (revue)

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Bilateral subthalamic nucleus stimulation for generalized dystonia after bilateral pallidotomy.

Identifieur interne : 003849 ( Ncbi/Merge ); précédent : 003848; suivant : 003850

Bilateral subthalamic nucleus stimulation for generalized dystonia after bilateral pallidotomy.

Auteurs : Erich Talamoni Fonoff [Brésil] ; Wuilker Knoner Campos ; Maurício Mandel ; Eduardo Joaquim Lopes Alho ; Manoel Jacobsen Teixeira

Source :

RBID : pubmed:23038611

English descriptors

Abstract

Thalamotomies and pallidotomies were commonly performed before the deep brain stimulation (DBS) era. Although ablative procedures can lead to significant dystonia improvement, longer periods of analysis reveal disease progression and functional deterioration. Today, the same patients seek additional treatment possibilities.

DOI: 10.1002/mds.25127
PubMed: 23038611

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pubmed:23038611

Le document en format XML

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<title xml:lang="en">Bilateral subthalamic nucleus stimulation for generalized dystonia after bilateral pallidotomy.</title>
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<name sortKey="Fonoff, Erich Talamoni" sort="Fonoff, Erich Talamoni" uniqKey="Fonoff E" first="Erich Talamoni" last="Fonoff">Erich Talamoni Fonoff</name>
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<nlm:affiliation>Division of Functional Neurosurgery, Department of Neurology of School of Medicine of University of São Paulo, São Paulo SP, Brazil. fonoffet@usp.br</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Division of Functional Neurosurgery, Department of Neurology of School of Medicine of University of São Paulo, São Paulo SP</wicri:regionArea>
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<name sortKey="Campos, Wuilker Knoner" sort="Campos, Wuilker Knoner" uniqKey="Campos W" first="Wuilker Knoner" last="Campos">Wuilker Knoner Campos</name>
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<name sortKey="Mandel, Mauricio" sort="Mandel, Mauricio" uniqKey="Mandel M" first="Maurício" last="Mandel">Maurício Mandel</name>
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<name sortKey="Alho, Eduardo Joaquim Lopes" sort="Alho, Eduardo Joaquim Lopes" uniqKey="Alho E" first="Eduardo Joaquim Lopes" last="Alho">Eduardo Joaquim Lopes Alho</name>
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<name sortKey="Teixeira, Manoel Jacobsen" sort="Teixeira, Manoel Jacobsen" uniqKey="Teixeira M" first="Manoel Jacobsen" last="Teixeira">Manoel Jacobsen Teixeira</name>
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<title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Female</term>
<term>Functional Laterality</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pallidotomy (methods)</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>Treatment Outcome</term>
<term>Young Adult</term>
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<term>Deep Brain Stimulation</term>
<term>Pallidotomy</term>
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<term>Subthalamic Nucleus</term>
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<term>Dystonic Disorders</term>
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<term>Adult</term>
<term>Female</term>
<term>Functional Laterality</term>
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<div type="abstract" xml:lang="en">Thalamotomies and pallidotomies were commonly performed before the deep brain stimulation (DBS) era. Although ablative procedures can lead to significant dystonia improvement, longer periods of analysis reveal disease progression and functional deterioration. Today, the same patients seek additional treatment possibilities.</div>
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<ArticleTitle>Bilateral subthalamic nucleus stimulation for generalized dystonia after bilateral pallidotomy.</ArticleTitle>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Thalamotomies and pallidotomies were commonly performed before the deep brain stimulation (DBS) era. Although ablative procedures can lead to significant dystonia improvement, longer periods of analysis reveal disease progression and functional deterioration. Today, the same patients seek additional treatment possibilities.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Four patients with generalized dystonia who previously had undergone bilateral pallidotomy came to our service seeking additional treatment because of dystonic symptom progression. Bilateral subthalamic nucleus DBS (B-STN-DBS) was the treatment of choice. The patients were evaluated with the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and the Unified Dystonia Rating Scale (UDRS) before and 2 years after surgery.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">All patients showed significant functional improvement, averaging 65.3% in BFMDRS (P = .014) and 69.2% in UDRS (P = .025).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results suggest that B-STN-DBS may be an interesting treatment option for generalized dystonia, even for patients who have already undergone bilateral pallidotomy.</AbstractText>
<CopyrightInformation>Copyright © 2012 Movement Disorder Society.</CopyrightInformation>
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