Brain Organochlorines and Lewy Pathology: The Honolulu-Asia Aging Study
Identifieur interne : 003815 ( Ncbi/Merge ); précédent : 003814; suivant : 003816Brain Organochlorines and Lewy Pathology: The Honolulu-Asia Aging Study
Auteurs : G. Webster Ross [États-Unis] ; John E. Duda [États-Unis] ; Robert D. Abbott [États-Unis] ; Edo Pellizzari [États-Unis] ; Helen Petrovitch [États-Unis] ; Diane B. Miller [États-Unis] ; James P. O Allaghan [États-Unis] ; Caroline M. Tanner [États-Unis] ; Joseph V. Noorigian [États-Unis] ; Kamal Masaki [États-Unis] ; Lenore Launer [États-Unis] ; Lon R. White [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Hydrocarbons, Chlorinated.
- geographic : Hawaii.
- metabolism : Brain.
- pathology : Aging, Brain, Lewy Bodies.
- Aged, Aged, 80 and over, Asian Americans, Cohort Studies, Humans, Male.
Abstract
Although organochlorines have been reported more frequently in Parkinson’s disease (PD) brains than controls, the association with brain Lewy pathology is unknown. Honolulu-Asia Aging Study (HAAS) participants, exposed to organochlorines from a variety of sources during mid-life, represent a population well suited to determine the relationship of brain organochlorines with Lewy pathology in decedents from the longitudinal HAAS.
Study design included the measurement of 21 organochlorine levels in frozen occipital lobe samples from HAAS decedents. Alpha-synuclein immunostaining performed on 225 brains was used to identify Lewy bodies and Lewy neurites.
With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found to be present in at least one brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. Prevalence of Lewy pathology was 75% (6/8) among brains with any 2 of the 3 compounds, 48.8% (79/162) among those with 1, and 32.7% (18/55) for those with neither (P=0.007 test for trend). While findings persisted after removing cases with PD and dementia with Lewy bodies, and when adjustments were made for age at death, body mass index, pack-years of cigarette smoking, and coffee intake (p=0.013), results were insignificant when correcting for multiple testing.
While consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study.
Url:
DOI: 10.1002/mds.25144
PubMed: 22976848
PubMed Central: 3474594
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Brain Organochlorines and Lewy Pathology: The Honolulu-Asia Aging Study</title>
<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
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<author><name sortKey="O Allaghan, James P" sort="O Allaghan, James P" uniqKey="O Allaghan J" first="James P." last="O Allaghan">James P. O Allaghan</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
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<author><name sortKey="Noorigian, Joseph V" sort="Noorigian, Joseph V" uniqKey="Noorigian J" first="Joseph V." last="Noorigian">Joseph V. Noorigian</name>
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<author><name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore" sort="Launer, Lenore" uniqKey="Launer L" first="Lenore" last="Launer">Lenore Launer</name>
<affiliation wicri:level="2"><nlm:aff id="A12">National Institute on Aging, National Institutes of Health, Bethesda, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Institute on Aging, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Aging (pathology)</term>
<term>Asian Americans</term>
<term>Brain (metabolism)</term>
<term>Brain (pathology)</term>
<term>Cohort Studies</term>
<term>Hawaii</term>
<term>Humans</term>
<term>Hydrocarbons, Chlorinated (metabolism)</term>
<term>Lewy Bodies (pathology)</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hydrocarbons, Chlorinated</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Hawaii</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aging</term>
<term>Brain</term>
<term>Lewy Bodies</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Asian Americans</term>
<term>Cohort Studies</term>
<term>Humans</term>
<term>Male</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Although organochlorines have been reported more frequently in Parkinson’s disease (PD) brains than controls, the association with brain Lewy pathology is unknown. Honolulu-Asia Aging Study (HAAS) participants, exposed to organochlorines from a variety of sources during mid-life, represent a population well suited to determine the relationship of brain organochlorines with Lewy pathology in decedents from the longitudinal HAAS.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Study design included the measurement of 21 organochlorine levels in frozen occipital lobe samples from HAAS decedents. Alpha-synuclein immunostaining performed on 225 brains was used to identify Lewy bodies and Lewy neurites.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found to be present in at least one brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. Prevalence of Lewy pathology was 75% (6/8) among brains with any 2 of the 3 compounds, 48.8% (79/162) among those with 1, and 32.7% (18/55) for those with neither (P=0.007 test for trend). While findings persisted after removing cases with PD and dementia with Lewy bodies, and when adjustments were made for age at death, body mass index, pack-years of cigarette smoking, and coffee intake (p=0.013), results were insignificant when correcting for multiple testing.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">While consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study.</p>
</sec>
</div>
</front>
</TEI>
<double pmid="22976848"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain Organochlorines and Lewy Pathology: The Honolulu-Asia Aging Study</title>
<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Veterans Affairs Pacific Islands Health Care System, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Pacific Health Research and Education Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research and Education Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Duda, John E" sort="Duda, John E" uniqKey="Duda J" first="John E." last="Duda">John E. Duda</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Philadelphia Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia, Pennsylvania</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A7">Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Perelman School of Medicine at the University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Pacific Health Research and Education Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research and Education Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A8">Division of Biostatistics, University of Virginia School of Medicine, Charlottesville, Virginia</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
<wicri:cityArea>Division of Biostatistics, University of Virginia School of Medicine, Charlottesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pellizzari, Edo" sort="Pellizzari, Edo" uniqKey="Pellizzari E" first="Edo" last="Pellizzari">Edo Pellizzari</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Research Triangle Institute, Research Triangle Park, North Carolina</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Research Triangle Institute, Research Triangle Park</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Veterans Affairs Pacific Islands Health Care System, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Pacific Health Research and Education Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research and Education Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Miller, Diane B" sort="Miller, Diane B" uniqKey="Miller D" first="Diane B." last="Miller">Diane B. Miller</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Centers for Disease Control, National Institute for Occupational Safety and Health, Morgantown, West Virginia</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie-Occidentale</region>
</placeName>
<wicri:cityArea>Centers for Disease Control, National Institute for Occupational Safety and Health, Morgantown</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="O Allaghan, James P" sort="O Allaghan, James P" uniqKey="O Allaghan J" first="James P." last="O Allaghan">James P. O Allaghan</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Centers for Disease Control, National Institute for Occupational Safety and Health, Morgantown, West Virginia</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie-Occidentale</region>
</placeName>
<wicri:cityArea>Centers for Disease Control, National Institute for Occupational Safety and Health, Morgantown</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<affiliation wicri:level="2"><nlm:aff id="A11">The Parkinson’s Institute, Sunnyvale, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Noorigian, Joseph V" sort="Noorigian, Joseph V" uniqKey="Noorigian J" first="Joseph V." last="Noorigian">Joseph V. Noorigian</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Philadelphia Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia, Pennsylvania</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore" sort="Launer, Lenore" uniqKey="Launer L" first="Lenore" last="Launer">Lenore Launer</name>
<affiliation wicri:level="2"><nlm:aff id="A12">National Institute on Aging, National Institutes of Health, Bethesda, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Institute on Aging, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22976848</idno>
<idno type="pmc">3474594</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474594</idno>
<idno type="RBID">PMC:3474594</idno>
<idno type="doi">10.1002/mds.25144</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">000287</idno>
<idno type="wicri:Area/Pmc/Curation">000287</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000209</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Brain Organochlorines and Lewy Pathology: The Honolulu-Asia Aging Study</title>
<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Veterans Affairs Pacific Islands Health Care System, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Pacific Health Research and Education Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research and Education Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Duda, John E" sort="Duda, John E" uniqKey="Duda J" first="John E." last="Duda">John E. Duda</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Philadelphia Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia, Pennsylvania</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A7">Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Perelman School of Medicine at the University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Pacific Health Research and Education Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research and Education Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A8">Division of Biostatistics, University of Virginia School of Medicine, Charlottesville, Virginia</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
<wicri:cityArea>Division of Biostatistics, University of Virginia School of Medicine, Charlottesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pellizzari, Edo" sort="Pellizzari, Edo" uniqKey="Pellizzari E" first="Edo" last="Pellizzari">Edo Pellizzari</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Research Triangle Institute, Research Triangle Park, North Carolina</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Research Triangle Institute, Research Triangle Park</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Veterans Affairs Pacific Islands Health Care System, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Pacific Health Research and Education Institute, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research and Education Institute, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Miller, Diane B" sort="Miller, Diane B" uniqKey="Miller D" first="Diane B." last="Miller">Diane B. Miller</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Centers for Disease Control, National Institute for Occupational Safety and Health, Morgantown, West Virginia</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie-Occidentale</region>
</placeName>
<wicri:cityArea>Centers for Disease Control, National Institute for Occupational Safety and Health, Morgantown</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="O Allaghan, James P" sort="O Allaghan, James P" uniqKey="O Allaghan J" first="James P." last="O Allaghan">James P. O Allaghan</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Centers for Disease Control, National Institute for Occupational Safety and Health, Morgantown, West Virginia</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie-Occidentale</region>
</placeName>
<wicri:cityArea>Centers for Disease Control, National Institute for Occupational Safety and Health, Morgantown</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<affiliation wicri:level="2"><nlm:aff id="A11">The Parkinson’s Institute, Sunnyvale, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson’s Institute, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Noorigian, Joseph V" sort="Noorigian, Joseph V" uniqKey="Noorigian J" first="Joseph V." last="Noorigian">Joseph V. Noorigian</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Philadelphia Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia, Pennsylvania</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore" sort="Launer, Lenore" uniqKey="Launer L" first="Lenore" last="Launer">Lenore Launer</name>
<affiliation wicri:level="2"><nlm:aff id="A12">National Institute on Aging, National Institutes of Health, Bethesda, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Institute on Aging, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Kuakini Medical Center/ Honolulu-Asia Aging Study, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Department of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Although organochlorines have been reported more frequently in Parkinson’s disease (PD) brains than controls, the association with brain Lewy pathology is unknown. Honolulu-Asia Aging Study (HAAS) participants, exposed to organochlorines from a variety of sources during mid-life, represent a population well suited to determine the relationship of brain organochlorines with Lewy pathology in decedents from the longitudinal HAAS.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Study design included the measurement of 21 organochlorine levels in frozen occipital lobe samples from HAAS decedents. Alpha-synuclein immunostaining performed on 225 brains was used to identify Lewy bodies and Lewy neurites.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found to be present in at least one brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. Prevalence of Lewy pathology was 75% (6/8) among brains with any 2 of the 3 compounds, 48.8% (79/162) among those with 1, and 32.7% (18/55) for those with neither (P=0.007 test for trend). While findings persisted after removing cases with PD and dementia with Lewy bodies, and when adjustments were made for age at death, body mass index, pack-years of cigarette smoking, and coffee intake (p=0.013), results were insignificant when correcting for multiple testing.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">While consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study.</p>
</sec>
</div>
</front>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain organochlorines and Lewy pathology: the Honolulu-Asia Aging Study.</title>
<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name>
<affiliation wicri:level="1"><nlm:affiliation>Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii 96819, USA. george.ross@va.gov</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii 96819</wicri:regionArea>
<wicri:noRegion>Hawaii 96819</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Duda, John E" sort="Duda, John E" uniqKey="Duda J" first="John E" last="Duda">John E. Duda</name>
</author>
<author><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D" last="Abbott">Robert D. Abbott</name>
</author>
<author><name sortKey="Pellizzari, Edo" sort="Pellizzari, Edo" uniqKey="Pellizzari E" first="Edo" last="Pellizzari">Edo Pellizzari</name>
</author>
<author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
</author>
<author><name sortKey="Miller, Diane B" sort="Miller, Diane B" uniqKey="Miller D" first="Diane B" last="Miller">Diane B. Miller</name>
</author>
<author><name sortKey="O Callaghan, James P" sort="O Callaghan, James P" uniqKey="O Callaghan J" first="James P" last="O'Callaghan">James P. O'Callaghan</name>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name>
</author>
<author><name sortKey="Noorigian, Joseph V" sort="Noorigian, Joseph V" uniqKey="Noorigian J" first="Joseph V" last="Noorigian">Joseph V. Noorigian</name>
</author>
<author><name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name>
</author>
<author><name sortKey="Launer, Lenore" sort="Launer, Lenore" uniqKey="Launer L" first="Lenore" last="Launer">Lenore Launer</name>
</author>
<author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R" last="White">Lon R. White</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2012">2012</date>
<idno type="doi">10.1002/mds.25144</idno>
<idno type="RBID">pubmed:22976848</idno>
<idno type="pmid">22976848</idno>
<idno type="wicri:Area/PubMed/Corpus">000C47</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Brain organochlorines and Lewy pathology: the Honolulu-Asia Aging Study.</title>
<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name>
<affiliation wicri:level="1"><nlm:affiliation>Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii 96819, USA. george.ross@va.gov</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii 96819</wicri:regionArea>
<wicri:noRegion>Hawaii 96819</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Duda, John E" sort="Duda, John E" uniqKey="Duda J" first="John E" last="Duda">John E. Duda</name>
</author>
<author><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D" last="Abbott">Robert D. Abbott</name>
</author>
<author><name sortKey="Pellizzari, Edo" sort="Pellizzari, Edo" uniqKey="Pellizzari E" first="Edo" last="Pellizzari">Edo Pellizzari</name>
</author>
<author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
</author>
<author><name sortKey="Miller, Diane B" sort="Miller, Diane B" uniqKey="Miller D" first="Diane B" last="Miller">Diane B. Miller</name>
</author>
<author><name sortKey="O Callaghan, James P" sort="O Callaghan, James P" uniqKey="O Callaghan J" first="James P" last="O'Callaghan">James P. O'Callaghan</name>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name>
</author>
<author><name sortKey="Noorigian, Joseph V" sort="Noorigian, Joseph V" uniqKey="Noorigian J" first="Joseph V" last="Noorigian">Joseph V. Noorigian</name>
</author>
<author><name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name>
</author>
<author><name sortKey="Launer, Lenore" sort="Launer, Lenore" uniqKey="Launer L" first="Lenore" last="Launer">Lenore Launer</name>
</author>
<author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R" last="White">Lon R. White</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2012" type="published">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
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<term>Aged, 80 and over</term>
<term>Aging (pathology)</term>
<term>Asian Americans</term>
<term>Brain (metabolism)</term>
<term>Brain (pathology)</term>
<term>Cohort Studies</term>
<term>Hawaii</term>
<term>Humans</term>
<term>Hydrocarbons, Chlorinated (metabolism)</term>
<term>Lewy Bodies (pathology)</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hydrocarbons, Chlorinated</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Hawaii</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aging</term>
<term>Brain</term>
<term>Lewy Bodies</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Asian Americans</term>
<term>Cohort Studies</term>
<term>Humans</term>
<term>Male</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Although organochlorines have been reported more frequently in Parkinson's disease (PD) brains than in controls, the association with brain Lewy pathology is unknown. Honolulu-Asia Aging Study (HAAS) participants, exposed to organochlorines from a variety of sources during midlife, represent a population well suited to determining the relationship of brain organochlorines with Lewy pathology in decedents from the longitudinal HAAS. The study design included the measurement of 21 organochlorine levels in frozen occipital lobe samples from HAAS decedents. Alpha-synuclein immunostaining performed on 225 brains was used to identify Lewy bodies and Lewy neurites. With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found in at least 1 brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. The prevalence of Lewy pathology was 75% (6 of 8) among brains with any 2 of the 3 compounds, 48.8% (79 of 162) among those with 1, and 32.7% (18 of 55) for those with neither (P = .007 test for trend). Although findings persisted after removing cases with PD and dementia with Lewy bodies and after adjustment for age at death, body mass index, pack-years of cigarette smoking, and coffee intake (P = .013), the results were insignificant when correcting for multiple testing. Although consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study.</div>
</front>
</TEI>
</pubmed>
</double>
</record>
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